Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0204 | 0.4632 | 0.4547 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0204 | 0.4632 | 0.4547 |
Echinococcus multilocularis | neuroligin | 0.0028 | 0.0281 | 0.0606 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0.0281 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0281 | 0.0281 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Giardia lamblia | Rrm3p helicase | 0.0204 | 0.4632 | 0.5 |
Trypanosoma cruzi | UDP-glucoronosyl and UDP-glucosyl transferase, putative | 0.0422 | 1 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0204 | 0.4632 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | UDP-glucoronosyl and UDP-glucosyl transferase | 0.0023 | 0.0157 | 0.0157 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0204 | 0.4632 | 0.4547 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3631 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.4632 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3631 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.3631 | 0.3631 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0028 | 0.0281 | 0.0606 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3631 | 0.3631 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0204 | 0.4632 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.3631 | 0.3631 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0157 | 0.0157 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0204 | 0.4632 | 0.5 |
Brugia malayi | UDP-glucoronosyl and UDP-glucosyl transferase family protein | 0.0023 | 0.0157 | 0.0433 |
Schistosoma mansoni | acetylcholinesterase | 0.0028 | 0.0281 | 0.0606 |
Echinococcus granulosus | neuroligin | 0.0028 | 0.0281 | 0.0606 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0281 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0204 | 0.4632 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0028 | 0.0281 | 0.0606 |
Mycobacterium leprae | Possible glycosyl transferase | 0.0023 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0157 | 0.0157 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0016 | 0.00000016146 | 0.00000034854 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0204 | 0.4632 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.3631 | 0.7838 |
Mycobacterium leprae | Possible glycosyl transferase | 0.0023 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0157 | 0.0157 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0204 | 0.4632 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0016 | 0.00000016146 | 0.00000034854 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0.0281 | 1 |
Mycobacterium leprae | Probable glycosyltransferase | 0.0023 | 0.0157 | 0.5 |
Mycobacterium leprae | possible glycosyltransferase | 0.0023 | 0.0157 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3631 | 0.3631 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0016 | 0.00000016146 | 0.00000034854 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0204 | 0.4632 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Schistosoma mansoni | hypothetical protein | 0.0204 | 0.4632 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.3631 | 0.7838 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0028 | 0.0281 | 0.0606 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0204 | 0.4632 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.3631 | 0.7838 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0281 | 0.0773 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0281 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.93 uM | Inhibition of human serum BuChE | ChEMBL. | 17008100 |
IC50 (binding) | = 0.93 uM | Inhibition of human serum BuChE | ChEMBL. | 17008100 |
IC50 (binding) | = 2.18 uM | Inhibition of human erythrocyte AchE | ChEMBL. | 17008100 |
IC50 (binding) | = 2.18 uM | Inhibition of human erythrocyte AchE | ChEMBL. | 17008100 |
Ratio IC50 (binding) | = 0.43 | Ratio of IC50 for BuChE to IC50 for AchE | ChEMBL. | 17008100 |
Ratio IC50 (binding) | = 2.34 | Ratio of IC50 for AchE to IC50 for BuChE | ChEMBL. | 17008100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.