Detailed information for compound 421702

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 234.334 | Formula: C15H22O2
  • H donors: 0 H acceptors: 0 LogP: 4.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1OO[C@@H](C=C1)CC12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C15H22O2/c1-2-14(17-16-3-1)10-15-7-11-4-12(8-15)6-13(5-11)9-15/h1-2,11-14H,3-10H2/t11?,12?,13?,14-,15?/m0/s1
  • InChiKey: ZYDZLTQJNYPNNJ-IHXHZNKUSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0177 0.3905
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi TAR-binding protein 0.0074 0.0289 0.1344
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0029 0.065
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0116 0.2565
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.003 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.005 0.0204
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus granulosus FTZ F1 alpha 0.0024 0.005 0.006
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0116 0.0092
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.005 0.0204
Trypanosoma cruzi DNA polymerase eta, putative 0.0091 0.037 0.8168
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.211 1 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.006 0.0084
Echinococcus multilocularis chromobox protein 1 0.0071 0.0277 0.0599
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0415
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.005 0.006
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0655 0.15
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0029 0.065
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0234 0.108
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0177 0.0585
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0116 0.0365
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.005 0.0204
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0655 0.15
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.006 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0029 0.065
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0582
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0042 0.0415
Loa Loa (eye worm) runx1 0.0057 0.0209 0.0963
Schistosoma mansoni lozenge 0.0057 0.0209 0.0438
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0029
Leishmania major DNA polymerase kappa, putative 0.0019 0.0029 0.065
Echinococcus granulosus tar DNA binding protein 0.0074 0.0289 0.0629
Brugia malayi Heterochromatin protein 1 0.0071 0.0277 0.1285
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0234 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0142 0.3129
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.005 0.0204
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0054 0.1967
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0029 0.065
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0025 0.0084
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.005 0.006
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0926
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0022 0.0042 0.0926
Echinococcus multilocularis dna polymerase eta 0.0091 0.037 0.0822
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0022 0.0042 0.0926
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0029 0.0295
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.005 0.006
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0116 0.2565
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.006 0.218
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0166 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.005 0.0204
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.005 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.005 0.0204
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0116 0.0092
Brugia malayi ecdysteroid receptor 0.0024 0.005 0.0204
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi polk-prov protein 0.0019 0.0029 0.0105
Brugia malayi hypoxia-induced factor 1 0.0307 0.14 0.6644
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1515 0.7163 1
Mycobacterium tuberculosis Probable reductase 0.0247 0.1114 0.1532
Echinococcus granulosus smad 0.0026 0.0064 0.0093
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0128 0.0378
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0042 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0029 0.065
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0042 0.0165
Loa Loa (eye worm) RecQ helicase 0.0025 0.0054 0.0224
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0217
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0029 0.065
Plasmodium vivax phosphodiesterase gamma, putative 0.0022 0.0042 0.0582
Loa Loa (eye worm) hypothetical protein 0.0431 0.1991 0.9467
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0158 0.0691 0.1586
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.005 0.0204
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.006 0.0084
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.006 0.218
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0816
Loa Loa (eye worm) hypothetical protein 0.0454 0.2103 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.004
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0042 0.0926
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0022 0.0042 0.0926
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Leishmania major DNA polymerase eta, putative 0.0091 0.037 0.8168
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0289 0.1344
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0142 0.5136
Brugia malayi hypothetical protein 0.005 0.0177 0.0809
Trypanosoma brucei DNA polymerase eta, putative 0.0091 0.037 0.8168
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0053 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.005 0.006
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0214 0.0986
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0116 0.0519
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.005 0.006
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.006 0.218
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Giardia lamblia Myb 1-like protein 0.0061 0.0229 0.26
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.005 0.0204
Mycobacterium ulcerans hypothetical protein 0.0024 0.0053 0.0029
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0108 0.0453 0.0607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.005 0.0204
Schistosoma mansoni hypothetical protein 0.015 0.0655 0.15
Plasmodium falciparum phosphodiesterase delta, putative 0.0022 0.0042 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.005 0.0204
Schistosoma mansoni aryl hydrocarbon receptor 0.0099 0.041 0.0917
Loa Loa (eye worm) hypothetical protein 0.0332 0.1522 0.7229
Leishmania major DNA polymerase eta, putative 0.0048 0.0166 0.3661
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0234 0.03
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0142 0.5136
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0165
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni DNA polymerase eta 0.0091 0.037 0.0822
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0053 0.0816
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0029 0.0124
Schistosoma mansoni chromobox protein 0.0071 0.0277 0.0599
