Detailed information for compound 423202

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1757.22 | Formula: C84H145N27O14
  • H donors: 23 H acceptors: 18 LogP: 1.38 Rotable bonds: 76
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1[nH]cnc1)CC(C)C)CC(C)C)Cc1[nH]cnc1)Cc1[nH]cnc1)CC(C)C)Cc1[nH]cnc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)N)CC(C)C)CCCCN)CCCCN)CC(C)C)CC(C)C
  • InChi: 1S/C84H145N27O14/c1-47(2)29-62(103-72(113)57(89)21-13-17-25-85)76(117)100-58(22-14-18-26-86)73(114)99-59(23-15-19-27-87)74(115)104-65(32-50(7)8)79(120)105-63(30-48(3)4)77(118)101-60(24-16-20-28-88)75(116)109-68(36-54-40-92-44-96-54)82(123)108-67(34-52(11)12)81(122)110-70(38-56-42-94-46-98-56)84(125)111-69(37-55-41-93-45-97-55)83(124)107-66(33-51(9)10)80(121)106-64(31-49(5)6)78(119)102-61(71(90)112)35-53-39-91-43-95-53/h39-52,57-70H,13-38,85-89H2,1-12H3,(H2,90,112)(H,91,95)(H,92,96)(H,93,97)(H,94,98)(H,99,114)(H,100,117)(H,101,118)(H,102,119)(H,103,113)(H,104,115)(H,105,120)(H,106,121)(H,107,124)(H,108,123)(H,109,116)(H,110,122)(H,111,125)/t57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-/m0/s1
  • InChiKey: KTQJQBGCVPMTOH-ZNTUHGOWSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.6064 0.6758
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.1028 0.1028
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0667 0.0743
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0667 0.0743
Schistosoma mansoni amine GPCR 0.002 0.0667 0.0667
Echinococcus multilocularis g protein coupled receptor 0.002 0.0667 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0059 0.6064 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni hypothetical protein 0.0059 0.6064 0.6064
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0667 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Echinococcus multilocularis serotonin receptor 0.002 0.0667 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.1028 0.1145
Leishmania major cytochrome p450-like protein 0.0059 0.6064 0.5
Brugia malayi Cytochrome P450 family protein 0.0059 0.6064 0.6758
Echinococcus granulosus g-protein coupled receptor 0.002 0.0667 0.0743
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0667 0.0743
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0667 0.0667
Echinococcus granulosus voltage gated potassium channel 0.0023 0.1028 0.1145
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Brugia malayi ecdysteroid receptor 0.0025 0.1252 0.1396
Brugia malayi GnHR receptor homolog 0.002 0.0667 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.1252 0.1396
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0667 0.0743
Brugia malayi neuropeptide F receptor 0.002 0.0667 0.0743
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.1252 0.1396
Schistosoma mansoni amine GPCR 0.002 0.0667 0.0667
Brugia malayi steroid hormone receptor 0.0025 0.1252 0.1396
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0667 0.0667
Echinococcus multilocularis g protein coupled receptor 0.002 0.0667 0.0743
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.1252 0.1396
Echinococcus granulosus neuropeptide s receptor 0.002 0.0667 0.0743
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0667 0.0743
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.1252 0.1396
Brugia malayi nuclear hormone receptor 0.0025 0.1252 0.1396
Schistosoma mansoni histamine h1 receptor 0.002 0.0667 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0667 0.0667
Brugia malayi Cytochrome P450 family protein 0.0059 0.6064 0.6758
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0667 0.0743
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.1252 0.1396
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0059 0.6064 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0667 0.0743
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0059 0.6064 0.5
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.008 0.8972 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0667 0.0667
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.1252 0.1396
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus sex peptide receptor 0.002 0.0667 0.0743
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.1252 0.1252
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0059 0.6064 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.1252 0.1396
Echinococcus granulosus neuropeptide receptor 0.002 0.0667 0.0743
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0059 0.6064 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.1252 0.1396
Echinococcus multilocularis neuropeptide receptor 0.002 0.0667 0.0743
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.1028 0.1145
Brugia malayi cytochrome P450 0.0059 0.6064 0.6758
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0667 0.0743
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.1252 1
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.7495 0.8354
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.1252 0.1396
Echinococcus granulosus g protein coupled receptor 0.002 0.0667 0.0743
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0667 0.0743
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0667 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0667 0.0667
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.1252 0.1396
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.6064 0.6758
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.1252 0.1396
Brugia malayi Dopamine receptor protein 2 0.002 0.0667 0.0743
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.1252 0.1396
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0667 0.0743
Echinococcus granulosus serotonin receptor 0.002 0.0667 0.0743
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0059 0.6064 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0667 0.0743
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0667 0.0743
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0059 0.6064 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.6064 0.6758
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.8236 1
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0667 0.0743
Brugia malayi Melatonin receptor type 1A 0.002 0.0667 0.0743
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0667 0.0743
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0667 0.0667
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0667 0.0743
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0667 0.0743
