Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.005 | 0.0079 | 0.0055 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0132 |
Plasmodium falciparum | casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.004 | 0.0039 | 0.0014 |
Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.1023 | 0.4102 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.004 | 0.0039 | 0.0039 |
Giardia lamblia | Casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Brugia malayi | Csnk2b protein | 0.0076 | 0.0187 | 0.0163 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.1456 | 0.5894 | 0.5884 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.005 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0046 | 0.0063 | 0.0039 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Brugia malayi | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Onchocerca volvulus | 0.0046 | 0.0063 | 0.0039 | |
Mycobacterium ulcerans | secreted antigen 85-A FbpA | 0.0043 | 0.0054 | 0.0072 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0038 | 0.0031 | 0.0031 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus granulosus | glutamate receptor 2 | 0.005 | 0.0079 | 0.0079 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.004 | 0.0039 | 0.0014 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0046 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0063 | 0.0039 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trypanosoma brucei | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.004 | 0.0039 | 0.0014 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0993 | 0.398 | 0.3966 |
Loa Loa (eye worm) | esterase D | 0.0043 | 0.0054 | 0.003 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | glutamate receptor 2 | 0.005 | 0.0079 | 0.0079 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Loa Loa (eye worm) | Csnk2b protein | 0.0076 | 0.0187 | 0.0163 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0038 | 0.0031 | 0.0031 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.245 | 1 | 1 |
Plasmodium falciparum | casein kinase II beta chain | 0.0076 | 0.0187 | 0.5 |
Mycobacterium tuberculosis | Probable conserved exported protein | 0.0043 | 0.0054 | 0.0072 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0065 | 0.0143 | 0.0119 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0038 | 0.0031 | 0.0031 |
Brugia malayi | Esterase D | 0.0043 | 0.0054 | 0.003 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0157 |
Trypanosoma cruzi | Casein kinase II subunit beta, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | calpain A | 0.0068 | 0.0157 | 0.0157 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0076 | 0.0187 | 0.0163 |
Mycobacterium leprae | SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) | 0.1023 | 0.4102 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.004 | 0.0039 | 0.0014 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Mycobacterium tuberculosis | Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular | 0.0043 | 0.0054 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0143 | 0.0119 |
Toxoplasma gondii | ck2 beta subunit | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium tuberculosis | Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind | 0.0043 | 0.0054 | 0.0072 |
Brugia malayi | Glutamate receptor 2 precursor | 0.004 | 0.0039 | 0.0014 |
Mycobacterium ulcerans | secreted Mpt51/Mpb51 antigen protein FbpD | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.0833 | 0.1983 |
Brugia malayi | Glutamate receptor 1 precursor | 0.004 | 0.0039 | 0.0014 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Mycobacterium leprae | SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR | 0.0043 | 0.0054 | 0.0072 |
Schistosoma mansoni | casein kinase II beta subunit | 0.0076 | 0.0187 | 0.0163 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Brugia malayi | calpain family protein 1 | 0.0065 | 0.0143 | 0.0119 |
Onchocerca volvulus | 0.245 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0054 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.245 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0025 | 0.0025 |
Echinococcus granulosus | calpain A | 0.0068 | 0.0157 | 0.0157 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Mycobacterium tuberculosis | Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) | 0.0043 | 0.0054 | 0.0072 |
Mycobacterium leprae | Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) | 0.0043 | 0.0054 | 0.0072 |
Mycobacterium tuberculosis | Possible conserved membrane protein | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Plasmodium vivax | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | S formylglutathione hydrolase | 0.0043 | 0.0054 | 0.0054 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.0076 | 0.0187 | 0.0187 |
Leishmania major | protein kinase ck2 regulatory subunit, putative | 0.0076 | 0.0187 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0043 | 0.0054 | 0.0072 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0076 | 0.0187 | 0.0163 |
Schistosoma mansoni | glutamate receptor AMPA | 0.004 | 0.0039 | 0.0014 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.005 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0143 | 0.0119 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.245 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.004 | 0.0039 | 0.0014 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.005 | 0.0079 | 0.0079 |
Echinococcus granulosus | S formylglutathione hydrolase | 0.0043 | 0.0054 | 0.0054 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.004 | 0.0039 | 0.0039 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0063 | 0.0039 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0068 | 0.0157 | 0.0157 |
Mycobacterium ulcerans | secreted antigen 85-B FbpB | 0.0043 | 0.0054 | 0.0072 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.0076 | 0.0187 | 0.0187 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0068 | 0.0157 | 0.0132 |
Schistosoma mansoni | glutamate receptor AMPA | 0.004 | 0.0039 | 0.0014 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0076 | 0.0187 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0025 | 0.0025 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.0076 | 0.0187 | 1 |
Toxoplasma gondii | casein kinase ii regulatory subunit protein | 0.0076 | 0.0187 | 1 |
Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.1023 | 0.4102 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.004 | 0.0039 | 0.0039 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 862.3 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
IC50 (binding) | = 862.3 uM | Inhibition of Mycobacterium tuberculosis recombinant antigen 85C mycolyltransferase | ChEMBL. | 17010479 |
MIC (functional) | 0 | Growth inhibition of Mycobacterium avium 2447 | ChEMBL. | 17010479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.