TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 515.557 | Formula: C29H29N3O6
H donors: 3 H acceptors: 4 LogP: 3.87 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: O=C(O[C@@H]1NC(=O)[C@H]1NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)CCc1ccccc1
InChi: 1S/C29H29N3O6/c33-24(17-16-20-10-4-1-5-11-20)38-28-25(27(35)32-28)31-26(34)23(18-21-12-6-2-7-13-21)30-29(36)37-19-22-14-8-3-9-15-22/h1-15,23,25,28H,16-19H2,(H,30,36)(H,31,34)(H,32,35)/t23-,25+,28-/m0/s1
InChiKey: YYTYMENWZQHVGX-CKOJHNACSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Rattus norvegicus	Cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Papain family cysteine protease containing protein	Cathepsin B	339 aa	337 aa	21.4 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin B	339 aa	275 aa	25.5 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	339 aa	278 aa	27.0 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin B	339 aa	304 aa	26.6 %
Onchocerca volvulus		Cathepsin B	339 aa	319 aa	38.9 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	339 aa	301 aa	23.6 %
Onchocerca volvulus		Cathepsin B	339 aa	330 aa	35.2 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin B	339 aa	273 aa	28.9 %
Dictyostelium discoideum	cysteine proteinase 5 precursor	Cathepsin B	339 aa	303 aa	22.4 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Cathepsin B	339 aa	327 aa	30.3 %
Schistosoma japonicum	Cathepsin C precursor, putative	Cathepsin B	339 aa	332 aa	26.8 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	339 aa	284 aa	21.8 %
Plasmodium falciparum	serine repeat antigen 8	Cathepsin B	339 aa	272 aa	25.0 %
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	Cathepsin B	339 aa	304 aa	27.0 %
Plasmodium vivax	vivapain-1	Cathepsin B	339 aa	289 aa	22.5 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium yoelii	cysteine proteinase precursor	Cathepsin B	339 aa	273 aa	20.1 %
Cryptosporidium hominis	preprocathepsin c precursor	Cathepsin B	339 aa	282 aa	29.4 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	Cathepsin B	339 aa	367 aa	25.9 %
Plasmodium berghei	dipeptidyl aminopeptidase 2	Cathepsin B	339 aa	314 aa	24.5 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Cathepsin B	339 aa	326 aa	51.2 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin B	339 aa	319 aa	27.0 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin B	339 aa	310 aa	29.4 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	339 aa	285 aa	25.6 %
Theileria parva	cathepsin C, putative	Cathepsin B	339 aa	295 aa	26.1 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin B	339 aa	284 aa	26.4 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Cathepsin B	339 aa	274 aa	27.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Cathepsin B	339 aa	283 aa	22.6 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Cathepsin B	339 aa	334 aa	29.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	339 aa	302 aa	24.5 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin B	339 aa	293 aa	26.6 %
Dictyostelium discoideum	cysteine protease	Cathepsin B	339 aa	283 aa	24.7 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin B	339 aa	303 aa	23.8 %
Plasmodium knowlesi	knowpain-2	Cathepsin B	339 aa	302 aa	24.8 %
Giardia lamblia	Encystation-specific protease	Cathepsin B	339 aa	272 aa	23.5 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Cathepsin B	339 aa	294 aa	28.9 %
Plasmodium vivax	unspecified product	Cathepsin B	339 aa	297 aa	22.6 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	Cathepsin B	339 aa	287 aa	22.6 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin B	339 aa	300 aa	27.3 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin B	339 aa	273 aa	28.9 %
Babesia bovis	preprocathepsin c precursor, putative	Cathepsin B	339 aa	282 aa	29.8 %
Plasmodium berghei	berghepain-1	Cathepsin B	339 aa	273 aa	19.8 %
Plasmodium knowlesi	knowpain-4	Cathepsin B	339 aa	304 aa	24.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin B	339 aa	275 aa	22.5 %
Cryptosporidium parvum	preprocathepsin c precursor, putative	Cathepsin B	339 aa	287 aa	30.3 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin B	339 aa	273 aa	28.9 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Cathepsin B	339 aa	312 aa	26.3 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin B	339 aa	304 aa	28.9 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	339 aa	298 aa	23.8 %
Theileria parva	cysteine proteinase, putative	Cathepsin B	339 aa	305 aa	22.6 %
Neospora caninum	hypothetical protein	Cathepsin B	339 aa	321 aa	28.3 %
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Cathepsin B	339 aa	319 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	cathepsin L precursor	0.002	0.0117	0.017
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Giardia lamblia	Cathepsin L-like protease	0.002	0.0117	0.018
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.0943	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0951	0.1852
Schistosoma mansoni	hypothetical protein	0.0046	0.0943	0.1837
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Plasmodium falciparum	serine repeat antigen 1	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0117	0.017
