TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 971.135 | Formula: C47H62N12O9S
H donors: 10 H acceptors: 10 LogP: 1.28 Rotable bonds: 15
Rule of 5 violations (Lipinski): 3
SMILES: CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@H](NC(=O)[C@@H](NC1=O)Cc1cnc[nH]1)Cc1cccs1)CCC2)Cc1cc2c([nH]1)cccc2)C(=O)N)NC(=O)C
InChi: 1S/C47H62N12O9S/c1-3-4-13-34(52-27(2)60)42(63)56-37-24-40(61)50-17-8-7-15-33(41(48)62)54-43(64)35(21-29-20-28-11-5-6-14-32(28)53-29)57-46(67)39-16-9-18-59(39)47(68)38(23-31-12-10-19-69-31)58-44(65)36(55-45(37)66)22-30-25-49-26-51-30/h5-6,10-12,14,19-20,25-26,33-39,53H,3-4,7-9,13,15-18,21-24H2,1-2H3,(H2,48,62)(H,49,51)(H,50,61)(H,52,60)(H,54,64)(H,55,66)(H,56,63)(H,57,67)(H,58,65)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
InChiKey: OTHFWXHVFSKNEO-OFDRTADWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	Starlite/ChEMBL	References
Homo sapiens	melanocortin 3 receptor	Starlite/ChEMBL	References
Homo sapiens	melanocortin 5 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium berghei	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana		Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Toxoplasma gondii	beta-1 tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium hominis	beta-catenin-like repeat protein	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	ko:K07375 tubulin beta, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta-4 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Entamoeba histolytica	tubulin family protein	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	BEN-1 protein	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Babesia bovis	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin beta 1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei gambiense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-1 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Toxoplasma gondii	beta-tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma congolense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-1 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-4 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	BEN-1 protein	Get druggable targets OG5_126611	All targets in OG5_126611
Theileria parva	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin alpha chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Trichomonas vaginalis	tubulin gamma chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Brugia malayi	Tubulin beta-1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin beta 1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium falciparum	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma mansoni	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium yoelii	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Toxoplasma gondii	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta-2A chain	Get druggable targets OG5_126611	All targets in OG5_126611
Brugia malayi	beta-tubulin, identical	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Neospora caninum	hypothetical protein	Get druggable targets OG5_126611	All targets in OG5_126611
Plasmodium vivax	tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	ko:K07375 tubulin beta, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma brucei gambiense	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	Tubulin beta 2C chain	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin, beta 4A class IVa	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania mexicana	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Loa Loa (eye worm)	tubulin beta-1 chain	Get druggable targets OG5_126611	All targets in OG5_126611
Giardia lamblia	Beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus granulosus	tubulin beta 4A class IVa	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania braziliensis	beta-tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania major	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Cryptosporidium parvum	tubulin beta chain	Get druggable targets OG5_126611	All targets in OG5_126611
Leishmania infantum	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	beta tubulin	Get druggable targets OG5_126611	All targets in OG5_126611
Trypanosoma cruzi	beta tubulin, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Schistosoma japonicum	Tubulin beta-7 chain, putative	Get druggable targets OG5_126611	All targets in OG5_126611
Entamoeba histolytica	tubulin family protein	Get druggable targets OG5_126611	All targets in OG5_126611
Echinococcus multilocularis	tubulin subunit beta	Get druggable targets OG5_126611	All targets in OG5_126611

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	melanocortin 5 receptor	325 aa	311 aa	20.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.014	0.0525	0.0628
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.014	0.0525	0.4504
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0045	0.048
Plasmodium falciparum	importin beta, putative	0.0028	0.0072	0.0079
Leishmania major	GTP-binding protein, putative	0.0021	0.0043	0.0322
Loa Loa (eye worm)	tubulin beta-2A chain	0.0027	0.007	0.06
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0045	0.048
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0115	0.0115
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0045	0.0132
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0325	0.0942
Onchocerca volvulus		0.014	0.0525	0.5564
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.0263	0.0312
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0022	0.0047	0.0355
Trypanosoma brucei	beta tubulin	0.0027	0.007	0.0547
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0191	0.0225
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.014	0.0525	0.429
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Schistosoma mansoni	hypothetical protein	0.0011	0.0003	0.001
