Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin B3 1 | 0.0064 | 0.0737 | 0.0832 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4202 | 0.4184 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0737 | 0.0832 |
Entamoeba histolytica | cyclin family protein | 0.0064 | 0.0737 | 0.169 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0737 | 0.0832 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0064 | 0.0737 | 0.0707 |
Echinococcus multilocularis | cyclin b3 | 0.0064 | 0.0737 | 0.0832 |
Entamoeba histolytica | cyclin, putative | 0.0064 | 0.0737 | 0.169 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4202 | 0.4184 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0198 | 0.8501 | 1 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0737 | 0.0832 |
Schistosoma mansoni | cyclins | 0.0064 | 0.0737 | 0.0832 |
Trypanosoma cruzi | cyclin, putative | 0.0124 | 0.4202 | 1 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0737 | 0.0832 |
Entamoeba histolytica | cyclin, putative | 0.0124 | 0.4202 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0064 | 0.0737 | 0.0707 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4202 | 0.4184 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4202 | 0.4184 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0198 | 0.8501 | 1 |
Echinococcus granulosus | cyclin B | 0.0124 | 0.4202 | 0.4924 |
Trichomonas vaginalis | cyclin D, putative | 0.0064 | 0.0737 | 0.0707 |
Echinococcus granulosus | cyclin b3 | 0.0064 | 0.0737 | 0.0832 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0124 | 0.4202 | 0.4924 |
Trichomonas vaginalis | cyclins, putative | 0.0075 | 0.1383 | 0.1355 |
Entamoeba histolytica | cyclin family protein | 0.0064 | 0.0737 | 0.169 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0737 | 0.0832 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0124 | 0.4202 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4202 | 0.4184 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0737 | 0.0832 |
Schistosoma mansoni | cyclin B | 0.0124 | 0.4202 | 0.4924 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0487 | 0.0572 |
Onchocerca volvulus | 0.0124 | 0.4202 | 0.5 | |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0737 | 0.0832 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.0032 | 0.0038 |
Echinococcus multilocularis | cyclin B3 1 | 0.0064 | 0.0737 | 0.0832 |
Trichomonas vaginalis | cyclin B, putative | 0.0124 | 0.4202 | 0.4184 |
Trichomonas vaginalis | cyclin D, putative | 0.0064 | 0.0737 | 0.0707 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0737 | 0.0832 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0198 | 0.8501 | 1 |
Leishmania major | cyclin | 0.0124 | 0.4202 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0124 | 0.4202 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0198 | 0.8501 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0737 | 0.0832 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0032 | 0.0038 |
Trichomonas vaginalis | cyclin A, putative | 0.0124 | 0.4202 | 0.4184 |
Trypanosoma cruzi | cyclin 6, putative | 0.0124 | 0.4202 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0032 | 0.0038 |
Echinococcus granulosus | cyclins | 0.0064 | 0.0737 | 0.0832 |
Giardia lamblia | Cyclin A | 0.0064 | 0.0737 | 0.169 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0737 | 0.0832 |
Schistosoma mansoni | cyclin B3 | 0.0198 | 0.8501 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0124 | 0.4202 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0124 | 0.4202 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0124 | 0.4202 | 0.4924 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4202 | 0.4184 |
Echinococcus multilocularis | cyclins | 0.0064 | 0.0737 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.4202 | 0.4943 |
Trichomonas vaginalis | cyclins, putative | 0.0124 | 0.4202 | 0.4184 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.0737 | 0.0707 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0124 | 0.4202 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.0064 | 0.0737 | 0.0707 |
Giardia lamblia | Hypothetical protein | 0.0064 | 0.0737 | 0.169 |
Plasmodium falciparum | cyclin | 0.0064 | 0.0737 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.4202 | 0.4943 |
Echinococcus multilocularis | cyclin B | 0.0124 | 0.4202 | 0.4924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 285.8 % | Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Activity (functional) | = 285.8 % | Inhibition of transthyretin amyloidosis assessed as fibril formation pH 4.4 at 100 uM | ChEMBL. | 17948976 |
IC50 (binding) | = 6 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells | ChEMBL. | 17477517 |
IC50 (binding) | = 6 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells | ChEMBL. | 17477517 |
Inhibition (functional) | = 0 % | Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Inhibition (functional) | = 0 % | Inhibition of transthyretin fibril formation at pH 4.4 at 100 uM | ChEMBL. | 17948976 |
Ki (binding) | = 2 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA | ChEMBL. | 17477517 |
Ki (binding) | = 2 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA | ChEMBL. | 17477517 |
Ki (binding) | = 2.5 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADH | ChEMBL. | 17477517 |
Ki (binding) | = 2.5 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADH | ChEMBL. | 17477517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.