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus granulosus	dro:myosuppressin receptor	0.0093	0.2401	0.2401
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.002	0.0117	0.017
Brugia malayi	Dopamine receptor protein 2	0.0093	0.2401	0.3483
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.2401	0.2401
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.6698	0.6698
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2175	0.9008
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0089	0.5
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Brugia malayi	GnHR receptor homolog	0.0093	0.2401	0.3483
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0117	0.0136
Brugia malayi	MH2 domain containing protein	0.0237	0.6894	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0951	0.4135
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2175	0.4133
Loa Loa (eye worm)	hypothetical protein	0.0027	0.033	0.0479
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0117	0.0228
Schistosoma mansoni	hypothetical protein	0.01	0.2623	0.5107
Giardia lamblia	Cathepsin B precursor	0.002	0.0117	0.018
Echinococcus granulosus	neuropeptide s receptor	0.0093	0.2401	0.2401
Toxoplasma gondii	cathepsin CPC2	0.002	0.0117	0.0136
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.0943	0.1369
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1341	0.1945
Echinococcus multilocularis	cathepsin b	0.0181	0.5136	0.5136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0046	0.0943	0.0943
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.002	0.0117	0.0136
Echinococcus multilocularis	neuropeptide s receptor	0.0093	0.2401	0.2401
Giardia lamblia	Cathepsin B precursor	0.002	0.0117	0.018
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.017
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2175	0.4133
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2175	0.2175
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.2401	0.2401
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Brugia malayi	putative neuropeptide receptor	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.2401	0.4675
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0117	0.0136
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0951	0.1709
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.002	0.0117	0.0228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0117	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0117	0.0136
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0951	0.4135
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0089	0.0128
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.2175	0.9008
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2175	0.4234
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.0117	0.0056
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0117	0.017
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2175	0.4133
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2175	0.4133
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.002	0.0117	0.0136
Schistosoma mansoni	cathepsin S (C01 family)	0.002	0.0117	0.0228
Echinococcus granulosus	cathepsin l1	0.0086	0.2175	0.2175
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0317	0.046
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0117	0.0228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Onchocerca volvulus		0.0059	0.1341	0.5356
Plasmodium falciparum	serine repeat antigen 7	0.002	0.0117	0.0136
Plasmodium falciparum	serine repeat antigen 8	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0317	0.046
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Giardia lamblia	Cathepsin L precursor	0.002	0.0117	0.018
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.2401	0.2401
Echinococcus multilocularis	lamin	0.0026	0.0317	0.0317
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Echinococcus granulosus	lamin	0.0026	0.0317	0.0317
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0093	0.2401	0.3483
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.1669	0.3132
Giardia lamblia	Cathepsin L precursor	0.002	0.0117	0.018
Schistosoma mansoni	adenoreceptor	0.0093	0.2401	0.4675
Schistosoma mansoni	ap endonuclease	0.0019	0.0089	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0439
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0951	0.1709
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.002	0.0117	0.0136
Echinococcus multilocularis	musashi	0.0026	0.0317	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Toxoplasma gondii	preprocathepsin c precursor, putative	0.002	0.0117	0.0136
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.2401	0.2401
Onchocerca volvulus		0.0093	0.2401	1
Echinococcus granulosus	GPCR family 2	0.0046	0.0943	0.0943
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Echinococcus granulosus	cathepsin b	0.0181	0.5136	0.5136
Plasmodium vivax	vivapain-1	0.0047	0.0951	0.4135
Schistosoma mansoni	opsin-like receptor	0.0093	0.2401	0.4675
Brugia malayi	Cytochrome P450 family protein	0.0049	0.1033	0.1498
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0965	0.1879
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0027	0.033	0.0479
