Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.0047 | 0.0343 | 0.0343 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | nuclear receptor NHR-88 | 0.009 | 0.3199 | 0.3199 |
Giardia lamblia | Hypothetical protein | 0.0062 | 0.1305 | 0.1645 |
Leishmania major | cyclin | 0.0119 | 0.5186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclin B | 0.0119 | 0.5186 | 0.5186 |
Plasmodium vivax | protein kinase Crk2 | 0.005 | 0.0541 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0541 | 0.0541 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.019 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.005 | 0.0541 | 0.0541 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclin dependent kinase | 0.005 | 0.0541 | 0.0541 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0.0574 | 0.0071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.005 | 0.0541 | 0.0541 |
Trichomonas vaginalis | cyclin B3, putative | 0.0062 | 0.1305 | 0.1645 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.0541 | 0.0541 |
Schistosoma mansoni | cyclin B | 0.0119 | 0.5186 | 0.5186 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0343 | 0.0343 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.009 | 0.3199 | 0.3199 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.009 | 0.3199 | 0.3199 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0119 | 0.5186 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.009 | 0.3199 | 0.3199 |
Onchocerca volvulus | 0.009 | 0.3199 | 0.6169 | |
Brugia malayi | cell division control protein 2 homolog | 0.005 | 0.0541 | 0.0541 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.009 | 0.3199 | 0.3199 |
Schistosoma mansoni | cyclins | 0.0062 | 0.1305 | 0.1305 |
Trichomonas vaginalis | cyclin B, putative | 0.0119 | 0.5186 | 1 |
Echinococcus multilocularis | cyclins | 0.0062 | 0.1305 | 0.1305 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | cyclins | 0.0062 | 0.1305 | 0.1305 |
Brugia malayi | nuclear hormone receptor | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0.0574 | 0.0071 |
Trichomonas vaginalis | cyclins, putative | 0.0119 | 0.5186 | 1 |
Toxoplasma gondii | AGC kinase | 0.0051 | 0.0574 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Giardia lamblia | Cyclin A | 0.0062 | 0.1305 | 0.1645 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0.0574 | 0.0071 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.005 | 0.0541 | 0.8787 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.009 | 0.3199 | 0.3199 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0051 | 0.0574 | 0.0071 |
Trichomonas vaginalis | cyclin B, putative | 0.0119 | 0.5186 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.048 | 0.048 |
Echinococcus granulosus | cyclins | 0.0062 | 0.1305 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1024 | 0.1024 |
Echinococcus multilocularis | cyclins | 0.0062 | 0.1305 | 0.1305 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0051 | 0.0574 | 0.0574 |
Echinococcus granulosus | FTZ F1 alpha | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclins | 0.0062 | 0.1305 | 0.1305 |
Echinococcus granulosus | cyclins | 0.0062 | 0.1305 | 0.1305 |
Trichomonas vaginalis | cyclin B, putative | 0.0119 | 0.5186 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0051 | 0.0574 | 0.0071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.005 | 0.0541 | 0.0541 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0343 | 0.0343 |
Brugia malayi | Protein kinase domain containing protein | 0.0051 | 0.0574 | 0.0574 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.009 | 0.3199 | 0.6169 |
Onchocerca volvulus | Bile acid receptor homolog | 0.009 | 0.3199 | 0.6169 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0343 | 0.0343 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0119 | 0.5186 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0072 | 0.2029 | 0.3203 |
Echinococcus multilocularis | cyclin B3 1 | 0.0062 | 0.1305 | 0.1305 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0119 | 0.5186 | 0.5186 |
Trichomonas vaginalis | cyclin B, putative | 0.0119 | 0.5186 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.1305 | 0.1645 |
Loa Loa (eye worm) | steroid hormone receptor | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | cyclins, putative | 0.0119 | 0.5186 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0119 | 0.5186 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0343 | 0.0343 |
Echinococcus granulosus | cyclins | 0.0062 | 0.1305 | 0.1305 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.009 | 0.3199 | 0.3199 |
Entamoeba histolytica | cyclin family protein | 0.0062 | 0.1305 | 0.1645 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclins | 0.0062 | 0.1305 | 0.1305 |
