Detailed information for compound 422249

Basic information

Technical information
  • TDR Targets ID: 422249
  • Name: 2-[[2-(3,4-dichloro-N-methylanilino)acetyl]am ino]benzoic acid
  • MW: 353.2 | Formula: C16H14Cl2N2O3
  • H donors: 2 H acceptors: 3 LogP: 4.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1C(=O)O)CN(c1ccc(c(c1)Cl)Cl)C
  • InChi: 1S/C16H14Cl2N2O3/c1-20(10-6-7-12(17)13(18)8-10)9-15(21)19-14-5-3-2-4-11(14)16(22)23/h2-8H,9H2,1H3,(H,19,21)(H,22,23)
  • InChiKey: NAKPRUBXTZBAJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[2-(3,4-dichloro-N-methyl-anilino)acetyl]amino]benzoic acid
  • 2-[[2-(3,4-dichloro-N-methylanilino)-1-oxoethyl]amino]benzoic acid
  • 2-[2-[(3,4-dichlorophenyl)-methyl-amino]ethanoylamino]benzoic acid
  • 2-[[2-[(3,4-dichlorophenyl)-methylamino]acetyl]amino]benzoic acid
  • 2-[[2-[(3,4-dichlorophenyl)-methyl-amino]acetyl]amino]benzoic acid
  • 2-[[2-[(3,4-dichlorophenyl)-methylamino]-1-oxoethyl]amino]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0076 0.0783 0.0736
Mycobacterium ulcerans hypothetical protein 0.0041 0.0368 0.037
Mycobacterium tuberculosis Conserved protein 0.0041 0.0368 0.037
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0368 0.0929
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0349 0.579
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0783 0.0736
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0349 0.0299
Schistosoma mansoni amine GPCR 0.0076 0.0783 0.0783
Trichomonas vaginalis esterase, putative 0.0041 0.0368 0.0376
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0349 0.0354
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus cpg binding protein 0.0064 0.0636 0.0588
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.005 0.0475 0.0496
Schistosoma mansoni aldehyde dehydrogenase 0.0255 0.2902 0.2902
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.005 0.0475 0.0162
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2657 0.3053
Schistosoma mansoni neuropeptide receptor 0.0076 0.0783 0.0783
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0783 0.0736
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Schistosoma mansoni hypothetical protein 0.0016 0.0069 0.0069
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0738 0.8598 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0016 0.0069 0.0051
Schistosoma mansoni tar DNA-binding protein 0.019 0.2124 0.2124
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0368 0.0929
Schistosoma mansoni amine GPCR 0.0076 0.0783 0.0783
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0255 0.2902 0.2866
Leishmania major dehydrogenase/oxidoreductase-like protein 0.005 0.0475 0.1487
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0058 0.0565 0.0601
Schistosoma mansoni hypothetical protein 0.0053 0.0517 0.0517
Brugia malayi RNA binding protein 0.019 0.2124 0.6082
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0058 0.0565 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0076 0.0783 0.2147
Echinococcus multilocularis allatostatin A receptor 0.0076 0.0783 0.0736
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0115 0.0187
Schistosoma mansoni hypothetical protein 0.0016 0.0069 0.0069
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0738 0.8598 1
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.005 0.0475 0.0475
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1568 0.445
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0349 0.0348
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.005 0.0475 0.0496
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0598 0.0639
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.005 0.0475 0.1244
Echinococcus granulosus GPCR family 2 0.0016 0.0069 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0349 0.579
Trichomonas vaginalis glutaminase, putative 0.027 0.3076 0.3543
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0368 0.037
Onchocerca volvulus 0.0031 0.0248 0.0755
Schistosoma mansoni tar DNA-binding protein 0.019 0.2124 0.2124
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0349 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0248 0.0577
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0075 0.0023
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0783 0.0736
Mycobacterium ulcerans oxidoreductase 0.005 0.0475 0.0496
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0076 0.0783 0.0736
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0076 0.0783 0.2147
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.005 0.0475 0.0496
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Schistosoma mansoni hypothetical protein 0.0076 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Brugia malayi glutaminase DH11.1 0.027 0.3076 0.8875
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium tuberculosis Conserved protein 0.0041 0.0368 0.037
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.005 0.0475 0.0272
Mycobacterium ulcerans lipase LipD 0.0041 0.0368 0.037
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Echinococcus granulosus tachykinin peptides receptor 99D 0.0076 0.0783 0.0736
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0349 0.0354
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0051
