Detailed information for compound 42575

Basic information

Technical information
  • TDR Targets ID: 42575
  • Name: 2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-5 -prop-2-enyl-2,3-dihydro-1-benzofuran-6-one
  • MW: 356.412 | Formula: C21H24O5
  • H donors: 0 H acceptors: 1 LogP: 3.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCC1=CC2(OC)C(=CC1=O)OC(C2C)c1ccc(c(c1)OC)OC
  • InChi: 1S/C21H24O5/c1-6-7-15-12-21(25-5)13(2)20(26-19(21)11-16(15)22)14-8-9-17(23-3)18(10-14)24-4/h6,8-13,20H,1,7H2,2-5H3
  • InChiKey: VDYACOATPFOZIO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-allyl-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-2,3-dihydrobenzofuran-6-one
  • kadsurenone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.009 0.0089
Entamoeba histolytica Skb1 methyltransferase, putative 0.0665 0.4089 1
Schistosoma mansoni hypothetical protein 0.0073 0.0333 0.0485
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0101 0.019
Loa Loa (eye worm) hypothetical protein 0.0943 0.5855 0.5855
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0335 0.0333
Echinococcus multilocularis thymidine kinase 0.0283 0.167 0.1668
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0335 0.0488
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.503 0.5029
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2379 0.2378
Schistosoma mansoni thymidine kinase 0.0283 0.167 0.2466
Schistosoma mansoni hypothetical protein 0.1085 0.6754 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0335 0.0335
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.095 0.0948
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0111 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0335 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0101 0.019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0335 0.0488
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0117 0.0107
Brugia malayi MH1 domain containing protein 0.0026 0.0035 0.0034
Schistosoma mansoni lamin 0.0057 0.0236 0.0342
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.1806 0.426
Brugia malayi hypothetical protein 0.0275 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.0275 0.1617 0.1616
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0593 0.1273
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0125 0.0262
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0335 0.0333
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0228 0.0546
Echinococcus multilocularis metabotropic glutamate receptor 5 0.003 0.0061 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.101 0.1008
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0125 0.0262
Brugia malayi nuclear receptor NHR-67 0.0034 0.009 0.009
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.018 0.0538
Echinococcus multilocularis muscleblind protein 1 0.1596 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.009 0.0126
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0335 0.0335
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.009 0.009
Brugia malayi hypothetical protein 0.0073 0.0333 0.0333
Brugia malayi CXXC zinc finger family protein 0.0059 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0034 0.0085 0.0118
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.009 0.0089
Schistosoma mansoni shk1 kinase-binding protein 0.0665 0.4089 0.6051
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0123
Schistosoma mansoni cpg binding protein 0.0062 0.0266 0.0386
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0728 0.1071
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Trypanosoma cruzi thymidine kinase, putative 0.0548 0.3346 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0335 0.0333
Echinococcus multilocularis RUN 0.0021 0.0005 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0728 0.1071
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0111 0.0221
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.056 0.0559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0125 0.0177
Echinococcus multilocularis transfer RNA-Ile 0.0283 0.167 0.1668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0135 0.0293
Giardia lamblia Thymidine kinase 0.0548 0.3346 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0111 0.0089
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.009 0.0126
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0728 0.1071
Schistosoma mansoni alpha-glucosidase 0.0146 0.08 0.1177
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0228 0.0683
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0277 0.0276
Loa Loa (eye worm) hypothetical protein 0.0045 0.016 0.0158
Leishmania major hypothetical protein, conserved 0.0056 0.0228 0.0448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.018 0.0429
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0335 0.0488
Loa Loa (eye worm) hypothetical protein 0.0056 0.0224 0.0223
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.027 0.0268
Brugia malayi carbohydrate phosphorylase 0.0108 0.056 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0238
Loa Loa (eye worm) Smad1 0.0026 0.0035 0.0033
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0277 0.0275
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.018 0.0299
Brugia malayi RNA binding protein 0.0135 0.0728 0.0728
Echinococcus granulosus muscleblind protein 0.1596 1 1
Entamoeba histolytica hypothetical protein 0.0073 0.0333 0.0557
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0184 0.0183
