Detailed information for compound 421763

Basic information

Technical information
  • TDR Targets ID: 421763
  • Name: 4-(1-adamantyl)-N-[(E)-pyridin-2-ylmethyliden eamino]quinoline-2-carboxamide
  • MW: 410.511 | Formula: C26H26N4O
  • H donors: 1 H acceptors: 3 LogP: 6.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nc2ccccc2c(c1)C12CC3CC(C2)CC(C1)C3)N/N=C/c1ccccn1
  • InChi: 1S/C26H26N4O/c31-25(30-28-16-20-5-3-4-8-27-20)24-12-22(21-6-1-2-7-23(21)29-24)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-8,12,16-19H,9-11,13-15H2,(H,30,31)/b28-16+
  • InChiKey: BBIYKJBIJKNDQE-LQKURTRISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1-adamantyl)-N-[(E)-2-pyridylmethyleneamino]quinoline-2-carboxamide
  • 4-(1-adamantyl)-N-[(E)-2-pyridylmethyleneamino]-2-quinolinecarboxamide
  • 4-(1-adamantyl)-N-[(E)-2-pyridylmethyleneamino]quinaldamide
  • 4-(1-adamantyl)-N-(pyridin-2-ylmethylideneamino)quinoline-2-carboxamide
  • 4-(1-adamantyl)-N-(2-pyridylmethyleneamino)quinoline-2-carboxamide
  • 4-(1-adamantyl)-N-(2-pyridylmethyleneamino)-2-quinolinecarboxamide
  • 4-(1-adamantyl)-N-(2-pyridylmethyleneamino)quinaldamide
  • AIDS-176995
  • AIDS176995
  • 4-Adamantan-1-yl-quinoline-2-carboxylic acid pyridin-2-yl-methylene-hydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0065 0.0057
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0106 0.018
Loa Loa (eye worm) carbonic anhydrase 3 0.0257 0.5405 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Loa Loa (eye worm) hypothetical protein 0.0036 0.0657 0.1202
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.00118324 1 1
Schistosoma mansoni ap endonuclease 0.0022 0.0354 0.0354
Leishmania major DNA polymerase kappa, putative 0.0024 0.041 0.0758
Echinococcus multilocularis thyroid hormone receptor alpha 0.00118324 1 1
Schistosoma mansoni thyroid hormone receptor 0.00118324 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0143 0.0249
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0006 0.0023 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0143 0.0134
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0143 0.0249
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0354 0.3086
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0257 0.5405 1
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.00118324 1 1
Echinococcus granulosus dna polymerase eta 0.0017 0.0247 0.0238
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0354 0.0655
Brugia malayi hypothetical protein 0.0006 0.0023 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.00118324 1 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0299 0.0553
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0143 0.0134
Brugia malayi photoreceptor-specific nuclear receptor 0.00118324 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0354 0.0655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0143 0.0249
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0143 0.0143
Echinococcus granulosus dna polymerase kappa 0.0047 0.0904 0.0896
Loa Loa (eye worm) hypothetical protein 0.0006 0.0023 0.0027
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.041 0.0758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0143 0.0249
Schistosoma mansoni hypothetical protein 0.0471 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.00118324 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0904 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0354 0.3914
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.1395 0.1395
Echinococcus granulosus retinoic acid receptor rxr beta a 0.00118324 1 1
Giardia lamblia DINP protein human, muc B family 0.0024 0.041 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0143 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.00118324 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0143 0.0249
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0904 0.1673
Brugia malayi polk-prov protein 0.0036 0.0657 0.1202
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0065 0.0065
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.00118324 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Brugia malayi nuclear hormone receptor 0.00118324 1 1
Onchocerca volvulus 0.00118324 1 0.5
Plasmodium falciparum carbonic anhydrase 0.0059 0.1147 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.00118324 1 1
Echinococcus granulosus cpg binding protein 0.0035 0.0639 0.0631
Echinococcus granulosus carbonic anhydrase 0.0059 0.1147 0.1139
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0023 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0247 0.0456
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0059 0.1147 0.2108
Brugia malayi hypothetical protein 0.0006 0.0023 0.0027
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0163 0.1322
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0257 0.5405 1
Brugia malayi Nuclear hormone receptor-like 1 0.00118324 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0143 0.0134
Schistosoma mansoni cpg binding protein 0.0035 0.0639 0.0639
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0354 0.0655
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0009 0.0009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0354 1
Schistosoma mansoni nuclear hormone receptor 0.00118324 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0143 0.0134
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.00118324 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0143 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Brugia malayi Nuclear hormone receptor family member nhr-3 0.00118324 1 1
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0247 0.0456
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0143 0.2273
Brugia malayi Nuclear hormone receptor family member nhr-14 0.00118324 1 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0109 0.0185
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0143 0.0143
Schistosoma mansoni carbonic anhydrase 0.0059 0.1147 0.1147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0143 0.0249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00118324 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0143 0.0134
Echinococcus granulosus carbonic anhydrase 0.0059 0.1147 0.1139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.00118324 1 1
