Detailed information for compound 421588

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 220.307 | Formula: C14H20O2
  • H donors: 0 H acceptors: 0 LogP: 3.29 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1OO[C@@H](C=C1)C12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C14H20O2/c1-2-13(16-15-3-1)14-7-10-4-11(8-14)6-12(5-10)9-14/h1-2,10-13H,3-9H2/t10?,11?,12?,13-,14?/m0/s1
  • InChiKey: ZGFAIPFMYPMZJM-PRTVBDMESA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.006 0.218
Schistosoma mansoni coup transcription factor 0.0024 0.005 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0072 0.2608
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0029 0.0124
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1515 0.7163 1
Onchocerca volvulus 0.0073 0.0287 0.1155
Plasmodium falciparum glutathione reductase 0.0108 0.0453 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0022 0.0042 0.0926
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.006 0.218
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Echinococcus granulosus chromobox protein 1 0.0071 0.0277 0.0599
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.006 0.0084
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0116 0.4201
Schistosoma mansoni hypothetical protein 0.004 0.0127 0.0242
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.0234 0.0497
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0142 0.5136
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.006 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.005 0.0204
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.005 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0053 0.0816
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0177 0.3905
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0042 0.004
Brugia malayi Thioredoxin reductase 0.0108 0.0453 0.2127
Loa Loa (eye worm) hypoxia-induced factor 1 0.0307 0.14 0.6644
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.211 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Schistosoma mansoni aryl hydrocarbon receptor 0.0099 0.041 0.0917
Onchocerca volvulus 0.0454 0.2103 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0045 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0087 0.0378
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0029 0.065
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0042 0.0165
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0022 0.0042 0.0926
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Loa Loa (eye worm) hypothetical protein 0.005 0.0177 0.0809
Brugia malayi hypothetical protein 0.015 0.0655 0.3089
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.005 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0042 0.0165
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.0926
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0234 0.5157
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0029 0.065
Brugia malayi RNA binding protein 0.0074 0.0289 0.1344
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.022
Echinococcus granulosus dna polymerase kappa 0.0062 0.0234 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.006 0.218
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.005 0.0204
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Trichomonas vaginalis C-MYB, putative 0.0061 0.0227 0.8213
Onchocerca volvulus 0.0026 0.006 0.005
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0234 0.0497
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0116 0.2283
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0116 0.2565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.005 0.0204
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0053 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.4614
Mycobacterium tuberculosis Probable dehydrogenase 0.0247 0.1114 0.1532
Brugia malayi polk-prov protein 0.0019 0.0029 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Loa Loa (eye worm) hypothetical protein 0.0091 0.037 0.1731
Echinococcus multilocularis dna polymerase eta 0.0091 0.037 0.0822
Loa Loa (eye worm) transcription factor SMAD2 0.0389 0.1792 0.8518
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.006 0.0084
Echinococcus multilocularis muscleblind protein 0.0153 0.0668 0.1531
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0214 0.0986
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0064 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Echinococcus granulosus Smad4 0.0026 0.0064 0.0093
Plasmodium falciparum thioredoxin reductase 0.0108 0.0453 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.005 0.006
Loa Loa (eye worm) Smad1 0.0026 0.0064 0.027
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0234 0.108
Plasmodium falciparum phosphodiesterase delta, putative 0.0022 0.0042 0.0415
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.005 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.005 0.0204
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.006 0.218
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.018 0.0795 1
Echinococcus granulosus smad 0.0026 0.0064 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.005 0.0204
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0816
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0093
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0064 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0025 0.0084
Loa Loa (eye worm) glutathione reductase 0.0108 0.0453 0.2127
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.005 0.0204
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.005 0.0204
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0022 0.0042 0.004
Leishmania major hypothetical protein, conserved 0.005 0.0177 0.3905
Loa Loa (eye worm) runx1 0.0057 0.0209 0.0963
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0064 0.0093
Loa Loa (eye worm) hypothetical protein 0.0431 0.1991 0.9467
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0029
Echinococcus multilocularis chromobox protein 1 0.0071 0.0277 0.0599
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0277 0.1285
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0595 0.2774 0.2757
Brugia malayi hypothetical protein 0.0032 0.0092 0.0404
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.022
Schistosoma mansoni hypothetical protein 0.0899 0.4224 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0028 0.0069 0.0293
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0289 0.1344
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.006 0.218
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.006 0.218
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Onchocerca volvulus 0.0031 0.0087 0.0178
Giardia lamblia hypothetical protein 0.0022 0.0042 0.0163
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0042 0.004
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0582
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0116 0.0519
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0127 0.0569
Echinococcus multilocularis Smad4 0.0026 0.0064 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0029 0.065