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0277 0.0275
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0005 0.0004
Onchocerca volvulus 0.0059 0.0245 0.0409
Echinococcus granulosus geminin 0.1085 0.6754 0.6754
Schistosoma mansoni alpha glucosidase 0.0038 0.0111 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0335 0.0333
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0335 0.0488
Onchocerca volvulus 0.0057 0.0236 0.0395
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2379 0.2378
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0542 0.0542
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.009 0.0089
Loa Loa (eye worm) beta-lactamase 0.004 0.0125 0.0123
Echinococcus multilocularis Glycosyl transferase, family 35 0.0108 0.056 0.0559
Brugia malayi hypothetical protein 0.0747 0.4611 0.4611
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.095 0.0948
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.009 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0335 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.101 0.1488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0238
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0111 0.0221
Onchocerca volvulus 0.0057 0.0236 0.0395
Trichomonas vaginalis ribonuclease H1, putative 0.0045 0.0155 0.0352
Echinococcus granulosus protein arginine N methyltransferase 5 0.0665 0.4089 0.4088
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0335 0.0563
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0018 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0335 0.0335
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.009 0.0089
Echinococcus multilocularis cpg binding protein 0.0062 0.0266 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0728 0.1071
Leishmania major arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640 0.0426 0.2573 0.7632
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.017 0.0147
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.1485 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0035 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0335 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0059
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0283 0.167 0.1668
Brugia malayi MH1 domain containing protein 0.0026 0.0035 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0335 0.0335
Schistosoma mansoni cpg binding protein 0.0062 0.0266 0.0386
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.1399 0.1397
Brugia malayi Pre-SET motif family protein 0.0429 0.2596 0.2596
Brugia malayi beta-lactamase 0.004 0.0125 0.0124
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.1806 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.101 0.1488
Schistosoma mansoni lipoxygenase 0.0059 0.0245 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0238
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0115
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0277 0.0595
Trypanosoma brucei ingi protein (ORF1) 0.0051 0.0198 0.0592
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.101 0.1008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0335 0.0333
Schistosoma mansoni lozenge 0.0118 0.0623 0.0915
Toxoplasma gondii ribonuclease HI protein 0.0045 0.0155 0.018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0184 0.0182
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.018 0.018
Brugia malayi nuclear receptor RXR 0.0039 0.0117 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0111 0.0089
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0005 0.0004
Echinococcus granulosus cpg binding protein 0.0062 0.0266 0.0264
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0083
Echinococcus multilocularis thymidine kinase 0.0283 0.167 0.1668
Brugia malayi beta-lactamase family protein 0.004 0.0125 0.0124
Brugia malayi MH2 domain containing protein 0.0026 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0057 0.0236 0.0235
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.018 0.0178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0115
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0335 0.0333
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0228 0.0546
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.101 0.1008
Brugia malayi Nuclear hormone receptor E75 0.0034 0.009 0.009
Brugia malayi follicle stimulating hormone receptor 0.0241 0.1399 0.1398
Echinococcus granulosus expressed conserved protein 0.0099 0.0501 0.05
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0335 0.0333
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0277 0.0595
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.018 0.0178
Loa Loa (eye worm) hypothetical protein 0.0055 0.0219 0.0217
Schistosoma mansoni phosphoglucomutase 0.0045 0.0155 0.0221
Loa Loa (eye worm) hypothetical protein 0.0237 0.1375 0.1373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.027 0.0392
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0117 0.035
Loa Loa (eye worm) hypothetical protein 0.0063 0.027 0.0268
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0245 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0001
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0067 0.0067
Echinococcus multilocularis Smad4 0.0026 0.0035 0.0033
Onchocerca volvulus Ribonuclease H1 homolog 0.0045 0.0155 0.0255
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0335 0.0333
Echinococcus granulosus microtubule associated protein 2 0.0667 0.4101 0.41