Brugia malayi	beta-lactamase family protein	0.0075	0.0263	0.2776
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0036	0.0105
Brugia malayi	beta-lactamase family protein	0.0075	0.0263	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0562	0.4819
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0032	0.0031
Echinococcus granulosus	chromobox protein 1	0.0072	0.025	0.0725
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0086	0.0248
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0045	0.0132
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0045	0.039
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0021	0.0016
Onchocerca volvulus		0.014	0.0525	0.5564
Leishmania major	cytochrome p450-like protein	0.002	0.004	0.0299
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0072	0.021
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0087	0.0748
Schistosoma mansoni	thyroid hormone receptor	0.0157	0.0595	0.1726
Plasmodium vivax	tubulin beta chain, putative	0.0027	0.007	0.0076
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0045	0.0045
Loa Loa (eye worm)	beta-tubulin	0.0027	0.007	0.06
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0003	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0075	0.0082
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0207	0.2185
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0099	0.0115
Giardia lamblia	Beta tubulin	0.0027	0.007	0.4449
Brugia malayi	M-phase phosphoprotein, mpp8	0.0012	0.0007	0.0074
Toxoplasma gondii	hypothetical protein	0.005	0.0163	0.0192
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.014	0.0525	0.0628
Echinococcus granulosus	tubulin subunit beta	0.0027	0.007	0.0203
Schistosoma mansoni	hypothetical protein	0.0012	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0047	0.015	0.1287
Trypanosoma brucei	cytochrome P450, putative	0.002	0.004	0.0299
Schistosoma mansoni	hypothetical protein	0.0047	0.015	0.0435
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0045	0.0132
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0027	0.007	0.0076
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0036	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0263	0.2255
Echinococcus granulosus	geminin	0.0862	0.3449	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0045	0.048
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0311	0.122	1
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0051	0.0392
Trichomonas vaginalis	tubulin alpha chain, putative	0.0027	0.007	0.0076
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0325	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.006
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0022	0.0047	0.0355
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0149	0.0562	0.5931
Echinococcus granulosus	beta tubulin	0.0027	0.007	0.0203
Toxoplasma gondii	exonuclease III APE	0.0019	0.0036	0.0039
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0265	0.0315
Echinococcus multilocularis	dnaJ subfamily B	0.0395	0.1558	0.1558
Echinococcus multilocularis	chromobox protein 2	0.0012	0.0007	0.0007
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0065	0.007
Brugia malayi	Smad1	0.0017	0.0027	0.0282
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.014	0.0525	0.429
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0005	0.0005
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0045	0.0132
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.014	0.0525	0.1523
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0013	0.0039
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.0175	0.1414
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0265	0.0311
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0036	0.0035
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Entamoeba histolytica	tubulin family protein	0.0027	0.007	0.1215
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0045	0.039
Schistosoma mansoni	hypothetical protein	0.0862	0.3449	1
Echinococcus granulosus	chromobox protein 2	0.0012	0.0007	0.002
Echinococcus granulosus	leucyl aminopeptidase	0.0022	0.0047	0.0135
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.0263	0.0762
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0115	0.0334
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0051	0.0053
Echinococcus granulosus	cytochrome P450 2K1	0.0011	0.0003	0.001
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0122	0.1296
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.0263	0.0308
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.014	0.0525	0.429
Schistosoma mansoni	ap endonuclease	0.0019	0.0036	0.0105
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.0263	0.0312
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.0021	0.0016
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Brugia malayi	Heterochromatin protein 1	0.0072	0.025	0.264
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0032	0.0031
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.0526	0.0526
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0005	0.0005
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0126	0.0365
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0062	0.0478
Brugia malayi	Aminopeptidase ZK353.6 in chromosome III	0.0022	0.0047	0.0492
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.014	0.0525	0.0628
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0043	0.0043
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0115	0.0334
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0043	0.0047
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.051	0.1479
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0263	0.0762
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0007	0.0007
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0045	0.0132
Giardia lamblia	Beta tubulin	0.0027	0.007	0.4449
Loa Loa (eye worm)	Smad1	0.0017	0.0027	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0045	0.048
