Detailed information for compound 423381

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1708.92 | Formula: C91H101N23O12
  • H donors: 20 H acceptors: 15 LogP: 5.6 Rotable bonds: 56
    Rule of 5 violations (Lipinski): 4
  • SMILES: NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)N)Cc1cnc[nH]1)Cc1ccc(cc1)O)Cc1ccccc1)Cc1cnc[nH]1)Cc1ccccc1)Cc1cnc[nH]1
  • InChi: 1S/C91H101N23O12/c92-67(36-54-18-5-1-6-19-54)81(117)107-77(43-61-48-96-51-102-61)89(125)110-74(40-58-31-33-64(115)34-32-58)83(119)108-72(38-56-22-9-3-10-23-56)84(120)111-76(42-60-47-101-69-29-16-14-27-66(60)69)87(123)114-79(45-63-50-98-53-104-63)90(126)112-75(41-59-46-100-68-28-15-13-26-65(59)68)86(122)109-73(39-57-24-11-4-12-25-57)85(121)113-78(44-62-49-97-52-103-62)88(124)105-70(30-17-35-99-91(94)95)82(118)106-71(80(93)116)37-55-20-7-2-8-21-55/h1-16,18-29,31-34,46-53,67,70-79,100-101,115H,17,30,35-45,92H2,(H2,93,116)(H,96,102)(H,97,103)(H,98,104)(H,105,124)(H,106,118)(H,107,117)(H,108,119)(H,109,122)(H,110,125)(H,111,120)(H,112,126)(H,113,121)(H,114,123)(H4,94,95,99)/t67-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-/m0/s1
  • InChiKey: ODBZDYIERFDRTN-BTINJRJPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0124 0.0109
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.1651 0.1638
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0076 0.0658 0.0644
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0157 0.0142
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0073 0.0054
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0206 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0076 0.0658 0.0658
Trypanosoma brucei glucose transporter 2A 0.0033 0.0206 0.0191
Leishmania major glucose transporter, lmgt1 0.0033 0.0206 0.0187
Brugia malayi nuclear hormone receptor 0.0076 0.0658 0.0644
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0194 0.1323
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0142 0.1344 0.1344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0206 0.0966
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trypanosoma brucei sugar transporter, putative 0.0015 0.0019 0.0004
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0974 1 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi hypothetical protein 0.0032 0.0197 0.0182
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0036 0.0239 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0076 0.0658 0.0658
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0206 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni nAChR subunit 0.0053 0.0418 0.0404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0115 0.1064 0.1051
Brugia malayi CXXC zinc finger family protein 0.0029 0.0162 0.0148
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0115 0.1064 0.1051
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0194 0.1187
Brugia malayi Sugar transporter family protein 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0289 0.2872 0.2861
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0062 0.0511 0.0497
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0262 0.0247
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0115 0.1064 0.1051
Schistosoma mansoni coup transcription factor 0.0076 0.0658 0.0644
Onchocerca volvulus 0.0115 0.1064 0.8444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0053 0.0418 0.0404
Entamoeba histolytica protein kinase, putative 0.0033 0.0211 0.1476
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Leishmania major cathepsin L-like protease 0.0107 0.0977 0.096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1814 0.1802
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0408 0.4107 0.4098
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0284 0.0269
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0118 0.1096 0.1082
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0429 0.0411
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0115 0.1064 0.1051
Schistosoma mansoni glucose transport protein 0.0106 0.0964 0.095
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi hypothetical protein 0.0015 0.0019 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0204 0.1987 0.1975
Schistosoma mansoni glucose transport protein 0.0106 0.0964 0.095
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0359 0.0345
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0115 0.1064 0.1051
Schistosoma mansoni thyroid hormone receptor 0.0076 0.0658 0.0644
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0076 0.0658 0.0644
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0194 0.0909
Echinococcus multilocularis glycine receptor subunit beta 0.0115 0.1064 0.1051
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0028 0.0157 0.0157
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.011 0.0095
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0211 0.0193
Brugia malayi Cam kinase protein 1 0.0033 0.0211 0.0196
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0115 0.1064 0.1051
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0197 0.0182
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0211 0.0197
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0076 0.0658 0.0644
Brugia malayi major facilitator superfamily protein 0.0015 0.0019 0.0004
Onchocerca volvulus 0.0053 0.0418 0.3222
Schistosoma mansoni hypothetical protein 0.0106 0.0964 0.095
Onchocerca volvulus 0.0053 0.0418 0.3222
Loa Loa (eye worm) fibroinase 0.0028 0.0157 0.0157
Echinococcus multilocularis nAChR subunit 0.0062 0.0511 0.0497
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0076 0.0658 0.0644