Mycobacterium leprae Conserved hypothetical protein 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis sex peptide receptor 0.002 0.0667 0.0743
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0059 0.6064 0.5
Schistosoma mansoni hypothetical protein 0.002 0.0667 0.0667
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0059 0.6064 0.5
Echinococcus multilocularis somatostatin receptor 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0059 0.6064 0.5
Brugia malayi nuclear receptor NHR-88 0.0025 0.1252 0.1396
Schistosoma mansoni opsin-like receptor 0.002 0.0667 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Schistosoma mansoni cytochrome P450 0.0059 0.6064 0.6064
Schistosoma mansoni myosin xvIII 0.002 0.0667 0.0667
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.8236 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Schistosoma mansoni biogenic amine receptor 0.002 0.0667 0.0667
Echinococcus granulosus somatostatin receptor 0.002 0.0667 0.0743
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0059 0.6064 0.5
Loa Loa (eye worm) CYP4Cod1 0.0059 0.6064 0.6758
Echinococcus multilocularis fmrfamide receptor 0.002 0.0667 0.0743
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.1252 0.1396
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0667 0.0743
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0667 0.0743
Echinococcus granulosus g protein coupled receptor 0.002 0.0667 0.0743
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0667 0.0743
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.1252 0.1396
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0667 0.0743
Schistosoma mansoni amine GPCR 0.002 0.0667 0.0667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.1252 0.1396
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0059 0.6064 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0667 0.0743
Echinococcus multilocularis fmrfamide receptor 0.002 0.0667 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Schistosoma mansoni adenoreceptor 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0059 0.6064 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.1252 0.1396
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0667 0.0743
Echinococcus granulosus neuropeptide receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0667 0.0743
Echinococcus multilocularis allatostatin A receptor 0.002 0.0667 0.0743
Schistosoma mansoni biogenic amine receptor 0.002 0.0667 0.0667
Loa Loa (eye worm) cytochrome P450 0.0059 0.6064 0.6758
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0667 0.0743
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0667 0.0743
Echinococcus multilocularis g protein coupled receptor 0.002 0.0667 0.0743
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0667 0.0743
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0667 0.0743
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.1252 0.1396
Brugia malayi G-protein coupled receptor 0.002 0.0667 0.0743
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0667 0.0667
Brugia malayi Serotonin receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus allatostatin A receptor 0.002 0.0667 0.0743
Schistosoma mansoni thyroid hormone receptor 0.0025 0.1252 0.1252
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0667 0.0743
Echinococcus multilocularis neuropeptide receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0667 0.0743
Brugia malayi Cytochrome P450 family protein 0.0059 0.6064 0.6758
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0667 0.0743
Schistosoma mansoni voltage-gated potassium channel 0.0087 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.1252 0.1396
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.1252 0.1252
Schistosoma mansoni biogenic amine receptor 0.002 0.0667 0.0667
Onchocerca volvulus 0.0025 0.1252 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0059 0.6064 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.1252 0.1396
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Schistosoma mansoni neuropeptide receptor 0.002 0.0667 0.0667
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0059 0.6064 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0667 0.0743
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.1252 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.1252 0.1396
Brugia malayi Dopamine receptor 0.002 0.0667 0.0743
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0667 0.0743
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.1252 0.1396
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0667 0.0743
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.1028 0.1145
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0667 0.0743
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.1252 0.1252
Toxoplasma gondii cytochrome p450 superfamily protein 0.0059 0.6064 0.5
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0059 0.6064 0.5
Echinococcus granulosus g protein coupled receptor 0.002 0.0667 0.0743
Leishmania major cytochrome p450-like protein 0.0059 0.6064 0.5
Echinococcus granulosus FTZ F1 alpha 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.1252 0.1396
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Echinococcus multilocularis serotonin receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0059 0.6064 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0059 0.6064 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.1252 0.1252
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0667 0.0667
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0667 0.0743
Schistosoma mansoni neuropeptide receptor 0.002 0.0667 0.0667
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0059 0.6064 0.5
Brugia malayi sulfakinin receptor protein 0.002 0.0667 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0667 0.0743
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0667 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.1252 0.1396
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0059 0.6064 0.5
Schistosoma mansoni amine GPCR 0.002 0.0667 0.0667
Brugia malayi Dopamine receptor protein 1 0.002 0.0667 0.0743
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0059 0.6064 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.1252 0.1396
Schistosoma mansoni hypothetical protein 0.002 0.0667 0.0667
Brugia malayi neuropeptide F receptor 0.002 0.0667 0.0743
Echinococcus granulosus potassium voltage gated channel subfamily H 0.008 0.8972 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0059 0.6064 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0667 0.0743
