Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.014 | 0.0606 | 0.059 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.207 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0095 | 0.132 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.157 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.014 | 0.0606 | 0.059 |
Onchocerca volvulus | 0.014 | 0.0606 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0095 | 0.1561 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.014 | 0.0606 | 0.3792 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0095 | 0.132 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0095 | 0.0078 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0042 | 0.0025 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0095 | 0.132 |
Leishmania major | pteridine reductase 1 | 0.014 | 0.0606 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0095 | 0.0078 |
Leishmania major | oxidoreductase-like protein | 0.014 | 0.0606 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.014 | 0.0606 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.014 | 0.0606 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.014 | 0.0606 | 0.059 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.014 | 0.0606 | 0.1532 |
Trypanosoma brucei | oxidoreductase-like protein | 0.014 | 0.0606 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.014 | 0.0606 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.207 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0095 | 0.132 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0095 | 0.0078 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0151 | 0.0861 |
Onchocerca volvulus | 0.014 | 0.0606 | 1 | |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Schistosoma mansoni | dihydropteridine reductase | 0.014 | 0.0606 | 0.3792 |
Echinococcus granulosus | geminin | 0.0338 | 0.157 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0606 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.014 | 0.0606 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.207 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.014 | 0.0606 | 0.059 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0151 | 0.0861 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0042 | 0.0428 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0017 | 0.0278 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.1017 | 0.1002 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0095 | 0.0078 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0151 | 0.0861 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.014 | 0.0606 | 0.059 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0017 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0095 | 0.0501 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0042 | 0.0428 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0095 | 0.0078 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0095 | 0.132 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | oxidoreductase | 0.014 | 0.0606 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0095 | 0.132 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.207 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0095 | 0.132 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0095 | 0.0501 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.014 | 0.0606 | 0.3792 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.014 | 0.0606 | 0.059 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0151 | 0.0861 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0095 | 0.0078 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0042 | 0.0025 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0095 | 0.0078 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.014 | 0.0606 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.014 | 0.0606 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0095 | 0.0078 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0095 | 0.1561 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0095 | 0.1561 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.014 | 0.0606 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0095 | 0.132 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Echinococcus multilocularis | geminin | 0.0338 | 0.157 | 0.404 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0095 | 0.132 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.014 | 0.0606 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.014 | 0.0606 | 0.0516 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0095 | 0.0202 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0809 | 0.3862 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.014 | 0.0606 | 1 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.014 | 0.0606 | 0.059 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.207 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0151 | 0.227 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0017 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.207 | 1 | 1 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0095 | 0.0501 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0095 | 0.1561 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.014 | 0.0606 | 0.059 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.014 | 0.0606 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0042 | 0.0025 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0042 | 0.0428 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0151 | 0.0348 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.014 | 0.0606 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.014 | 0.0606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0042 | 0.0428 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0042 | 0.0428 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0095 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0095 | 0.132 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0095 | 0.0078 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.014 | 0.0606 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0151 | 0.2485 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0042 | 0.0025 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.014 | 0.0606 | 0.059 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.014 | 0.0606 | 0.0516 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0095 | 0.0078 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.014 | 0.0606 | 0.059 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.014 | 0.0606 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0095 | 0.132 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.014 | 0.0606 | 0.059 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.014 | 0.0606 | 0.059 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.014 | 0.0606 | 0.059 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.014 | 0.0606 | 0.059 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.157 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.014 | 0.0606 | 0.059 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.207 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0151 | 0.0348 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.014 | 0.0606 | 0.059 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0151 | 0.0861 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0095 | 0.132 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.014 | 0.0606 | 0.059 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0042 | 0.0693 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.73 uM | Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells after 120 hrs by MTT assay | ChEMBL. | 17402726 |
IC50 (functional) | = 2.61 uM | Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC2 cells after 120 hrs by MTT assay | ChEMBL. | 17402726 |
IC50 (ADMET) | > 15 uM | Cytotoxicity against DG75 cells after 120 hrs by MTT assay | ChEMBL. | 17402726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.