TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 202.204 | Formula: C9H14O5
H donors: 3 H acceptors: 5 LogP: 0.71 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C=CCCC[C@@H]([C@H](C(=O)O)O)C(=O)O
InChi: 1S/C9H14O5/c1-2-3-4-5-6(8(11)12)7(10)9(13)14/h2,6-7,10H,1,3-5H2,(H,11,12)(H,13,14)/t6-,7+/m0/s1
InChiKey: HAAMULIEFZJXEA-NKWVEPMBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0023	0.0435	0.0641
Entamoeba histolytica	hypothetical protein	0.0028	0.0664	1
Brugia malayi	hypothetical protein	0.0025	0.0541	0.0702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0023	0.0435	0.0544
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0048	0.1429	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.1424	0.2017
Leishmania major	cathepsin L-like protease	0.005	0.1524	1
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0435	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0048	0.1424	0.2017
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0012	0.0029	0.0029
Schistosoma mansoni	aldehyde dehydrogenase	0.0048	0.1429	0.2684
Brugia malayi	ecdysone receptor	0.0023	0.0435	0.0544
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0048	0.1424	0.2674
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0048	0.1424	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0048	0.1424	0.2674
Schistosoma mansoni	aryl hydrocarbon receptor	0.0038	0.1056	0.1981
Echinococcus granulosus	roundabout 2	0.0015	0.012	0.012
Onchocerca volvulus		0.0039	0.1081	0.2061
Echinococcus multilocularis	nuclear receptor nhr 48	0.0023	0.0435	0.0435
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0048	0.1424	0.2017
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Brugia malayi	nuclear receptor NHR-67	0.0023	0.0435	0.0544
Brugia malayi	Nuclear hormone receptor-like 1	0.0048	0.1424	0.2017
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Schistosoma mansoni	nuclear hormone receptor	0.0048	0.1424	0.2674
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Echinococcus granulosus	twitchin	0.0012	0.0003	0.0003
Schistosoma mansoni	nuclear receptor nhr-48	0.0023	0.0435	0.0813
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0149	0.5363	0.788
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0066	0.2148	0.2148
Schistosoma mansoni	transcription factor LCR-F1	0.0028	0.0664	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0129	0.4598	0.6775
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.0717	0.4453
Schistosoma mansoni	cathepsin F (C01 family)	0.0013	0.0069	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0015	0.012	0.0177
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.1424	0.1424
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.1424	0.2017
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0048	0.1424	0.2674
Echinococcus multilocularis	cathepsin L cysteine protease	0.0013	0.0069	0.0069
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.01	0.3444	0.3444
Brugia malayi	hypothetical protein	0.0028	0.0664	0.0885
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0088	0.0038
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0048	0.1429	1
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0435	0.0813
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.1424	0.1424
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Onchocerca volvulus		0.0048	0.1424	0.276
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0023	0.0435	0.0435
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0023	0.0435	0.0544
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0058	0.1829	0.1829
Giardia lamblia	Hypothetical protein	0.005	0.1503	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0435	0.0435
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0023	0.0435	0.0641
Echinococcus multilocularis	transfer RNA-Lys	0.0028	0.0665	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0069	0.0102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Loa Loa (eye worm)	cysteine protease	0.0013	0.0069	0.0102
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0013	0.0069	0.0069
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0048	0.1424	0.1424
Onchocerca volvulus	Protein ultraspiracle homolog	0.0048	0.1424	0.276
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0113	0.0208
Brugia malayi	PAS domain containing protein	0.0038	0.1056	0.1469
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0435	0.0435
Brugia malayi	nuclear receptor NHR-88	0.0048	0.1424	0.2017
Brugia malayi	Steroid receptor seven-up type 2	0.0048	0.1424	0.2017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0435	0.0435
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0048	0.1424	0.2017
Schistosoma mansoni	retinoic acid receptor RXR	0.0048	0.1424	0.2674
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0048	0.1424	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0541	0.0797
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0048	0.1429	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0048	0.1424	0.2098
Loa Loa (eye worm)	fibroinase	0.0013	0.0069	0.0102
Onchocerca volvulus		0.0136	0.4886	0.9813
Leishmania major	cathepsin L-like protease	0.005	0.1524	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0013	0.0069	0.0102
Echinococcus multilocularis	roundabout 2	0.0015	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0048	0.1429	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Schistosoma mansoni	RAR-like nuclear receptor	0.0048	0.1424	0.2674
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0023	0.0435	0.0544
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0541	0.0702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0435	0.0435
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0048	0.1424	0.2098
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.5317	1
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Brugia malayi	tailless protein	0.0023	0.0435	0.0544
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0013	0.0069	0.0102
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0435	0.0544
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0058	0.1829	0.1829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0029	0.0048
