Detailed information for compound 422376

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1055.27 | Formula: C58H74N10O9
  • H donors: 8 H acceptors: 9 LogP: 4.87 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCC[C@H](C(=O)N[C@@H]1CC(=O)NCCCCC(NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@H](NC(=O)[C@H]3N(C1=O)C1CCCCC1C3)Cc1ccc(cc1)c1ccccc1)CCC2)Cc1c[nH]c2c1cccc2)C(=O)N)NC(=O)C
  • InChi: 1S/C58H74N10O9/c1-3-4-19-44(62-35(2)69)53(72)65-47-33-51(70)60-28-13-12-21-43(52(59)71)63-54(73)45(31-40-34-61-42-20-10-9-18-41(40)42)64-55(74)49-23-14-29-67(49)57(76)46(30-36-24-26-38(27-25-36)37-15-6-5-7-16-37)66-56(75)50-32-39-17-8-11-22-48(39)68(50)58(47)77/h5-7,9-10,15-16,18,20,24-27,34,39,43-50,61H,3-4,8,11-14,17,19,21-23,28-33H2,1-2H3,(H2,59,71)(H,60,70)(H,62,69)(H,63,73)(H,64,74)(H,65,72)(H,66,75)/t39?,43?,44-,45-,46-,47-,48?,49-,50-/m0/s1
  • InChiKey: GDBQVVGENJRXGO-KUQDGXLASA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Echinococcus granulosus hypothetical protein 0.0164 0.1032 0.2218
Loa Loa (eye worm) uridine phosphorylase 0.0134 0.08 0.2194
Trypanosoma brucei uridine phosphorylase 0.0134 0.08 1
Brugia malayi beta-lactamase family protein 0.0037 0.0069 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0134 0.0289
Onchocerca volvulus 0.0164 0.1032 0.2101
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Schistosoma mansoni opsin-like receptor 0.0164 0.1032 0.2218
Schistosoma mansoni biogenic amine (5HT) receptor 0.0164 0.1032 0.2218
Trichomonas vaginalis hypothetical protein 0.1355 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0134 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.019
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0164 0.1032 0.2218
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0069 0.0064
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0092 0.0485 0.0445
Schistosoma mansoni purine nucleoside phosphorylase 0.0645 0.4651 1
Brugia malayi MTAP 0.0134 0.08 0.172
Treponema pallidum uridine phosphorylase (udp) 0.0134 0.08 1
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Toxoplasma gondii phosphorylase family protein 0.0134 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Brugia malayi Serotonin receptor 0.0164 0.1032 0.2218
Brugia malayi G protein-coupled receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0134 0.0209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus multilocularis neuropeptide receptor 0.0164 0.1032 0.1604
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Onchocerca volvulus 0.0164 0.1032 0.2101
Brugia malayi Dopamine receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus biogenic amine 5HT receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis geminin 0.0339 0.2349 0.3652
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.0069
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0164 0.1032 0.2218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Echinococcus multilocularis purine nucleoside phosphorylase 0.0645 0.4651 0.7232
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0092 0.0485 0.0485
Echinococcus multilocularis neuropeptides capa receptor 0.0164 0.1032 0.1604
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0172 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Brugia malayi putative neuropeptide receptor 0.0164 0.1032 0.2218
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.0069
Brugia malayi AKH receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0164 0.1032 0.1604
Mycobacterium leprae probable uridine phosphorylase 0.0134 0.08 0.0736
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0134 0.08 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0164 0.1032 0.1604
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0134 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus multilocularis g protein coupled receptor 0.0164 0.1032 0.1604
Onchocerca volvulus 0.0164 0.1032 0.2101
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0069 0.0027
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0134 0.08 1
Echinococcus multilocularis fmrfamide receptor 0.0164 0.1032 0.1604
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0058 0.0233 0.0227
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0081 0.0406 0.0366
Echinococcus granulosus dro:myosuppressin receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Schistosoma mansoni neuropeptide receptor 0.0164 0.1032 0.2218
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0092 0.0485 0.048
Echinococcus granulosus neuropeptide FF receptor 2 0.0164 0.1032 0.2218
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Echinococcus multilocularis g-protein coupled receptor 0.0164 0.1032 0.1604
Schistosoma mansoni biogenic amine receptor 0.0164 0.1032 0.2218
