Detailed information for compound 422545

Basic information

Technical information
  • TDR Targets ID: 422545
  • Name: 1-(cyclopropylmethyl)-2-methyl-9-(trifluorome thyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzox azin-7-one
  • MW: 338.324 | Formula: C17H17F3N2O2
  • H donors: 1 H acceptors: 1 LogP: 2.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1COc2c(N1CC1CC1)cc1c(c2)[nH]c(=O)cc1C(F)(F)F
  • InChi: 1S/C17H17F3N2O2/c1-9-8-24-15-6-13-11(4-14(15)22(9)7-10-2-3-10)12(17(18,19)20)5-16(23)21-13/h4-6,9-10H,2-3,7-8H2,1H3,(H,21,23)
  • InChiKey: YAQFNSNOLMJAPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(cyclopropylmethyl)-2-methyl-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[5,6-g][1,4]benzoxazin-7-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Schistosoma mansoni histamine h1 receptor 0.0073 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.3024 0.3024
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.3024 0.3024
Schistosoma mansoni biogenic amine receptor 0.0073 1 1
Echinococcus granulosus g-protein coupled receptor 0.0073 1 1
Echinococcus granulosus serotonin receptor 0.0073 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0073 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 1 1
Schistosoma mansoni amine GPCR 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.3024 0.3024
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.3024 0.3024
Schistosoma mansoni neuropeptide receptor 0.0073 1 1
Brugia malayi hypothetical protein 0.0073 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi GnHR receptor homolog 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus somatostatin receptor 0.0073 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0073 1 1
Brugia malayi G-protein coupled receptor 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.3024 0.3024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.3024 0.3024
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0073 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 1 1
Schistosoma mansoni neuropeptide receptor 0.0073 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.3024 0.3024
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.3024 0.3024
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0073 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0073 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.3024 0.3024
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Onchocerca volvulus 0.0073 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0324 0.0324
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.3024 0.3024
Echinococcus granulosus sex peptide receptor 0.0073 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.3024 0.3024
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 1 1
Brugia malayi ORL1-like opioid receptor 0.0073 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi Dopamine receptor protein 2 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0073 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 1 1
Brugia malayi steroid hormone receptor 0.0033 0.3024 0.3024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.3024 0.3024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.3024 0.3024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 1 1
Brugia malayi putative neuropeptide receptor 0.0073 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0324 0.0324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.3024 0.3024
Onchocerca volvulus Neuropeptide F receptor homolog 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 1 1
Brugia malayi Dopamine receptor 0.0073 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 1 1
Brugia malayi hypothetical protein 0.0073 1 1
Brugia malayi Dopamine receptor protein 1 0.0073 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0073 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0073 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus g protein coupled receptor 0.0073 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.3024 0.3024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.3024 0.3024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0324 0.0324
Echinococcus granulosus neuropeptide s receptor 0.0073 1 1
Schistosoma mansoni thyroid hormone receptor 0.0033 0.3024 0.3024
Brugia malayi hypothetical protein 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0073 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi sulfakinin receptor protein 0.0073 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0073 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0073 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Echinococcus granulosus allatostatin A receptor 0.0073 1 1
Schistosoma mansoni opsin-like receptor 0.0073 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Schistosoma mansoni opsin-like receptor 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.3024 0.3024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Echinococcus multilocularis neuropeptide receptor A26 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.3024 0.3024
Brugia malayi G protein-coupled receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Brugia malayi putative neuropeptide receptor NPR1 0.0073 1 1
Echinococcus multilocularis neuropeptide receptor 0.0073 1 1
Brugia malayi hypothetical protein 0.0073 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.3024 0.3024
Brugia malayi hypothetical protein 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.3024 0.3024
Echinococcus granulosus neuropeptide receptor 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Echinococcus granulosus g protein coupled receptor 0.0073 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.3024 0.3024
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.3024 0.3024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus g protein coupled receptor 0.0073 1 1
Schistosoma mansoni biogenic amine receptor 0.0073 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0073 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 1 1
Schistosoma mansoni neuropeptide receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni opsin-like receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi G-protein coupled receptor 0.0073 1 1
Brugia malayi neuropeptide F receptor 0.0073 1 1
Schistosoma mansoni coup transcription factor 0.0033 0.3024 0.3024
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 1 1
Brugia malayi AKH receptor 0.0073 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 1 1
