Detailed information for compound 422105

Basic information

Technical information
  • TDR Targets ID: 422105
  • Name: 3-[(1S,2R,3S,4S,6R,7S)-6-[2-[(5-amino-1H-1,2, 4-triazol-3-yl)sulfanyl]acetyl]oxy-4-ethenyl- 3-hydroxy-2,4,7,8-tetramethyl-11-oxo-1-bicycl o[5.3.1]undecanyl]propanoic acid
  • MW: 508.631 | Formula: C24H36N4O6S
  • H donors: 4 H acceptors: 7 LogP: 2.96 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=C[C@]1(C)C[C@@H](OC(=O)CSc2nnc([nH]2)N)[C@]2(C)C(C)CC[C@]([C@H]([C@@H]1O)C)(C2=O)CCC(=O)O
  • InChi: 1S/C24H36N4O6S/c1-6-22(4)11-15(34-17(31)12-35-21-26-20(25)27-28-21)23(5)13(2)7-9-24(19(23)33,10-8-16(29)30)14(3)18(22)32/h6,13-15,18,32H,1,7-12H2,2-5H3,(H,29,30)(H3,25,26,27,28)/t13?,14-,15+,18-,22+,23-,24-/m0/s1
  • InChiKey: WLHAHMBFOWBEAT-PDQPPYKKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(1S,2R,3S,4S,6R,7S)-6-[2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetyl]oxy-3-hydroxy-2,4,7,8-tetramethyl-11-oxo-4-vinyl-1-bicyclo[5.3.1]undecanyl]propanoic acid
  • 3-[(1S,2R,3S,4S,6R,7S)-6-[2-[(5-amino-1H-1,2,4-triazol-3-yl)thio]-1-oxoethoxy]-3-hydroxy-2,4,7,8-tetramethyl-11-oxo-4-vinyl-1-bicyclo[5.3.1]undecanyl]propanoic acid
  • 3-[(1S,2R,3S,4S,6R,7S)-6-[2-[(5-azanyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanoyloxy]-4-ethenyl-3-hydroxy-2,4,7,8-tetramethyl-11-oxo-1-bicyclo[5.3.1]undecanyl]propanoic acid
  • 3-[(1S,2R,3S,4S,6R,7S)-6-[2-[(5-amino-1H-1,2,4-triazol-3-yl)thio]acetyl]oxy-3-hydroxy-11-keto-2,4,7,8-tetramethyl-4-vinyl-1-bicyclo[5.3.1]undecanyl]propionic acid
  • 3-[(1S,2R,3S,4S,6R,7S)-6-[2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]ethanoyloxy]-4-ethenyl-3-hydroxy-2,4,7,8-tetramethyl-11-oxo-1-bicyclo[5.3.1]undecanyl]propanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Brugia malayi beta-lactamase family protein 0.0036 0.0224 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0519 0.0519
Onchocerca volvulus 0.1284 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0247 0.0247
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0033 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0224 0.0186
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0215 0.0215
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0075 0.0075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0317 0.0317
Toxoplasma gondii ABC1 family protein 0.0036 0.0224 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Brugia malayi ecdysone receptor 0.0035 0.0215 0.0215
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0255 0.0255
Schistosoma mansoni cpg binding protein 0.0035 0.022 0.022
Brugia malayi nuclear receptor NHR-67 0.0035 0.0215 0.0215
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0026
Brugia malayi beta-lactamase 0.0036 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0073 0.0519 0.0487
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0519 0.0519
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0039 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1813 0.1813
Leishmania major DNA polymerase kappa, putative 0.0024 0.0135 0.0097
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0519 0.0519
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0124 0.0085
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0317 0.0283
Echinococcus multilocularis somatostatin receptor 0.0011 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0302 0.0302
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1773 0.1773
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0033 0.0033
Brugia malayi Dopamine receptor 0.0011 0.0033 0.0033
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0519 0.0487
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis Polycystic kidney disease protein 0.0046 0.0302 0.0302
Onchocerca volvulus 0.0036 0.0224 0.0192
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0124 0.0124
Trichomonas vaginalis set domain proteins, putative 0.0276 0.2104 0.4451
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0033 0.0033
Brugia malayi polk-prov protein 0.0036 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0224
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0026 0.0026
Echinococcus granulosus RUN 0.0046 0.0302 0.0302
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0033 0.0033
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1284 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Plasmodium vivax SET domain protein, putative 0.0035 0.0221 0.019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0075 0.0072
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0033 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0519 0.0519
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Loa Loa (eye worm) doublecortin family protein 0.0046 0.0302 0.0302
Onchocerca volvulus 0.0035 0.0221 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0331 0.0701
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0519 0.0519
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0519 0.0519
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.0215 0.0215
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0519 0.0519
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0033 0.0033
Brugia malayi Dopamine receptor protein 1 0.0011 0.0033 0.0033
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0055 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0224 0.0474
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Brugia malayi Cytochrome P450 family protein 0.0012 0.0039 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0247 0.0247
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1284 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0519 0.0519
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1284 1 1
Brugia malayi hypothetical protein 0.0039 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Plasmodium falciparum LCCL domain-containing protein 0.0046 0.0302 0.0181
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1284 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0046 0.0302 0.0302
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.3665 0.3665
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0247 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0519 0.0519
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni coup transcription factor 0.0073 0.0519 0.0519
Brugia malayi conserved hypotetical protein 0.0035 0.0215 0.0215
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0224
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0519 0.0519
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0215 0.0215
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0033 0.0033
Brugia malayi nuclear hormone receptor 0.0035 0.0215 0.0215
Schistosoma mansoni histamine h1 receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis sex peptide receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0124 0.0262
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0224 0.0221
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0035 0.5