Schistosoma mansoni	leucine aminopeptidase	0.0022	0.0047	0.0135
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0062	0.0528
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0062	0.007
Trichomonas vaginalis	hypothetical protein	0.2065	0.8314	1
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0045	0.0481
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0263	0.0312
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.014	0.0525	0.0628
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Onchocerca volvulus		0.0146	0.055	0.5828
Echinococcus multilocularis	Chromo domain	0.0012	0.0007	0.0007
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0036	0.0035
Schistosoma mansoni	hypothetical protein	0.0395	0.1558	0.4518
Echinococcus multilocularis	Tubulin beta 2C chain	0.0027	0.007	0.007
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.014	0.0525	0.0628
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0007	0.0074
Brugia malayi	Tubulin beta-1 chain	0.0027	0.007	0.0739
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.004	0.0299
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0045	0.039
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0036	0.0269
Echinococcus multilocularis	Tubulin beta 2C chain	0.0027	0.007	0.007
Trichomonas vaginalis	tubulin, putative	0.0027	0.007	0.0076
Echinococcus granulosus	Tubulin beta 2C chain	0.0027	0.007	0.0203
Schistosoma mansoni	cytochrome P450	0.0011	0.0003	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0045	0.039
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.06
Echinococcus granulosus	Tubulin beta 2C chain	0.0027	0.007	0.0203
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0099	0.0115
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0027	0.0078
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0045	0.048
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.014	0.0525	0.429
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0042
Echinococcus multilocularis	snurportin 1	0.0298	0.1166	0.1166
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.0263	0.0312
Loa Loa (eye worm)	retinol dehydrogenase 12	0.014	0.0525	0.4504
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.0115	0.209
Schistosoma mansoni	tubulin subunit beta	0.0027	0.007	0.0203
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0137	0.1095
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.025	0.0293
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Schistosoma mansoni	hypothetical protein	0.0047	0.015	0.0435
Loa Loa (eye worm)	transcription factor SMAD2	0.0244	0.0947	0.8125
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0045	0.0132
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0043	0.0043
Mycobacterium ulcerans	beta-lactamase	0.0075	0.0263	0.0312
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0045	0.039
Brugia malayi	nuclear receptor RXR	0.0011	0.0005	0.0051
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.0263	0.0312
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.0623	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Echinococcus multilocularis	Smad4	0.0017	0.0027	0.0027
Mycobacterium tuberculosis	Probable oxidoreductase	0.014	0.0525	0.0628
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0022	0.0047	0.0355
Loa Loa (eye worm)	helicase	0.0012	0.0007	0.006
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0108	0.0397	0.3236
Loa Loa (eye worm)	acetyltransferase	0.014	0.0526	0.4511
Echinococcus multilocularis	Tubulin beta 2C chain	0.0027	0.007	0.007
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Brugia malayi	nuclear hormone receptor	0.0021	0.0045	0.048
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0051	0.0053
Brugia malayi	Pre-SET motif family protein	0.0214	0.0825	0.8705
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.014	0.0525	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.006
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0007	0.002
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0115	0.092
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0207	0.1776
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.006
Onchocerca volvulus		0.0028	0.0072	0.0759
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.0115	0.0135
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0263	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0086	0.0734
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.016	0.0188
Brugia malayi	Inositol-1	0.0039	0.0115	0.1217
Toxoplasma gondii	leucyl aminopeptidase LAP	0.0108	0.0397	0.0474
Echinococcus granulosus	tubulin beta 4A class IVa	0.0027	0.007	0.0203
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.2065	0.8314	1
Leishmania major	oxidoreductase-like protein	0.014	0.0525	0.429
Leishmania major	hypothetical protein, conserved	0.0075	0.0263	0.2134
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0075	0.0082
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.004	0.0299
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0202	0.0586
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.016	0.0188
Brugia malayi	Cytochrome P450 family protein	0.003	0.0083	0.0871
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0036	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0045	0.048
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0045	0.0045
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0265	0.0315
Schistosoma mansoni	hypothetical protein	0.0298	0.1166	0.3381
Echinococcus multilocularis	geminin	0.0862	0.3449	0.3449
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0022	0.0047	0.0355
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.0526	0.1525
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0265	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0263	0.2134
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0479	0.1899	0.2281