Echinococcus granulosus g protein coupled receptor 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0069 0.0027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Echinococcus granulosus methylthioadenosine phosphorylase 0.0134 0.08 0.172
Echinococcus multilocularis neuropeptide s receptor 0.0164 0.1032 0.1604
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0092 0.0485 0.1332
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0134 0.08 0.2194
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0069 0.0027
Schistosoma mansoni hypothetical protein 0.0164 0.1032 0.2218
Echinococcus multilocularis purine nucleoside phosphorylase 0.0645 0.4651 0.7232
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0164 0.1032 0.2218
Schistosoma mansoni opsin-like receptor 0.0164 0.1032 0.2218
Schistosoma mansoni biogenic amine receptor 0.0164 0.1032 0.2218
Entamoeba histolytica hypothetical protein 0.0134 0.08 1
Schistosoma mansoni amine GPCR 0.0164 0.1032 0.2218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0069 0.0149
Echinococcus granulosus 7TM GPCR rhodopsin 0.0164 0.1032 0.2218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0134 0.0289
Echinococcus granulosus alpha 1A adrenergic receptor 0.0164 0.1032 0.2218
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0114 0.0654 0.0649
Echinococcus granulosus tachykinin peptides receptor 99D 0.0164 0.1032 0.2218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Loa Loa (eye worm) hypothetical protein 0.0511 0.3645 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0092 0.0485 0.048
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Onchocerca volvulus 0.0164 0.1032 0.2101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0092 0.0485 0.048
Echinococcus multilocularis neuropeptide Y receptor 0.0164 0.1032 0.1604
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.019
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0645 0.4651 0.4628
Echinococcus granulosus G protein coupled receptor 139 0.0164 0.1032 0.2218
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.08 0.08
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0092 0.0485 0.1044
Schistosoma mansoni neuropeptide f receptor 76f 0.0164 0.1032 0.2218
Brugia malayi ORL1-like opioid receptor 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0069 0.0027
Schistosoma mansoni growth hormone secretagogue receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis neuropeptide FF receptor 2 0.0164 0.1032 0.1604
Plasmodium falciparum purine nucleoside phosphorylase 0.0134 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0092 0.0485 0.1332
Echinococcus multilocularis orexin receptor type 2 0.0164 0.1032 0.1604
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0092 0.0485 0.1044
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0164 0.1032 0.1604
Onchocerca volvulus 0.0092 0.0485 0.0908
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0058 0.0233 0.0227
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Schistosoma mansoni histamine h1 receptor 0.0164 0.1032 0.2218
Schistosoma mansoni amine GPCR 0.0164 0.1032 0.2218
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0511 0.3645 0.7838
Echinococcus granulosus neuropeptide receptor A26 0.0164 0.1032 0.2218
Schistosoma mansoni neuropeptide F-like receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0134 0.08 1
Schistosoma mansoni neuropeptide receptor 0.0164 0.1032 0.2218
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Schistosoma mansoni hypothetical protein 0.0164 0.1032 0.2218
Schistosoma mansoni neuropeptide receptor 0.0164 0.1032 0.2218
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0164 0.1032 0.2218
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0069 0.0149
Brugia malayi uridine phosphorylase family protein 0.0134 0.08 0.172
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus multilocularis G-protein coupled receptor, putative 0.0164 0.1032 0.1604
Onchocerca volvulus 0.0164 0.1032 0.2101
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0164 0.1032 0.2218
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1355 1 1
Brugia malayi Dopamine receptor protein 1 0.0164 0.1032 0.2218
Leishmania major methylthioadenosine phosphorylase, putative 0.0134 0.08 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0164 0.1032 0.1604
Echinococcus granulosus geminin 0.0339 0.2349 0.505
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0092 0.0485 0.0445
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0172 0.1093 0.1093
Echinococcus granulosus serotonin receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus multilocularis purine nucleoside phosphorylase 0.0511 0.3645 0.5668
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0027
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Echinococcus granulosus neuropeptide Y receptor 0.0164 0.1032 0.2218