Brugia malayi hypothetical protein 0.0073 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.3024 0.3024
Onchocerca volvulus 0.0073 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.3024 0.3024
Onchocerca volvulus 0.0073 1 1
Schistosoma mansoni adenoreceptor 0.0073 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi nuclear receptor NHR-88 0.0033 0.3024 0.3024
Echinococcus multilocularis orexin receptor type 2 0.0073 1 1
Brugia malayi hypothetical protein 0.0017 0.0324 0.0324
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 1 1
Onchocerca volvulus 0.0033 0.3024 0.3024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0073 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.3024 0.3024
Brugia malayi RE15519p 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Brugia malayi Serotonin receptor 0.0073 1 1
Schistosoma mansoni myosin xvIII 0.0073 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.3024 0.3024
Echinococcus multilocularis neuropeptide receptor 0.0073 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0324 0.0324
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 1 1
Schistosoma mansoni hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni biogenic amine receptor 0.0073 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 1 1
Brugia malayi hypothetical protein 0.0073 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.3024 0.3024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi ecdysteroid receptor 0.0033 0.3024 0.3024
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 1 1
Echinococcus multilocularis serotonin receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0073 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.3024 0.3024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Echinococcus granulosus hypothetical protein 0.0073 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus multilocularis fmrfamide receptor 0.0073 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0073 1 1
Echinococcus multilocularis fmrfamide receptor 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0073 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.3024 0.3024
Schistosoma mansoni amine GPCR 0.0073 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.3024 0.3024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.3024 0.3024
Onchocerca volvulus 0.0073 1 1
Brugia malayi follicle stimulating hormone receptor 0.0073 1 1
Schistosoma mansoni nuclear hormone receptor 0.0033 0.3024 0.3024
Echinococcus granulosus fmrfamide receptor 0.0073 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 1 1
Brugia malayi hypothetical protein 0.0017 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi hypothetical protein 0.0073 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 1 1
Echinococcus multilocularis allatostatin A receptor 0.0073 1 1
Schistosoma mansoni amine GPCR 0.0073 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.3024 0.3024
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0073 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0073 1 1
Brugia malayi nuclear receptor RXR 0.0017 0.0324 0.0324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.3024 0.3024
Echinococcus granulosus orexin receptor type 2 0.0073 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 1 1
Schistosoma mansoni hypothetical protein 0.0073 1 1
Echinococcus multilocularis somatostatin receptor 0.0073 1 1
Echinococcus multilocularis g protein coupled receptor 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi Serotonin receptor 0.0073 1 1
Brugia malayi neuropeptide F receptor 0.0073 1 1
Schistosoma mansoni hypothetical protein 0.0073 1 1
Echinococcus multilocularis g protein coupled receptor 0.0073 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.3024 0.3024
Schistosoma mansoni amine GPCR 0.0073 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0324 0.0324
Brugia malayi nuclear hormone receptor 0.0033 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 1 1
Echinococcus multilocularis serotonin receptor 0.0073 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.3024 0.3024
Echinococcus granulosus neuropeptide Y receptor 0.0073 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0324 0.0324
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 1 1
Echinococcus multilocularis sex peptide receptor 0.0073 1 1
Schistosoma mansoni neuropeptide receptor 0.0073 1 1
Brugia malayi larval opioid receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Brugia malayi Melatonin receptor type 1A 0.0073 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.3024 0.3024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.3024 0.3024
Schistosoma mansoni hypothetical protein 0.0073 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Brugia malayi hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.3024 0.3024
Schistosoma mansoni thyroid hormone receptor 0.0033 0.3024 0.3024
Echinococcus granulosus tm gpcr rhodopsin 0.0073 1 1
Echinococcus granulosus FTZ F1 alpha 0.0033 0.3024 0.3024
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.3024 0.3024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0073 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.3024 0.3024
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.3024 0.3024
Schistosoma mansoni amine GPCR 0.0073 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.3024 0.3024
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 1 1
Echinococcus granulosus neuropeptide receptor 0.0073 1 1
Echinococcus multilocularis g protein coupled receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.3024 0.3024
Onchocerca volvulus 0.0073 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0324 0.0324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 1 1
Onchocerca volvulus 0.0073 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 1 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.9 nM Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay ChEMBL. 17439112
EC50 (functional) = 1.9 nM Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay ChEMBL. 17439112
Efficacy (functional) = 65 % Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay ChEMBL. 17439112
Efficacy (functional) = 65 % Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay ChEMBL. 17439112
Ki (binding) = 4 nM Displacement of [3H]DHT from human AR expressed in MDA-MB-453 cells ChEMBL. 17439112
Ki (binding) = 4 nM Displacement of [3H]DHT from human AR expressed in MDA-MB-453 cells ChEMBL. 17439112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.