Mycobacterium ulcerans glutaminase 0.027 0.3076 0.3539
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.005 0.0475 0.0496
Brugia malayi Tachykinin-like peptides receptor 99D 0.0076 0.0783 0.2147
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0368 0.037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0349 0.1044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0368 0.0318
Onchocerca volvulus 0.0076 0.0783 0.2809
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0783 0.0736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0368 0.037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0282 0.0676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1568 0.1568
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0075 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0248 0.0248
Brugia malayi AKH receptor 0.0076 0.0783 0.2147
Echinococcus multilocularis G-protein coupled receptor, putative 0.0076 0.0783 0.0736
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.022 0.0169
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0368 0.037
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0368 0.037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0783 0.0736
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0076 0.0783 0.0736
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.2902 0.3336
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0598 0.1603
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0783 0.0783
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0565 0.0601
Schistosoma mansoni myosin xvIII 0.0076 0.0783 0.0783
Onchocerca volvulus 0.0076 0.0783 0.2809
Onchocerca volvulus 0.006 0.0596 0.2089
Schistosoma mansoni neuropeptide F-like receptor 0.0076 0.0783 0.0783
Onchocerca volvulus 0.0076 0.0783 0.2809
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.2902 0.3336
Echinococcus granulosus dro:myosuppressin receptor 0.0076 0.0783 0.0736
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0255 0.2902 0.2866
Echinococcus granulosus neuropeptide receptor A26 0.0076 0.0783 0.0736
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.005 0.0475 0.0496
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1568 0.1524
Echinococcus multilocularis serotonin receptor 0.0076 0.0783 0.0736
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0368 0.6158
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0368 0.037
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0076 0.0783 0.0736
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0783 0.0736
Echinococcus multilocularis neuropeptide FF receptor 2 0.0076 0.0783 0.0736
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0076 0.0783 0.2809
Brugia malayi GnHR receptor homolog 0.0076 0.0783 0.2147
Onchocerca volvulus 0.005 0.0475 0.1627
Echinococcus granulosus g-protein coupled receptor 0.0076 0.0783 0.0736
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.2968 0.3413
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Loa Loa (eye worm) hypothetical protein 0.0049 0.0465 0.1215
Loa Loa (eye worm) TYRA-2 protein 0.0076 0.0783 0.2147
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0076 0.0783 0.0783
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0783 0.0736
Loa Loa (eye worm) beta-lactamase 0.0041 0.0368 0.0929
Brugia malayi larval opioid receptor 0.0076 0.0783 0.2147
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0368 0.037
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0076 0.0783 0.0783
Echinococcus granulosus neuropeptide receptor 0.0076 0.0783 0.0736
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0383 0.0161
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0076 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Brugia malayi G protein-coupled receptor 0.0076 0.0783 0.2147
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0383 0.0394
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1577 0.4477
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0248 0.0198
Toxoplasma gondii ABC1 family protein 0.0041 0.0368 0.037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0069 0.0018
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0383 0.0333
Schistosoma mansoni tar DNA-binding protein 0.019 0.2124 0.2124
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0076 0.0783 0.2147
Onchocerca volvulus 0.0076 0.0783 0.2809
Schistosoma mansoni opsin-like receptor 0.0076 0.0783 0.0783
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Loa Loa (eye worm) TAR-binding protein 0.019 0.2124 0.6082
Onchocerca volvulus 0.0076 0.0783 0.2809
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0076 0.0783 0.2147
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus hypothetical protein 0.0076 0.0783 0.0736
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0465 0.1215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Schistosoma mansoni opsin-like receptor 0.0076 0.0783 0.0783
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0368 0.0143
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0076 0.0783 0.0736
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0248 0.0248
Schistosoma mansoni cpg binding protein 0.0064 0.0636 0.0636
Echinococcus multilocularis dro:myosuppressin receptor 0.0076 0.0783 0.0736