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.004
Brugia malayi hypothetical protein 0.0943 0.5855 0.5855
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0111 0.0221
Echinococcus granulosus ribonuclease H1 0.0045 0.0155 0.0153
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0552 0.0811
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0106 0.0105
Onchocerca volvulus 0.0489 0.2972 0.5071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0001
Onchocerca volvulus 0.004 0.0125 0.0204
Loa Loa (eye worm) hypothetical protein 0.0747 0.4611 0.461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0333 0.0331
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0817 1
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0117 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0333 0.0485
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0277 0.0402
Schistosoma mansoni hypothetical protein 0.0303 0.1794 0.265
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.0082 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.101 0.1488
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.017 0.0147
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Echinococcus multilocularis protein patched 0.0045 0.016 0.0158
Loa Loa (eye worm) DR-78 0.0034 0.009 0.0089
Schistosoma mansoni hypothetical protein 0.0056 0.0228 0.033
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0728 0.0726
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0542 0.054
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0335 0.0333
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.009 0.0145
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0277 0.0275
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0125 0.0373
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.1806 0.5174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0335 0.0335
Schistosoma mansoni hypothetical protein 0.0025 0.0032 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0335 0.0335
Trichomonas vaginalis thymidine kinase, putative 0.0548 0.3346 1
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0335 0.0488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.018 0.0429
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.009 0.0126
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.009 0.009
Brugia malayi TAR-binding protein 0.0135 0.0728 0.0728
Brugia malayi Smad1 0.0026 0.0035 0.0034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0125 0.0123
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.018 0.0172
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0051 0.0198 0.0592
Leishmania major thymidine kinase, putative 0.0548 0.3346 1
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.009 0.009
Schistosoma mansoni patched 1 0.0045 0.016 0.0229
Brugia malayi CHE-14 protein 0.0045 0.016 0.0159
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0125 0.0262
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0061 0.0061
Onchocerca volvulus 0.0034 0.009 0.0145
Schistosoma mansoni hypothetical protein 0.0044 0.0149 0.0213
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0067 0.0066
Brugia malayi hypothetical protein 0.0039 0.0117 0.0116
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.1596 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0179 0.101 0.1009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0335 0.0333
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.009 0.0089
Trypanosoma brucei arginine N-methyltransferase, type II 0.0426 0.2573 0.769
Leishmania major hypothetical protein, conserved 0.004 0.0125 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Loa Loa (eye worm) glutamate receptor 0.0024 0.0025 0.0023
Onchocerca volvulus 0.0747 0.4611 0.7872
Schistosoma mansoni hypothetical protein 0.0044 0.0149 0.0213
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0155 0.0221
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.1617 0.1616
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0035 0.0033
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0035 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0125 0.0262
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0082 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.016 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0072 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0238
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0117 0.0115
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Echinococcus multilocularis protein dispatched 1 0.0052 0.02 0.0198
Brugia malayi Augmenter of liver regeneration 0.0033 0.0082 0.0082
Toxoplasma gondii histone arginine methyltransferase PRMT5 0.0665 0.4089 1
Echinococcus granulosus tar DNA binding protein 0.0135 0.0728 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0335 0.0335
Trypanosoma brucei RNA helicase, putative 0.0303 0.1794 0.5361
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Schistosoma mansoni phosphoglucomutase 0.0045 0.0155 0.0221
Schistosoma mansoni smad1 5 8 and 0.0026 0.0035 0.0044
Toxoplasma gondii ABC1 family protein 0.004 0.0125 0.0106
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0117 0.0165
Loa Loa (eye worm) hypothetical protein 0.0943 0.5855 0.5855
Echinococcus granulosus smad 0.0026 0.0035 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0101 0.019
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0228 0.0365
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0111 0.0221