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0263	0.0308
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.2065	0.8314	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.014	0.0525	0.5543
Schistosoma mansoni	chromobox protein	0.0012	0.0007	0.002
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.014	0.0525	0.0628
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0062	0.0066
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0007	0.002
Brugia malayi	cytosol aminopeptidase	0.0022	0.0047	0.0492
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0265	0.0769
Schistosoma mansoni	tubulin subunit beta	0.0027	0.007	0.0203
Schistosoma mansoni	chromobox protein	0.0072	0.025	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0027	0.0078
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0043	0.0133	0.0386
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.0526	0.5552
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.014	0.0525	0.0591
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0136	0.0509	0.1476
Echinococcus multilocularis	beta tubulin	0.0027	0.007	0.007
Schistosoma mansoni	coup transcription factor	0.0021	0.0045	0.0132
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0115	0.092
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.0263	0.0312
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.014	0.0525	0.0628
Giardia lamblia	Beta tubulin	0.0027	0.007	0.4449
Brugia malayi	hypothetical protein	0.0016	0.0025	0.0268
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.0263	0.0312
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.2065	0.8314	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0072	0.0615
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0045	0.0045
Trichomonas vaginalis	esterase, putative	0.0075	0.0263	0.0308
Schistosoma mansoni	ran	0.0021	0.0043	0.0124
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0045	0.048
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.014	0.0525	0.0628
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.015	0.015
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.014	0.0525	0.5543
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.0556	0.4542
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.015	0.0435
Schistosoma mansoni	dihydropteridine reductase	0.014	0.0525	0.1523
Echinococcus granulosus	beta tubulin	0.0027	0.007	0.0203
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0065	0.0074
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0086	0.0086
Brugia malayi	CHD4 protein	0.0013	0.0013	0.0141
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0207	0.1776
Onchocerca volvulus		0.0075	0.0263	0.2786
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0136	0.0509	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.006
Brugia malayi	MH2 domain containing protein	0.0017	0.0027	0.0282
Echinococcus multilocularis	beta tubulin	0.0027	0.007	0.007
Echinococcus multilocularis	cpg binding protein	0.0029	0.0078	0.0078
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0083	0.0708
Echinococcus granulosus	Tubulin beta 2C chain	0.0027	0.007	0.0203
Echinococcus multilocularis	GPCR, family 2	0.0047	0.015	0.015
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0032	0.0031
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0051	0.0053
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0045	0.0045
Chlamydia trachomatis	oxoacy-ACP reductase	0.014	0.0525	0.0323
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0005	0.0051
Entamoeba histolytica	Ran family GTPase	0.0021	0.0043	0.0687
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0122	0.0139
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0045	0.0132
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Schistosoma mansoni	cpg binding protein	0.0029	0.0078	0.0226
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.0013	0.0115
Schistosoma mansoni	tubulin subunit beta	0.0027	0.007	0.0203
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.025	0.2145
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0045	0.0481
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0045	0.0132
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0115	0.0334
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0325	0.0942
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0263	0.0312
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0012	0.0007	0.0004
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0007	0.002
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0135	0.0154
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.2065	0.8314	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0051	0.085
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0007	0.002
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0263	0.2255
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.0115	0.013
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0265	0.0315
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0325	0.0325
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.0108	0.0397	0.3236
Brugia malayi	Protein cec-1.	0.0012	0.0007	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.006
Schistosoma mansoni	PwLAP aminopeptidase (M17 family)	0.0022	0.0047	0.0135
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.014	0.0525	0.0628
Echinococcus granulosus	dnaJ subfamily B	0.0395	0.1558	0.4518
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0263	0.0312
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0126	0.0143
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0022	0.0047	0.0355
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Schistosoma mansoni	tubulin subunit beta	0.0027	0.007	0.0203
Schistosoma mansoni	importin beta-1	0.0028	0.0072	0.021
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0005	0.0014
Loa Loa (eye worm)	MH2 domain-containing protein	0.0244	0.0947	0.8125