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0118 0.1096 0.1082
Plasmodium vivax hexose transporter 0.0106 0.0964 0.095
Schistosoma mansoni glucose transporter 0.0015 0.0019 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0076 0.0658 0.516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus granulosus survival motor neuron protein 1 0.021 0.2046 0.2034
Giardia lamblia Casein kinase II beta chain 0.0038 0.0262 0.1832
Plasmodium vivax vivapain-2 0.0028 0.0157 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) GABA receptor subunit 0.0062 0.0511 0.0511
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0211 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.006 0.0229
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0249 0.023
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0194 0.018
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0118 0.1096 0.1082
Loa Loa (eye worm) isocitrate dehydrogenase 0.0974 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.031 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Onchocerca volvulus 0.0115 0.1064 0.8444
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0076 0.0658 0.0644
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0511 0.0497
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0053 0.0418 0.0404
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4107 0.4098
Loa Loa (eye worm) DR-78 0.0036 0.0239 0.0239
Onchocerca volvulus 0.0019 0.006 0.0331
Schistosoma mansoni glucose transport protein 0.0106 0.0964 0.095
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Brugia malayi mbt repeat family protein 0.0048 0.0359 0.0345
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0211 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0113 0.1036 0.1023
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.0239 0.1775
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0977 0.0964
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0211 0.0197
Echinococcus multilocularis casein kinase ii subunit beta 0.0038 0.0262 0.0247
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Brugia malayi hypothetical protein 0.0036 0.0239 0.0224
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0019 0.0019
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0249 0.023
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.1651 0.1635
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.004 0.0284 0.0284
Brugia malayi hypothetical protein 0.004 0.0284 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus granulosus General substrate transporter 0.0091 0.0809 0.0795
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0284 0.0269
Schistosoma mansoni protein kinase 0.0033 0.0211 0.0196
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0053 0.0418 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0211 0.0196
Brugia malayi hypothetical protein 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Schistosoma mansoni unc-13 (munc13) 0.0118 0.1096 0.1082
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0115 0.1064 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0076 0.0658 0.0644
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.004 0.0284 0.0269
Brugia malayi Cathepsin L-like precursor 0.0019 0.006 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0118 0.1096 0.1082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0157 0.0142
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0974 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0496 0.0482
Loa Loa (eye worm) nuclear receptor NHR-67 0.0036 0.0239 0.0239
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0115 0.1064 0.1051
Onchocerca volvulus Putative nachr subunit 0.0115 0.1064 0.8444
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Echinococcus granulosus nuclear receptor nhr 48 0.0036 0.0239 0.0224
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0076 0.0658 0.0644
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0262 0.0247
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0076 0.0658 0.0644
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0157 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0118 0.1096 1
Giardia lamblia Kinase, CMGC CK2 0.0142 0.1344 1
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Brugia malayi Sugar transporter family protein 0.0015 0.0019 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0977 0.0964
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0053 0.0418 0.0404
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Leishmania major cathepsin L-like protease 0.0107 0.0977 0.096
Echinococcus granulosus cathepsin L cysteine proteinase 0.0028 0.0157 0.0142
Loa Loa (eye worm) Csnk2b protein 0.0038 0.0262 0.0262
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0124 0.0109
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0076 0.0658 0.0644
Onchocerca volvulus 0.0062 0.0511 0.3973
Trypanosoma brucei RNA helicase, putative 0.0335 0.3347 0.3337
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0076 0.0658 0.0658
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0115 0.1064 0.1051
Echinococcus granulosus glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Schistosoma mansoni retinoic acid receptor RXR 0.0242 0.2377 0.2366
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0279 0.2772 0.2772
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0118 0.1096 0.1082
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.0964 0.095
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.1332 0.6679
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0511 0.0497