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0221 0.0221
Brugia malayi intermediate filament protein 0.0027 0.0152 0.0152
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0331 0.03
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0033 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0229 0.0229
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0035 0.0215 0.0215
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0519 0.0519
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0224 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0035
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0055 0.0055
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0224 0.0224
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0519 0.0519
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0519 0.0519
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.1262 0.1262
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0124 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0519 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0224 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0299 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0033 0.0033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0519 0.0519
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0124 0.0124
Schistosoma mansoni opsin-like receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0224
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0317 0.028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0519 0.0519
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0215 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0519 0.0519
Echinococcus multilocularis geminin 0.0167 0.1255 0.1255
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0224 0.0189
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0033 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0222 0.0222
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0224 0.0474
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis tumor protein p63 0.0334 0.2558 0.2558
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.021 0.0445
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0215 0.0215
Schistosoma mansoni myosin xvIII 0.0011 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0519 0.0519
Leishmania major DNA polymerase eta, putative 0.0017 0.0075 0.0037
Entamoeba histolytica hypothetical protein 0.0036 0.0222 0.7113
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Schistosoma mansoni microtubule-associated protein tau 0.0802 0.6222 0.6222
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0048 0.0317 0.0317
Echinococcus granulosus somatostatin receptor 0.0011 0.0033 0.0033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) RecQ helicase 0.0023 0.0124 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Echinococcus granulosus histone acetyltransferase KAT2B 0.0164 0.1225 0.1225
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0215 0.0182
Schistosoma mansoni rab6-interacting 0.0046 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.0036 0.0222 0.7113
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0039 0.0003
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1284 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.0215 0.0215
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Echinococcus granulosus g protein coupled receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Brugia malayi larval opioid receptor 0.0011 0.0033 0.0033
Schistosoma mansoni intermediate filament proteins 0.0027 0.0152 0.0152
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1737 0.1734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0221 0.019
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0124 0.0124
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0003 0.0006
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0519 0.0519
Schistosoma mansoni hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0033 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0026 0.0026
Schistosoma mansoni nuclear receptor 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0226
Echinococcus granulosus Polycystic kidney disease protein 0.0046 0.0302 0.0302
Schistosoma mansoni lipoxygenase 0.0201 0.1519 0.1519
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0519 0.0519
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0033 0.0033
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0124 0.0262
Mycobacterium ulcerans beta-lactamase 0.0036 0.0224 0.0186
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0247 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0519 0.0519
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0033 0.0033
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.0215 0.0215
Schistosoma mansoni amine GPCR 0.0011 0.0033 0.0033
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0018 0.0018
Echinococcus granulosus intermediate filament protein 0.0027 0.0152 0.0152
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni zinc finger protein 0.0035 0.0215 0.0215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0519 0.0519
Brugia malayi putative neuropeptide receptor 0.0011 0.0033 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0519 0.0519
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0224 0.0224
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis DNA polymerase eta, putative 0.0048 0.0317 0.0671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Brugia malayi Dopamine receptor protein 2 0.0011 0.0033 0.0033
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0035 0.0004
Echinococcus granulosus g protein coupled receptor 0.0011 0.0033 0.0033
Brugia malayi nuclear hormone receptor 0.0073 0.0519 0.0519
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Plasmodium vivax multidomain scavenger receptor, putative 0.0046 0.0302 0.0271
Echinococcus multilocularis microtubule associated protein 2 0.0802 0.6222 0.6222
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0075 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0033 0.0033
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.1262 0.1262
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0205 0.0205
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0035 0.0131
Echinococcus multilocularis thymidylate synthase 0.1284 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0611 0.4728 1
Entamoeba histolytica hypothetical protein 0.0036 0.0222 0.7113
Echinococcus multilocularis lamin dm0 0.0027 0.0152 0.0152
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0033 0.0033
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0033 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0033 0.0033
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0224 0.0221
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0224 0.0221
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0003 0.0006
Schistosoma mansoni biogenic amine receptor 0.0011 0.0033 0.0033
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0519 0.0519