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0036	0.0269
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.025	0.0293
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0045	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0263	0.2255
Leishmania major	3-oxoacyl-ACP reductase, putative	0.014	0.0525	0.429
Brugia malayi	hypothetical protein	0.0146	0.055	0.5806
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.015	0.015
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0072	0.0072
Onchocerca volvulus		0.0012	0.0007	0.0074
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0265	0.0311
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0036	0.0269
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.0263	0.0312
Echinococcus multilocularis	smad	0.0017	0.0027	0.0027
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.014	0.0525	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0045	0.039
Toxoplasma gondii	ABC1 family protein	0.0075	0.0263	0.0312
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0086	0.0248
Schistosoma mansoni	chromobox protein	0.0012	0.0007	0.002
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.0115	0.0096
Brugia malayi	RNA binding protein	0.0061	0.0207	0.2185
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.014	0.0525	0.0624
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0072	0.0567
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0207	0.06
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Toxoplasma gondii	beta tubulin	0.0027	0.007	0.008
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0032	0.0031
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0086	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.006
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0019	0.0014
Plasmodium falciparum	M17 leucyl aminopeptidase	0.0108	0.0397	0.0469
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0051	0.0392
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.0108	0.0397	0.0474
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0265	0.0315
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.0027	0.0078
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0086	0.0099
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0032	0.0031
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0032	0.0031
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0045	0.0132
Onchocerca volvulus		0.0043	0.0133	0.1411
Brugia malayi	MH2 domain containing protein	0.0017	0.0027	0.0282
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.06
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.014	0.0525	0.0628
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Schistosoma mansoni	tubulin subunit beta	0.0027	0.007	0.0203
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.014	0.0525	0.429
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.06
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0062	0.0066
Echinococcus granulosus	snurportin 1	0.0298	0.1166	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0263	0.2255
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.004	0.0341
Brugia malayi	beta-tubulin, identical	0.0027	0.007	0.0739
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0007	0.0007
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0325	0.3429
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0005	0.0014
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.004	0.0341
Loa Loa (eye worm)	beta-lactamase	0.0075	0.0263	0.2255
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0043	0.0847
Loa Loa (eye worm)	BEN-1 protein	0.0027	0.007	0.06
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0072	0.0079
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0137	0.1095
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0045	0.048
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0265	0.0265
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0263	0.0308
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0263	0.0312
Onchocerca volvulus		0.0012	0.0007	0.0074
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.0825	0.7073
Echinococcus granulosus	smad	0.0017	0.0027	0.0078
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0043	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0265	0.2274
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0263	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0007	0.006
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0147	0.0556	0.4542
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.2065	0.8314	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0263	0.2255
Echinococcus multilocularis	tubulin subunit beta	0.0027	0.007	0.007
Brugia malayi	Cytochrome P450 family protein	0.002	0.004	0.042
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0112	0.2029
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.014	0.0525	0.0628
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0137	0.1095
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.0108	0.0397	0.0469
Schistosoma mansoni	smad	0.0017	0.0027	0.0078
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0045	0.0132
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0036	0.0039
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.0027	0.0229
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0126	0.0143
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.002	0.004	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Brugia malayi	chromobox protein homolog 3	0.004	0.0122	0.1292
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0032	0.0031
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.014	0.0525	0.0628
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0027	0.007	0.0076
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0012	0.0007	0.0004
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0039	0.0115	0.0135
Loa Loa (eye worm)	BEN-1 protein	0.0027	0.007	0.06