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0667 0.0743
Brugia malayi G-protein coupled receptor 0.002 0.0667 0.0743
Schistosoma mansoni amine GPCR 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0667 0.0667
Trypanosoma brucei cytochrome P450, putative 0.0059 0.6064 0.5
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Brugia malayi RE15519p 0.002 0.0667 0.0743
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0667 0.0667
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0667 0.0743
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0667 0.0743
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0667 0.0743
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0667 0.0667
Brugia malayi putative neuropeptide receptor 0.002 0.0667 0.0743
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.008 0.8972 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0667 0.0743
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.1252 0.1396
Schistosoma mansoni thyroid hormone receptor 0.0025 0.1252 0.1252
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0667 0.0667
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0667 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.1252 0.1396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Echinococcus granulosus fmrfamide receptor 0.002 0.0667 0.0743
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.1252 0.1396
Echinococcus multilocularis orexin receptor type 2 0.002 0.0667 0.0743
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0059 0.6064 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0667 0.0667
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0667 0.0743
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.1252 0.1252
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.1028 0.1145
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0059 0.6064 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.1252 0.1396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.1252 0.1396
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0667 0.0743
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.1252 0.1396
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.6064 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.1252 0.1252
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0059 0.6064 0.5
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Brugia malayi larval opioid receptor 0.002 0.0667 0.0743
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0667 0.0743
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0667 0.0667
Echinococcus granulosus orexin receptor type 2 0.002 0.0667 0.0743
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.1252 0.1396
Schistosoma mansoni opsin-like receptor 0.002 0.0667 0.0667
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0667 0.0667
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0667 0.0743
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0667 0.0743
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0667 0.0743
Brugia malayi Serotonin receptor 0.002 0.0667 0.0743
Schistosoma mansoni opsin-like receptor 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.1252 0.1252
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0667 0.0667
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0059 0.6064 0.5
Brugia malayi ORL1-like opioid receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni coup transcription factor 0.0025 0.1252 0.1252
Brugia malayi Cytochrome P450 family protein 0.0059 0.6064 0.6758
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0667 0.0743
Brugia malayi G protein-coupled receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.1252 0.1396
Brugia malayi AKH receptor 0.002 0.0667 0.0743
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0667 0.0667
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0059 0.6064 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.1252 0.1396
Brugia malayi hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus multilocularis 0.0059 0.6064 0.6758
Schistosoma mansoni hypothetical protein 0.002 0.0667 0.0667
Schistosoma mansoni nuclear hormone receptor 0.0025 0.1252 0.1252
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0059 0.6064 0.5
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0059 0.6064 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.1252 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0059 0.6064 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0667 0.0743
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.1252 0.1252
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0667 0.0743
Schistosoma mansoni hypothetical protein 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0059 0.6064 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0667 0.0743
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0667 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.1252 0.1396
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.6064 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0059 0.6064 0.5
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0059 0.6064 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Schistosoma mansoni neuropeptide receptor 0.002 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0025 0.1252 0.1396
Loa Loa (eye worm) hypothetical protein 0.0023 0.1028 0.1145
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0667 0.0743
Schistosoma mansoni neuropeptide receptor 0.002 0.0667 0.0667
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.1252 0.1252
Leishmania major cytochrome p450-like protein 0.0059 0.6064 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.1252 0.1396
Mycobacterium leprae putative cytochrome p450 0.0059 0.6064 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus hypothetical protein 0.002 0.0667 0.0743
Echinococcus granulosus cytochrome P450 2K1 0.0059 0.6064 0.6758
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.008 0.8972 1
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0667 0.0743
Loa Loa (eye worm) hypothetical protein 0.002 0.0667 0.0743
Brugia malayi follicle stimulating hormone receptor 0.002 0.0667 0.0743

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 8 ug ml-1 Antibacterial activity against Streptococcus mutans after 16 to 20 hrs ChEMBL. 17296741

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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