Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0116 | 0.1198 | 0.1802 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0116 | 0.1198 | 0.1802 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0344 | 0.6648 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0116 | 0.1198 | 0.1802 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0116 | 0.1198 | 0.1802 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0116 | 0.1198 | 0.1802 |
Brugia malayi | Dihydrofolate reductase | 0.014 | 0.1779 | 0.2676 |
Echinococcus granulosus | NCK adaptor protein | 0.0101 | 0.0853 | 0.1283 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0116 | 0.1198 | 0.1802 |
Echinococcus multilocularis | dihydrofolate reductase | 0.014 | 0.1779 | 0.2676 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0116 | 0.1198 | 0.1802 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0116 | 0.1198 | 0.1802 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0101 | 0.0853 | 0.1283 |
Loa Loa (eye worm) | SRC-1 | 0.0116 | 0.1198 | 0.1802 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0066 | 0 | 0.5 |
Brugia malayi | SRC-1 | 0.0116 | 0.1198 | 0.1802 |
Brugia malayi | hypothetical protein | 0.0163 | 0.2338 | 0.3517 |
Schistosoma mansoni | adapter molecule crk | 0.0101 | 0.0853 | 0.1283 |
Schistosoma mansoni | nck2/grb4 | 0.0101 | 0.0853 | 0.1283 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0116 | 0.1198 | 0.1802 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0116 | 0.1198 | 0.1802 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0163 | 0.2338 | 0.1148 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0101 | 0.0853 | 0.1283 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0344 | 0.6648 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0116 | 0.1198 | 0.1802 |
Brugia malayi | thymidylate synthase | 0.0344 | 0.6648 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0116 | 0.1198 | 0.1802 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0484 | 1 | 0.5 |
Onchocerca volvulus | 0.0344 | 0.6648 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0853 | 0.1283 |
Schistosoma mansoni | tyrosine kinase | 0.0116 | 0.1198 | 0.1802 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0116 | 0.1198 | 0.1802 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0116 | 0.1198 | 0.1802 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0101 | 0.0853 | 0.1283 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0484 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0116 | 0.1198 | 0.1802 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0116 | 0.1198 | 0.1802 |
Brugia malayi | Variant SH3 domain containing protein | 0.0101 | 0.0853 | 0.1283 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0116 | 0.1198 | 0.1802 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0116 | 0.1198 | 0.1802 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0101 | 0.0853 | 0.1283 |
Schistosoma mansoni | tyrosine kinase | 0.0116 | 0.1198 | 0.1802 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0484 | 1 | 0.5 |
Echinococcus multilocularis | NCK adaptor protein | 0.0101 | 0.0853 | 0.1283 |
Chlamydia trachomatis | dihydrofolate reductase | 0.014 | 0.1779 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0116 | 0.1198 | 0.1802 |
Echinococcus granulosus | dihydrofolate reductase | 0.014 | 0.1779 | 0.2676 |
Schistosoma mansoni | dihydrofolate reductase | 0.014 | 0.1779 | 0.2676 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0101 | 0.0853 | 0.1283 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0163 | 0.2338 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0101 | 0.0853 | 0.1283 |
Brugia malayi | Variant SH3 domain containing protein | 0.0101 | 0.0853 | 0.1283 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0484 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0116 | 0.1198 | 0.1802 |
Schistosoma mansoni | tyrosine kinase | 0.0116 | 0.1198 | 0.1802 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0116 | 0.1198 | 0.1802 |
Brugia malayi | dihydrofolate reductase family protein | 0.014 | 0.1779 | 0.2676 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0116 | 0.1198 | 0.1802 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0101 | 0.0853 | 0.1283 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0116 | 0.1198 | 0.1802 |
Schistosoma mansoni | tyrosine kinase | 0.0116 | 0.1198 | 0.1802 |
Loa Loa (eye worm) | thymidylate synthase | 0.0344 | 0.6648 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.014 | 0.1779 | 0.2676 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0116 | 0.1198 | 0.1802 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0344 | 0.6648 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0344 | 0.6648 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0344 | 0.6648 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0344 | 0.6648 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0484 | 1 | 0.5 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0101 | 0.0853 | 0.1283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 1.61 ug.hr/ml | AUC in dog at 3 mg/kg, po | ChEMBL. | 17441705 |
CL (ADMET) | = 22.96 ml/min.kg | Clearance in dog at 1 mg/kg, iv and 3 mg/kg, po | ChEMBL. | 17441705 |
F (ADMET) | = 68 % | Bioavailability in dog at 1 mg/kg, iv and 3 mg/kg, po | ChEMBL. | 17441705 |
t1/2 (ADMET) | = 2.93 hr | Half life in dog at 1 mg/kg, iv | ChEMBL. | 17441705 |
t1/2 (ADMET) | = 3.04 hr | Half life in dog at 3 mg/kg, po | ChEMBL. | 17441705 |
Vdss (ADMET) | = 3508 ml/kg | Volume of distribution at steady state in dog at 1 mg/kg, iv and 3 mg/kg, po | ChEMBL. | 17441705 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.