Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin B | 0.0101 | 0.3256 | 0.4924 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0162 | 0.6587 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0101 | 0.3256 | 0.3239 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0571 | 0.0832 |
Giardia lamblia | Cyclin A | 0.0052 | 0.0571 | 0.169 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0571 | 0.0832 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.3256 | 0.4924 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0571 | 0.0832 |
Trichomonas vaginalis | cyclin A, putative | 0.0101 | 0.3256 | 0.3239 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 1 | 0.5 |
Echinococcus granulosus | cyclin B3 1 | 0.0052 | 0.0571 | 0.0832 |
Echinococcus multilocularis | cyclin B | 0.0101 | 0.3256 | 0.4924 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0042 | 0.0025 | 0.0038 |
Entamoeba histolytica | cyclin family protein | 0.0052 | 0.0571 | 0.169 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.3256 | 0.4924 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3256 | 0.4943 |
Entamoeba histolytica | cyclin family protein | 0.0052 | 0.0571 | 0.169 |
Trichomonas vaginalis | cyclins, putative | 0.0061 | 0.1072 | 0.105 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0101 | 0.3256 | 0.3239 |
Trichomonas vaginalis | cyclins, putative | 0.0101 | 0.3256 | 0.3239 |
Trichomonas vaginalis | cyclin D, putative | 0.0052 | 0.0571 | 0.0547 |
Trichomonas vaginalis | cyclins, putative | 0.0101 | 0.3256 | 0.3239 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0571 | 0.0832 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0571 | 0.0832 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0162 | 0.6587 | 1 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0571 | 0.0832 |
Entamoeba histolytica | cyclin, putative | 0.0101 | 0.3256 | 1 |
Leishmania major | cyclin | 0.0101 | 0.3256 | 1 |
Schistosoma mansoni | cyclin B | 0.0101 | 0.3256 | 0.4924 |
Onchocerca volvulus | 0.0101 | 0.3256 | 0.5 | |
Trypanosoma cruzi | cyclin, putative | 0.0101 | 0.3256 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0101 | 0.3256 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0162 | 0.6587 | 1 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.0571 | 0.169 |
Trichomonas vaginalis | cyclins, putative | 0.0052 | 0.0571 | 0.0547 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0571 | 0.0832 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0571 | 0.0547 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0571 | 0.0832 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0162 | 0.6587 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.0052 | 0.0571 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0377 | 0.0572 |
Plasmodium falciparum | cyclin | 0.0052 | 0.0571 | 0.0547 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0571 | 0.0832 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0101 | 0.3256 | 1 |
Echinococcus granulosus | cyclin b3 | 0.0052 | 0.0571 | 0.0832 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0101 | 0.3256 | 0.3239 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 1 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0101 | 0.3256 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0042 | 0.0025 | 0.0038 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0042 | 0.0025 | 0.0038 |
Trypanosoma cruzi | cyclin, putative | 0.0101 | 0.3256 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0101 | 0.3256 | 0.3239 |
Trichomonas vaginalis | cyclin D, putative | 0.0052 | 0.0571 | 0.0547 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0101 | 0.3256 | 1 |
Schistosoma mansoni | cyclins | 0.0052 | 0.0571 | 0.0832 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0101 | 0.3256 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0101 | 0.3256 | 0.3239 |
Echinococcus multilocularis | cyclin b3 | 0.0052 | 0.0571 | 0.0832 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0571 | 0.0832 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0101 | 0.3256 | 0.3239 |
Trichomonas vaginalis | cyclin B, putative | 0.0052 | 0.0571 | 0.0547 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0162 | 0.6587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3256 | 0.4943 |
Entamoeba histolytica | cyclin, putative | 0.0052 | 0.0571 | 0.169 |
Echinococcus granulosus | cyclins | 0.0052 | 0.0571 | 0.0832 |
Echinococcus multilocularis | cyclins | 0.0052 | 0.0571 | 0.0832 |
Trichomonas vaginalis | cyclin B3, putative | 0.0052 | 0.0571 | 0.0547 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.1 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells | ChEMBL. | 17477517 |
IC50 (binding) | = 6.1 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells | ChEMBL. | 17477517 |
Ki (binding) | = 4.1 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA | ChEMBL. | 17477517 |
Ki (binding) | = 4.1 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA | ChEMBL. | 17477517 |
Ki (binding) | = 5.5 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADH | ChEMBL. | 17477517 |
Ki (binding) | = 5.5 uM | Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to NADH | ChEMBL. | 17477517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.