Echinococcus granulosus lamin 0.0057 0.0236 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0335 0.0335
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0335 0.0335
Echinococcus multilocularis smad 0.0026 0.0035 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.083 0.0828
Onchocerca volvulus 0.0129 0.0688 0.1166
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0335 0.0488
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0005 0.0004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0728 0.0726
Schistosoma mansoni metabotropic glutamate receptor 0.02 0.1141 0.1683
Echinococcus multilocularis lamin 0.0057 0.0236 0.0235
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Echinococcus granulosus thymidine kinase 0.0283 0.167 0.1668
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0228 0.0546
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0111 0.011
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0082 0.0246
Loa Loa (eye worm) runx1 0.0118 0.0623 0.0621
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0335 0.0333
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.2259 0.2258
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0125 0.013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0335 0.0333
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0117 0.0107
Loa Loa (eye worm) Skb1 methyltransferase 0.0665 0.4089 0.4088
Brugia malayi ecdysteroid receptor 0.0073 0.0335 0.0335
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.018 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0125 0.013
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.018 0.0299
Brugia malayi hypothetical protein 0.0021 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.056 0.0559
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.018 0.0299
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0728 0.0728
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.101 0.1008
Trypanosoma brucei glucosidase, putative 0.0038 0.0111 0.0333
Schistosoma mansoni lamin 0.0057 0.0236 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0101 0.019
Loa Loa (eye worm) hypothetical protein 0.0106 0.0542 0.054
Schistosoma mansoni hypothetical protein 0.006 0.0254 0.0368
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0728 0.0726
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0277 0.0595
Trypanosoma brucei thymidine kinase 0.0548 0.3346 1
Echinococcus multilocularis Protein lozenge 0.0118 0.0623 0.0621
Entamoeba histolytica thymidine kinase, putative 0.0548 0.3346 0.8133
Brugia malayi intermediate filament protein 0.0057 0.0236 0.0236
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.016 0.0158
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.1617 0.1616
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0047 0.017 0.065
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0236 0.0235
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.056 0.1129
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0728 0.1071
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0024 0.0025 0.0029
Trypanosoma brucei ribonuclease H1 0.0045 0.0155 0.0462
Echinococcus multilocularis protein arginine N methyltransferase 5 0.0665 0.4089 0.4088
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0228 0.0448
Brugia malayi nuclear receptor NHR-88 0.0073 0.0335 0.0335
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0335 0.0333
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0335 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0111 0.0221
Onchocerca volvulus 0.0034 0.009 0.0145
Echinococcus granulosus glycogen phosphorylase 0.0108 0.056 0.0559
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.1806 0.426
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0335 0.0488
Schistosoma mansoni hypothetical protein 0.0044 0.0149 0.0213
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0198 0.0592
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0335 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0101 0.019
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0111 0.0072
Onchocerca volvulus 0.0063 0.027 0.0452
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0335 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0079 0.0122
Schistosoma mansoni survival motor neuron protein 0.0056 0.0228 0.033
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0106 0.0105
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.009 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0056 0.0054
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0228 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Onchocerca volvulus Glycogen phosphorylase homolog 0.0108 0.056 0.0949
Schistosoma mansoni smad 0.0026 0.0035 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.004
Brugia malayi nuclear receptor RXR 0.0034 0.009 0.009
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.4101 0.6069
Entamoeba histolytica hypothetical protein 0.0073 0.0333 0.0557
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0085 0.0085
Trichomonas vaginalis esterase, putative 0.004 0.0125 0.0262
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0101 0.0047
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0117 0.0115
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0335 0.0333
Schistosoma mansoni intermediate filament proteins 0.0057 0.0236 0.0342
Schistosoma mansoni glycogen phosphorylase 0.0108 0.056 0.0822
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.009 0.0089
