Detailed information for compound 424951

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.419 | Formula: C20H26O3
  • H donors: 0 H acceptors: 3 LogP: 2.84 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C2[C@@H]3[C@@]2(C(=O)[C@]21CC[C@@H]1[C@]([C@H]2C3)(C)CCC(=O)C1(C)C)C
  • InChi: 1S/C20H26O3/c1-17(2)11-5-8-20-12(18(11,3)7-6-13(17)21)9-10-14(15(20)22)19(10,4)16(20)23/h10-12,14H,5-9H2,1-4H3/t10-,11+,12-,14?,18+,19+,20-/m1/s1
  • InChiKey: ZYMHAOMKSGLSHJ-XDNFRISMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major fk506-binding protein 1-like protein 0.1383 0.9825 1
Plasmodium vivax aspartyl protease, putative 0.0119 0.0701 0.0713
Echinococcus granulosus FK506 binding protein 2 0.019 0.1213 0.1213
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.1217 0.8626 0.8626
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0018 0.0018
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.019 0.1213 0.1223
Echinococcus multilocularis Tetratricopeptide repeat protein 1 0.0024 0.0013 0.0013
Plasmodium vivax aspartyl proteinase, putative 0.0505 0.3485 0.3547
Loa Loa (eye worm) hypothetical protein 0.0042 0.0141 0.0143
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0052 0.0052
Trichomonas vaginalis chaperone binding protein, putative 0.0024 0.0013 0.0014
Trypanosoma brucei small glutamine-rich tetratricopeptide repeat protein, putative 0.0024 0.0013 0.0014
Loa Loa (eye worm) TPR Domain containing protein 0.0024 0.0013 0.0013
Schistosoma mansoni heat shock protein 70 0.0024 0.0013 0.0013
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.1383 0.9825 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.019 0.1213 0.3481
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.019 0.1213 0.1223
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0052 0.0052
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.1407 1 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0505 0.3485 0.3547
Echinococcus granulosus Tetratricopeptide repeat protein 1 0.0024 0.0013 0.0013
Plasmodium vivax Hsp70/Hsp90 organizing protein, putative 0.0024 0.0013 0.0014
Trypanosoma brucei TPR-repeat-containing chaperone protein DNAJ, putative 0.0028 0.0043 0.0043
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.019 0.1213 0.1213
Loa Loa (eye worm) hypothetical protein 0.0505 0.3485 0.3547
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1213 0.1234
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0013 0.0014
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.019 0.1213 0.5
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0051 0.0207 0.0207
Schistosoma mansoni cathepsin D (A01 family) 0.0786 0.5512 0.5512
Echinococcus granulosus glutamate receptor 4 0.0042 0.0141 0.0141
Toxoplasma gondii tetratricopeptide repeat domain containing protein 0.0024 0.0013 0.0038
Trichomonas vaginalis immunophilin, putative 0.1383 0.9825 1
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Leishmania major stress-inducible protein STI1 homolog 0.0028 0.0043 0.0043
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.019 0.1213 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1213
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0018 0.0018
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.019 0.1213 0.1234
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.1383 0.9825 1
Brugia malayi hypothetical protein 0.0024 0.0013 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.1383 0.9825 1
Plasmodium vivax plasmepsin V, putative 0.0119 0.0701 0.0713
Loa Loa (eye worm) aspartyl protease 6 0.0119 0.0701 0.0713
Echinococcus granulosus glutamate receptor 1 0.0042 0.0141 0.0141
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.019 0.1213 0.3481
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1213 0.1234
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Plasmodium vivax aspartyl protease, putative 0.0119 0.0701 0.0713
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Trypanosoma cruzi N-acetyltransferase subunit Nat1, putative 0.0024 0.0013 0.0013
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0505 0.3485 0.3547
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0505 0.3485 1
Plasmodium vivax aspartyl protease, putative 0.0119 0.0701 0.0713
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0013 0.0013
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.1383 0.9825 1
Onchocerca volvulus Tetratricopeptide repeat protein 5 homolog 0.0024 0.0013 0.0106
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.032 0.0326
Trichomonas vaginalis chaperone binding protein, putative 0.0024 0.0013 0.0013
Echinococcus granulosus glutamate receptor subunit protein glur 0.0051 0.0207 0.0207
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0505 0.3485 0.3485
Trypanosoma brucei hypothetical protein, conserved 0.019 0.1213 0.1234
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0052 0.0052
Trypanosoma cruzi small glutamine-rich tetratricopeptide repeat protein, putative 0.0024 0.0013 0.0014
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0024 0.0013 0.0014
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.032 0.0325
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0024 0.0013 0.0014
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.1387 0.9855 1
Trichomonas vaginalis chaperone binding protein, putative 0.0024 0.0013 0.0014
Leishmania major small glutamine-rich tetratricopeptide repeat protein, putative 0.0024 0.0013 0.0014
Entamoeba histolytica TPR repeat protein 0.0024 0.0013 0.0013
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.019 0.1213 0.1231
Echinococcus multilocularis small glutamine rich tetratricopeptide 0.0024 0.0013 0.0013