Echinococcus granulosus	chromobox protein 1	0.0072	0.025	0.0725
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0147	0.0556	0.4542
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.014	0.0525	0.0628
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.014	0.0525	0.0628
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.06
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.016	0.0188
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0126	0.0148
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0137	0.1095
Loa Loa (eye worm)	hypothetical protein	0.0146	0.055	0.4718
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0042
Brugia malayi	Importin beta-1 subunit	0.0028	0.0072	0.0765
Brugia malayi	RNA, U transporter 1	0.0079	0.0281	0.2964
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0325	0.0942
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.2065	0.8314	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0027	0.007	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0007	0.0074
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.014	0.0525	0.0628
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0045	0.048
Plasmodium vivax	SET domain protein, putative	0.0031	0.0086	0.0095
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0043	0.0322
Toxoplasma gondii	hypothetical protein	0.0026	0.0065	0.0074
Onchocerca volvulus		0.0032	0.0087	0.0923
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0263	0.0308
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.0371	0.3919
Trypanosoma brucei	beta tubulin	0.0027	0.007	0.0547
Schistosoma mansoni	ap endonuclease	0.0019	0.0036	0.0105
Mycobacterium tuberculosis	Possible oxidoreductase	0.014	0.0525	0.0628
Echinococcus granulosus	cpg binding protein	0.0029	0.0078	0.0226
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0007	0.002
Chlamydia trachomatis	cytosol aminopeptidase	0.0108	0.0397	0.0164
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0062	0.0478
Schistosoma mansoni	hypothetical protein	0.0047	0.015	0.0435
Loa Loa (eye worm)	tubulin beta chain	0.0027	0.007	0.06
Brugia malayi	MH1 domain containing protein	0.0017	0.0027	0.0282
Leishmania major	hypothetical protein, conserved	0.0025	0.0062	0.0478
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0045	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0045	0.048
Brugia malayi	steroid hormone receptor	0.0021	0.0045	0.048
Brugia malayi	hypothetical protein	0.0025	0.0062	0.065
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.014	0.0525	0.429
Echinococcus multilocularis	Tubulin beta 2C chain	0.0027	0.007	0.007
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0045	0.048
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.014	0.0525	0.0628
Echinococcus multilocularis	chromobox protein 1	0.0072	0.025	0.025
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0036	0.0035
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.0263	0.0263
Schistosoma mansoni	hypothetical protein	0.0102	0.0371	0.1077
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0045	0.0045
Loa Loa (eye worm)	CYP4Cod1	0.002	0.004	0.0341
Onchocerca volvulus		0.0075	0.0263	0.2786
Schistosoma mansoni	tubulin subunit beta	0.0027	0.007	0.0203
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0207	0.1776
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0112	0.0127
Trypanosoma cruzi	beta tubulin, putative	0.0027	0.007	0.0547
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0072	0.0083
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0045	0.0045
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0298	0.1166	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0207	0.06
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0072	0.0621
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.015	0.1584
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0135	0.1428
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0325	0.2786
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0263	0.0308
Leishmania major	pteridine reductase 1	0.014	0.0525	0.429
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0036	0.0563
Echinococcus granulosus	Smad4	0.0017	0.0027	0.0078
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0115	0.092
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0045	0.039
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0022	0.0047	0.0355
Schistosoma mansoni	hypothetical protein	0.0011	0.0005	0.0015
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0065	0.1248
Mycobacterium ulcerans	leucyl aminopeptidase	0.0108	0.0397	0.0474
Schistosoma mansoni	hypothetical protein	0.0862	0.3449	1
Schistosoma mansoni	cpg binding protein	0.0029	0.0078	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0042
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0045	0.048
Brugia malayi	hypothetical protein	0.0011	0.0005	0.0051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0149	0.0562	0.5931
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0115	0.013
Schistosoma mansoni	smad1 5 8 and	0.0017	0.0027	0.0078
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0086	0.0248
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0043	0.0124
Onchocerca volvulus		0.0075	0.0263	0.2786
Trypanosoma brucei	aminopeptidase, putative	0.0022	0.0047	0.0355
Echinococcus multilocularis	leucyl aminopeptidase	0.0022	0.0047	0.0047
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.015	0.0435
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0112	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0045	0.0132
Mycobacterium ulcerans	lipase LipD	0.0075	0.0263	0.0312
Echinococcus multilocularis	leucyl aminopeptidase	0.0022	0.0047	0.0047
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0045	0.039
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0045	0.0481
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0005	0.0015