Echinococcus granulosus	g protein coupled receptor	0.0093	0.2401	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0231	0.6698	0.9716
Entamoeba histolytica	hypothetical protein	0.002	0.0117	0.0136
Plasmodium vivax	unspecified product	0.002	0.0117	0.0136
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0093	0.2401	0.2401
Schistosoma mansoni	amine GPCR	0.0093	0.2401	0.4675
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0117	0.0136
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2175	0.4234
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.002	0.0117	0.0136
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0093	0.2401	0.2401
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0093	0.2401	0.3483
Onchocerca volvulus		0.0093	0.2401	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0093	0.2401	0.2401
Brugia malayi	intermediate filament protein	0.0026	0.0317	0.046
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0951	0.4135
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.5136	1
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.2401	0.2401
Brugia malayi	fibroinase precursor	0.002	0.0117	0.017
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.0117	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1341	0.1945
Brugia malayi	Melatonin receptor type 1A	0.0093	0.2401	0.3483
Plasmodium falciparum	serine repeat antigen 4	0.002	0.0117	0.0136
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.2401	0.2401
Giardia lamblia	Cathepsin B precursor	0.007	0.1669	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.2401	0.2401
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	0.6894	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0046	0.0943	0.0943
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0093	0.2401	0.2401
Plasmodium falciparum	serine repeat antigen 3	0.002	0.0117	0.0136
Onchocerca volvulus		0.0093	0.2401	1
Schistosoma mansoni	hypothetical protein	0.0093	0.2401	0.4675
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0093	0.2401	0.3483
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2175	0.2175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.002	0.0117	0.0136
Onchocerca volvulus		0.0093	0.2401	1
Giardia lamblia	Cathepsin B precursor	0.002	0.0117	0.018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0117	0.0228
Schistosoma mansoni	amine GPCR	0.0093	0.2401	0.4675
Loa Loa (eye worm)	cysteine protease	0.0086	0.2175	0.3155
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2175	0.3155
Onchocerca volvulus		0.0093	0.2401	1
Brugia malayi	ORL1-like opioid receptor	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Echinococcus multilocularis	somatostatin receptor	0.0093	0.2401	0.2401
Brugia malayi	latrophilin 2 splice variant baaae	0.01	0.2623	0.3805
Schistosoma mansoni	myosin xvIII	0.0093	0.2401	0.4675
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Giardia lamblia	Cathepsin L precursor	0.002	0.0117	0.018
Plasmodium vivax	vivapain-2	0.0086	0.2175	1
Giardia lamblia	Cathepsin L precursor	0.002	0.0117	0.018
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Giardia lamblia	Hypothetical protein	0.002	0.0117	0.018
Echinococcus multilocularis	allatostatin A receptor	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Echinococcus multilocularis	GPCR, family 2	0.0046	0.0943	0.0943
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.2401	0.3483
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.0943	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0317	0.0618
Onchocerca volvulus		0.0093	0.2401	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0951	0.1709
Schistosoma mansoni	cathepsin C	0.002	0.0117	0.0228
Onchocerca volvulus		0.0093	0.2401	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Schistosoma mansoni	biogenic amine receptor	0.0093	0.2401	0.4675
Schistosoma mansoni	neuropeptide receptor	0.0093	0.2401	0.4675
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Echinococcus multilocularis	cathepsin L	0.0047	0.0951	0.0951
Brugia malayi	Cathepsin L-like precursor	0.0027	0.033	0.0479
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2175	0.3155
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.2401	0.3483
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0093	0.2401	0.4675
Entamoeba histolytica	cysteine protease, putative	0.002	0.0117	0.0136
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0089	0.5
Echinococcus multilocularis	tumor protein p63	0.0337	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.017
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.5136	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.0943	0.0943
Echinococcus multilocularis	serotonin receptor	0.0093	0.2401	0.2401
Onchocerca volvulus		0.0093	0.2401	1
Schistosoma mansoni	hypothetical protein	0.0093	0.2401	0.4675
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.5136	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0943	0.1369
Entamoeba histolytica	cysteine protease, putative	0.002	0.0117	0.0136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0951	0.138
Giardia lamblia	Cathepsin B precursor	0.007	0.1669	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.1669	0.325
