Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium leprae | SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) | 0.1023 | 0.4102 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0046 | 0.0063 | 0.0039 |
Toxoplasma gondii | casein kinase ii regulatory subunit protein | 0.0076 | 0.0187 | 1 |
Trypanosoma brucei | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium ulcerans | secreted Mpt51/Mpb51 antigen protein FbpD | 0.0043 | 0.0054 | 0.0072 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0025 | 0.0025 |
Echinococcus multilocularis | S formylglutathione hydrolase | 0.0043 | 0.0054 | 0.0054 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0076 | 0.0187 | 0.0163 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Brugia malayi | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.0833 | 0.1983 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.005 | 0.0079 | 0.0079 |
Plasmodium falciparum | casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Loa Loa (eye worm) | esterase D | 0.0043 | 0.0054 | 0.003 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Brugia malayi | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0063 | 0.0039 |
Leishmania major | protein kinase ck2 regulatory subunit, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0132 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.0076 | 0.0187 | 0.0187 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0038 | 0.0031 | 0.0031 |
Toxoplasma gondii | ck2 beta subunit | 0.0076 | 0.0187 | 1 |
Mycobacterium tuberculosis | Possible conserved membrane protein | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | glutamate receptor AMPA | 0.004 | 0.0039 | 0.0014 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Schistosoma mansoni | casein kinase II beta subunit | 0.0076 | 0.0187 | 0.0163 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.1456 | 0.5894 | 0.5884 |
Echinococcus multilocularis | glutamate receptor 2 | 0.004 | 0.0039 | 0.0039 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Loa Loa (eye worm) | Csnk2b protein | 0.0076 | 0.0187 | 0.0163 |
Mycobacterium tuberculosis | Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular | 0.0043 | 0.0054 | 0.0072 |
Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.1023 | 0.4102 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0993 | 0.398 | 0.3966 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0025 | 0.0025 |
Onchocerca volvulus | 0.0046 | 0.0063 | 0.0039 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0063 | 0.0039 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0143 | 0.0119 |
Brugia malayi | Csnk2b protein | 0.0076 | 0.0187 | 0.0163 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0157 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | calpain A | 0.0068 | 0.0157 | 0.0157 |
Echinococcus multilocularis | calpain A | 0.0068 | 0.0157 | 0.0157 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | glutamate receptor 2 | 0.005 | 0.0079 | 0.0079 |
Mycobacterium tuberculosis | Probable conserved exported protein | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.245 | 1 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0038 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Mycobacterium leprae | SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR | 0.0043 | 0.0054 | 0.0072 |
Mycobacterium tuberculosis | Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind | 0.0043 | 0.0054 | 0.0072 |
Brugia malayi | Glutamate receptor 2 precursor | 0.004 | 0.0039 | 0.0014 |
Brugia malayi | Esterase D | 0.0043 | 0.0054 | 0.003 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.004 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0076 | 0.0187 | 0.0163 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium ulcerans | secreted antigen 85-B FbpB | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.005 | 0.0079 | 0.0079 |
Onchocerca volvulus | 0.245 | 1 | 1 | |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0065 | 0.0143 | 0.0119 |
Giardia lamblia | Casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.004 | 0.0039 | 0.0014 |
Schistosoma mansoni | glutamate receptor NMDA | 0.005 | 0.0079 | 0.0055 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.0076 | 0.0187 | 0.0187 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Plasmodium falciparum | casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.1023 | 0.4102 | 1 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0068 | 0.0157 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0143 | 0.0119 |
Schistosoma mansoni | glutamate receptor NMDA | 0.004 | 0.0039 | 0.0014 |
Echinococcus granulosus | S formylglutathione hydrolase | 0.0043 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) | 0.0043 | 0.0054 | 0.0072 |
Echinococcus granulosus | glutamate receptor 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0046 | 0.0063 | 0.0063 |
Mycobacterium ulcerans | secreted antigen 85-A FbpA | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.004 | 0.0039 | 0.0039 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.004 | 0.0039 | 0.0014 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0132 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.245 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0038 | 0.0031 | 0.0031 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.004 | 0.0039 | 0.0014 |
Mycobacterium leprae | Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 42.6 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
IC50 (binding) | = 42.6 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
MIC (functional) | = 259.7 ug ml-1 | Growth inhibition of Mycobacterium avium 2447 | ChEMBL. | 17010479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.