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0134 0.08 1
Brugia malayi neuropeptide F receptor 0.0164 0.1032 0.2218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Hypothetical protein 0.0134 0.08 0.0761
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0164 0.1032 0.2218
Schistosoma mansoni biogenic amine (5HT) receptor 0.0164 0.1032 0.2218
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0134 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus rhodopsin orphan GPCR 0.0164 0.1032 0.2218
Schistosoma mansoni dihydropteridine reductase 0.0092 0.0485 0.1044
Brugia malayi G-protein coupled receptor 0.0164 0.1032 0.2218
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0069 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0081 0.0406 0.0401
Plasmodium falciparum enoyl-acyl carrier reductase 0.1355 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0164 0.1032 0.2218
Onchocerca volvulus 0.0164 0.1032 0.2101
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0092 0.0485 0.0485
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0645 0.4651 1
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0134 0.08 0.0761
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0645 0.4651 0.4651
Echinococcus multilocularis uridine phosphorylase 1 0.0134 0.08 0.1244
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0092 0.0485 0.0445
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0164 0.1032 0.2218
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0645 0.4651 0.4648
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus sex peptide receptor 0.0164 0.1032 0.2218
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0134 0.08 1
Brugia malayi RE15519p 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0027
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0134 0.08 0.0795
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0164 0.1032 0.1604
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0134 0.08 1
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1355 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0164 0.1032 0.2218
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0033 0.0042 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0134 0.0289
Echinococcus granulosus neuropeptides capa receptor 0.0164 0.1032 0.2218
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0164 0.1032 0.2218
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Echinococcus multilocularis neuropeptide receptor A26 0.0164 0.1032 0.1604
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0092 0.0485 0.0755
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0134 0.08 0.172
Mycobacterium ulcerans lipase LipD 0.0037 0.0069 0.0064
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0092 0.0485 0.0445
Echinococcus granulosus rhodopsin orphan GPCR 0.0164 0.1032 0.2218
Onchocerca volvulus 0.0164 0.1032 0.2101
Schistosoma mansoni amine GPCR 0.0164 0.1032 0.2218
Echinococcus multilocularis fmrfamide receptor 0.0164 0.1032 0.1604
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium tuberculosis Possible oxidoreductase 0.0092 0.0485 0.0445
Echinococcus granulosus rhodopsin orphan GPCR 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0092 0.0485 0.0445
Brugia malayi larval opioid receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Brugia malayi follicle stimulating hormone receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0164 0.1032 0.1604
Schistosoma mansoni amine GPCR 0.0164 0.1032 0.2218
Loa Loa (eye worm) TYRA-2 protein 0.0164 0.1032 0.283
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Echinococcus granulosus somatostatin receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0164 0.1032 0.1604
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0164 0.1032 0.1604
Echinococcus granulosus neuropeptide receptor 0.0164 0.1032 0.2218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0069 0.0027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0164 0.1032 0.1604
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0092 0.0485 0.048
Onchocerca volvulus 0.0164 0.1032 0.2101
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Toxoplasma gondii ABC1 family protein 0.0037 0.0069 0.0069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0134 0.0368
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0092 0.0485 0.048
Echinococcus multilocularis purine nucleoside phosphorylase 0.0645 0.4651 0.7232
Onchocerca volvulus 0.0164 0.1032 0.2101
Schistosoma mansoni opsin-like receptor 0.0164 0.1032 0.2218
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Trypanosoma brucei pteridine reductase 1 0.0092 0.0485 0.6068
Schistosoma mansoni alpha-1 adrenergic receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0134 0.0289
Echinococcus granulosus tm gpcr rhodopsin 0.0164 0.1032 0.2218