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0093	0.2401	0.4675
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0117	0.017
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.1341	0.1945
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1341	0.1945
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.2175	0.4133
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.2401	0.4675
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0951	0.4135
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Echinococcus granulosus	neuropeptide receptor	0.0093	0.2401	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0136
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.1033	0.1498
Schistosoma mansoni	hypothetical protein	0.0046	0.0943	0.1837
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.002	0.0117	0.017
Echinococcus multilocularis	neuropeptide receptor A26	0.0093	0.2401	0.2401
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0093	0.2401	0.4675
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0093	0.2401	0.3483
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	amine GPCR	0.0093	0.2401	0.4675
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0117	0.017
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.2401	0.2401
Brugia malayi	Serotonin receptor	0.0093	0.2401	0.3483
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.1033	0.2012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Brugia malayi	Dopamine receptor	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.2175	0.3155
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.2401	0.4675
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.2401	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.0117	0.018
Brugia malayi	Dopamine receptor protein 1	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0027	0.033	0.0479
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0951	0.4135
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1341	0.6001
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.002	0.0117	0.0136
Onchocerca volvulus		0.0093	0.2401	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0117	0.0136
Onchocerca volvulus		0.0086	0.2175	0.9008
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.2401	0.2401
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1341	0.1945
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0117	0.0136
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.5136	0.745
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1341	0.6001
Echinococcus multilocularis	lamin dm0	0.0026	0.0317	0.0317
Schistosoma mansoni	hypothetical protein	0.0093	0.2401	0.4675
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Onchocerca volvulus		0.0086	0.2175	0.9008
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	cathepsin F-like cysteine proteinase	0.0027	0.033	0.0479
Onchocerca volvulus		0.0049	0.1033	0.4012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Echinococcus granulosus	G protein coupled receptor 139	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0951	0.4135
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2175	0.2175
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0093	0.2401	0.4675
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0117	0.017
Brugia malayi	neuropeptide F receptor	0.0093	0.2401	0.3483
Brugia malayi	Serotonin receptor	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0117	0.0136
Echinococcus granulosus	sex peptide receptor	0.0093	0.2401	0.2401
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Schistosoma mansoni	opsin-like receptor	0.0093	0.2401	0.4675
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0093	0.2401	0.4675
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0093	0.2401	0.2401
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.2175	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.5136	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0093	0.2401	0.3483
Echinococcus multilocularis	sex peptide receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0951	0.4135
Echinococcus multilocularis	dro:myosuppressin receptor	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2175	0.3155
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0147	0.4071	0.5905
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2175	0.2175
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0093	0.2401	0.2401
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0117	0.0136
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0951	0.1852
Echinococcus multilocularis	cathepsin L	0.002	0.0117	0.0117
Brugia malayi	cathepsin F-like cysteine proteinase	0.002	0.0117	0.017
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus granulosus	7TM GPCR rhodopsin	0.0093	0.2401	0.2401
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0117	0.017
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.002	0.0117	0.018
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0093	0.2401	0.4675
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.2401	0.4675
Echinococcus granulosus	cathepsin L	0.0047	0.0951	0.0951
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0093	0.2401	0.3483