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0816
Trichomonas vaginalis MYB3r3, putative 0.0061 0.0227 0.8213
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0045 0.0047
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.006 0.0084
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0029 0.005
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0158 0.0691 0.1586
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0277 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0042 0.0165
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.118
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.022
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis C-MYB, putative 0.0061 0.0227 0.8213
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0214 0.0986
Loa Loa (eye worm) glutathione reductase 0.0108 0.0453 0.2127
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) hypothetical protein 0.018 0.0795 0.376
Loa Loa (eye worm) PDE1B protein 0.0022 0.0042 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0029 0.065
Plasmodium falciparum glutathione reductase 0.0037 0.0116 0.2146
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Echinococcus multilocularis transfer RNA-Lys 0.0073 0.0287 0.0624
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.018 0.0795 0.1835
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0116 0.0092
Brugia malayi hypothetical protein 0.0032 0.0092 0.0404
Loa Loa (eye worm) Smad1 0.0026 0.0064 0.027
Leishmania major protein kinase, putative 0.0026 0.006 0.1331
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.018 0.0795 1
Trichomonas vaginalis MYB72, putative 0.0061 0.0227 0.8213
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.005 0.0204
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0595 0.2774 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0029 0.065
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0028 0.0069 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.006 0.218
Echinococcus granulosus dna polymerase eta 0.0091 0.037 0.0822
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0029 0.001
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.0926
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus granulosus Smad4 0.0026 0.0064 0.0093
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0054 0.1967
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0022 0.0042 0.004
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0022 0.0042 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0234 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0289 0.1344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.005 0.0204
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.005 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0234 0.5157
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0582
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.006 0.1331
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0029
Brugia malayi chromobox protein homolog 3 0.004 0.0128 0.0574
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0116 0.2565
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.005 0.0204
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus multilocularis Protein lozenge 0.0057 0.0209 0.0438
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Echinococcus granulosus muscleblind protein 0.0153 0.0668 0.1531
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.0234 0.0497
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.005 0.006
Brugia malayi bHLH-PAS transcription factor 0.0073 0.0287 0.1335
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Leishmania major DNA damage repair protein, putative 0.0019 0.0029 0.065
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.005 0.006
Brugia malayi hypothetical protein 0.0454 0.2103 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.0234 0.0497
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0093
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0022 0.0042 0.004
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0042 0.0926
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Mycobacterium tuberculosis Probable oxidoreductase 0.0274 0.1245 0.1716
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.005 0.006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0025 0.0084
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0116 0.2565
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.005 0.0204
Brugia malayi hypothetical protein 0.015 0.0655 0.3089
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0177 0.3905
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0142 0.0448
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0053 0.0048
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.0234 0.108
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0234 0.5157
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.004
Onchocerca volvulus 0.0454 0.2103 1
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0177 0.3674
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0214 0.0986
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.118
Brugia malayi hypothetical protein 0.0332 0.1522 0.7229
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0064 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Brugia malayi RNA binding protein 0.0074 0.0289 0.1344
Loa Loa (eye worm) transcription factor SMAD2 0.0389 0.1792 0.8518
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0234 0.5157
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0072 0.2608
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0093
Echinococcus granulosus chromobox protein 1 0.0071 0.0277 0.0599
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.006 0.1331
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0234 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.005 0.0204
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.006 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0028 0.0069 0.0293
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0029 0.065
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1515 0.7163 1
Brugia malayi MH2 domain containing protein 0.0389 0.1792 0.8518
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.006 0.218
Onchocerca volvulus 0.0073 0.0287 0.1155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.005 0.0204
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0217
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0595 0.2774 0.2757
Loa Loa (eye worm) hypothetical protein 0.0123 0.0526 0.2474
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0053 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.005 0.006
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.005 0.006
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0247 0.1114 0.1491
Leishmania major hypothetical protein, conserved 0.005 0.0177 0.3905
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.005 0.006
Plasmodium falciparum phosphodiesterase gamma, putative 0.0022 0.0042 0.0415
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0064 0.0093
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0926
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0177 0.3562
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0668 0.1531
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0093
Trypanosoma brucei unspecified product 0.0043 0.0142 0.3129