Schistosoma mansoni DNA polymerase eta 0.0017 0.0247 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Brugia malayi ecdysteroid receptor 0.00118324 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0247 0.0247
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0143 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-41 0.00118324 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0354 0.8435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00118324 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.00118324 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0059 0.1147 0.2108
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0247 0.5442
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.00118324 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0143 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0143 0.0249
Echinococcus multilocularis carbonic anhydrase 0.0059 0.1147 0.1139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.00118324 1 1
Brugia malayi Steroid receptor seven-up type 2 0.00118324 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0109 0.01
Brugia malayi nuclear receptor NHR-88 0.0012 0.0143 0.0249
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Trypanosoma brucei unspecified product 0.0011 0.0136 0.0251
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0143 0.2273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0143 0.0249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00118324 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1234 1
Leishmania major carbonic anhydrase-like protein 0.0257 0.5405 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0257 0.5405 1
Brugia malayi nuclear hormone receptor 0.0012 0.0143 0.0249
Onchocerca volvulus Bile acid receptor homolog 0.00118324 1 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0299 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Echinococcus multilocularis cpg binding protein 0.0035 0.0639 0.0631
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0009 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00118324 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Schistosoma mansoni hypothetical protein 0.0135 0.278 0.278
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0023 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0143 0.0143
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0354 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.00118324 1 0.5
Echinococcus granulosus carbonic anhydrase II 0.0257 0.5405 0.5401
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.00118324 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0354 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0904 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0657 0.1216
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0354 0.064
Echinococcus granulosus FTZ F1 alpha 0.00118324 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.00118324 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0143 0.0134
Loa Loa (eye worm) hypothetical protein 0.0059 0.1147 0.2108
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0904 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0023 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00118324 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0023 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0143 0.0249
Trypanosoma brucei unspecified product 0.004 0.0741 0.1371
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0143 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.041 0.0758
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Schistosoma mansoni ap endonuclease 0.0022 0.0354 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0299 0.0553
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0143 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00118324 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.00118324 1 1
Loa Loa (eye worm) steroid hormone receptor 0.00118324 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0059 0.1147 0.1147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Toxoplasma gondii hypothetical protein 0.0059 0.1147 0.9292
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00118324 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0354 0.8634
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00118324 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0143 0.0249
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0009 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0904 1
Onchocerca volvulus 0.0012 0.0143 0.2273
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0109 0.01
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0059 0.1147 0.2108
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0257 0.5405 0.5405
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0143 0.0143
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.00118324 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0354 0.3559
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0065 0.0057
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0143 0.2273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0143 0.0249
Trypanosoma brucei RNA helicase, putative 0.0135 0.278 0.5143
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0354 0.3559
Schistosoma mansoni coup transcription factor 0.0012 0.0143 0.0143
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.00118324 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Echinococcus multilocularis FTZ F1 alpha 0.00118324 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.00118324 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0247 0.0441
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0904 0.0896
Brugia malayi steroid hormone receptor 0.0012 0.0143 0.0249
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0059 0.1147 0.2108
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0065 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00118324 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0904 0.1673
Brugia malayi CXXC zinc finger family protein 0.0033 0.0599 0.1094
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0257 0.5405 0.5405
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0143 0.0249
Echinococcus granulosus ecdysone induced protein 78C 0.00118324 1 1
Toxoplasma gondii exonuclease III APE 0.0022 0.0354 0.2868