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1355 1 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus tm gpcr rhodopsin 0.0164 0.1032 0.2218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Echinococcus multilocularis serotonin receptor 0.0164 0.1032 0.1604
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0092 0.0485 0.6068
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0069 0.0027
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0092 0.0485 0.0485
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0164 0.1032 0.1604
Echinococcus granulosus fmrfamide receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Schistosoma mansoni methylthioadenosine phosphorylase 0.0134 0.08 0.172
Echinococcus granulosus rhodopsin orphan GPCR 0.0164 0.1032 0.2218
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.019
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus multilocularis G protein coupled receptor 139 0.0164 0.1032 0.1604
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0134 0.08 1
Echinococcus granulosus tm gpcr rhodopsin 0.0164 0.1032 0.2218
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0058 0.0233 0.0191
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.6431 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0092 0.0485 0.1044
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Echinococcus multilocularis g protein coupled receptor 0.0164 0.1032 0.1604
Chlamydia trachomatis AMP nucleosidase 0.0134 0.08 0.0331
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0645 0.4651 0.4614
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Brugia malayi Melatonin receptor type 1A 0.0164 0.1032 0.2218
Onchocerca volvulus 0.0164 0.1032 0.2101
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Brugia malayi GnHR receptor homolog 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Onchocerca volvulus 0.0092 0.0485 0.0908
Echinococcus granulosus biogenic amine 5HT receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Onchocerca volvulus 0.0164 0.1032 0.2101
Onchocerca volvulus Neuropeptide F receptor homolog 0.0164 0.1032 0.2101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0069 0.0149
Echinococcus multilocularis purine nucleoside phosphorylase 0.0645 0.4651 0.7232
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0164 0.1032 0.2218
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0069 0.0069
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1355 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0069 0.019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0164 0.1032 0.1604
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0069 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0164 0.1032 0.2218
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0051 0.0179 0.0174
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0134 0.08 1
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0033 0.0042 0.0037
Echinococcus multilocularis somatostatin receptor 0.0164 0.1032 0.1604
Trichomonas vaginalis esterase, putative 0.0037 0.0069 0.0069
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0092 0.0485 0.6068
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0081 0.0406 0.0401
Echinococcus multilocularis neuropeptide Y receptor 0.0164 0.1032 0.1604
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0092 0.0485 0.0419
Loa Loa (eye worm) oxidoreductase 0.0092 0.0485 0.1332
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.08 0.0761
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0092 0.0485 0.6068
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0134 0.08 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus g protein coupled receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0164 0.1032 0.283
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0134 0.08 0.08
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0645 0.4651 1
Echinococcus granulosus g protein coupled receptor 0.0164 0.1032 0.2218
Brugia malayi neuropeptide F receptor 0.0164 0.1032 0.2218
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0164 0.1032 0.2218
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0092 0.0485 0.0485
Schistosoma mansoni myosin xvIII 0.0164 0.1032 0.2218
Onchocerca volvulus 0.0164 0.1032 0.2101
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0092 0.0485 0.048
Onchocerca volvulus 0.0164 0.1032 0.2101
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0092 0.0485 0.048
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0134 0.08 0.0795
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0164 0.1032 0.283
Loa Loa (eye worm) G-protein coupled receptor 0.0164 0.1032 0.283
Loa Loa (eye worm) neuropeptide F receptor 0.0164 0.1032 0.283
Treponema pallidum hypothetical protein 0.0028 0.0005 0.0061