Schistosoma mansoni alpha-glucosidase 0.0146 0.08 0.1177
Brugia malayi hypothetical protein 0.0036 0.0102 0.0102
Brugia malayi Nuclear hormone receptor E75 0.0034 0.009 0.009
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0125 0.0123
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0035 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.027 0.0392
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.4101 0.41
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0035 0.0033
Brugia malayi hypothetical protein 0.0034 0.009 0.009
Brugia malayi MH2 domain containing protein 0.0376 0.2259 0.2259
Schistosoma mansoni nuclear receptor 0.0034 0.009 0.0126
Brugia malayi nuclear hormone receptor 0.0034 0.009 0.009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0125 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0054 0.0049
Brugia malayi Skb1 methyltransferase family protein 0.0665 0.4089 0.4089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.009 0.0089
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0047 0.017 0.0331
Onchocerca volvulus 0.004 0.0125 0.0204
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0277 0.0416
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0542 0.1083
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0335 0.0488
Onchocerca volvulus 0.004 0.0125 0.0204
Schistosoma mansoni coup transcription factor 0.0073 0.0335 0.0488
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0032 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0056 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.0082 0.0081
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0082 0.0189
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Echinococcus granulosus lamin dm0 0.0057 0.0236 0.0235
Brugia malayi RNase H family protein 0.0045 0.0155 0.0154
Brugia malayi RNase H family protein 0.0045 0.0155 0.0154
Giardia lamblia Deoxynucleoside kinase 0.0385 0.2314 0.6765
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0005 0.0004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.016 0.0158
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.027 0.0268
Brugia malayi conserved hypotetical protein 0.0034 0.009 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0125 0.0262
Brugia malayi hypothetical protein 0.0039 0.0117 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Echinococcus multilocularis geminin 0.1085 0.6754 0.6754
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Echinococcus granulosus metabotropic glutamate receptor 5 0.003 0.0061 0.0059
Plasmodium vivax hypothetical protein, conserved 0.004 0.0125 0.0292
Loa Loa (eye worm) hypothetical protein 0.1596 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0125 0.0177
Brugia malayi hypothetical protein 0.056 0.3422 0.3422
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.009 0.0089
Schistosoma mansoni hypothetical protein 0.0395 0.2379 0.3517
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0236 0.0236
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.0082 0.0081
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0335 0.0333
Brugia malayi tailless protein 0.0034 0.009 0.009
Giardia lamblia Glycogen phosphorylase 0.0108 0.056 0.1271
Brugia malayi Pre-SET motif family protein 0.0063 0.027 0.027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0123
Schistosoma mansoni nuclear receptor 0.0034 0.009 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.009 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0101 0.019
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0335 0.0333
Brugia malayi beta-lactamase family protein 0.004 0.0125 0.0124
Plasmodium vivax SET domain protein, putative 0.0063 0.027 0.0648
Trichomonas vaginalis set domain proteins, putative 0.0489 0.2972 0.8868
Loa Loa (eye worm) glycogen phosphorylase 0.0108 0.056 0.0559
Trypanosoma cruzi thymidine kinase, putative 0.0548 0.3346 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.018 0.0172
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.009 0.0089
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.083 0.0828
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0117 0.0165
Schistosoma mansoni nuclear hormone receptor 0.0034 0.009 0.0126
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0111 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.027 0.0392
Plasmodium vivax protein arginine N-methyltransferase 5, putative 0.0665 0.4089 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0111 0.0221
Schistosoma mansoni phosphoglucomutase 0.0045 0.0155 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0001
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0817 0.5086
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0542 0.054
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0048 0.0046
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0035 0.0044
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0335 0.0563
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.2259 0.2258
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0045 0.0155 0.5
Leishmania major ribonuclease H1, putative 0.0045 0.0155 0.0221
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0245 0.0243
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.009 0.0089
Brugia malayi nuclear hormone receptor 0.0073 0.0335 0.0335
Onchocerca volvulus 0.0073 0.0335 0.0563
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0335 0.0335