Echinococcus multilocularis somatostatin receptor 0.0076 0.0783 0.0736
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0058 0.0565 0.0601
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0069 0.0018
Trichomonas vaginalis hypothetical protein 0.0738 0.8598 1
Echinococcus granulosus neuropeptide s receptor 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0076 0.0783 0.2809
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0596 0.1597
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0076 0.0783 0.2147
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0783 0.0736
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0341 0.684
Brugia malayi hypothetical protein 0.0262 0.2982 0.8598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Leishmania major dehydrogenase/oxidoreductase-like protein 0.005 0.0475 0.1487
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0598 0.1917
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0076 0.0783 0.0783
Schistosoma mansoni hypothetical protein 0.0076 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0929
Toxoplasma gondii aldehyde dehydrogenase 0.0255 0.2902 0.3336
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0783 0.0736
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Echinococcus multilocularis geminin 0.0349 0.4013 0.3982
Loa Loa (eye worm) melatonin receptor type 1A 0.0076 0.0783 0.2147
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0783 0.0783
Mycobacterium tuberculosis Conserved protein 0.0041 0.0368 0.037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0929
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1577 0.1577
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.005 0.0475 0.0496
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0929
Schistosoma mansoni amine GPCR 0.0076 0.0783 0.0783
Brugia malayi G-protein coupled receptor 0.0076 0.0783 0.2147
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0076 0.0783 0.2809
Schistosoma mansoni ap endonuclease 0.0039 0.0349 0.0349
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.005 0.0475 0.0426
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0069 0.0051
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0076 0.0783 0.0736
Echinococcus granulosus sex peptide receptor 0.0076 0.0783 0.0736
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus orexin receptor type 2 0.0076 0.0783 0.0736
Echinococcus granulosus neuropeptide FF receptor 2 0.0076 0.0783 0.0736
Loa Loa (eye worm) retinol dehydrogenase 12 0.005 0.0475 0.1244
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni tar DNA-binding protein 0.019 0.2124 0.2124
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0598 0.0549
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni neuropeptide receptor 0.0076 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Brugia malayi Melatonin receptor type 1A 0.0076 0.0783 0.2147
Brugia malayi beta-lactamase 0.0041 0.0368 0.0929
Onchocerca volvulus 0.0076 0.0783 0.2809
Echinococcus granulosus G protein coupled receptor 139 0.0076 0.0783 0.0736
Echinococcus granulosus 7tm_1 domain containing protein 0.0076 0.0783 0.0736
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0517 0.1366
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0783 0.0736
Echinococcus granulosus g protein coupled receptor 0.0076 0.0783 0.0736
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0341 0.9747
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0076 0.0783 0.0783
Loa Loa (eye worm) acetyltransferase 0.0143 0.1577 0.4477
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0076 0.0783 0.2147
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.005 0.0475 0.0496
Schistosoma mansoni histamine h1 receptor 0.0076 0.0783 0.0783
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0248 0.0198
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis orexin receptor type 2 0.0076 0.0783 0.0736
Brugia malayi Pre-SET motif family protein 0.0206 0.2322 0.6663
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0738 0.8598 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0783 0.0783
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1577 0.1534
Brugia malayi putative neuropeptide receptor 0.0076 0.0783 0.2147
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0075 0.0023
Schistosoma mansoni neuropeptide f receptor 76f 0.0076 0.0783 0.0783
Echinococcus granulosus tar DNA binding protein 0.019 0.2124 0.2084
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0075 0.0023
Schistosoma mansoni survival motor neuron protein 0.0053 0.0517 0.0517
Echinococcus multilocularis sex peptide receptor 0.0076 0.0783 0.0736
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0051 0.0051
Mycobacterium tuberculosis Probable oxidoreductase 0.0058 0.0565 0.0601
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0929
Loa Loa (eye worm) hypothetical protein 0.0262 0.2982 0.8598
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium ulcerans aldehyde dehydrogenase 0.0255 0.2902 0.3336
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Onchocerca volvulus 0.0076 0.0783 0.2809
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0368 0.037
Echinococcus multilocularis neuropeptides capa receptor 0.0076 0.0783 0.0736
Brugia malayi CXXC zinc finger family protein 0.006 0.0596 0.1597
