Detailed information for compound 425398

Basic information

Technical information
  • TDR Targets ID: 425398
  • Name: 2-hydroxy-3-phenylbenzoic acid
  • MW: 214.217 | Formula: C13H10O3
  • H donors: 2 H acceptors: 3 LogP: 3.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cccc(c1O)c1ccccc1
  • InChi: 1S/C13H10O3/c14-12-10(9-5-2-1-3-6-9)7-4-8-11(12)13(15)16/h1-8,14H,(H,15,16)
  • InChiKey: ZJWUEJOPKFYFQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxy-3-phenyl-benzoic acid
  • 3-phenylsalicylic acid
  • 304-06-3
  • BRN 2693467
  • EINECS 206-148-4
  • NSC 109101
  • 3-Biphenylcarboxylic acid, 2-hydroxy-
  • NSC1886
  • Salicylic acid, 3-phenyl-
  • Usaf do-59
  • WLN: QVR BQ CR
  • [1,1'-Biphenyl]-3-carboxylic acid, 2-hydroxy-
  • m-Phenylsalicylic acid
  • InChI=1/C13H10O3/c14-12-10(9-5-2-1-3-6-9)7-4-8-11(12)13(15)16/h1-8,14H,(H,15,16
  • NSC109101
  • ST5443663
  • (1,1'-Biphenyl)-3-carboxylic acid, 2-hydroxy-
  • 3-10-00-01159 (Beilstein Handbook Reference)
  • 3-Biphenylcarboxylic acid, 2-hydroxy- (7CI,8CI)
  • AI3-17391

