Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.0482 | 0.5047 |
Entamoeba histolytica | Flap nuclease, putative | 0.0027 | 0.0482 | 0.0562 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 0.0482 | 0.0503 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0028 | 0.0531 | 0.0819 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0023 | 0.0336 | 0.0422 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0525 | 0.1739 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0023 | 0.0336 | 0.0695 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.4491 | 0.4373 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0035 | 0.0748 | 0.055 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0142 | 0.4491 | 0.4373 |
Brugia malayi | Isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.1456 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.1182 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.021 | 0.0165 |
Schistosoma mansoni | cpg binding protein | 0.0092 | 0.2742 | 0.4331 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.021 | 0.0385 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.2019 | 0.385 |
Echinococcus multilocularis | cpg binding protein | 0.0097 | 0.2924 | 0.5692 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0014 | 0.0017 | 0.0026 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0023 | 0.0336 | 0.0422 |
Onchocerca volvulus | 0.0031 | 0.063 | 0.2251 | |
Brugia malayi | CHD4 protein | 0.0017 | 0.0129 | 0.0224 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0482 | 0.0277 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 0.0482 | 0.0718 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.1012 | 0.0819 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.1333 | 0.1147 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.2019 | 0.385 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0021 | 0.0283 | 0.0402 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.505 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0023 | 0.0336 | 0.0422 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.093 | 0.3981 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.1036 | 0.374 |
Onchocerca volvulus | 0.0092 | 0.2742 | 1 | |
Schistosoma mansoni | cpg binding protein | 0.0097 | 0.2924 | 0.4619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.2974 | 0.5793 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.1036 | 0.4564 |
Brugia malayi | CXXC zinc finger family protein | 0.0092 | 0.2742 | 0.5426 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.093 | 0.3353 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.2974 | 0.5793 |
Loa Loa (eye worm) | histone methyltransferase | 0.0028 | 0.0531 | 0.1414 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.093 | 0.2817 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0017 | 0.0129 | 0.0204 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.021 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.021 | 0.0284 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.063 | 0.1761 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0035 | 0.0748 | 0.055 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0099 | 0.2974 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0035 | 0.0748 | 0.126 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.021 | 0.0165 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.0482 | 0.1239 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.0482 | 0.0926 |
Brugia malayi | Heterochromatin protein 1 | 0.0071 | 0.2019 | 0.3988 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.2019 | 0.319 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0035 | 0.0748 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0482 | 0.0277 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.2019 | 0.385 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0035 | 0.0748 | 0.055 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 0.0482 | 0.1501 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 0.0482 | 0.5047 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.03 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.126 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.2974 | 0.4697 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.021 | 0.0332 |
Schistosoma mansoni | cpg binding protein | 0.0097 | 0.2924 | 0.4619 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0482 | 0.0277 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.2974 | 0.5793 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0035 | 0.0748 | 0.055 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0023 | 0.0336 | 0.0422 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Trichomonas vaginalis | helicase, putative | 0.0021 | 0.0266 | 0.031 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.2019 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.2974 | 0.4697 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0028 | 0.0519 | 0.1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.0997 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0035 | 0.0748 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.126 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 0.0482 | 0.0718 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.126 |
Brugia malayi | hypothetical protein | 0.0158 | 0.504 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0024 | 0.0391 | 0.0618 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.126 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0028 | 0.0531 | 0.0819 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.021 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0099 | 0.2974 | 0.5887 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 0.0482 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0158 | 0.504 | 0.7961 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0195 | 0.6331 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.504 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0158 | 0.504 | 0.7961 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0071 | 0.2019 | 0.6646 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0525 | 0.1739 |
Brugia malayi | isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.1456 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.021 | 0.0332 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0158 | 0.505 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.1036 | 0.4564 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.2176 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.4491 | 0.4373 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0023 | 0.0336 | 0.0531 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.093 | 0.1819 |
Echinococcus granulosus | cpg binding protein | 0.0097 | 0.2924 | 0.5692 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.126 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0035 | 0.0748 | 0.0997 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.1228 | 0.1887 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0035 | 0.0748 | 0.1112 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.2974 | 0.4697 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.2019 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.504 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0035 | 0.0748 | 0.055 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.504 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0023 | 0.0336 | 0.0695 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0158 | 0.504 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.2974 | 0.5793 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0158 | 0.504 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0092 | 0.2742 | 0.9186 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.093 | 0.3981 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0032 | 0.0672 | 0.2552 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0174 | 0.5605 | 1 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.2019 | 0.319 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0266 | 0.031 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.1012 | 0.0819 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.1012 | 0.0819 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.2019 | 0.385 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.1012 | 0.0819 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.9 uM | Inhibition of Sprague-Dawley rat brain microsome HO2 | ChEMBL. | 17339115 |
IC50 (binding) | = 2.7 uM | Inhibition of Sprague-Dawley rat spleen microsome HO1 | ChEMBL. | 17339115 |
Inhibition (binding) | = 10 % | Inhibition of Sprague-Dawley rat brain microsome HO2 at 0.1 uM relative to control | ChEMBL. | 17339115 |
Inhibition (binding) | = 60 % | Inhibition of Sprague-Dawley rat brain microsome HO2 at 100 uM relative to control | ChEMBL. | 17339115 |
Inhibition (binding) | = 80 % | Inhibition of Sprague-Dawley rat spleen microsome HO1 at 100 uM relative to control | ChEMBL. | 17339115 |
Ratio IC50 (binding) | = 1.4 | Selectivity index, ratio of IC50 for Sprague-Dawley rat brain HO2 to IC50 for Sprague-Dawley rat spleen HO1 | ChEMBL. | 17339115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.