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0349 0.0009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1568 0.445
Brugia malayi Dopamine receptor 0.0076 0.0783 0.2147
Brugia malayi RE15519p 0.0076 0.0783 0.2147
Echinococcus granulosus g protein coupled receptor 0.0076 0.0783 0.0736
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0076 0.0783 0.2147
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0076 0.0783 0.0736
Leishmania major 3-oxoacyl-ACP reductase, putative 0.005 0.0475 0.1487
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0783 0.2147
Loa Loa (eye worm) hypothetical protein 0.0034 0.0282 0.0676
Brugia malayi Serotonin receptor 0.0076 0.0783 0.2147
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0349 0.0299
Echinococcus granulosus 7TM GPCR rhodopsin 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0076 0.0783 0.2809
Brugia malayi G-protein coupled receptor 0.0076 0.0783 0.2147
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0076 0.0783 0.2147
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Loa Loa (eye worm) oxidoreductase 0.005 0.0475 0.1244
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0465 0.1215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1568 0.1568
Brugia malayi RNA recognition motif domain containing protein 0.019 0.2124 0.6082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0783 0.0783
Echinococcus granulosus neuropeptide receptor 0.0076 0.0783 0.0736
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Brugia malayi neuropeptide F receptor 0.0076 0.0783 0.2147
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0031 0.0248 0.0577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.005 0.0475 0.0496
Echinococcus granulosus neuropeptide Y receptor 0.0076 0.0783 0.0736
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0076 0.0783 0.0783
Trypanosoma brucei pteridine reductase 1 0.005 0.0475 0.8251
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0929
Loa Loa (eye worm) G-protein coupled receptor 0.0076 0.0783 0.2147
Brugia malayi TAR-binding protein 0.019 0.2124 0.6082
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Schistosoma mansoni biogenic amine receptor 0.0076 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.2982 0.2945
Schistosoma mansoni cpg binding protein 0.006 0.0596 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Schistosoma mansoni hypothetical protein 0.0016 0.0069 0.0069
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0014 0.0051 0.0051
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0783 0.0736
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.005 0.0475 0.0496
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0783 0.0736
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0598 0.0549
Onchocerca volvulus Neuropeptide F receptor homolog 0.0076 0.0783 0.2809
Schistosoma mansoni biogenic amine receptor 0.0076 0.0783 0.0783
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0783 0.0736
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0076 0.0783 0.0736
Schistosoma mansoni tar DNA-binding protein 0.019 0.2124 0.2124
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0076 0.0783 0.2147
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0738 0.8598 1
Onchocerca volvulus 0.0041 0.0368 0.1215
Schistosoma mansoni neuropeptide receptor 0.0076 0.0783 0.0783
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0368 0.6158
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni dihydropteridine reductase 0.005 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus serotonin receptor 0.0076 0.0783 0.0736
Schistosoma mansoni hypothetical protein 0.0349 0.4013 0.4013
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0368 0.0376
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.005 0.0475 0.0496
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0349 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0598 0.0639
Schistosoma mansoni growth hormone secretagogue receptor 0.0076 0.0783 0.0783
Brugia malayi Dopamine receptor protein 1 0.0076 0.0783 0.2147
Mycobacterium ulcerans beta-lactamase 0.0041 0.0368 0.037
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0368 0.0376
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0255 0.2902 1
Onchocerca volvulus 0.0076 0.0783 0.2809
Echinococcus granulosus allatostatin A receptor 0.0076 0.0783 0.0736
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0783 0.0783
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.005 0.0475 0.1244
Onchocerca volvulus 0.0076 0.0783 0.2809
Echinococcus multilocularis dnaJ subfamily B 0.0856 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis cpg binding protein 0.0064 0.0636 0.0588
Schistosoma mansoni biogenic amine receptor 0.0076 0.0783 0.0783
Brugia malayi Serotonin receptor 0.0076 0.0783 0.2147
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Schistosoma mansoni amine GPCR 0.0076 0.0783 0.0783
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Schistosoma mansoni amine GPCR 0.0076 0.0783 0.0783
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0076 0.0783 0.0736
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0368 0.037
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0255 0.2902 0.3336