Mycobacterium ulcerans	oxidoreductase	0.014	0.0525	0.0628
Loa Loa (eye worm)	inositol-1	0.0039	0.0115	0.0989
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0036	0.031
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.0108	0.0397	0.0474
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0045	0.0132
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0045	0.048
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0311	0.122	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.0263	0.0312
Brugia malayi	Valyl-tRNA synthetase	0.0012	0.0007	0.0074
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0005	0.0042
Schistosoma mansoni	ran	0.0021	0.0043	0.0124
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.0027	0.0027
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Echinococcus granulosus	Tubulin beta 2C chain	0.0027	0.007	0.0203
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0022	0.0047	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0263	0.2255
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0122	0.0139
Echinococcus granulosus	ankyrin repeat domain containing protein 17	0.0022	0.0047	0.0135
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.0108	0.0397	0.3236
Trypanosoma brucei	pteridine reductase 1	0.014	0.0525	0.429
Brugia malayi	Aminopeptidase W07G4.4 in chromosome V	0.0022	0.0047	0.0492
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0045	0.0132
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0027	0.007	0.007
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.015	0.1584
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0036	0.0382
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0012	0.0007	0.0004
Leishmania major	mitochondrial DNA polymerase beta	0.0311	0.122	1
Plasmodium falciparum	tubulin beta chain	0.0027	0.007	0.0076
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0065	0.007
Schistosoma mansoni	chromobox protein	0.0072	0.025	0.0725
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.0013	0.0039
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.0027	0.0229
Brugia malayi	MH2 domain containing protein	0.0244	0.0947	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.0263	0.2776
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0086	0.0086
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Schistosoma mansoni	Smad4	0.0017	0.0027	0.0078
Brugia malayi	Pre-SET motif family protein	0.0031	0.0086	0.0904
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.0263	0.2255
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.0108	0.0397	0.0436
Echinococcus multilocularis	chromobox protein 1	0.0072	0.025	0.025
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0079	0.0228
Mycobacterium tuberculosis	Possible oxidoreductase	0.014	0.0525	0.0628
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0115	0.013
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0062	0.0478
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0022	0.0047	0.0355
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.0027	0.0078
Schistosoma mansoni	hypothetical protein	0.0047	0.015	0.0435
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0325	0.0325
Brugia malayi	TAR-binding protein	0.0061	0.0207	0.2185
Trypanosoma brucei	oxidoreductase-like protein	0.014	0.0525	0.429
Mycobacterium ulcerans	hypothetical protein	0.0164	0.0623	0.0746
Schistosoma mansoni	hypothetical protein	0.0136	0.0509	0.1476
Schistosoma mansoni	thyroid hormone receptor	0.0157	0.0595	0.1726
Loa Loa (eye worm)	tubulin beta-1 chain	0.0027	0.007	0.06
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0126	0.0143
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0072	0.0567
Loa Loa (eye worm)	oxidoreductase	0.014	0.0525	0.4504
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0126	0.0148
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0005	0.0051
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0036	0.0035
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Echinococcus granulosus	leucine aminopeptidase protein	0.0108	0.0397	0.1151
Onchocerca volvulus		0.0243	0.0944	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0115	0.092
Trichomonas vaginalis	tubulin gamma chain, putative	0.0027	0.007	0.0076
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0263	0.0308
Mycobacterium leprae	Probable lipase LipE	0.0075	0.0263	0.0312
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0265	0.0277
Loa Loa (eye worm)	aminopeptidase in chromosome V	0.0022	0.0047	0.04
Loa Loa (eye worm)	aminopeptidase in chromosome III	0.0022	0.0047	0.04
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.0108	0.0397	0.3236
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.0263	0.2134
Loa Loa (eye worm)	hypothetical protein	0.014	0.0525	0.4504
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.0027	0.0027
Onchocerca volvulus		0.0021	0.0045	0.0481
Brugia malayi	SET domain containing protein	0.0013	0.0014	0.0148
Trypanosoma brucei	beta tubulin	0.0027	0.007	0.0547
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0045	0.048
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.2065	0.8314	1
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.0944	0.1128
Echinococcus multilocularis	Tubulin beta 2C chain	0.0027	0.007	0.007
Mycobacterium ulcerans	short chain dehydrogenase	0.014	0.0525	0.0628
Echinococcus granulosus	leucyl aminopeptidase	0.0022	0.0047	0.0135
Loa Loa (eye worm)	hypothetical protein	0.004	0.0122	0.105
Brugia malayi	hypothetical protein	0.0012	0.0007	0.0074
Brugia malayi	hypothetical protein	0.0011	0.0005	0.0051
Trichomonas vaginalis	ran, putative	0.0021	0.0043	0.0043
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.0263	0.0312
Echinococcus granulosus	Chromo domain	0.0012	0.0007	0.002
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0371	0.3184
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.015	0.1287
Brugia malayi	Probable ClpP-like protease	0.0076	0.0265	0.2798