Brugia malayi beta-lactamase 0.0037 0.0069 0.0149
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0069 0.0868
Schistosoma mansoni adenoreceptor 0.0164 0.1032 0.2218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0134 0.0289
Echinococcus granulosus neuropeptide receptor 0.0164 0.1032 0.2218
Treponema pallidum pfs protein (pfs) 0.0134 0.08 1
Brugia malayi G-protein coupled receptor 0.0164 0.1032 0.2218
Echinococcus granulosus neuropeptide Y receptor 0.0164 0.1032 0.2218
Schistosoma mansoni uridine phosphorylase 0.0134 0.08 0.172
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0164 0.1032 0.2218
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0134 0.08 0.1244
Echinococcus multilocularis sex peptide receptor 0.0164 0.1032 0.1604
Loa Loa (eye worm) beta-lactamase 0.0037 0.0069 0.019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0164 0.1032 0.1604
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1355 1 1
Brugia malayi Dopamine receptor protein 2 0.0164 0.1032 0.2218
Brugia malayi beta-lactamase family protein 0.0037 0.0069 0.0149
Loa Loa (eye worm) retinol dehydrogenase 12 0.0092 0.0485 0.1332
Schistosoma mansoni neuropeptide F-like receptor 0.0164 0.1032 0.2218
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Leishmania major pteridine reductase 1 0.0092 0.0485 0.6068
Schistosoma mansoni amine GPCR 0.0164 0.1032 0.2218
Echinococcus multilocularis neuropeptide receptor 0.0164 0.1032 0.1604
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0092 0.0485 0.0445
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0645 0.4651 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0164 0.1032 0.2218
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0134 0.08 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0092 0.0485 0.6068
Onchocerca volvulus 0.0164 0.1032 0.2101
Brugia malayi sulfakinin receptor protein 0.0164 0.1032 0.2218
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Schistosoma mansoni neuropeptide receptor 0.0164 0.1032 0.2218
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0134 0.08 0.172
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus orexin receptor type 2 0.0164 0.1032 0.2218
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0069 0.0868
Onchocerca volvulus 0.0164 0.1032 0.2101
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0092 0.0485 0.0485
Echinococcus granulosus uridine phosphorylase 1 0.0134 0.08 0.172
Onchocerca volvulus 0.0164 0.1032 0.2101
Onchocerca volvulus 0.0164 0.1032 0.2101
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0164 0.1032 0.2101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0164 0.1032 0.1604
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0164 0.1032 0.2218
Echinococcus multilocularis dro:myosuppressin receptor 0.0164 0.1032 0.1604
Trichomonas vaginalis aldehyde oxidase, putative 0.0172 0.1093 0.1093
Mycobacterium tuberculosis Possible oxidoreductase 0.0092 0.0485 0.0445
Brugia malayi G protein-coupled receptor F59B2.13 0.0164 0.1032 0.2218
Leishmania major nucleoside phosphorylase-like protein 0.0134 0.08 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0092 0.0485 0.6068
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium ulcerans hypothetical protein 0.0037 0.0069 0.0064
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium ulcerans oxidoreductase 0.0092 0.0485 0.048
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0164 0.1032 0.283
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Brugia malayi Tachykinin-like peptides receptor 99D 0.0164 0.1032 0.2218
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0092 0.0485 0.0419
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0069 0.0069
Loa Loa (eye worm) G-protein coupled receptor 0.0164 0.1032 0.283
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0069 0.0868
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0164 0.1032 0.2218
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0164 0.1032 0.2218
Echinococcus multilocularis purine nucleoside phosphorylase 0.0645 0.4651 0.7232
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0164 0.1032 0.2218
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Schistosoma mansoni hypothetical protein 0.0339 0.2349 0.505
Echinococcus granulosus 7tm_1 domain containing protein 0.0164 0.1032 0.2218
Echinococcus multilocularis allatostatin A receptor 0.0164 0.1032 0.1604
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Schistosoma mansoni purine nucleoside phosphorylase 0.0645 0.4651 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium ulcerans beta-lactamase 0.0037 0.0069 0.0064
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0092 0.0485 0.048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0134 0.0209
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0092 0.0485 0.6068