Trypanosoma cruzi | cyclin 6, putative | 0.0119 | 0.5186 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.005 | 0.0541 | 0.0541 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0047 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.009 | 0.3199 | 0.3199 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.009 | 0.3199 | 0.6169 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0.0574 | 0.0071 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0541 | 0.0541 |
Brugia malayi | steroid hormone receptor | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | cyclins, putative | 0.0119 | 0.5186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5186 | 0.5186 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | FTZ F1 alpha | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.005 | 0.0541 | 0.0541 |
Trichomonas vaginalis | cyclin D, putative | 0.0062 | 0.1305 | 0.1645 |
Schistosoma mansoni | coup transcription factor | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.009 | 0.3199 | 0.3199 |
Plasmodium falciparum | cyclin | 0.0062 | 0.1305 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.009 | 0.3199 | 0.3199 |
Entamoeba histolytica | cyclin, putative | 0.0062 | 0.1305 | 0.1645 |
Echinococcus granulosus | cyclin b3 | 0.0062 | 0.1305 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | cyclin B | 0.0119 | 0.5186 | 0.5186 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0047 | 0.0343 | 0.0343 |
Entamoeba histolytica | cyclin family protein | 0.0062 | 0.1305 | 0.1645 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0047 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5186 | 0.5186 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.005 | 0.0541 | 0.0541 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0047 | 0.0343 | 0.0343 |
Schistosoma mansoni | thyroid hormone receptor | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0343 | 0.0343 |
Schistosoma mansoni | nuclear hormone receptor | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0.0574 | 0.0071 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.005 | 0.0541 | 0.0541 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0047 | 0.0343 | 0.0343 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.009 | 0.3199 | 0.3199 |
Echinococcus granulosus | cyclin B3 1 | 0.0062 | 0.1305 | 0.1305 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.019 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0051 | 0.0574 | 0.0574 |
Trichomonas vaginalis | cyclins, putative | 0.0062 | 0.1305 | 0.1645 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0047 | 0.0343 | 0.0343 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.019 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0062 | 0.1305 | 0.1305 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.009 | 0.3199 | 0.3199 |
Trypanosoma cruzi | cyclin, putative | 0.0119 | 0.5186 | 1 |
Echinococcus multilocularis | cyclins | 0.0062 | 0.1305 | 0.1305 |
Entamoeba histolytica | protein kinase, putative | 0.0051 | 0.0574 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | cyclin D, putative | 0.0062 | 0.1305 | 0.1645 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.005 | 0.0541 | 0.0541 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | cyclin B, putative | 0.0062 | 0.1305 | 0.1645 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0119 | 0.5186 | 0.5186 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0119 | 0.5186 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.009 | 0.3199 | 0.3199 |
Trichomonas vaginalis | cyclins, putative | 0.0119 | 0.5186 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0119 | 0.5186 | 1 |
Echinococcus multilocularis | cyclins | 0.0062 | 0.1305 | 0.1305 |
Entamoeba histolytica | cyclin, putative | 0.0119 | 0.5186 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.005 | 0.0541 | 0.0541 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0343 | 0.0343 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0.0574 | 0.0071 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.005 | 0.0541 | 0.0541 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0047 | 0.0343 | 0.0343 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclins | 0.0062 | 0.1305 | 0.1305 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0051 | 0.0574 | 0.0574 |
Trichomonas vaginalis | AGC family protein kinase | 0.0051 | 0.0574 | 0.0071 |
Onchocerca volvulus | 0.0119 | 0.5186 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0343 | 0.0343 |
Trypanosoma cruzi | cyclin, putative | 0.0119 | 0.5186 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0051 | 0.0574 | 0.0071 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.009 | 0.3199 | 0.3199 |
Echinococcus multilocularis | cyclin b3 | 0.0062 | 0.1305 | 0.1305 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.009 | 0.3199 | 0.3199 |
Schistosoma mansoni | cyclin B3 | 0.019 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.009 | 0.3199 | 0.3199 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.