Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y1 | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor Y2 | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | G protein coupled receptor 139 | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus granulosus | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma mansoni | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | neuropeptide Y receptor Y1 | 384 aa | 345 aa | 22.0 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | neuropeptide Y receptor Y2 | 381 aa | 388 aa | 20.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0037 | 0.0851 | 0.0851 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0851 | 0.111 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0716 | 0.0934 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.1117 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0179 | 0.6924 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0072 | 0.2333 | 0.2333 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0196 | 0.7666 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0179 | 0.6924 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0167 | 0.0167 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 0.2333 | 0.3043 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0179 | 0.6924 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0167 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.3843 | 0.3843 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0716 | 0.0934 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0851 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0716 | 0.0934 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0986 | 0.1212 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0716 | 0.0716 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0716 | 0.0716 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0851 | 0.111 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0485 | 0.047 |
Schistosoma mansoni | neuropeptide receptor | 0.0196 | 0.7666 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0851 | 0.111 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 0.2333 | 0.3043 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 0.2333 | 0.3205 |
Trichomonas vaginalis | hypothetical protein | 0.0179 | 0.6924 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.1117 | 0.1405 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0167 | 0.0218 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0716 | 0.0934 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0851 | 0.111 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0716 | 0.0716 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 0.2333 | 0.3205 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.0986 | 0.0986 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0179 | 0.6924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0615 | 0.0615 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0851 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0167 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0072 | 0.2333 | 0.2333 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 0.2333 | 0.3043 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0716 | 0.0934 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.3843 | 0.3843 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0716 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0716 | 0.0716 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0167 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.1117 | 0.1405 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0179 | 0.6924 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0851 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0716 | 0.0934 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0716 | 0.0934 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0167 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0167 | 0.0218 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 0.2333 | 0.3043 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0716 | 0.0934 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0179 | 0.6924 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0179 | 0.6924 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0196 | 0.7666 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0196 | 0.7666 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0179 | 0.6924 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2396 | 0.3125 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0986 | 0.0986 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0167 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0072 | 0.2333 | 0.3043 |
Schistosoma mansoni | chromobox protein | 0.0072 | 0.2333 | 0.3043 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0167 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0851 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2396 | 0.2396 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.0986 | 0.7399 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0986 | 0.1212 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0167 | 0.0218 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0167 | 0.0218 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.3843 | 0.3843 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0716 | 0.0934 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0485 | 0.047 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.2396 | 0.2396 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.3843 | 0.3843 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Reduction of food intake in C57BL/6 mouse after 0.74 umol/kg, sc after 72 hrs | ChEMBL. | 17425299 | |
Activity (functional) | Reduction of food intake in C57BL/6 mouse at 0.74 umol/kg, sc after 24 hrs | ChEMBL. | 17425299 | |
Activity (functional) | Reduction of food intake in C57BL/6 mouse at 0.74 umol/kg, sc after 48 hrs | ChEMBL. | 17425299 | |
Activity (functional) | Reduction of food intake in C57BL/6 mouse at 0.74 umol/kg, sc after 4 hrs | ChEMBL. | 17425299 | |
Activity (functional) | 0 | Reduction of food intake in C57BL/6 mouse at 0.74 umol/kg, sc after 4 hrs | ChEMBL. | 17425299 |
Activity (functional) | 0 | Reduction of food intake in C57BL/6 mouse at 0.74 umol/kg, sc after 24 hrs | ChEMBL. | 17425299 |
Activity (functional) | 0 | Reduction of food intake in C57BL/6 mouse at 0.74 umol/kg, sc after 48 hrs | ChEMBL. | 17425299 |
Activity (functional) | 0 | Reduction of food intake in C57BL/6 mouse after 0.74 umol/kg, sc after 72 hrs | ChEMBL. | 17425299 |
EC50 (functional) | = 4 nM | Agonist activity at human NPY2 by [35S]GTPgammaS cAMP accumulation assay | ChEMBL. | 17425299 |
Ki (binding) | = 11 nM | Displacement of [125I]PYY from human NPY2 | ChEMBL. | 17425299 |
Ki (binding) | > 1000 nM | Displacement of [125I]PYY from human NPY1 | ChEMBL. | 17425299 |
Ki (binding) | > 1000 nM | Displacement of [125I]PYY from human NPY5 | ChEMBL. | 17425299 |
Ki (binding) | > 1000 nM | Displacement of [125I]PYY from human NPY1 | ChEMBL. | 17425299 |
Ki (binding) | > 1000 nM | Displacement of [125I]PYY from human NPY5 | ChEMBL. | 17425299 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.