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0045	0.048
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0042
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Loa Loa (eye worm)	cytochrome P450	0.0011	0.0003	0.0029
Brugia malayi	beta-lactamase	0.0075	0.0263	0.2776
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0045	0.048
Echinococcus multilocularis	leucyl aminopeptidase	0.0022	0.0047	0.0047
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0149	0.0562	0.4819
Echinococcus multilocularis	leucine aminopeptidase protein	0.0108	0.0397	0.0397
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.016	0.0463
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0157	0.0595	0.0595
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.014	0.0525	0.0525
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0045	0.0132
Brugia malayi	cytochrome P450	0.0011	0.0003	0.0036
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0072	0.0757
Echinococcus granulosus	tubulin beta 1 chain	0.0027	0.007	0.0203
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0043	0.045
Echinococcus granulosus	GPCR family 2	0.0047	0.015	0.0435
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0062	0.0066
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0043	0.0322
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0045	0.0132
Brugia malayi	Cytochrome P450 family protein	0.002	0.004	0.042
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.014	0.0525	0.1523
Brugia malayi	ecdysteroid receptor	0.0021	0.0045	0.048
Trypanosoma brucei	beta tubulin	0.0027	0.007	0.0547
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0045	0.0132
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0045	0.048
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0311	0.122	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0072	0.0208
Echinococcus multilocularis	tubulin beta 1 chain	0.0027	0.007	0.007
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0207	0.0207
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0325	0.0942
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.0013	0.0013
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0005	0.0014
Echinococcus multilocularis		0.0011	0.0003	0.0003
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.0263	0.0312
Brugia malayi	MH1 domain containing protein	0.0017	0.0027	0.0282
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0265	0.0315
Leishmania major	beta tubulin	0.0027	0.007	0.0547
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0036	0.0036
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0045	0.0132
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0043	0.0365
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0265	0.0769
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0045	0.039
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0005	0.0042
Toxoplasma gondii	beta-1 tubulin, putative	0.0027	0.007	0.008
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0135	0.0154
Toxoplasma gondii	beta-tubulin, putative	0.0027	0.007	0.008
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0017	0.0027	0.0078
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.014	0.0525	0.0628
Loa Loa (eye worm)	tubulin beta-4 chain	0.0027	0.007	0.06
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0032	0.0031
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.016	0.016
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0045	0.0045
Echinococcus granulosus	Tubulin beta 2C chain	0.0027	0.007	0.0203
Entamoeba histolytica	tubulin family protein	0.0027	0.007	0.1215
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.014	0.0525	0.0628
Plasmodium falciparum	enoyl-acyl carrier reductase	0.2065	0.8314	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0 %	Agonist activity at human MC4R expressed in CHO cells assessed as cAMP accumulation at 5 uM relative to [125I]NDPalphaMSH	ChEMBL.	17455928
Activity (functional)	= 0 %	Agonist activity at human MC4R expressed in CHO cells assessed as cAMP accumulation at 5 uM relative to [125I]NDPalphaMSH	ChEMBL.	17455928
Activity (functional)	= 3 %	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation at 5 uM relative to [125I]NDPalphaMSH	ChEMBL.	17455928
Activity (functional)	= 3 %	Agonist activity at human MC3R expressed in CHO cells assessed as cAMP accumulation at 5 uM relative to [125I]NDPalphaMSH	ChEMBL.	17455928
EC50 (functional)	= 540 nM	Agonist activity at human melanocortin receptor 1b expressed in CHO cells assessed as cAMP accumulation	ChEMBL.	17455928
EC50 (functional)	> 1500 nM	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL.	17455928
EC50 (functional)	> 1500 nM	Agonist activity at human MC5R expressed in CHO cells assessed as cAMP accumulation	ChEMBL.	17455928
IC50 (binding)	> 5000 nM	Displacement of [125I]NDPalphaMSH from human cloned melanocortin receptor 1b expressed in CHO cells	ChEMBL.	17455928
IC50 (binding)	> 5000 nM	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL.	17455928
IC50 (binding)	> 5000 nM	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL.	17455928
IC50 (binding)	> 5000 nM	Displacement of [125I]NDPalphaMSH from human cloned melanocortin receptor 1b expressed in CHO cells	ChEMBL.	17455928
IC50 (binding)	> 5000 nM	Displacement of [125I]NDPalphaMSH from human cloned MC3R expressed in CHO cells	ChEMBL.	17455928
IC50 (binding)	> 5000 nM	Displacement of [125I]NDPalphaMSH from human cloned MC5R expressed in CHO cells	ChEMBL.	17455928
Inhibition (binding)	= 3 %	Inhibition of human cloned MC4R expressed in CHO cells at 5 uM relative to [125I]NDPalphaMSH	ChEMBL.	17455928
Inhibition (binding)	= 3 %	Inhibition of human cloned MC4R expressed in CHO cells at 5 uM relative to [125I]NDPalphaMSH	ChEMBL.	17455928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL413437

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 422809