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0222 0.0222
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0075 0.0075
Schistosoma mansoni neuropeptide receptor 0.0011 0.0033 0.0033
Echinococcus granulosus lamin dm0 0.0027 0.0152 0.0152
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0033 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0221 0.0221
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.0215 0.0215
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0224 0.0221
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0519 0.0519
Schistosoma mansoni biogenic amine receptor 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0046 0.0302 0.027
Brugia malayi neuropeptide F receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0331 0.0701
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0035 0.0035
Echinococcus granulosus cpg binding protein 0.0035 0.022 0.022
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0033 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0519 0.0519
Echinococcus multilocularis cpg binding protein 0.0035 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0519 0.0519
Brugia malayi ecdysteroid receptor 0.0073 0.0519 0.0519
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0224 0.0474
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0033 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0508 0.0508
Brugia malayi nuclear receptor NHR-88 0.0073 0.0519 0.0519
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0033 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0224 0.0224
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0039 0.0247 0.0247
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0039 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0026 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0006
Onchocerca volvulus 0.0035 0.0215 0.0182
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0247 0.0247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Schistosoma mansoni neuropeptide receptor 0.0011 0.0033 0.0033
Brugia malayi GnHR receptor homolog 0.0011 0.0033 0.0033
Echinococcus granulosus thymidylate synthase 0.1284 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0075 0.004
Schistosoma mansoni DNA helicase recq5 0.0023 0.0124 0.0124
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0027 0.0152 0.012
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0519 0.0519
Brugia malayi nuclear receptor RXR 0.0035 0.0215 0.0215
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0075 0.162
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0519 0.0519
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0247 0.0247
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0519 0.0487
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0033 0.0033
Echinococcus granulosus dnaJ subfamily B 0.0475 0.3665 0.3665
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0033 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0226 0.0193
Echinococcus granulosus dna polymerase eta 0.0017 0.0075 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0075 0.0075
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0033 0.0033
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Echinococcus multilocularis lamin 0.0027 0.0152 0.0152
Brugia malayi RE15519p 0.0011 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Brugia malayi G protein-coupled receptor 0.0011 0.0033 0.0033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0519 0.0519
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis musashi 0.0027 0.0152 0.0152
Echinococcus granulosus microtubule associated protein 2 0.0802 0.6222 0.6222
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0135 0.0101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.0124
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0519 0.0519
Schistosoma mansoni hypothetical protein 0.0167 0.1255 0.1255
Schistosoma mansoni opsin-like receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0519 0.0519
Loa Loa (eye worm) beta-lactamase 0.0036 0.0224 0.0224
Mycobacterium ulcerans thymidylate synthase 0.1284 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.004
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0039 0.0039
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0033 0.0033
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0148
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0033 0.0033
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis dna polymerase eta 0.0017 0.0075 0.0075
Mycobacterium tuberculosis Hypothetical protein 0.0611 0.4728 0.4726
Schistosoma mansoni amine GPCR 0.0011 0.0033 0.0033
Echinococcus granulosus allatostatin A receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0224 0.0221
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0124 0.0124
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0033 0.0033
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0033 0.0033
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0519 0.0519
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0049 0.0326 0.0294
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0215 0.0182
Schistosoma mansoni hypothetical protein 0.0036 0.0222 0.0222
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0075 0.0041
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0026 0.0026
Schistosoma mansoni DNA helicase recq1 0.0023 0.0124 0.0124
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0033 0.0033
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0033 0.0033
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0247 0.0247
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0611 0.4728 0.4709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0006
Brugia malayi AKH receptor 0.0011 0.0033 0.0033
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0326 0.0326
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0033 0.0033
Brugia malayi steroid hormone receptor 0.0073 0.0519 0.0519
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.0215 0.0215
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0033 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0018 0.0018
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0033 0.0033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0033 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0221 0.0221
Brugia malayi Doublecortin family protein 0.0046 0.0302 0.0302
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0033 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0224 0.0224
Schistosoma mansoni biogenic amine receptor 0.0011 0.0033 0.0033
Trypanosoma brucei unspecified product 0.004 0.0257 0.0224
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor 0.0035 0.0215 0.0215
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0135 0.0132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0519 0.0519
Brugia malayi hypothetical protein 0.0046 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0326
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0033 0.0033