Loa Loa (eye worm)	hypothetical protein	0.005	0.1503	0.2215
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0048	0.1424	0.2674
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0119	0.4207	0.6199
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1081	0.1593
Echinococcus multilocularis	jun protein	0.0066	0.2148	0.2148
Echinococcus multilocularis	cysteine protease	0.0013	0.0069	0.0069
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0048	0.1429	0.9347
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.1424	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Echinococcus granulosus	FTZ F1 alpha	0.0048	0.1424	0.1424
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0048	0.1429	0.1429
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0435	0.0813
Brugia malayi	follicle stimulating hormone receptor	0.0185	0.6787	1
Echinococcus multilocularis	neuroglian	0.0012	0.0003	0.0003
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0048	0.1429	0.1429
Brugia malayi	nuclear receptor RXR	0.0023	0.0435	0.0544
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.01	0.3444	0.3444
Loa Loa (eye worm)	hypothetical protein	0.005	0.1503	0.2215
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0048	0.1424	0.2674
Onchocerca volvulus		0.0023	0.0435	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0435	0.0544
Echinococcus granulosus	nuclear receptor nhr 48	0.0023	0.0435	0.0435
Schistosoma mansoni	cathepsin F (C01 family)	0.0013	0.0069	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Echinococcus granulosus	jun protein	0.0066	0.2148	0.2148
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0048	0.1424	0.2017
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0048	0.1424	0.276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0046	0.1353	0.8824
Brugia malayi	bZIP transcription factor family protein	0.0066	0.2148	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0015	0.012	0.0177
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0435	0.0435
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0013	0.0069	0.5
Echinococcus multilocularis	tumor protein p63	0.0267	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0048	0.1424	0.2017
Loa Loa (eye worm)	nuclear hormone receptor	0.0023	0.0435	0.0641
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.0717	0.4451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0113	0.0113
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.1424	0.2017
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0023	0.0435	0.0745
Trypanosoma cruzi	major cysteine proteinase, putative	0.004	0.1102	0.7098
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.1524	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0541	0.1012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.1424	0.2017
Brugia malayi	hypothetical protein	0.0025	0.0541	0.0702
Schistosoma mansoni	jun-related protein	0.0054	0.1662	0.3122
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0025	0.0541	0.1012
Plasmodium vivax	vivapain-2	0.0013	0.0069	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0023	0.0435	0.0435
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0013	0.0069	0.5
Loa Loa (eye worm)	ctsf protein	0.0013	0.0069	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Schistosoma mansoni	coup transcription factor	0.0048	0.1424	0.2674
Schistosoma mansoni	cellular tumor antigen P53	0.0039	0.1081	0.2028
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0541	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0029	0.0042
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0048	0.1424	0.2017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Echinococcus granulosus	neuroglian	0.0012	0.0003	0.0003
Onchocerca volvulus		0.0052	0.1591	0.3099
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.1424	0.2017
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0048	0.1424	0.1424
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0048	0.1424	0.2017
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0013	0.0069	0.0069
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0048	0.1424	0.2098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0048	0.1424	0.2098
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.1424	0.1424
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0048	0.1424	0.1424
Brugia malayi	Fibroblast growth factor family protein	0.005	0.1503	0.2134
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0023	0.0435	0.0813
Brugia malayi	photoreceptor-specific nuclear receptor	0.0048	0.1424	0.2017
Brugia malayi	nuclear hormone receptor	0.0023	0.0435	0.0544
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0048	0.1424	0.2674
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0025	0.0541	0.0541
Onchocerca volvulus		0.0028	0.0665	0.1213
Brugia malayi	nuclear receptor RXR	0.0025	0.0541	0.0702
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0185	0.6787	1
Onchocerca volvulus	Bile acid receptor homolog	0.0048	0.1424	0.276
Echinococcus granulosus	ecdysone induced protein 78C	0.0048	0.1424	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0541	0.0797
Echinococcus multilocularis	cysteine protease	0.0013	0.0069	0.0069
Schistosoma mansoni	hypothetical protein	0.0028	0.0664	0.1244
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0541	0.0702
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0023	0.0435	0.0435
Schistosoma mansoni	zinc finger protein	0.0023	0.0435	0.0813
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0048	0.1424	0.2098
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.5317	1
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.0717	0.4451
Onchocerca volvulus		0.0023	0.0435	0.0745
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.1524	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0023	0.0435	0.0745
Brugia malayi	hypoxia-induced factor 1	0.0119	0.4207	0.616
Loa Loa (eye worm)	DR-78	0.0023	0.0435	0.0641
Entamoeba histolytica	hypothetical protein	0.0028	0.0664	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0023	0.0435	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Brugia malayi	hypothetical protein	0.0052	0.1591	0.2265
Brugia malayi	hypothetical protein	0.0129	0.4598	0.6742