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0247 0.0238
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0059 0.1147 0.2108
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0143 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00118324 1 1
Trypanosoma brucei unspecified product 0.0011 0.0136 0.0251
Schistosoma mansoni RAR-like nuclear receptor 0.00118324 1 1
Echinococcus multilocularis carbonic anhydrase 0.0059 0.1147 0.1139
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0143 0.0249
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0143 0.0134
Schistosoma mansoni cpg binding protein 0.0033 0.0599 0.0599
Schistosoma mansoni nuclear receptor 0.0006 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0657 0.1216
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.00118324 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0247 0.0441
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0143 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.00118324 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00118324 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0023 0.0027
Echinococcus multilocularis carbonic anhydrase 0.0059 0.1147 0.1139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0143 0.0249
Loa Loa (eye worm) hypothetical protein 0.0017 0.0247 0.0441
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0059 0.1147 0.2108
Brugia malayi steroid hormone receptor 0.00118324 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0023 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.00118324 1 1
Schistosoma mansoni thyroid hormone receptor 0.00118324 1 1
Echinococcus multilocularis dna polymerase eta 0.0017 0.0247 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-1 0.00118324 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0471 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.00118324 1 1
Echinococcus granulosus carbonic anhydrase 0.0059 0.1147 0.1139
Brugia malayi nuclear receptor RXR 0.0006 0.0023 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0143 0.0134
Leishmania major DNA polymerase eta, putative 0.0017 0.0247 0.0456
Brugia malayi ecdysteroid receptor 0.0012 0.0143 0.0249
Schistosoma mansoni nuclear receptor 0.0006 0.0009 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.00118324 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0143 0.0134
Echinococcus multilocularis carbonic anhydrase II 0.0257 0.5405 0.5401
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0904 0.1673
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.00118324 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0257 0.5405 1
Onchocerca volvulus 0.0033 0.0599 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.00118324 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0143 0.0249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0143 0.0249
Brugia malayi nuclear receptor NHR-88 0.00118324 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0059 0.1147 0.1147
Loa Loa (eye worm) hypothetical protein 0.0059 0.1147 0.2108
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0257 0.5405 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0143 0.0249
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0599 0.1094
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.00118324 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0143 0.0134
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0143 0.0143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.00118324 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0354 0.0345
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0354 0.5
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0247 0.0238
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0023 0.0023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0065 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0741 0.1371
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0354 0.064
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0354 0.0345
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0143 0.0134
Loa Loa (eye worm) hypothetical protein 0.0006 0.0023 0.0027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0143 0.0134
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0143 0.0134
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0059 0.1147 0.2108
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0247 0.0441
Schistosoma mansoni coup transcription factor 0.00118324 1 1
Loa Loa (eye worm) hypothetical protein 0.00118324 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0059 0.1147 0.1147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0143 0.0134
Schistosoma mansoni hypothetical protein 0.0059 0.1147 0.1147
Schistosoma mansoni zinc finger protein 0.0006 0.0009 0.0009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.041 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0354 0.0655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0143 0.0249
Trypanosoma brucei carbonic anhydrase-like protein 0.0257 0.5405 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0143 0.0249
Schistosoma mansoni cpg binding protein 0.0035 0.0639 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0143 0.0249
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0143 0.0143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0143 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0143 0.0249
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0143 0.0249
Loa Loa (eye worm) hypothetical protein 0.0006 0.0023 0.0027

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = -5.54 Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv by microplate alamar blue assay ChEMBL. 17107805
Inhibition (functional) = 84 % Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv at 6.250 ug/mL relative to isoniazid by microplate alamar blue assay ChEMBL. 17107805
Inhibition (functional) = 84 % Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv at 6.250 ug/mL relative to isoniazid by microplate alamar blue assay ChEMBL. 17107805
Log IC50 (functional) = 5.54 Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis H37Rv by microplate alamar blue assay ChEMBL. 17107805

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mycobacterium tuberculosis ChEMBL23 17107805

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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