Toxoplasma gondii aspartyl protease ASP1 0.0505 0.3485 1
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0024 0.0013 0.0013
Echinococcus multilocularis stress induced phosphoprotein 1 0.0028 0.0043 0.0043
Onchocerca volvulus 0.0119 0.0701 0.5639
Plasmodium falciparum plasmepsin II 0.0505 0.3485 0.3547
Brugia malayi TPR Domain containing protein 0.0024 0.0013 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0505 0.3485 0.3485
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0071 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.1197 0.8481 0.8631
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0028 0.0043 0.0043
Echinococcus granulosus glutamate receptor 2 0.0062 0.0288 0.0288
Onchocerca volvulus 0.0119 0.0701 0.5639
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.1383 0.9825 1
Echinococcus multilocularis O glycosyltransferase 0.0024 0.0013 0.0013
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0018 0.0018
Trichomonas vaginalis fk506-binding protein, putative 0.019 0.1213 0.1234
Trichomonas vaginalis fk506 binding protein, putative 0.019 0.1213 0.1234
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0013 0.0013
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0018 0.0018
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0071 0.0354 0.0354
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.019 0.1213 0.1234
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.1383 0.9825 1
Onchocerca volvulus 0.019 0.1213 0.9763
Loa Loa (eye worm) hypothetical protein 0.0119 0.0701 0.0713
Echinococcus multilocularis fk506 binding protein 0.1383 0.9825 0.9825
Loa Loa (eye worm) TPR Domain containing protein 0.0024 0.0013 0.0013
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0215 0.1388 0.1388
Plasmodium falciparum plasmepsin I 0.0505 0.3485 0.3547
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0701 0.0701
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Leishmania major peptidylprolyl isomerase-like protein 0.1383 0.9825 1
Trichomonas vaginalis chaperone binding protein, putative 0.0024 0.0013 0.0013
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0119 0.0701 0.201
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.019 0.1213 0.1223
Schistosoma mansoni DNAj homolog subfamily C member 0.0028 0.0043 0.0043
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1383 0.9825 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1383 0.9825 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.019 0.1213 0.3481
Plasmodium falciparum plasmepsin X 0.0119 0.0701 0.0713
Brugia malayi Pepsin A precursor 0.0119 0.0701 0.0711
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Loa Loa (eye worm) TPR Domain containing protein 0.0024 0.0013 0.0014
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0024 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0141 0.0143
Plasmodium falciparum plasmepsin VII 0.0119 0.0701 0.0713
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.019 0.1213 0.1234
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.019 0.1213 0.3481
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0018 0.0018
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0052 0.0052
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.1383 0.9825 0.9825
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1383 0.9825 1
Giardia lamblia Hypothetical protein 0.019 0.1213 0.1223
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0024 0.0013 0.0014
Plasmodium falciparum Hsp70/Hsp90 organizing protein 0.0024 0.0013 0.0014
Leishmania major stress-induced protein sti1 0.0024 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0013 0.0014
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.1383 0.9825 1
Plasmodium falciparum plasmepsin VIII, putative 0.0119 0.0701 0.0713
Brugia malayi TPR Domain containing protein 0.0024 0.0013 0.0013
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0052 0.0052
Trichomonas vaginalis fk506-binding protein, putative 0.019 0.1213 0.1234
Plasmodium falciparum plasmepsin VI 0.0505 0.3485 0.3547
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.019 0.1213 0.5
Loa Loa (eye worm) hypothetical protein 0.0119 0.0701 0.0713
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.019 0.1213 0.1223
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.1217 0.8626 0.8626
Toxoplasma gondii aspartyl protease ASP3 0.0119 0.0701 0.201
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0024 0.0013 0.0013
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0505 0.3485 0.3485
Plasmodium vivax aspartyl proteinase, putative 0.0119 0.0701 0.0713
Trichomonas vaginalis fk506-binding protein, putative 0.1383 0.9825 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Echinococcus granulosus mitochondrial import receptor subunit tom34 0.0024 0.0013 0.0013
Onchocerca volvulus 0.0194 0.1242 1
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0013 0.0014
Brugia malayi TPR Domain containing protein 0.0024 0.0013 0.0013
Brugia malayi hypothetical protein 0.0119 0.0701 0.0711
Echinococcus granulosus O glycosyltransferase 0.0024 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.0028 0.0043 0.0044
Schistosoma mansoni immunophilin 0.1407 1 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0018 0.0018
Echinococcus granulosus STIP1 y and U box containing protein 1 0.0024 0.0013 0.0013
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0024 0.0013 0.0014
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0024 0.0013 0.0013
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0018 0.0018
Schistosoma mansoni immunophilin 0.1217 0.8626 0.8626