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0051 0.0051
Onchocerca volvulus 0.0076 0.0783 0.2809
Schistosoma mansoni hypothetical protein 0.0076 0.0783 0.0783
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.2982 0.2945
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0929
Toxoplasma gondii exonuclease III APE 0.0039 0.0349 0.0348
Echinococcus multilocularis G protein coupled receptor 139 0.0076 0.0783 0.0736
Brugia malayi neuropeptide F receptor 0.0076 0.0783 0.2147
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0103 0.1098 0.3071
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.005 0.0475 0.0426
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0368 0.0318
Echinococcus granulosus neuropeptides capa receptor 0.0076 0.0783 0.0736
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1568 0.1524
Echinococcus granulosus alpha 1A adrenergic receptor 0.0076 0.0783 0.0736
Brugia malayi hypothetical protein 0.0076 0.0783 0.2147
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0076 0.0783 0.0736
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.005 0.0475 0.0496
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0783 0.2147
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0014 0.0051 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0783 0.0736
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0738 0.8598 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0349 0.0121
Schistosoma mansoni cpg binding protein 0.0064 0.0636 0.0636
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0349 0.0348
Echinococcus multilocularis g-protein coupled receptor 0.0076 0.0783 0.0736
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0349 0.7017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.005 0.0475 0.0496
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0069 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.0076 0.0783 0.0736
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0783 0.0783
Echinococcus multilocularis tar DNA binding protein 0.019 0.2124 0.2084
Loa Loa (eye worm) neuropeptide F receptor 0.0076 0.0783 0.2147
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0738 0.8598 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Echinococcus granulosus geminin 0.0349 0.4013 0.3982
Plasmodium falciparum enoyl-acyl carrier reductase 0.0738 0.8598 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0368 0.037
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0076 0.0783 0.0736
Schistosoma mansoni ap endonuclease 0.0039 0.0349 0.0349
Echinococcus multilocularis neuropeptide Y receptor 0.0076 0.0783 0.0736
Schistosoma mansoni glutaminase 0.027 0.3076 0.3076
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0349 0.0348
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0041 0.0368 0.1215
Brugia malayi beta-lactamase family protein 0.0041 0.0368 0.0929
Echinococcus granulosus rhodopsin orphan GPCR 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0076 0.0783 0.2809
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0383 0.0394
Echinococcus granulosus somatostatin receptor 0.0076 0.0783 0.0736
Echinococcus multilocularis neuropeptide receptor A26 0.0076 0.0783 0.0736
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0076 0.0783 0.2809
Echinococcus multilocularis neuropeptide receptor 0.0076 0.0783 0.0736
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0076 0.0783 0.0736
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.2124 0.6082
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0368 0.0376
Echinococcus granulosus fmrfamide receptor 0.0076 0.0783 0.0736
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0248 0.0248
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0076 0.0783 0.0783
Echinococcus granulosus tm gpcr rhodopsin 0.0076 0.0783 0.0736
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0118 0.0067
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0738 0.8598 1
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0014 0.0051 0.0051
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.005 0.0475 0.0496
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.005 0.0475 0.8251
Mycobacterium tuberculosis Possible oxidoreductase 0.005 0.0475 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1568 0.1568
Schistosoma mansoni alpha-1 adrenergic receptor 0.0076 0.0783 0.0783
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Brugia malayi putative neuropeptide receptor NPR1 0.0076 0.0783 0.2147
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0368 0.0376
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0368 0.6158
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Loa Loa (eye worm) hypothetical protein 0.005 0.0475 0.1244
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0118 0.0067
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Trypanosoma brucei oxidoreductase-like protein 0.0058 0.0565 1
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0051 0.0051
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.005 0.0475 1
Schistosoma mansoni adenoreceptor 0.0076 0.0783 0.0783
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1405 0.1405
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni hypothetical protein 0.0016 0.0069 0.0069
