Detailed information for compound 421962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.41 | Formula: C21H20N4O
  • H donors: 1 H acceptors: 2 LogP: 5.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cnc(c2n1cnc2)Nc1c(C)cccc1C
  • InChi: 1S/C21H20N4O/c1-14-5-4-6-15(2)20(14)24-21-19-11-22-13-25(19)18(12-23-21)16-7-9-17(26-3)10-8-16/h4-13H,1-3H3,(H,23,24)
  • InChiKey: LVCXGWHKLCPVBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0143 0.0632 0.0594
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0143 0.0632 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0167 0.0419
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0127 0.0087
Mycobacterium tuberculosis Conserved protein 0.0037 0.0127 0.0087
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.004 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0143 0.0632 0.0594
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0127 0.0087
Echinococcus multilocularis geminin 0.0343 0.1582 0.396
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Schistosoma mansoni tyrosine kinase 0.0045 0.0167 0.1059
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0143 0.0632 0.0594
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.007 0.0501
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.0256
Loa Loa (eye worm) TK protein kinase 0.0036 0.0125 0.1426
Brugia malayi protein-tyrosine kinase 0.0041 0.0146 0.2317
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.003
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0143 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.1462
Schistosoma mansoni tyrosine kinase 0.0045 0.0167 0.1059
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0143 0.0632 1
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.2113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Brugia malayi hypothetical protein 0.0025 0.007 0.1109
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0143 0.0632 0.0594
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.0501
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0167 0.1059
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0125 0.0312
Trypanosoma brucei pteridine reductase 1 0.0143 0.0632 1
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0143 0.0632 0.0594
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0143 0.0632 0.3994
Brugia malayi beta-lactamase 0.0037 0.0127 0.2008
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0143 0.0632 0.0594
Brugia malayi beta-lactamase family protein 0.0037 0.0127 0.2008
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0167 0.1059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0168 0.2663
Loa Loa (eye worm) retinol dehydrogenase 12 0.0143 0.0632 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.2113 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0143 0.0632 0.0594
Loa Loa (eye worm) beta-lactamase 0.0037 0.0127 0.1462
Trichomonas vaginalis esterase, putative 0.0037 0.0127 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0127 0.0087
Loa Loa (eye worm) hypothetical protein 0.0143 0.0632 1
Trypanosoma brucei oxidoreductase-like protein 0.0143 0.0632 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0127 0.0318
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0143 0.0632 0.0594
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0167 0.1059
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0167 0.1059
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.0501
Schistosoma mansoni hypothetical protein 0.0343 0.1582 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0127 0.0087
Onchocerca volvulus 0.0143 0.0632 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0143 0.0632 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0127 0.2008
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0127 0.0087
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.007 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Mycobacterium tuberculosis Conserved protein 0.0037 0.0127 0.0087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.1462
Schistosoma mansoni dihydropteridine reductase 0.0143 0.0632 0.3994
Trichomonas vaginalis hypothetical protein 0.2113 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0167 0.0419
Mycobacterium tuberculosis Probable oxidoreductase 0.0143 0.0632 0.0594
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.0256
Mycobacterium ulcerans lipase LipD 0.0037 0.0127 0.0087
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0146 0.0366
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.2113 1 1
Leishmania major hypothetical protein, conserved 0.0025 0.007 0.0501
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0127 0.0087
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0143 0.0632 0.0594
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0127 0.0087
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0143 0.0632 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0127 0.0802
Plasmodium falciparum enoyl-acyl carrier reductase 0.2113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0143 0.0632 1
Mycobacterium ulcerans oxidoreductase 0.0143 0.0632 0.0594
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0005 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0167 0.0419
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0127 0.0087
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0143 0.0632 1
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0143 0.0632 0.0511
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0127 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0168 0.1064
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0146 0.0925
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0127 0.0087
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0146 0.0366
Brugia malayi SRC-1 0.0045 0.0167 0.2651
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0168 0.1064
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0143 0.0632 0.3994
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.014 0.0351
Leishmania major pteridine reductase 1 0.0143 0.0632 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0143 0.0632 0.0594
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0127 0.0087
Echinococcus granulosus geminin 0.0343 0.1582 1
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0143 0.0632 0.0594
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0146 0.0366
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.2113 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.1462
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0143 0.0632 0.0511
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.004 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0168 0.1064
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.2113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0005 0.0029
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0143 0.0632 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0127 0.1462
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.014 0.0887
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0168 0.0421
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0143 0.0632 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0127 0.0087
Leishmania major oxidoreductase-like protein 0.0143 0.0632 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0127 0.0802
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.004 0.064
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.007 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0501
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0029
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0167 0.0419
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0167 0.0419
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.1462
Entamoeba histolytica protein kinase, putative 0.0036 0.0125 0.1426
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.004 0.0256
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0143 0.0632 0.0594
Mycobacterium ulcerans hypothetical protein 0.0037 0.0127 0.0087
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0127 0.0087
Loa Loa (eye worm) oxidoreductase 0.0143 0.0632 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0167 0.1059
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0167 0.0419
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0127 0.1462
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0167 0.1059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0168 0.2161
Echinococcus granulosus tyrosine kinase 0.0041 0.0146 0.0925
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0168 0.0421
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.2113 1 1
Schistosoma mansoni hypothetical protein 0.0343 0.1582 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0143 0.0632 0.0594
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0167 0.1059
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0143 0.0632 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0127 0.1462
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0127 0.1462
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.1462
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0143 0.0632 0.0594
Mycobacterium ulcerans beta-lactamase 0.0037 0.0127 0.0087
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0143 0.0632 0.0594
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0125 0.0789
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0167 0.1059
Loa Loa (eye worm) SRC-1 0.0045 0.0167 0.2148
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0143 0.0632 0.0594
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1073 0.1037
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0143 0.0632 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0143 0.0632 0.0594
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0143 0.0632 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0167 0.0419
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0146 0.0925
Brugia malayi beta-lactamase family protein 0.0037 0.0127 0.2008
Onchocerca volvulus 0.0143 0.0632 1
Loa Loa (eye worm) TK protein kinase 0.0041 0.0146 0.1791
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0143 0.0632 0.1582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0168 0.1064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0168 0.1064
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0143 0.0632 0.0594
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0167 0.0419
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Mycobacterium tuberculosis Conserved protein 0.0037 0.0127 0.0087
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0167 0.0419
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0127 0.0087
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.003
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0127 0.0087
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0143 0.0632 0.0594
Toxoplasma gondii ABC1 family protein 0.0037 0.0127 0.0087
Leishmania major hypothetical protein, conserved 0.0037 0.0127 0.1462
Brugia malayi hypothetical protein 0.0016 0.0028 0.0443
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0143 0.0632 0.0594
Mycobacterium ulcerans short chain dehydrogenase 0.0143 0.0632 0.0594
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0127 0.0802
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.004 0.0101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.1462
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.3994 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.015 uM Inhibition of cSrc by coupled spectrophotometric enzyme assay ChEMBL. 17095233
IC50 (binding) = 0.015 uM Inhibition of cSrc by coupled spectrophotometric enzyme assay ChEMBL. 17095233
Inhibition (binding) = 12.5 % Inhibition of cSrc in COS7 cells at 1 uM by ELISA ChEMBL. 17095233
Inhibition (binding) = 12.5 % Inhibition of cSrc in COS7 cells at 1 uM by ELISA ChEMBL. 17095233

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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