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0052 0.0052
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.019 0.1213 0.5
Echinococcus granulosus glutamate receptor 2 0.0071 0.0354 0.0354
Echinococcus granulosus stress induced phosphoprotein 1 0.0028 0.0043 0.0043
Schistosoma mansoni fk506 binding protein 0.019 0.1213 0.1213
Schistosoma mansoni cathepsin D (A01 family) 0.0786 0.5512 0.5512
Loa Loa (eye worm) TPR domain-containing protein 0.0024 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.019 0.1213 0.1234
Schistosoma mansoni protein phosphatase-5 0.0024 0.0013 0.0013
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0052 0.0052
Brugia malayi Eukaryotic aspartyl protease family protein 0.0119 0.0701 0.0711
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.1407 1 1
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.019 0.1213 0.1213
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.019 0.1213 0.1234
Onchocerca volvulus 0.0024 0.0013 0.0106
Plasmodium falciparum plasmepsin IX 0.0119 0.0701 0.0713
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0013 0.0013
Echinococcus multilocularis glutamate receptor 2 0.0071 0.0354 0.0354
Schistosoma mansoni immunophilin 0.1407 1 1
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0018 0.0018
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Brugia malayi hypothetical protein 0.0119 0.0701 0.0711
Trypanosoma brucei stress-induced protein sti1, putative 0.0024 0.0013 0.0014
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0119 0.0701 0.0713
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.1383 0.9825 0.997
Onchocerca volvulus 0.0024 0.0013 0.0106
Plasmodium falciparum plasmepsin III 0.0119 0.0701 0.0713
Echinococcus multilocularis mitochondrial import receptor subunit tom34 0.0024 0.0013 0.0013
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.019 0.1213 0.1234
Echinococcus granulosus small glutamine rich tetratricopeptide 0.0024 0.0013 0.0013
Echinococcus multilocularis glutamate receptor 2 0.0067 0.032 0.032
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0024 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0013 0.0013
Schistosoma mansoni memapsin-2 (A01 family) 0.0119 0.0701 0.0701
Echinococcus multilocularis 0.019 0.1213 0.1213
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0043
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.019 0.1213 0.1231
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Plasmodium falciparum plasmepsin IV 0.0505 0.3485 0.3547
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.1383 0.9825 1
Loa Loa (eye worm) FKBP5 protein 0.1383 0.9825 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.1383 0.9825 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.1383 0.9825 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0141 0.0143
Plasmodium vivax plasmepsin IV, putative 0.0505 0.3485 0.3547
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0024 0.0013 0.0014
Echinococcus multilocularis STIP1 y and U box containing protein 1 0.0024 0.0013 0.0013
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0024 0.0013 0.0013
Brugia malayi aspartic protease BmAsp-1, identical 0.0119 0.0701 0.0711
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.1383 0.9825 0.9825
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0024 0.0013 0.0013
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0024 0.0013 0.0013
Schistosoma mansoni heat shock protein 70 0.0024 0.0013 0.0013
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0024 0.0013 0.0013
Echinococcus multilocularis glutamate receptor 4 0.0042 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.019 0.1213 0.1213
Schistosoma mansoni DNAj homolog subfamily C member 0.0028 0.0043 0.0043
Leishmania major hypothetical protein, conserved 0.0024 0.0013 0.0013
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.019 0.1213 0.1231
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0018 0.0018
Onchocerca volvulus 0.0028 0.0043 0.0345
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0024 0.0013 0.0014
Toxoplasma gondii aspartyl protease 0.0119 0.0701 0.201
Onchocerca volvulus Kinesin light chain homolog 0.0024 0.0013 0.0106
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.1383 0.9825 1
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.032 0.0325
Entamoeba histolytica TPR repeat protein 0.0024 0.0013 0.0013
Trypanosoma cruzi N-acetyltransferase subunit Nat1, putative 0.0024 0.0013 0.0013
Plasmodium falciparum plasmepsin V 0.0119 0.0701 0.0713
Echinococcus multilocularis glutamate receptor 2 0.0062 0.0288 0.0288
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.019 0.1213 0.1234
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.1383 0.9825 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0018 0.0018
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.019 0.1213 0.1234
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.1407 1 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0119 0.0701 0.0711
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0024 0.0013 0.0038
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.019 0.1213 0.5
Entamoeba histolytica heat shock protein STI1, putative 0.0024 0.0013 0.0013

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 91.4 % Vasorelaxant activity against KCl-induced contraction in Wistar rat aorta at 10 ug/ml ChEMBL. 17547457
IC50 (ADMET) > 150 uM Cytotoxicity against human HeLa cells by MTT method ChEMBL. 17547457
IC50 (ADMET) > 150 uM Cytotoxicity against human HeLa cells by MTT method ChEMBL. 17547457

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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