Loa Loa (eye worm) hypothetical protein 0.0153 0.0668 0.3151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.005 0.0204
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0116 0.1133
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0142 0.3129
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0029 0.065
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.005 0.006
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0116 0.0136
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus multilocularis geminin 0.0899 0.4224 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0307 0.14 0.6644
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0042 0.1517
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0234 0.8445
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.004 0.0375
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0595 0.2774 0.2757
Onchocerca volvulus 0.0026 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.022
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0022 0.0042 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.006 0.218
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0582
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Schistosoma mansoni coup transcription factor 0.0024 0.005 0.006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0289 0.1344
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trypanosoma brucei trypanothione reductase 0.0108 0.0453 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.006 0.218
Brugia malayi Smad1 0.0026 0.0064 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0217
Giardia lamblia hypothetical protein 0.0022 0.0042 0.0163
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0595 0.2774 0.3827
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.0234 0.3569
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0142 0.3129
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.005 0.0204
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0025 0.0084
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0064 0.0093
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0229 0.8263
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0042 0.1517
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0042 0.004
Plasmodium falciparum glutathione reductase 0.0108 0.0453 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0389 0.1792 0.8518
Brugia malayi nuclear hormone receptor 0.0024 0.005 0.0204
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Brugia malayi Thioredoxin reductase 0.0108 0.0453 0.2127
Trypanosoma brucei unspecified product 0.0062 0.0234 0.5157
Leishmania major cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Schistosoma mansoni thyroid hormone receptor 0.0024 0.005 0.006
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0061 0.0227 0.3471
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0247 0.1114 0.1532
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.005 0.006
Echinococcus multilocularis chromobox protein 1 0.0071 0.0277 0.0599
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0064 0.0093
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0053 0.0029
Toxoplasma gondii thioredoxin reductase 0.0108 0.0453 0.1586
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0029 0.065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0116 0.2565
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.005 0.006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0087 0.0378
Echinococcus granulosus dna polymerase kappa 0.0062 0.0234 0.0497
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.0415
Schistosoma mansoni single-minded 0.0099 0.041 0.0917
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0045 0.0047
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0029 0.005
Schistosoma mansoni nuclear hormone receptor 0.0024 0.005 0.006
Brugia malayi steroid hormone receptor 0.0024 0.005 0.0204
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0177 0.3905
Leishmania major protein kinase, putative 0.0026 0.006 0.1331
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0116 0.2283
Trichomonas vaginalis pc-MYB2, putative 0.0061 0.0227 0.8213
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0022 0.0042 0.004
Plasmodium falciparum thioredoxin reductase 0.0108 0.0453 1
Schistosoma mansoni Smad4 0.0026 0.0064 0.0093
Schistosoma mansoni hypothetical protein 0.0023 0.0045 0.0047
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0064 0.027
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.027
Leishmania major trypanothione reductase 0.0108 0.0453 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0655 0.15
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0116 0.2146
Trichomonas vaginalis MYB, putative 0.0061 0.0229 0.8263
Entamoeba histolytica hypothetical protein 0.015 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0574
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0116 0.0092
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.006 0.218
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0054 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.005 0.0204
Trypanosoma brucei unspecified product 0.0043 0.0142 0.3129
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0022 0.0042 0.004
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0277 0.1285
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0274 0.1245 0.1716
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.005 0.0204
Brugia malayi Muscleblind-like protein 0.0153 0.0668 0.3151
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.211 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0024 0.0174
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.005 0.0204
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.005 0.0204
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni thyroid hormone receptor 0.0024 0.005 0.006
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.005 0.006
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.006 0.1331
Echinococcus multilocularis smad 0.0026 0.0064 0.0093
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0274 0.1245 0.1676
Schistosoma mansoni hypothetical protein 0.0899 0.4224 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.006 0.218
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0042 0.0165
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0227 0.8213
Loa Loa (eye worm) thioredoxin reductase 0.0108 0.0453 0.2127
Brugia malayi glutathione reductase 0.0108 0.0453 0.2127
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0116 0.4201
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.006 0.218
Giardia lamblia Hypothetical protein 0.0022 0.0042 0.0163
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.005 0.006
Echinococcus granulosus chromobox protein 1 0.0071 0.0277 0.0599
Loa Loa (eye worm) hypothetical protein 0.0454 0.2103 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0105
Loa Loa (eye worm) hypothetical protein 0.005 0.0177 0.0809
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0064 0.0093
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0042 0.004
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0022 0.0042 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0158 0.0691 0.3262
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.006 0.0252