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0289 0.0629
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0092
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0029 0.065
Echinococcus multilocularis thioredoxin glutathione reductase 0.0108 0.0453 0.102
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0247 0.1114 0.1532
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0655 0.15
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni nuclear hormone receptor 0.0024 0.005 0.006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.005 0.0204
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0274 0.1245 0.1716
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.005 0.006
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.005 0.006
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0177 0.0585
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0053 0.0048
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.0234 0.0497
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.005 0.006
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0158 0.0691 0.1586
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0105
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0029 0.065
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0116 0.2565
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0029 0.065
Brugia malayi bHLH-PAS transcription factor 0.0073 0.0287 0.1335
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0274 0.1245 0.1716
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.005 0.006
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0595 0.2774 0.3827
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.005 0.006
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0142 0.5136
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.005 0.0204
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.006 0.218
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Leishmania major DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0177 0.3905
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.0795 0.2827
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.118
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0029 0.065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0277 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0029 0.065
Echinococcus multilocularis smad 0.0026 0.0064 0.0093
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0029 0.065
Schistosoma mansoni hypothetical protein 0.0023 0.0045 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Schistosoma mansoni DNA polymerase eta 0.0091 0.037 0.0822
Loa Loa (eye worm) RecQ helicase 0.0025 0.0054 0.0224
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0028 0.0069 0.0293
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.022
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0116 0.2146
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0177 0.3562
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0234 0.8445
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0655 0.15
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0142 0.0448
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Brugia malayi hypoxia-induced factor 1 0.0307 0.14 0.6644
Trichomonas vaginalis pc-MYB2, putative 0.0061 0.0227 0.8213
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0142 0.3129
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0116 0.1133
Loa Loa (eye worm) hypothetical protein 0.0153 0.0668 0.3151
Brugia malayi TAR-binding protein 0.0074 0.0289 0.1344
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0072 0.2608
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0277 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0042 0.004
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus granulosus geminin 0.0899 0.4224 1
Brugia malayi steroid hormone receptor 0.0024 0.005 0.0204
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0116 0.0136
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0177 0.3674
Schistosoma mansoni lozenge 0.0057 0.0209 0.0438
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0029
Brugia malayi Heterochromatin protein 1 0.0071 0.0277 0.1285
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Giardia lamblia Hypothetical protein 0.0022 0.0042 0.0163
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni thyroid hormone receptor 0.0024 0.005 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi glutathione reductase 0.0108 0.0453 0.2127
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0029
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.027
Trypanosoma brucei trypanothione reductase 0.0108 0.0453 1
Echinococcus granulosus FTZ F1 alpha 0.0024 0.005 0.006
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0029 0.065
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0234 0.021
Brugia malayi hypothetical protein 0.005 0.0177 0.0809
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0042 0.0415
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.211 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.006 0.218
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.005 0.006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.0234 0.108
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0029 0.001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0116 0.0365
Echinococcus multilocularis Protein lozenge 0.0057 0.0209 0.0438
Echinococcus granulosus thioredoxin glutathione reductase 0.0108 0.0453 0.102
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0128 0.0378
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.005 0.006
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0022 0.0042 0.004
Brugia malayi PAS domain containing protein 0.0099 0.041 0.1921
Plasmodium falciparum glutathione reductase 0.0037 0.0116 0.2146
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Leishmania major DNA polymerase kappa, putative 0.0019 0.0029 0.065
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.005 0.0204
Echinococcus granulosus chromobox protein 1 0.0071 0.0277 0.0599
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0116 0.2565
Schistosoma mansoni hypothetical protein 0.0899 0.4224 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0022 0.0042 0.004
Trichomonas vaginalis MYB72, putative 0.0061 0.0227 0.8213
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.0234 0.3569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0053 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.005 0.0204
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis C-MYB, putative 0.0061 0.0227 0.8213
Loa Loa (eye worm) MH2 domain-containing protein 0.0389 0.1792 0.8518
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0454 0.2103 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0091 0.037 0.8168
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0022 0.0042 0.004
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0054 0.007
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0229 0.8263
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0582
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.006 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.005 0.0204