Schistosoma mansoni rab6-interacting 0.0046 0.0302 0.0302
Echinococcus multilocularis RUN 0.0046 0.0302 0.0302
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0255 0.0255
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.1843 0.1843
Loa Loa (eye worm) hypothetical protein 0.0035 0.0221 0.0221
Onchocerca volvulus 0.0033 0.0205 0.0172
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0331 0.0331
Brugia malayi Pre-SET motif family protein 0.0035 0.0221 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Schistosoma mansoni cpg binding protein 0.0033 0.0205 0.0205
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0234 0.1773 0.1773
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0331 0.03
Brugia malayi hypothetical protein 0.0234 0.1773 0.1773
Onchocerca volvulus 0.0036 0.0224 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0519 0.0519
Onchocerca volvulus 0.0036 0.0224 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0033 0.0033
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0519 0.0519
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0519 0.0519
Schistosoma mansoni nuclear receptor 0.0035 0.0215 0.0215
Echinococcus granulosus dna polymerase kappa 0.0048 0.0317 0.0317
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0222 0.0222
Brugia malayi hypothetical protein 0.0039 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0221 0.0221
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0124 0.0092
Loa Loa (eye worm) hypothetical protein 0.0039 0.0247 0.0247
Echinococcus granulosus orexin receptor type 2 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0276 0.2104 0.2078
Brugia malayi Cytochrome P450 family protein 0.0012 0.0039 0.0039
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0224 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.006
Leishmania major hypothetical protein, conserved 0.0036 0.0224 0.0186
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0035 0.0004
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0032 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0044 0.0044
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0033 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1773 0.1773
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0201 0.1519 0.1519
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0224 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0317 0.0283
Giardia lamblia DINP protein human, muc B family 0.0024 0.0135 0.065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0302 0.0302
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Trichomonas vaginalis helicase, putative 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0124 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni loxhd1 0.0046 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni neuropeptide receptor 0.0011 0.0033 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0224 0.019
Echinococcus multilocularis dna polymerase kappa 0.0048 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Brugia malayi neuropeptide F receptor 0.0011 0.0033 0.0033
Brugia malayi hypothetical protein 0.0046 0.0302 0.0302
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0033 0.0033
Schistosoma mansoni amine GPCR 0.0011 0.0033 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.0215 0.0215
Schistosoma mansoni lipoxygenase 0.0119 0.0873 0.0873
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Brugia malayi Pre-SET motif family protein 0.0243 0.1843 0.1843
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0124 0.0124
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1284 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0124 0.0262
Brugia malayi Melatonin receptor type 1A 0.0011 0.0033 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Brugia malayi G-protein coupled receptor 0.0011 0.0033 0.0033
Echinococcus granulosus neuropeptide receptor 0.0011 0.0033 0.0033
Schistosoma mansoni opsin-like receptor 0.0011 0.0033 0.0033
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1284 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0519 0.0519
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0044 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0075
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0224 0.0193
Brugia malayi CXXC zinc finger family protein 0.0033 0.0205 0.0205
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0519 0.0519
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0152 0.0152
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0152 0.0152
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0221 0.0221
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0033 0.0033
Schistosoma mansoni polycystin 1-related 0.0046 0.0302 0.0302
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0033 0.0033
Brugia malayi hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0302 0.0302
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0124 0.009
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0299 1
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0033 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0033 0.0033
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0033 0.0033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Brugia malayi hypothetical protein 0.0036 0.0222 0.0222
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0124 0.3441
Brugia malayi tailless protein 0.0035 0.0215 0.0215
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0033 0.0033
Brugia malayi hypothetical protein 0.0611 0.4728 0.4728
Brugia malayi Serotonin receptor 0.0011 0.0033 0.0033
Echinococcus granulosus bloom syndrome protein 0.0023 0.0124 0.0124
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0033 0.0033
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0519 0.0519
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0033 0.0033
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0229 0.0229
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0481 0.045
Schistosoma mansoni DNA polymerase eta 0.0017 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0224 0.0474
Echinococcus granulosus geminin 0.0167 0.1255 0.1255
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0035 0.0215 0.0215
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0033 0.0033
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Brugia malayi hypothetical protein 0.0035 0.0215 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0003 0.0006
Echinococcus granulosus hypothetical protein 0.0011 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0039 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0317 0.0284
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0035 0.0215 0.0182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0224 0.0221
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0124 0.0124
Echinococcus granulosus lamin 0.0027 0.0152 0.0152
Brugia malayi hypothetical protein 0.0035 0.0215 0.0215
Mycobacterium tuberculosis Conserved protein 0.0036 0.0224 0.0221
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0519 0.0519
