Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.004 | 0.0039 | 0.0039 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0063 | 0.0039 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0038 | 0.0031 | 0.0031 |
Onchocerca volvulus | 0.245 | 1 | 1 | |
Mycobacterium tuberculosis | Possible conserved membrane protein | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | glutamate receptor AMPA | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.0076 | 0.0187 | 0.0187 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0157 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0132 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.004 | 0.0039 | 0.0014 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.004 | 0.0039 | 0.0039 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0046 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.004 | 0.0039 | 0.0014 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0065 | 0.0143 | 0.0119 |
Mycobacterium tuberculosis | Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Mycobacterium leprae | SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trypanosoma brucei | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0038 | 0.0031 | 0.0031 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus granulosus | glutamate receptor 2 | 0.005 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0143 | 0.0119 |
Onchocerca volvulus | 0.0046 | 0.0063 | 0.0039 | |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus granulosus | S formylglutathione hydrolase | 0.0043 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind | 0.0043 | 0.0054 | 0.0072 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.005 | 0.0079 | 0.0079 |
Schistosoma mansoni | casein kinase II beta subunit | 0.0076 | 0.0187 | 0.0163 |
Loa Loa (eye worm) | esterase D | 0.0043 | 0.0054 | 0.003 |
Echinococcus multilocularis | glutamate receptor 2 | 0.004 | 0.0039 | 0.0039 |
Schistosoma mansoni | glutamate receptor NMDA | 0.005 | 0.0079 | 0.0055 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0076 | 0.0187 | 0.0163 |
Toxoplasma gondii | ck2 beta subunit | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0038 | 0.0031 | 0.0031 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Brugia malayi | Csnk2b protein | 0.0076 | 0.0187 | 0.0163 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.1456 | 0.5894 | 0.5884 |
Echinococcus multilocularis | S formylglutathione hydrolase | 0.0043 | 0.0054 | 0.0054 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium tuberculosis | Probable conserved exported protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.0076 | 0.0187 | 0.0187 |
Schistosoma mansoni | glutamate receptor AMPA | 0.004 | 0.0039 | 0.0014 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium leprae | SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) | 0.1023 | 0.4102 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0132 |
Mycobacterium leprae | Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.005 | 0.0079 | 0.0079 |
Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.1023 | 0.4102 | 1 |
Toxoplasma gondii | casein kinase ii regulatory subunit protein | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.245 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.004 | 0.0039 | 0.0014 |
Mycobacterium ulcerans | secreted antigen 85-A FbpA | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0076 | 0.0187 | 0.0163 |
Brugia malayi | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Echinococcus multilocularis | calpain A | 0.0068 | 0.0157 | 0.0157 |
Mycobacterium ulcerans | secreted antigen 85-B FbpB | 0.0043 | 0.0054 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0143 | 0.0119 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0025 | 0.0025 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.004 | 0.0039 | 0.0014 |
Mycobacterium ulcerans | secreted Mpt51/Mpb51 antigen protein FbpD | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | glutamate receptor 2 | 0.005 | 0.0079 | 0.0079 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Plasmodium falciparum | casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.0833 | 0.1983 |
Brugia malayi | Esterase D | 0.0043 | 0.0054 | 0.003 |
Giardia lamblia | Casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0063 | 0.0039 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | calpain A | 0.0068 | 0.0157 | 0.0157 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0046 | 0.0063 | 0.0039 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.1023 | 0.4102 | 1 |
Loa Loa (eye worm) | Csnk2b protein | 0.0076 | 0.0187 | 0.0163 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0993 | 0.398 | 0.3966 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.245 | 1 | 1 |
Mycobacterium tuberculosis | Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular | 0.0043 | 0.0054 | 0.0072 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0068 | 0.0157 | 0.0157 |
Leishmania major | protein kinase ck2 regulatory subunit, putative | 0.0076 | 0.0187 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
IC50 (binding) | = 21 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
MIC (functional) | = 319 ug ml-1 | Growth inhibition of Mycobacterium avium 2447 | ChEMBL. | 17010479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.