Giardia lamblia UPL-1 0.0134 0.08 0.172
Schistosoma mansoni hypothetical protein 0.0339 0.2349 0.505
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0164 0.1032 0.1604
Echinococcus multilocularis neuropeptides capa receptor 0.0164 0.1032 0.1604
Brugia malayi hypothetical protein 0.0164 0.1032 0.2218
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0164 0.1032 0.2218
Echinococcus granulosus neuropeptides capa receptor 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0092 0.0485 0.6068
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1355 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Echinococcus granulosus neuropeptide s receptor 0.0164 0.1032 0.2218
Schistosoma mansoni hypothetical protein 0.0164 0.1032 0.2218
Trypanosoma brucei oxidoreductase-like protein 0.0092 0.0485 0.6068
Echinococcus granulosus g-protein coupled receptor 0.0164 0.1032 0.2218
Schistosoma mansoni methylthioadenosine phosphorylase 0.0134 0.08 0.172
Toxoplasma gondii phosphorylase family protein 0.0134 0.08 0.08
Echinococcus granulosus rhodopsin orphan GPCR 0.0164 0.1032 0.2218
Toxoplasma gondii Purine nucleoside phosphorylase 0.0134 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.0485 0.0445
Echinococcus multilocularis purine nucleoside phosphorylase 0.0511 0.3645 0.5668
Echinococcus granulosus purine nucleoside phosphorylase 0.0645 0.4651 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0164 0.1032 0.283
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0164 0.1032 0.1604
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0164 0.1032 0.283
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0069 0.0149
Schistosoma mansoni methylthioadenosine phosphorylase 0.0134 0.08 0.172
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis purine nucleoside phosphorylase 0.0645 0.4651 0.7232
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0069 0.0108
Loa Loa (eye worm) hypothetical protein 0.0164 0.1032 0.283
Loa Loa (eye worm) neuropeptide F receptor 0.0164 0.1032 0.283
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0134 0.08 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1552 0.1517
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0164 0.1032 0.1604
Echinococcus granulosus allatostatin A receptor 0.0164 0.1032 0.2218
Echinococcus granulosus rhodopsin orphan GPCR 0.0164 0.1032 0.2218
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0164 0.1032 0.2218
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0164 0.1032 0.2218
Schistosoma mansoni uridine phosphorylase 0.0134 0.08 0.172
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0092 0.0485 0.6068
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0092 0.0485 0.048
Schistosoma mansoni hypothetical protein 0.0164 0.1032 0.2218
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0485 0.048
Mycobacterium ulcerans short chain dehydrogenase 0.0092 0.0485 0.048
Loa Loa (eye worm) melatonin receptor type 1A 0.0164 0.1032 0.283
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0092 0.0485 0.1044
Brugia malayi Serotonin receptor 0.0164 0.1032 0.2218
Leishmania major hypothetical protein, conserved 0.0037 0.0069 0.0868
Schistosoma mansoni biogenic amine receptor 0.0164 0.1032 0.2218
Echinococcus multilocularis serotonin receptor 0.0164 0.1032 0.1604
Leishmania major oxidoreductase-like protein 0.0092 0.0485 0.6068

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 1 % Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation at 5 uM relative to [125I]NDPalphaMSH ChEMBL. 17455928
Activity (functional) = 97 % Agonist activity at human MC4R expressed in CHO cells assessed as cAMP accumulation at 5 uM relative to [125I]NDPalphaMSH ChEMBL. 17455928
EC50 (functional) = 17 nM Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation ChEMBL. 17455928
EC50 (functional) > 2500 nM Agonist activity at human melanocortin receptor 1b expressed in CHO cells assessed as cAMP accumulation ChEMBL. 17455928
IC50 (binding) = 10 nM Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells ChEMBL. 17455928
IC50 (binding) = 4400 nM Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells ChEMBL. 17455928
IC50 (binding) = 4700 nM Displacement of [125I]NDPalphaMSH from human cloned MC4R expressed in CHO cells ChEMBL. 17455928
IC50 (binding) = 7800 nM Displacement of [125I]NDPalphaMSH from human cloned melanocortin receptor 1b expressed in CHO cells ChEMBL. 17455928
Ratio IC50 (binding) = 440 Selectivity for human cloned MC5R over human cloned MC3R ChEMBL. 17455928
Ratio IC50 (binding) = 470 Selectivity for human cloned MC5R over human cloned MC4R ChEMBL. 17455928
Ratio IC50 (binding) = 780 Selectivity for human cloned MC5R over human cloned MC1bR ChEMBL. 17455928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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