Plasmodium falciparum	serine repeat antigen 2	0.002	0.0117	0.0136
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2175	0.3155
Schistosoma mansoni	cathepsin s	0.0027	0.033	0.0643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0117	0.0136
Schistosoma mansoni	opsin-like receptor	0.0093	0.2401	0.4675
Echinococcus granulosus	neuropeptide receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	neuropeptide FF receptor 2	0.0093	0.2401	0.2401
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.002	0.0117	0.0136
Entamoeba histolytica	cysteine protease, putative	0.002	0.0117	0.0136
Onchocerca volvulus		0.0093	0.2401	1
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2175	0.9008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0093	0.2401	0.4675
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Echinococcus granulosus	cysteine protease	0.0047	0.0951	0.0951
Echinococcus granulosus	7tm_1 domain containing protein	0.0093	0.2401	0.2401
Echinococcus granulosus	neuropeptide receptor A26	0.0093	0.2401	0.2401
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Loa Loa (eye worm)	hypothetical protein	0.01	0.2623	0.3805
Echinococcus granulosus	cathepsin b	0.0181	0.5136	0.5136
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.2401	0.4675
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0951	0.138
Schistosoma mansoni	neuropeptide receptor	0.0093	0.2401	0.4675
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Toxoplasma gondii	cathepsin B	0.007	0.1669	0.7577
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.017
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2175	0.3155
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0317	0.046
Giardia lamblia	Cathepsin B precursor	0.002	0.0117	0.018
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine protease, putative	0.0086	0.2175	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0089	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus granulosus	hypothetical protein	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0951	0.4135
Onchocerca volvulus		0.0086	0.2175	0.9008
Toxoplasma gondii	cathepsin CPL	0.0086	0.2175	1
Echinococcus granulosus	g-protein coupled receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.2401	0.2401
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0093	0.2401	0.2401
Schistosoma mansoni	hypothetical protein	0.0093	0.2401	0.4675
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.017
Giardia lamblia	Cathepsin L-like protease	0.002	0.0117	0.018
Loa Loa (eye worm)	ctsf protein	0.0086	0.2175	0.3155
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0147	0.4071	0.5905
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Echinococcus multilocularis	g-protein coupled receptor	0.0093	0.2401	0.2401
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.2175	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2175	0.3155
Giardia lamblia	Cysteine protease	0.002	0.0117	0.018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0117	0.0136
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.033	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0147	0.4071	0.5905
Echinococcus multilocularis	cysteine protease	0.0086	0.2175	0.2175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0089	0.0089
Giardia lamblia	Cysteine protease	0.002	0.0117	0.018
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.002	0.0117	0.0136
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.2401	0.4675
Schistosoma mansoni	hypothetical protein	0.0047	0.0965	0.1879
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Brugia malayi	putative neuropeptide receptor NPR1	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0951	0.4135
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0093	0.2401	0.4675
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.2401	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1341	0.1945
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0093	0.2401	0.4675
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	melatonin receptor type 1A	0.0093	0.2401	0.3483
Schistosoma mansoni	lamin	0.0026	0.0317	0.0618
Onchocerca volvulus		0.0093	0.2401	1
Brugia malayi	neuropeptide F receptor	0.0093	0.2401	0.3483
Plasmodium vivax	unspecified product	0.0027	0.033	0.1159
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0951	0.1709
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0093	0.2401	0.2401
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0093	0.2401	0.2401
Onchocerca volvulus		0.0093	0.2401	1
Onchocerca volvulus		0.0093	0.2401	1
Onchocerca volvulus		0.0026	0.0317	0.0877
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.2175	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.002	0.0117	0.0136
Schistosoma mansoni	neuropeptide receptor	0.0093	0.2401	0.4675
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Giardia lamblia	Cathepsin B precursor	0.007	0.1669	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0117	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0117	0.0136
Onchocerca volvulus		0.0093	0.2401	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1341	0.261
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.2175	0.2175
