Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0017 | 0.1445 | 0.2082 |
Schistosoma mansoni | DNA polymerase eta | 0.0017 | 0.1445 | 1 |
Onchocerca volvulus | 0.0012 | 0.004 | 0.5 | |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 1 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0017 | 0.1445 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1445 | 0.2082 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0017 | 0.1445 | 0.1411 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0017 | 0.1445 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2122 | 0.2122 |
Echinococcus multilocularis | dna polymerase kappa | 0.0047 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0017 | 0.1445 | 0.2082 |
Echinococcus multilocularis | dna polymerase eta | 0.0017 | 0.1445 | 0.1411 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0047 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6789 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2122 | 0.2122 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0047 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.7878 | 0.7878 |
Giardia lamblia | DINP protein human, muc B family | 0.0024 | 0.3568 | 0.5 |
Brugia malayi | polk-prov protein | 0.0035 | 0.6789 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0024 | 0.3568 | 0.3568 |
Leishmania major | DNA polymerase kappa, putative | 0.0024 | 0.3568 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.004 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0017 | 0.1445 | 0.2082 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.7878 | 0.7878 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.004 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0017 | 0.1445 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0017 | 0.1445 | 0.1411 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.6789 | 0.6789 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2122 | 0.2122 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0035 | 0.6789 | 0.6789 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0024 | 0.3568 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0017 | 0.1445 | 0.1445 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0017 | 0.1445 | 0.1411 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0013 | 0.0356 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0024 | 0.3568 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | 0 % | In vivo Sterol lowering activity at dose as 0.10 % of the diet. Values are expressed as the mean percent of control values; ND = no data | ChEMBL. | 6604817 |
Diet (functional) | 0 % | In vivo Sterol lowering activity at dose as 0.03 % of the diet. Values are expressed as the mean percent of control values; ND = no data | ChEMBL. | 6604817 |
Diet (functional) | 0 % | In vivo Sterol lowering activity at dose as 0.01 % of the diet. Values are expressed as the mean percent of control values; ND = no data | ChEMBL. | 6604817 |
Diet (functional) | 0 % | In vivo Triglyceride lowering activity at dose as 0.10 % of the diet. Values are expressed as the mean percent of control values; ND = no data | ChEMBL. | 6604817 |
Diet (functional) | 0 % | In vivo Triglyceride lowering activity at dose as 0.03 % of the diet. Values are expressed as the mean percent of control values; ND = no data | ChEMBL. | 6604817 |
Diet (functional) | 0 % | In vivo Triglyceride lowering activity at dose as 0.01 % of the diet. Values are expressed as the mean percent of control values; ND = no data | ChEMBL. | 6604817 |
Inhibition (binding) | % | Inhibition of acyl coenzyme A:cholesterol acyltransferase; Not determined | ChEMBL. | 6604817 |
Inhibition (binding) | 0 % | Inhibition of acyl coenzyme A:cholesterol acyltransferase; Not determined | ChEMBL. | 6604817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.