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2077	0.3061
Schistosoma mansoni	nuclear receptor	0.0023	0.0435	0.0813
Entamoeba histolytica	hypothetical protein	0.0028	0.0664	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0664	1
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.0717	0.4451
Echinococcus multilocularis	cathepsin L cysteine protease	0.0013	0.0069	0.0069
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0013	0.0069	0.0069
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0048	0.1429	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Brugia malayi	nuclear hormone receptor	0.0048	0.1424	0.2017
Loa Loa (eye worm)	steroid hormone receptor	0.0048	0.1424	0.2098
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0541	0.0797
Echinococcus granulosus	cathepsin l1	0.0013	0.0069	0.0069
Brugia malayi	bHLH-PAS transcription factor	0.0028	0.0665	0.0887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0048	0.1424	0.2098
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0025	0.0541	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Brugia malayi	steroid hormone receptor	0.0048	0.1424	0.2017
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0048	0.1424	0.1424
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0048	0.1424	0.1424
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.1524	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0023	0.0435	0.0813
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.0717	0.4451
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0113	0.0066
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Brugia malayi	hypothetical protein	0.0023	0.0435	0.0544
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0149	0.5363	0.7902
Brugia malayi	conserved hypotetical protein	0.0023	0.0435	0.0544
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.1424	0.1424
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0048	0.1424	0.1424
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.005	0.1524	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0048	0.1424	0.2674
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0013	0.0069	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Plasmodium vivax	vivapain-2	0.0013	0.0069	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Leishmania major	cathepsin L-like protease	0.005	0.1524	1
Echinococcus multilocularis	FTZ F1 alpha	0.0048	0.1424	0.1424
Brugia malayi	Fibroblast growth factor family protein	0.005	0.1503	0.2134
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Brugia malayi	ecdysteroid receptor	0.0048	0.1424	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Schistosoma mansoni	nuclear receptor	0.0023	0.0435	0.0813
Schistosoma mansoni	hypothetical protein	0.0054	0.1662	0.3122
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0013	0.0069	0.5
Echinococcus granulosus	single minded 2	0.0028	0.0665	0.0665
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0025	0.0541	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Onchocerca volvulus	Tyrosine kinase homolog	0.0139	0.4978	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0048	0.1429	0.2684
Brugia malayi	hypothetical protein	0.0023	0.0435	0.0544
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.003	0.0717	0.4453
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0048	0.1424	0.2098
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1524	1
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.0717	0.4453
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0028	0.0664	0.0664
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0013	0.0069	0.0069
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0435	0.0435
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0066	0.2148	0.2148
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0147	0.5317	0.5317
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0069	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0048	0.1424	0.1424
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0048	0.1424	0.1424
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0013	0.0069	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0435	0.0641
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0028	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1424	0.2098
Schistosoma mansoni	hypothetical protein	0.01	0.3444	0.6476
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0541	0.0797
Schistosoma mansoni	single-minded	0.0038	0.1056	0.1981
Trypanosoma cruzi	trans-sialidase, putative	0.003	0.0717	0.4453
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0023	0.0435	0.0544

Activities

Activity type	Activity value	Assay description	Source	Reference
Kcat (binding)	= 0.14 /s	Activity of recombinant Saccharomyces cerevisiae homoisocitrate dehydrogenase expressed in Escherichia coli Rosetta cells	ChEMBL.	17116397
Kcat (binding)	= 0.14 /s	Activity of recombinant Saccharomyces cerevisiae homoisocitrate dehydrogenase expressed in Escherichia coli Rosetta cells	ChEMBL.	17116397
Kcat (binding)	= 3 /s	Activity of Deinococcus radiodurans homoisocitrate dehydrogenase	ChEMBL.	17116397
Kcat/Km (binding)	= 0.000015 /s/microM	Ratio of kcat/km of recombinant Saccharomyces cerevisiae homoisocitrate dehydrogenase expressed in Escherichia coli Rosetta cells above 10 mM	ChEMBL.	17116397
Kcat/Km (binding)	= 0.000015 /s/microM	Ratio of kcat/km of recombinant Saccharomyces cerevisiae homoisocitrate dehydrogenase expressed in Escherichia coli Rosetta cells above 10 mM	ChEMBL.	17116397
Kcat/Km (binding)	= 0.0011 /s/microM	Ratio of kcat/km of Deinococcus radiodurans homoisocitrate dehydrogenase	ChEMBL.	17116397
Km (binding)	= 2700 uM	Activity of Deinococcus radiodurans homoisocitrate dehydrogenase	ChEMBL.	17116397
Km (binding)	= 9400 uM	Activity of recombinant Saccharomyces cerevisiae homoisocitrate dehydrogenase expressed in Escherichia coli Rosetta cells	ChEMBL.	17116397
Km (binding)	= 9400 uM	Activity of recombinant Saccharomyces cerevisiae homoisocitrate dehydrogenase expressed in Escherichia coli Rosetta cells	ChEMBL.	17116397

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL376566

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 423655