Schistosoma mansoni amine GPCR 0.0011 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Brugia malayi nuclear receptor NHR-88 0.0035 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0011 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0033 0.0033
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0215 0.0215
Echinococcus granulosus g protein coupled receptor 0.0011 0.0033 0.0033
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0026 0.0026
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.0215 0.0215
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0033 0.0033
Echinococcus granulosus serotonin receptor 0.0011 0.0033 0.0033
Schistosoma mansoni adenoreceptor 0.0011 0.0033 0.0033
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0026 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0331 0.03
Mycobacterium tuberculosis Conserved protein 0.0036 0.0224 0.0221
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0519 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0003 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.0215 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0224 0.0474
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0124 0.0124
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) acetyltransferase 0.0168 0.1262 0.1262
Onchocerca volvulus 0.0046 0.0302 0.027
Brugia malayi nuclear receptor RXR 0.0039 0.0247 0.0247
Loa Loa (eye worm) thymidylate synthase 0.1284 1 1
Brugia malayi sulfakinin receptor protein 0.0011 0.0033 0.0033
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1813 0.1813
Schistosoma mansoni neuropeptide receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0247 0.0247
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0247 0.0247
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0302
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0224 0.0221
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.021 0.0445
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0152 0.0152
Echinococcus granulosus sex peptide receptor 0.0011 0.0033 0.0033
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0519 0.0519
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0229 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0033 0.0033
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0048 0.0317 0.0285
Schistosoma mansoni hypothetical protein 0.0011 0.0033 0.0033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0519 0.0487
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0033 0.0033
Schistosoma mansoni lamin 0.0027 0.0152 0.0152
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0034 0.0034
Echinococcus granulosus tumor protein p63 0.0334 0.2558 0.2558
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0247 0.0247
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0519 0.0519
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0033 0.0033
Echinococcus multilocularis serotonin receptor 0.0011 0.0033 0.0033
Brugia malayi G-protein coupled receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0039 0.0039
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0033 0.0033
Onchocerca volvulus 0.0027 0.0152 0.012
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0034 0.0034
Mycobacterium ulcerans hypothetical protein 0.0036 0.0224 0.0186
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0033 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0317 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0519 0.0519
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0035 0.0215 0.0215
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0317 0.0283
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0044
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0299 0.0177
Loa Loa (eye worm) DR-78 0.0035 0.0215 0.0215
Brugia malayi ORL1-like opioid receptor 0.0011 0.0033 0.0033
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0033 0.0033
Schistosoma mansoni cpg binding protein 0.0035 0.022 0.022
Brugia malayi Serotonin receptor 0.0011 0.0033 0.0033
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1284 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0205 0.0205
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.0215 0.0215
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0317 0.028
Schistosoma mansoni survival motor neuron protein 0.0048 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0167 0.1255 0.1255
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0221 0.0221
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0224
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0519 0.0519
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0519 0.0519
Schistosoma mansoni lamin 0.0027 0.0152 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0226 0.0193
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.1262 0.1262
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.0215 0.0215
Echinococcus granulosus neuropeptide receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0201 0.1519 0.1519
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0044 0.0044
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0048 0.0317 0.0671
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1284 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0033 0.0033
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Schistosoma mansoni amine GPCR 0.0011 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0036 0.0224 0.0224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Mycobacterium tuberculosis Conserved protein 0.0036 0.0224 0.0221
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0317 0.0284
Mycobacterium ulcerans lipase LipD 0.0036 0.0224 0.0186
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0475 0.3665 0.3665
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0124 0.0089
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0035 0.0215 0.0215
Brugia malayi beta-lactamase family protein 0.0036 0.0224 0.0224
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0075 0.0075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0033 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0317 0.0283
Entamoeba histolytica hypothetical protein 0.0036 0.0222 0.7113
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0257 0.0224
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Echinococcus multilocularis serotonin receptor 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0073 0.0519 0.0519
Trichomonas vaginalis esterase, putative 0.0036 0.0224 0.0474
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0033 0.0033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0135 0.0097

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 64 ug ml-1 Antibacterial activity against Streptococcus pneumoniae A9585 after 24 hrs ChEMBL. 17156897
MIC (functional) > 128 ug ml-1 Antibacterial activity against Staphylococcus aureus A15090 after 24 hrs ChEMBL. 17156897

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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