Schistosoma mansoni	amine GPCR	0.0093	0.2401	0.4675
Giardia lamblia	Cathepsin L precursor	0.002	0.0117	0.018
Schistosoma mansoni	neuropeptide receptor	0.0093	0.2401	0.4675
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0117	0.0136
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.1669	0.7577
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0951	0.4135
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0951	0.0951
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0117	0.0136
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0089	0.5
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0117	0.0136
Echinococcus granulosus	lamin dm0	0.0026	0.0317	0.0317
Echinococcus granulosus	cathepsin L	0.002	0.0117	0.0117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.002	0.0117	0.0136
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.033	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	histamine h1 receptor	0.0093	0.2401	0.4675
Giardia lamblia	Hypothetical protein	0.002	0.0117	0.018
Brugia malayi	follicle stimulating hormone receptor	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.017
Echinococcus multilocularis	cathepsin b	0.0181	0.5136	0.5136
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.2401	0.2401
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.2401	0.4675
Brugia malayi	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	sulfakinin receptor protein	0.0093	0.2401	0.3483
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Echinococcus granulosus	allatostatin A receptor	0.0093	0.2401	0.2401
Onchocerca volvulus		0.0047	0.0965	0.3713
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.2401	0.4675
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.0943	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0951	0.4135
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0117	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.033	0.0479
Schistosoma mansoni	lamin	0.0026	0.0317	0.0618
Brugia malayi	G protein-coupled receptor F59B2.13	0.0093	0.2401	0.3483
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.002	0.0117	0.0136
Echinococcus granulosus	g protein coupled receptor	0.0093	0.2401	0.2401
Plasmodium vivax	vivapain-3	0.0047	0.0951	0.4135
Echinococcus multilocularis	cysteine protease	0.0086	0.2175	0.2175
Plasmodium falciparum	serine repeat antigen 6	0.002	0.0117	0.0136
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.2175	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0117	0.0228
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Onchocerca volvulus		0.0093	0.2401	1
Brugia malayi	G-protein coupled receptor	0.0093	0.2401	0.3483
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.5136	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0093	0.2401	0.3483
Brugia malayi	RE15519p	0.0093	0.2401	0.3483
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.2401	0.3483
Entamoeba histolytica	cysteine protease, putative	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1341	0.6001
Giardia lamblia	Cathepsin L precursor	0.002	0.0117	0.018
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.1669	0.7577
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0951	0.1852
Onchocerca volvulus		0.0026	0.0317	0.0877
Onchocerca volvulus		0.0093	0.2401	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2175	0.3155
Onchocerca volvulus		0.0093	0.2401	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0093	0.2401	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0093	0.2401	0.2401
Brugia malayi	larval opioid receptor	0.0093	0.2401	0.3483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.2401	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0027	0.033	0.0479
Brugia malayi	G protein-coupled receptor	0.0093	0.2401	0.3483
Plasmodium vivax	unspecified product	0.0047	0.0951	0.4135
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.0117	0.0056
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.2401	0.4675
Echinococcus granulosus	fmrfamide receptor	0.0093	0.2401	0.2401
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.002	0.0117	0.0136
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.2175	0.3155
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0117	0.017
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.2401	0.2401
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0951	0.1709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Echinococcus granulosus	g protein coupled receptor	0.0093	0.2401	0.2401
Giardia lamblia	Encystation-specific protease	0.002	0.0117	0.018
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.002	0.0117	0.0136
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0136
Schistosoma mansoni	biogenic amine receptor	0.0093	0.2401	0.4675
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.002	0.0117	0.0136
Echinococcus multilocularis	serotonin receptor	0.0093	0.2401	0.2401
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0317	0.046
Schistosoma mansoni	growth hormone secretagogue receptor	0.0093	0.2401	0.4675
Onchocerca volvulus		0.0086	0.2175	0.9008
Loa Loa (eye worm)	TYRA-2 protein	0.0093	0.2401	0.3483
Schistosoma mansoni	amine GPCR	0.0093	0.2401	0.4675