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0076 0.0658 0.0644
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0428 0.0413
Onchocerca volvulus 0.0115 0.1064 0.8444
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Entamoeba histolytica hypothetical protein 0.0024 0.011 0.0714
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Brugia malayi Probable isocitrate dehydrogenase 0.0118 0.1096 0.1082
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0051 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Toxoplasma gondii ck2 beta subunit 0.0038 0.0262 0.0243
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Brugia malayi nuclear receptor RXR 0.004 0.0284 0.0269
Brugia malayi Steroid receptor seven-up type 2 0.0076 0.0658 0.0644
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0211 0.0197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Loa Loa (eye worm) sugar transporter 0.0015 0.0019 0.0019
Trypanosoma cruzi cruzipain precursor, putative 0.0107 0.0977 0.0964
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Echinococcus granulosus cathepsin l1 0.0019 0.006 0.0045
Brugia malayi excitatory GABA receptor EXP-1A 0.0115 0.1064 0.1051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Schistosoma mansoni nAChR subunit 0.0053 0.0418 0.0404
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0124 0.0109
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Schistosoma mansoni hypothetical protein 0.0335 0.3347 0.3337
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0194 0.018
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0019 0.0004
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Echinococcus multilocularis General substrate transporter 0.0091 0.0809 0.0795
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0019 0.0004
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0053 0.0418 0.0404
Onchocerca volvulus 0.0028 0.0157 0.1111
Echinococcus multilocularis isocitrate dehydrogenase 0.0974 1 1
Schistosoma mansoni cpg binding protein 0.003 0.0179 0.0165
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0118 0.1096 0.1096
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0262 0.0247
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.011 0.0095
Onchocerca volvulus 0.0076 0.0658 0.516
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.011 0.0843
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0206 0.0191
Loa Loa (eye worm) nuclear hormone receptor 0.0036 0.0239 0.0239
Onchocerca volvulus 0.0028 0.0157 0.1111
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0211 0.0995
Schistosoma mansoni protein kinase 0.0033 0.0211 0.0196
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0038 0.0262 0.0243
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0048 0.0359 0.0359
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi Cation transporter family protein 0.0115 0.1064 0.1051
Plasmodium falciparum protein kinase 6 0.0449 0.454 0.4531
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0036 0.0239 0.0224
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0157 0.1066
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0239 0.0224
Brugia malayi Nuclear hormone receptor-like 1 0.0076 0.0658 0.0644
Echinococcus multilocularis casein kinase ii subunit alpha 0.0142 0.1344 0.1331
Brugia malayi cathepsin L-like precursor 0.0019 0.006 0.0045
Onchocerca volvulus 0.0028 0.0157 0.1111
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.011 0.0481
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0019 0.0004
Schistosoma mansoni RAR-like nuclear receptor 0.0076 0.0658 0.0644
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni nuclear receptor 0.0036 0.0239 0.0224
Echinococcus granulosus glycine receptor subunit beta 0.0115 0.1064 0.1051
Brugia malayi ecdysteroid receptor 0.0076 0.0658 0.0644
Brugia malayi hypothetical protein 0.0016 0.0032 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Onchocerca volvulus 0.0036 0.0239 0.1775
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0038 0.0262 0.0243
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Schistosoma mansoni protein kinase 0.0142 0.1344 0.1331
Onchocerca volvulus 0.0043 0.031 0.2347
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0974 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0157 0.0157
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.011 0.0091
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Onchocerca volvulus 0.0049 0.0378 0.2895
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0194 0.1887 0.1887
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.011 0.0095
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0206 0.0966
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0511 0.0497
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Brugia malayi conserved hypotetical protein 0.0036 0.0239 0.0224
Brugia malayi nuclear hormone receptor family member odr-7 0.0036 0.0239 0.0224
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis ecdysone induced protein 78C 0.0076 0.0658 0.0644
Loa Loa (eye worm) MBCTL1 0.0054 0.0428 0.0428
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0028 0.0157 0.0142
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0211 0.0197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0053 0.0418 0.0404
Loa Loa (eye worm) ACC-1 protein 0.0115 0.1064 0.1064
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Brugia malayi nuclear hormone receptor 0.0036 0.0239 0.0224
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0115 0.1064 0.1051
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.0964 0.0946