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0116 0.2565
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Plasmodium falciparum thioredoxin reductase 0.0037 0.0116 0.2146
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0247 0.1114 0.1532
Echinococcus granulosus bloom syndrome protein 0.0025 0.0054 0.007
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.005 0.0204
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.4614
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0204
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Plasmodium vivax thioredoxin reductase, putative 0.0108 0.0453 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0289 0.0629
Mycobacterium ulcerans hypothetical protein 0.0019 0.0029 0.0005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0247 0.1114 0.1532
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0042 0.004
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.037 0.1731
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Schistosoma mansoni hypothetical protein 0.0899 0.4224 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.005 0.006
Trichomonas vaginalis C-MYB, putative 0.0061 0.0227 0.8213
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0127 0.0569
Giardia lamblia DINP protein human, muc B family 0.0062 0.0234 0.2666
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0166 0.3661
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0022 0.0042 0.0926
Schistosoma mansoni smad 0.0026 0.0064 0.0093
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.006 0.218
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0234 0.03
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.022
Echinococcus granulosus thioredoxin glutathione reductase 0.0108 0.0453 0.102
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.005 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0116 0.2565
Loa Loa (eye worm) hypothetical protein 0.0058 0.0214 0.0986
Brugia malayi nuclear receptor NHR-88 0.0024 0.005 0.0204
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0042 0.1517
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.0795 0.2827
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0116 0.2146
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Echinococcus granulosus geminin 0.0899 0.4224 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Echinococcus multilocularis thioredoxin glutathione reductase 0.0108 0.0453 0.102
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0022 0.0042 0.0165
Mycobacterium tuberculosis Probable dehydrogenase 0.0247 0.1114 0.1532
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0274 0.1245 0.1716
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.005 0.006
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.018 0.0795 0.1835
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.118
Loa Loa (eye worm) hypothetical protein 0.0091 0.037 0.1731
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0277 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0042 0.0926
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0072 0.2608
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0165
Trichomonas vaginalis pc-MYB2, putative 0.0061 0.0227 0.8213
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0042 0.0926
Echinococcus granulosus single minded 2 0.0073 0.0287 0.0624
Schistosoma mansoni hypothetical protein 0.004 0.0127 0.0242
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0569
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0116 0.2283
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.006 0.1331
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0022 0.0042 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0234 0.5157
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0234 0.021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0042 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.4614
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0116 0.4201
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0022 0.0042 0.004
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0042 0.004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Loa Loa (eye worm) hypothetical protein 0.0431 0.1991 0.9467
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0024 0.0007
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0116 0.0365
Loa Loa (eye worm) hypothetical protein 0.0153 0.0668 0.3151
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0053 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.005 0.006
Trypanosoma cruzi trypanothione reductase, putative 0.0108 0.0453 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0022 0.0042 0.004
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.022
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0064 0.0093
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0042 0.0926
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0116 0.2565
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.0234 0.0497
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0234 0.8445
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.005 0.006
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0061 0.0229 0.0772
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.027
Brugia malayi PAS domain containing protein 0.0099 0.041 0.1921
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0029
Plasmodium vivax glutathione reductase, putative 0.0108 0.0453 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0247 0.1114 0.1532
Schistosoma mansoni chromobox protein 0.0071 0.0277 0.0599
Onchocerca volvulus 0.0024 0.0053 0.0016
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0054 0.0224
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0116 0.2565
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0042 0.0095
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0053 0.0048
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0042 0.1517
Loa Loa (eye worm) RNA binding protein 0.0074 0.0289 0.1344
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.005 0.006
Leishmania major hypothetical protein, conserved 0.0022 0.0042 0.0926
Mycobacterium ulcerans putative regulatory protein 0.0073 0.0287 0.0264
Mycobacterium leprae Possible regulatory protein 0.0026 0.006 0.001
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0289 0.0629
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0158 0.0691 0.3262
Echinococcus multilocularis muscleblind protein 0.0153 0.0668 0.1531
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Leishmania major DNA polymerase kappa, putative 0.0062 0.0234 0.5157
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.211 1 1
Onchocerca volvulus 0.0031 0.0087 0.0178
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0042 0.0415
Leishmania major hypothetical protein, conserved 0.0022 0.0042 0.0926
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0116 0.2565
Echinococcus multilocularis Smad4 0.0026 0.0064 0.0093
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0061 0.0229 0.8263
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0177 0.3562

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 125 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152
IC50 (functional) = 125 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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