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.2175	0.2175
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0089	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.2401	0.2401
Giardia lamblia	Cathepsin B precursor	0.002	0.0117	0.018
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.2401	0.2401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2175	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0093	0.2401	1
Plasmodium falciparum	serine repeat antigen 9	0.002	0.0117	0.0136
Plasmodium falciparum	serine repeat antigen 5	0.002	0.0117	0.0136
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0093	0.2401	0.2401
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0147	0.4071	0.5905
Brugia malayi	G-protein coupled receptor	0.0093	0.2401	0.3483
Brugia malayi	cathepsin L-like cysteine proteinase	0.002	0.0117	0.017
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.002	0.0117	0.0228
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Schistosoma mansoni	cathepsin B (C01 family)	0.002	0.0117	0.0228
Brugia malayi	cathepsin L-like precursor	0.0059	0.1341	0.1945
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.2401	0.2401
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.0117	0.018
Schistosoma mansoni	hypothetical protein	0.0046	0.0943	0.1837
Echinococcus multilocularis	G protein coupled receptor 139	0.0093	0.2401	0.2401
Schistosoma mansoni	ap endonuclease	0.0019	0.0089	0.0172
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.6698	0.6698
Leishmania major	cathepsin L-like protease	0.0086	0.2175	1
Plasmodium vivax	vivapain-2	0.0086	0.2175	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0093	0.2401	0.3483
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0093	0.2401	0.3483
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0089	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus granulosus	somatostatin receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	cathepsin l1	0.0059	0.1341	0.1341
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.2401	0.4675
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2175	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.1669	0.7577
Onchocerca volvulus		0.0086	0.2175	0.9008
Onchocerca volvulus		0.0086	0.2175	0.9008
Schistosoma mansoni	hypothetical protein	0.0046	0.0943	0.1837
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0093	0.2401	0.4675
Loa Loa (eye worm)	cathepsin B	0.007	0.1669	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.1341	0.248
Schistosoma mansoni	biogenic amine receptor	0.0093	0.2401	0.4675
Echinococcus granulosus	serotonin receptor	0.0093	0.2401	0.2401
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0951	0.4135
Toxoplasma gondii	cathepsin CPC1	0.002	0.0117	0.0136
Loa Loa (eye worm)	fibroinase	0.0086	0.2175	0.3155
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0093	0.2401	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2175	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.2175	0.3155
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Echinococcus granulosus	intermediate filament protein	0.0026	0.0317	0.0317
Giardia lamblia	Cysteine protease	0.002	0.0117	0.018
Loa Loa (eye worm)	hypothetical protein	0.0181	0.5136	0.745
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0117	0.0228
Brugia malayi	hypothetical protein	0.0231	0.6698	0.9716
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2175	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1033	0.1499
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.2401	0.2401
Echinococcus granulosus	orexin receptor type 2	0.0093	0.2401	0.2401
Giardia lamblia	Cysteine protease	0.002	0.0117	0.018
Echinococcus multilocularis	orexin receptor type 2	0.0093	0.2401	0.2401
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	0.6894	1
Onchocerca volvulus		0.0086	0.2175	0.9008
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.2401	0.2401
Brugia malayi	AKH receptor	0.0093	0.2401	0.3483
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.002	0.0117	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2401	0.3483
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0965	0.14

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.038 uM	Inhibition of recombinant human Cathepsin K	ChEMBL.	12467634
IC50 (binding)	= 0.038 uM	Inhibition of recombinant human Cathepsin K	ChEMBL.	12467634
IC50 (binding)	= 0.041 uM	Inhibition of recombinant human cathepsin S	ChEMBL.	12467634
IC50 (binding)	= 0.041 uM	Inhibition of recombinant human cathepsin S	ChEMBL.	12467634
IC50 (binding)	= 0.047 uM	Inhibition of recombinant human Cathepsin L	ChEMBL.	12467634
IC50 (binding)	= 0.047 uM	Inhibition of recombinant human Cathepsin L	ChEMBL.	12467634
IC50 (binding)	= 9.71 uM	Inhibition of recombinant rat Cathepsin B	ChEMBL.	12467634
IC50 (binding)	= 9.71 uM	Inhibition of recombinant rat Cathepsin B	ChEMBL.	12467634
IC50 (binding)	> 50 uM	Inhibition of human leukocyte elastase(HLE)	ChEMBL.	12467634
IC50 (binding)	> 50 uM	Inhibition of human leukocyte elastase(HLE)	ChEMBL.	12467634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL30356

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 42177