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0115 0.1064 0.1064
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.006
Loa Loa (eye worm) ctsf protein 0.0028 0.0157 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Onchocerca volvulus 0.0028 0.0157 0.1111
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0182
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.1651 0.1638
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0036 0.0239 0.0239
Leishmania major glucose transporter, lmgt3 0.0033 0.0206 0.0187
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0249 0.0234
Schistosoma mansoni nuclear receptor nhr-48 0.0036 0.0239 0.0224
Plasmodium vivax CDK-related protein kinase 6, putative 0.0449 0.454 0.4531
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0053 0.0418 0.0418
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0036 0.0239 0.0224
Schistosoma mansoni survival motor neuron protein 0.0043 0.031 0.0295
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Onchocerca volvulus 0.0028 0.0157 0.1111
Leishmania major isocitrate dehydrogenase, putative 0.0118 0.1096 0.1079
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.006 0.0339
Trypanosoma cruzi major cysteine proteinase, putative 0.0084 0.0739 0.0725
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0105 0.0957 0.0957
Brugia malayi hypothetical protein 0.021 0.2046 0.2034
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Onchocerca volvulus 0.0053 0.0418 0.3222
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0242 0.2377 0.2366
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0028 0.0157 0.0142
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0249 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0053 0.0418 0.0404
Loa Loa (eye worm) LGC-31 protein 0.0115 0.1064 0.1064
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0019 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0076 0.0658 0.0644
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0262 0.196
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0124 0.0105
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0262 0.1857
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0115 0.1064 0.1064
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.0239 0.1775
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.011 0.0095
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0157 0.0142
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.018 0.0166
Brugia malayi nuclear receptor RXR 0.0036 0.0239 0.0224
Brugia malayi lysyl-tRNA synthetase 0.0024 0.011 0.0095
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Toxoplasma gondii protein kinase, putative 0.0299 0.298 0.2966
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0076 0.0658 0.0644
Leishmania major hypothetical protein, conserved 0.0025 0.0124 0.0105
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0262 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0201 0.1958 0.1946
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0197 0.0182
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0974 1 1
Brugia malayi nuclear receptor NHR-67 0.0036 0.0239 0.0224
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Brugia malayi Nuclear hormone receptor E75 0.0036 0.0239 0.0224
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0206 0.0191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0118 0.1096 0.1096
Brugia malayi hypothetical protein 0.004 0.0284 0.0269
Schistosoma mansoni protein kinase 0.0033 0.0211 0.0196
Echinococcus multilocularis nAChR subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0194 0.018
Loa Loa (eye worm) sugar transporter 0.0106 0.0964 0.0964
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Trypanosoma cruzi hexose transporter 0.0033 0.0206 0.0191
Loa Loa (eye worm) hypothetical protein 0.0049 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.021 0.2046 0.2046
Echinococcus multilocularis cysteine protease 0.0028 0.0157 0.0142
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0974 1 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.011 0.0095
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0115 0.1064 0.1051
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.011 0.0843
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0206 0.0966
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0974 1 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0974 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.1036 0.9448
Loa Loa (eye worm) hypothetical protein 0.0054 0.0428 0.0428
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0019 0.0004
Leishmania major glucose transporter, lmgt2 0.0033 0.0206 0.0187
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Schistosoma mansoni nuclear receptor 0.0036 0.0239 0.0224
Schistosoma mansoni thyroid hormone receptor 0.0076 0.0658 0.0644
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0076 0.0658 0.0644
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0206 0.0191
Echinococcus granulosus cathepsin l cysteine peptidase 0.0028 0.0157 0.0142
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0428 0.0413
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.011 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0076 0.0658 0.0644
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.011 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0098 0.0881 0.0867
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0359 0.2748
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0157 0.0142
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0162 0.0162
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0964 0.4812