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.003 0.0007 0.0209
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.0232 1
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0079 0.0098 0.4048
Mycobacterium tuberculosis Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0125 0.0185 0.0166
Leishmania major trypanothione reductase 0.0047 0.0039 0.1696
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0039 0.002
Echinococcus granulosus cysteinyl tRNA synthetase 0.0079 0.0098 0.4229
Loa Loa (eye worm) hypothetical protein 0.015 0.0232 0.687
Giardia lamblia Cysteinyl-tRNA synthetase 0.0079 0.0098 1
Brugia malayi hypothetical protein 0.0051 0.0047 0.1377
Mycobacterium tuberculosis Probable reductase 0.0107 0.0152 0.0133
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0031 0.0009 0.0408
Echinococcus granulosus leucyl tRNA synthetase 0.0079 0.0098 0.4229
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.015 0.0232 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0094 0.2794
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0039 0.1696
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0209
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0107 0.0151 0.6399
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0044 0.0033 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0281
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0039 0.1696
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0039 0.1698
Toxoplasma gondii thioredoxin reductase 0.0047 0.0039 0.1696
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0174 0.0155
Echinococcus granulosus serotonin transporter 0.015 0.0232 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0174 0.0155
Plasmodium falciparum cysteine--tRNA ligase 0.0079 0.0098 0.4224
Onchocerca volvulus 0.0079 0.0098 0.2371
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0391 1
Plasmodium vivax cysteine--tRNA ligase, putative 0.0079 0.0098 0.4224
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0094 0.3881
Echinococcus granulosus dihydrofolate reductase 0.0044 0.0033 0.1421
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0055 0.162
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0738 0.1329 0.1313
Echinococcus multilocularis dihydrofolate reductase 0.0044 0.0033 0.1421
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase 0.017 0.027 0.1393
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0107 0.0151 0.0132
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0009 0.0408
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0055 0.162
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0009 0.0408
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0055 0.2359
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0064 0.0055
Plasmodium vivax glutathione reductase, putative 0.0047 0.0039 0.1696
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0047 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0064 0.2545
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0338 1
Brugia malayi Dihydrofolate reductase 0.0044 0.0033 0.0976
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0009 0.0408
Schistosoma mansoni sodium/chloride dependent transporter 0.015 0.0232 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0094 0.2794
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0031 0.0009 0.0243
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0079 0.0098 0.0089
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0064 0.0055
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0064 0.2769
Schistosoma mansoni dihydrofolate reductase 0.0044 0.0033 0.1151
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0152 0.0133
Brugia malayi Thioredoxin reductase 0.0047 0.0039 0.1167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0055 0.2119
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0079 0.0098 0.4224
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0152 0.0133
Mycobacterium ulcerans undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.017 0.027 0.026
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.015 0.0232 1
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0079 0.0098 0.4229
Loa Loa (eye worm) glutathione reductase 0.0047 0.0039 0.1167
Mycobacterium ulcerans glycosyltransferase 0.0036 0.0019 0.001
Onchocerca volvulus 0.015 0.0232 0.5858
Mycobacterium ulcerans thymidylate synthase 0.0107 0.0151 0.0142
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0044 0.0033 0.0014
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0152 0.0133
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0009 0.0408
Leishmania major dihydrofolate reductase-thymidylate synthase 0.015 0.0232 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0064 0.2769
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0094 0.3881
Brugia malayi glutathione reductase 0.0047 0.0039 0.1167
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.015 0.0232 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0094 0.3881
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0064 0.2772
Leishmania major cysteinyl-tRNA synthetase, putative 0.0079 0.0098 0.4224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0055 0.2119
Brugia malayi TAR-binding protein 0.0076 0.0094 0.2794
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.015 0.0232 1
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.0009 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0055 0.2119
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0064 0.2772
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.0009 0.0281
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5383 1 1
Chlamydia trachomatis cysteine--tRNA ligase 0.0079 0.0098 0.1474
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0094 0.2794
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0094 0.3881
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0079 0.0098 0.4224
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0079 0.0098 0.2905
Loa Loa (eye worm) dihydrofolate reductase 0.0044 0.0033 0.0976
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0174 0.0155
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0107 0.0151 0.0132
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0281 0.0475 1
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0079 0.0098 0.2509
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0738 0.1329 1
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0738 0.1329 0.1313
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0007 0.0305
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0031 0.0009 0.0409
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0152 0.0133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0055 0.2359
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0079 0.0098 1
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0009 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0094 0.3881
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0047 0.1189
Chlamydia trachomatis UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 0.017 0.027 0.535
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0039 0.1698
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0055 0.2359
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0007 0.0305
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0152 0.0133
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0064 0.0045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0174 0.0155
Mycobacterium leprae ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0125 0.0185 0.0166
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0005 0.0217
Plasmodium vivax SET domain protein, putative 0.003 0.0007 0.0304
Brugia malayi RNA binding protein 0.0076 0.0094 0.2794
Brugia malayi thymidylate synthase 0.0107 0.0151 0.4471
Treponema pallidum undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.017 0.027 0.4546
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0079 0.0098 0.2905
Echinococcus multilocularis serotonin transporter 0.015 0.0232 1
Treponema pallidum sodium- and chloride- dependent transporter 0.015 0.0232 0.3553
Onchocerca volvulus 0.0031 0.0009 0.0063
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0738 0.1329 0.1321
Loa Loa (eye worm) serotonin transporter b 0.015 0.0232 0.687
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0031 0.0009 0.0408
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0031 0.0009 0.0967
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0007 0.0305
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0094 0.4068
Trypanosoma brucei trypanothione reductase 0.0047 0.0039 0.1696
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0064 0.2545
Loa Loa (eye worm) solute carrier family 6 member 4 0.015 0.0232 0.687
Brugia malayi dihydrofolate reductase family protein 0.0044 0.0033 0.0976
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0039 0.1167
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.0009 0.0108
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0079 0.0098 0.4048
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0152 0.0133
Brugia malayi Pre-SET motif family protein 0.0207 0.0338 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0047 0.2002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.015 0.0232 0.687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0055 0.2359
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0007 0.0304
Loa Loa (eye worm) hypothetical protein 0.015 0.0232 0.687
Onchocerca volvulus 0.0236 0.0391 1
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.0281 0.0475 1
Onchocerca volvulus 0.0107 0.0151 0.3748
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0031 0.0009 0.0409
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0064 0.0055
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0044 0.0033 0.0024
Loa Loa (eye worm) thymidylate synthase 0.0107 0.0151 0.4471
Plasmodium falciparum glutathione reductase 0.0047 0.0039 0.1696
Loa Loa (eye worm) RNA binding protein 0.0076 0.0094 0.2794
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.5383 1 1
Plasmodium falciparum cysteine--tRNA ligase 0.0079 0.0098 0.4224
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0079 0.0098 0.4224
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.015 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0098 0.2905
Echinococcus multilocularis thymidylate synthase 0.0107 0.0151 0.6508
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.0009 0.0967
Loa Loa (eye worm) norepinephrine transporter 0.015 0.0232 0.687
Plasmodium falciparum thioredoxin reductase 0.0047 0.0039 0.1696
Loa Loa (eye worm) hypothetical protein 0.015 0.0232 0.687
Echinococcus granulosus thymidylate synthase 0.0107 0.0151 0.6508
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0079 0.0098 0.4224
Echinococcus granulosus tar DNA binding protein 0.0076 0.0094 0.4068

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 859 uM Inhibition of PTP1B ChEMBL. 17692525
IC50 (binding) = 859 uM Inhibition of PTP1B ChEMBL. 17692525
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.