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0783 0.0736
Loa Loa (eye worm) glutaminase 2 0.027 0.3076 0.8875
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0349 0.579
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni hypothetical protein 0.0856 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0383 0.0388
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0383 0.0388
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.005 0.0475 0.0496
Echinococcus multilocularis GPCR, family 2 0.0016 0.0069 0.0018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0069 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0368 0.0368
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Leishmania major oxidoreductase-like protein 0.0058 0.0565 0.1803
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.005 0.0475 0.0496
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0303 0.3459 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1568 0.1524
Mycobacterium tuberculosis Possible oxidoreductase 0.005 0.0475 0.0496
Loa Loa (eye worm) RNA binding protein 0.019 0.2124 0.6082
Brugia malayi beta-lactamase family protein 0.0041 0.0368 0.0929
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0349 0.0873
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0076 0.0783 0.0783
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0235 0.2657 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni aldehyde dehydrogenase 0.0255 0.2902 0.2902
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0349 0.0873
Mycobacterium ulcerans short chain dehydrogenase 0.005 0.0475 0.0496
Mycobacterium ulcerans short chain dehydrogenase 0.0058 0.0565 0.0601
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0076 0.0783 0.2147
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.005 0.0475 0.8251
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0598 0.0598
Echinococcus granulosus peptide allatostatin:somatostatin 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0058 0.0565 0.1972
Mycobacterium leprae Probable lipase LipE 0.0041 0.0368 0.037
Schistosoma mansoni hypothetical protein 0.0076 0.0783 0.0783
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0248 0.0198
Onchocerca volvulus 0.0076 0.0783 0.2809
Loa Loa (eye worm) histone methyltransferase 0.002 0.0118 0.0195
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.1285 0.1444
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0598 0.0639
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0051 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1568 0.1524
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Leishmania major hypothetical protein, conserved 0.0041 0.0368 0.111
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.005 0.0475 0.0496
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0076 0.0783 0.0783
Echinococcus multilocularis fmrfamide receptor 0.0076 0.0783 0.0736
Echinococcus granulosus g protein coupled receptor 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0076 0.0783 0.2809
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0248 0.023
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0783 0.0736
Onchocerca volvulus 0.0041 0.0368 0.1215
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0368 0.0376
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0565 0.0601
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni hypothetical protein 0.0349 0.4013 0.4013
Loa Loa (eye worm) glutaminase 0.027 0.3076 0.8875
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0069 0.0051
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.153 0.1486
Brugia malayi Dopamine receptor protein 2 0.0076 0.0783 0.2147
Echinococcus multilocularis serotonin receptor 0.0076 0.0783 0.0736
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0465 0.1215
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Schistosoma mansoni hypothetical protein 0.0034 0.0282 0.0282
Echinococcus multilocularis g protein coupled receptor 0.0076 0.0783 0.0736
Brugia malayi follicle stimulating hormone receptor 0.0303 0.3459 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2322 0.6663
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.005 0.0475 0.0496
Loa Loa (eye worm) hypothetical protein 0.0076 0.0783 0.2147
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.005 0.0475 0.8251
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0076 0.0783 0.0783
Schistosoma mansoni opsin-like receptor 0.0076 0.0783 0.0783
Leishmania major pteridine reductase 1 0.0058 0.0565 0.1803
Schistosoma mansoni neuropeptide receptor 0.0076 0.0783 0.0783
Brugia malayi ORL1-like opioid receptor 0.0076 0.0783 0.2147
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0069 0.0018
Onchocerca volvulus 0.0053 0.0517 0.1787
Brugia malayi sulfakinin receptor protein 0.0076 0.0783 0.2147
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0076 0.0783 0.0783

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.17 uM Inhibition of HCV 1b BK NS5B delta21 RNA polymerase expressed in Escherichia coli ChEMBL. 17402724
IC50 (functional) = 14 uM Antiviral activity in Huh7 cells containing HCV 1b BB7 replicon ChEMBL. 17402724
IC50 (ADMET) = 47 uM Cytotoxicity against Huh7 cells by MTS assay ChEMBL. 17402724

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.