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0157 0.1111
Echinococcus multilocularis thyroid hormone receptor alpha 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0428 0.0413
Loa Loa (eye worm) hypothetical protein 0.0226 0.2219 0.2219
Entamoeba histolytica protein kinase, putative 0.0033 0.0211 0.1476
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0157 0.1066
Echinococcus granulosus glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Entamoeba histolytica hypothetical protein 0.0062 0.0511 0.3732
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0053 0.0418 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0076 0.0658 0.0644
Onchocerca volvulus 0.0036 0.0239 0.1775
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0249 0.0234
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0194 0.018
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0019 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0211 0.0197
Echinococcus multilocularis survival motor neuron protein 1 0.021 0.2046 0.2034
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Plasmodium falciparum hexose transporter 0.0106 0.0964 0.095
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus casein kinase ii subunit beta 0.0038 0.0262 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0206 0.0966
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.1036 0.1023
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0019 0.0021
Plasmodium vivax unspecified product 0.0142 0.1344 0.1331
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0206 0.0191
Brugia malayi nuclear receptor NHR-88 0.0036 0.0239 0.0224
Brugia malayi Cation transporter family protein 0.0115 0.1064 0.1051
Echinococcus granulosus nAChR subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.011 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0076 0.0658 0.0644
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0428 0.0413
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0262 0.0247
Leishmania major cysteine peptidase A (CPA) 0.0028 0.0157 0.0138
Onchocerca volvulus 0.0062 0.0511 0.3973
Brugia malayi nuclear hormone receptor family member nhr-6 0.0036 0.0239 0.0224
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0036 0.0239 0.0224
Trypanosoma cruzi casein kinase II, putative 0.0142 0.1344 0.1331
Onchocerca volvulus Protein ultraspiracle homolog 0.0076 0.0658 0.516
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0359 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) hypothetical protein 0.0425 0.429 0.429
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Onchocerca volvulus 0.0028 0.0157 0.1111
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0036 0.0239 0.0224
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0019 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0359 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Brugia malayi tailless protein 0.0036 0.0239 0.0224
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0359 0.0345
Onchocerca volvulus 0.0028 0.0157 0.1111
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0211 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.006
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0206 0.0966
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0428 0.0413
Loa Loa (eye worm) hypothetical protein 0.0025 0.0124 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.011
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0206 0.0187
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Brugia malayi major facilitator superfamily protein 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Toxoplasma gondii isocitrate dehydrogenase 0.0974 1 1
Echinococcus granulosus cathepsin l1 0.0028 0.0157 0.0142
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0428 0.0413
Leishmania major casein kinase II, putative 0.0142 0.1344 0.1327
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0019 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0211 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0974 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.1036 0.1023
Entamoeba histolytica tartrate dehydrogenase, putative 0.0118 0.1096 0.8134
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0249 0.0234
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0038 0.0262 0.0247
Schistosoma mansoni zinc finger protein 0.0036 0.0239 0.0224
Brugia malayi hypothetical protein 0.0036 0.0239 0.0224
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0206 0.0966
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.004 0.0284 0.0269
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0124 0.0109
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0157 0.0142
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1814 0.1802
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0239 0.0224
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0239 0.0224
Trypanosoma brucei Casein kinase II 0.0142 0.1344 0.1331
Brugia malayi steroid hormone receptor 0.0076 0.0658 0.0644
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0115 0.1064 0.1051
Loa Loa (eye worm) cysteine protease 0.0028 0.0157 0.0157
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0284 0.0269
Brugia malayi nuclear receptor NHR-88 0.0076 0.0658 0.0644
Onchocerca volvulus Cathepsin F homolog 0.0028 0.0157 0.1111
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.011 0.0095
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0194 0.135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0211 0.0211
Schistosoma mansoni isocitrate dehydrogenase 0.0118 0.1096 0.1082