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0158 0.0691 0.3262
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0116 0.2146
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0668 0.1531
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0234 0.0497
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.004 0.0375
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Leishmania major protein kinase, putative 0.0026 0.006 0.1331
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0093
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.006 0.218
Brugia malayi nuclear hormone receptor 0.0024 0.005 0.0204
Leishmania major hypothetical protein, conserved 0.0022 0.0042 0.0926
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.005 0.006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0064 0.0093
Plasmodium falciparum phosphodiesterase gamma, putative 0.0022 0.0042 0.0415
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.005 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0214 0.0986
Echinococcus multilocularis chromobox protein 1 0.0071 0.0277 0.0599
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0569
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0247 0.1114 0.1532
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0042 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.005 0.0204
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0926
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.211 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0289 0.1344
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.027
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0042 0.004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.006 0.218
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0252
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0247 0.1114 0.1491
Trypanosoma brucei DNA polymerase eta, putative 0.0091 0.037 0.8168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0084
Brugia malayi Muscleblind-like protein 0.0153 0.0668 0.3151
Echinococcus granulosus dna polymerase eta 0.0091 0.037 0.0822
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.004
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Echinococcus multilocularis transfer RNA-Lys 0.0073 0.0287 0.0624
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.006 0.218
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0816
Schistosoma mansoni single-minded 0.0099 0.041 0.0917
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0158 0.0691 0.3262
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.005 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0165
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0022 0.0042 0.0165
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0165
Leishmania major hypothetical protein, conserved 0.0022 0.0042 0.0926
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0022 0.0042 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.005 0.0204
Brugia malayi chromobox protein homolog 3 0.004 0.0128 0.0574
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0029 0.005
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.006 0.1331
Loa Loa (eye worm) hypothetical protein 0.018 0.0795 0.376
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0926
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Trichomonas vaginalis MYB3r3, putative 0.0061 0.0227 0.8213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0042 0.0926
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.005 0.0204
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0116 0.2283
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.005 0.0204
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma brucei unspecified product 0.0062 0.0234 0.5157
Echinococcus granulosus bloom syndrome protein 0.0025 0.0054 0.007
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0116 0.2565
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0247 0.1114 0.1532
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.0234 0.0497
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0053 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.005 0.006
Leishmania major cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.005 0.0204
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0022 0.0042 0.0165
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0022 0.0042 0.0926
Loa Loa (eye worm) hypothetical protein 0.0058 0.0214 0.0986
Mycobacterium ulcerans hypothetical protein 0.0019 0.0029 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0108 0.0453 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0116 0.0365
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.005 0.006
Plasmodium vivax phosphodiesterase gamma, putative 0.0022 0.0042 0.0582
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0054 0.1967
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0574
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0582
Echinococcus granulosus muscleblind protein 0.0153 0.0668 0.1531
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0053 0.0029
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0053 0.0029
Loa Loa (eye worm) hypothetical protein 0.0332 0.1522 0.7229
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0274 0.1245 0.1676
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.006 0.0036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.005 0.006
Mycobacterium leprae Possible regulatory protein 0.0026 0.006 0.001
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0234 0.03
Loa Loa (eye worm) PDE1B protein 0.0022 0.0042 0.0165
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.037 0.1731
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0214 0.0986
Plasmodium falciparum thioredoxin reductase 0.0037 0.0116 0.2146
Schistosoma mansoni chromobox protein 0.0071 0.0277 0.0599
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.006 0.0084
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0022 0.0042 0.0926
Trypanosoma brucei unspecified product 0.0043 0.0142 0.3129
Mycobacterium ulcerans hypothetical protein 0.0024 0.0053 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1515 0.7163 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0042 0.1517
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0064 0.0093
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.005 0.006
Schistosoma mansoni chromobox protein 0.0071 0.0277 0.0599
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0061 0.0229 0.0772
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.005 0.006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0045 0.0047
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0108 0.0453 0.0607
Mycobacterium tuberculosis Probable oxidoreductase 0.0274 0.1245 0.1716
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0042 0.0926
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.005 0.0204
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0595 0.2774 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0526 0.2474
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0229 0.8263
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0022 0.0042 0.004
