Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.4326 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.4326 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 1 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.4326 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0446 | 0.9524 | 0.9524 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.4326 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.4326 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0467 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0467 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0467 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.4326 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0467 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.4326 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.4326 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.4326 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0467 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 230.41 % | Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Activity (functional) | = 230.41 % | Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM | ChEMBL. | 17948976 |
IC50 (binding) | = 0.87 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells | ChEMBL. | 17477517 |
IC50 (binding) | = 0.87 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells | ChEMBL. | 17477517 |
Inhibition (functional) | = 0 % | Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Inhibition (functional) | = 0 % | Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Ki (binding) | 0 | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA | ChEMBL. | 17477517 |
Ki (binding) | 0 | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADH | ChEMBL. | 17477517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.