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0211 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Plasmodium falciparum cysteine proteinase falcipain 3 0.0028 0.0157 0.0142
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0124 0.0109
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0658 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.011 0.0362
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0115 0.1064 0.1051
Onchocerca volvulus Bile acid receptor homolog 0.0076 0.0658 0.516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0115 0.1064 0.1051
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0262 0.0247
Onchocerca volvulus 0.0048 0.0359 0.2748
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Toxoplasma gondii isocitrate dehydrogenase 0.0974 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0211 0.0211
Brugia malayi hypothetical protein 0.0015 0.0019 0.0004
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0142 0.1344 0.1331
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni acetylcholine receptor-related 0.0053 0.0418 0.0404
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0378 0.0363
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0118 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0239 0.0224
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis nuclear receptor nhr 48 0.0036 0.0239 0.0224
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Brugia malayi orphan nuclear receptor NR2E1 0.0036 0.0239 0.0224
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0115 0.1064 0.1064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0974 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0076 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi Nuclear hormone receptor E75 0.0036 0.0239 0.0224
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0019 0.0004
Entamoeba histolytica cysteine protease, putative 0.0028 0.0157 0.1066
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.1332 0.6679
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Echinococcus granulosus FTZ F1 alpha 0.0076 0.0658 0.0644
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0206 0.0966
Leishmania major cathepsin L-like protease 0.0107 0.0977 0.096
Schistosoma mansoni hypothetical protein 0.0043 0.031 0.0295
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0211 0.0196
Loa Loa (eye worm) ACC-1 protein 0.0115 0.1064 0.1064
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.011 0.0685
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0019 0.0004
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0118 0.1096 0.1082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0124 0.0109
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0974 1 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus granulosus casein kinase ii subunit alpha 0.0142 0.1344 0.1331
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0974 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0115 0.1064 0.1051
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0194 0.1887 0.1875
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0115 0.1064 0.1051
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4107 0.4098
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.011 0.0095
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0115 0.1064 0.1064
Entamoeba histolytica casein kinase, putative 0.0142 0.1344 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0019 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Toxoplasma gondii cathepsin CPL 0.0028 0.0157 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0974 1 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Echinococcus granulosus nAChR subunit 0.0062 0.0511 0.0497
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0211 0.0211
Brugia malayi Cation transporter family protein 0.0115 0.1064 0.1051
Brugia malayi Isocitrate dehydrogenase 0.0974 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0115 0.1064 0.1051
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0359 0.0359
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Echinococcus multilocularis FTZ F1 alpha 0.0076 0.0658 0.0644
Brugia malayi Cathepsin L-like precursor 0.0019 0.006 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0076 0.0658 0.0644
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0115 0.1064 0.1051
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0073 0.0054
Brugia malayi hypothetical protein 0.0025 0.0124 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0076 0.0658 0.0658
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Brugia malayi Sugar transporter family protein 0.0106 0.0964 0.095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.0029 0.0162 0.0148
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0062 0.0511 0.0497
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0115 0.1064 0.1051
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0019 0.0004
Onchocerca volvulus 0.0029 0.0162 0.1158
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0118 0.1096 0.1082
Plasmodium falciparum protein kinase 7 0.0299 0.298 0.2969
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0249 0.0234
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0262 0.196
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0076 0.0658 0.0644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Onchocerca volvulus 0.0115 0.1064 0.8444
Loa Loa (eye worm) acetylcholine receptor protein 0.0053 0.0418 0.0418
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.0418 0.0404