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.005 0.0204
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0042 0.0415
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0158 0.0691 0.1586
Giardia lamblia Myb 1-like protein 0.0061 0.0229 0.26
Brugia malayi nuclear receptor NHR-88 0.0024 0.005 0.0204
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.118
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.0165
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0024 0.0174
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.005 0.006
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0029 0.0295
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0116 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0177 0.3562
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0116 0.4201
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0116 0.2565
Leishmania major trypanothione reductase 0.0108 0.0453 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Schistosoma mansoni smad 0.0026 0.0064 0.0093
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.4614
Schistosoma mansoni Smad4 0.0026 0.0064 0.0093
Loa Loa (eye worm) RNA binding protein 0.0074 0.0289 0.1344
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0116 0.2565
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0054 0.1967
Toxoplasma gondii thioredoxin reductase 0.0108 0.0453 0.1586
Mycobacterium ulcerans putative regulatory protein 0.0073 0.0287 0.0264
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.006 0.1331
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0234 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0234 0.5157
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0054 0.0224
Mycobacterium tuberculosis Probable reductase 0.0247 0.1114 0.1532
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0142 0.3129
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0029 0.005
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0289 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0042 0.1517
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Brugia malayi ecdysteroid receptor 0.0024 0.005 0.0204
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.027
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0217
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.005 0.0204
Echinococcus granulosus tar DNA binding protein 0.0074 0.0289 0.0629
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0022 0.0042 0.004
Echinococcus multilocularis geminin 0.0899 0.4224 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0025 0.0084
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0166 0.3661
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.005 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Onchocerca volvulus 0.0024 0.0053 0.0016
Plasmodium vivax glutathione reductase, putative 0.0108 0.0453 1
Leishmania major protein kinase, putative 0.0026 0.006 0.1331
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Brugia malayi Smad1 0.0026 0.0064 0.027
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0042 0.0926
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Loa Loa (eye worm) thioredoxin reductase 0.0108 0.0453 0.2127
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.005 0.006
Schistosoma mansoni thyroid hormone receptor 0.0024 0.005 0.006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0166 0.0545
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0064 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Leishmania major DNA polymerase eta, putative 0.0048 0.0166 0.3661
Brugia malayi hypothetical protein 0.0454 0.2103 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Trichomonas vaginalis pc-MYB2, putative 0.0061 0.0227 0.8213
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0655 0.15
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0116 0.2565
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.006 0.1331
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0116 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0116 0.2565
Loa Loa (eye worm) hypothetical protein 0.0454 0.2103 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Brugia malayi MH2 domain containing protein 0.0389 0.1792 0.8518
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0025 0.0084
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Leishmania major DNA polymerase eta, putative 0.0091 0.037 0.8168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0116 0.2565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Loa Loa (eye worm) hypothetical protein 0.0431 0.1991 0.9467
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0042 0.1517
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0029 0.065
Trichomonas vaginalis MYB, putative 0.0061 0.0229 0.8263
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0142 0.3129
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0024 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Schistosoma mansoni hypothetical protein 0.015 0.0655 0.15
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0022 0.0042 0.004
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0234 0.8445
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0116 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0165
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0042 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.005 0.0204
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.027
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0595 0.2774 0.2757
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Echinococcus granulosus single minded 2 0.0073 0.0287 0.0624
Giardia lamblia DINP protein human, muc B family 0.0062 0.0234 0.2666
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0415
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Leishmania major DNA damage repair protein, putative 0.0019 0.0029 0.065
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.005 0.006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.005 0.0204
Brugia malayi hypothetical protein 0.0332 0.1522 0.7229
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.005 0.006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0247 0.1114 0.1532
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0093
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0064 0.0093
Trypanosoma brucei unspecified product 0.0043 0.0142 0.3129
Loa Loa (eye worm) hypothetical protein 0.0153 0.0668 0.3151
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.022
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.018 0.0795 0.1835
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Plasmodium vivax thioredoxin reductase, putative 0.0108 0.0453 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0234 0.03
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0177 0.3905

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 100 % Hemolytic activity in human erythrocytes at 1 mM ChEMBL. 17079152
IC50 (functional) = 31 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152
IC50 (functional) = 31 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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