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0118 0.1096 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0211 0.0193
Brugia malayi Csnk2b protein 0.0038 0.0262 0.0247
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0157 0.0142
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.008 0.0328
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0279 0.2772 0.2761
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0262 0.1857
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0249 0.023
Schistosoma mansoni acetylcholine receptor subunit beta 0.0053 0.0418 0.0404
Echinococcus multilocularis tumor protein p63 0.0337 0.3369 0.3359
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0076 0.0658 0.0644
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0053 0.0418 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.1036 0.9448
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0115 0.1064 0.1064
Brugia malayi ecdysone receptor 0.0036 0.0239 0.0224
Plasmodium falciparum casein kinase 2, alpha subunit 0.0142 0.1344 0.1331
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus calcium dependent protein kinase 0.003 0.018 0.0166
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0062 0.0511 0.0497
Leishmania major protein kinase, putative 0.0033 0.0211 0.0192
Echinococcus multilocularis glycine receptor subunit beta 0.0115 0.1064 0.1051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0211 0.0197
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0076 0.0658 0.0644
Echinococcus granulosus glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.1036 0.1019
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0262 0.1857
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0511 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus granulosus tumor protein p63 0.0337 0.3369 0.3359
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0019 0.0004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0113 0.1036 0.1019
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0359 0.0345
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0118 0.1096 0.5481
Brugia malayi photoreceptor-specific nuclear receptor 0.0076 0.0658 0.0644
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0974 1 1
Schistosoma mansoni casein kinase II beta subunit 0.0038 0.0262 0.0247
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0118 0.1096 0.1082
Echinococcus multilocularis cysteine protease 0.0028 0.0157 0.0142
Echinococcus granulosus cpg binding protein 0.003 0.0179 0.0165
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0115 0.1064 0.1051
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.1036 0.1023
Plasmodium vivax vivapain-2 0.0028 0.0157 0.0142
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0204 0.1987 0.1987
Onchocerca volvulus 0.0115 0.1064 0.8444
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Loa Loa (eye worm) steroid hormone receptor 0.0076 0.0658 0.0658
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0076 0.0658 0.0644
Echinococcus multilocularis cpg binding protein 0.003 0.0179 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.003 0.0179 0.0165
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0974 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.004 0.0284 0.0269
Onchocerca volvulus 0.0115 0.1064 0.8444
Onchocerca volvulus Glucosylceramidase homolog 0.0134 0.1257 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0194
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0076 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Brugia malayi Probable isocitrate dehydrogenase 0.0118 0.1096 0.1082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.006 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0977 0.0964
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0359 0.0345
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Brugia malayi Casein kinase II, alpha chain 0.0142 0.1344 0.1331
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trypanosoma brucei glucose transporter 1E 0.0033 0.0206 0.0191
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0157 0.1111
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.1344 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0036 0.0239 0.0224
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0211 0.0197
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0076 0.0658 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0053 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0197 0.0182
Echinococcus granulosus glycine receptor subunit beta 0.0115 0.1064 0.1051
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0194 0.018
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0359 0.0345
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Brugia malayi mbt repeat family protein 0.0048 0.0359 0.0345
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0194 0.018
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0076 0.0658 0.0658
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0076 0.0658 0.0644
Plasmodium vivax sugar transporter, putative 0.0015 0.0019 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.006 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0118 0.1096 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0076 0.0658 0.0644
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0019 0.0004
Toxoplasma gondii CMGC kinase, CK2 family 0.0142 0.1344 0.1327

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 125 ug ml-1 Antibacterial activity against Streptococcus mutans after 16 to 20 hrs ChEMBL. 17296741

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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