Trichomonas vaginalis thymidine kinase, putative 0.0548 0.3346 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.009 0.0089
Echinococcus multilocularis muscleblind protein 0.1596 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0335 0.0488
Entamoeba histolytica hypothetical protein 0.0073 0.0333 0.0557
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.2596 0.2595
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0335 0.0335
Onchocerca volvulus 0.0055 0.0219 0.0365
Schistosoma mansoni Smad4 0.0026 0.0035 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0247 0.0246
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.056 0.1579
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0005 0.0004
Brugia malayi ecdysone receptor 0.0034 0.009 0.009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0032 0.003
Brugia malayi MH2 domain containing protein 0.0026 0.0035 0.0034
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0236 0.0235
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0005 0.0004
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0048 0.0046
Echinococcus multilocularis musashi 0.0057 0.0236 0.0235
Echinococcus multilocularis tumor protein p63 0.0374 0.2242 0.2241
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.016 0.0158
Brugia malayi hypothetical protein 0.0056 0.0228 0.0228
Trypanosoma brucei unspecified product 0.0051 0.0198 0.0592
Onchocerca volvulus 0.0056 0.0228 0.0381
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.095 0.0948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0335 0.0333
Schistosoma mansoni glycogen phosphorylase 0.0047 0.017 0.0243
Echinococcus granulosus Protein patched homolog 1 0.0045 0.016 0.0158
Entamoeba histolytica hypothetical protein 0.0073 0.0333 0.0557
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0125 0.0123
Echinococcus granulosus RUN 0.0021 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.018 0.0429
Echinococcus granulosus Glycosyl transferase family 35 0.0108 0.056 0.0559
Schistosoma mansoni glycogen phosphorylase 0.0108 0.056 0.0822
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0111 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0335 0.0333
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0184 0.0183
Brugia malayi Doublecortin family protein 0.0021 0.0005 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0005 0.0004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0245 0.0243
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.0046
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0426 0.2573 0.7663
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0335 0.0333
Loa Loa (eye worm) RNA binding protein 0.0135 0.0728 0.0726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0677 0.0995
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0335 0.0333
Schistosoma mansoni hypothetical protein 0.0044 0.0149 0.0213
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.009 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0335 0.0333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1806 0.5344
Brugia malayi hypothetical protein 0.0021 0.0005 0.0005
Echinococcus granulosus Smad4 0.0026 0.0035 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0335 0.0335
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.056 0.1129
Brugia malayi nuclear receptor NHR-88 0.0034 0.009 0.009
Brugia malayi steroid hormone receptor 0.0073 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0115
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0277 0.0827
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0219 0.0317
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.017 0.0147
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0123
Plasmodium falciparum protein arginine N-methyltransferase 5, putative 0.0665 0.4089 1
Brugia malayi hypothetical protein 0.0034 0.009 0.009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0335 0.0488
Echinococcus granulosus intermediate filament protein 0.0057 0.0236 0.0235
Onchocerca volvulus 0.0098 0.0496 0.0838
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.027 0.0392
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.018 0.0538
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0333 0.0331
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0817 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0101 0.019
Schistosoma mansoni zinc finger protein 0.0034 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0056 0.0228 0.0227
Schistosoma mansoni smad1 5 8 and 0.0026 0.0035 0.0044
Onchocerca volvulus 0.0943 0.5855 1
Echinococcus granulosus glycogen phosphorylase 0.0108 0.056 0.0559
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0117 0.0116
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.018 0.0259
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Trichomonas vaginalis thymidine kinase, putative 0.0548 0.3346 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0056 0.023 0.0228
Trypanosoma cruzi arginine N-methyltransferase, type II, putative 0.0426 0.2573 0.7632
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0333
Echinococcus multilocularis ribonuclease H1 0.0045 0.0155 0.0153
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.095 0.0948
Echinococcus granulosus thymidine kinase 0.0283 0.167 0.1668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0335 0.0333
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.027 0.0268
Echinococcus multilocularis lamin dm0 0.0057 0.0236 0.0235
Schistosoma mansoni cpg binding protein 0.0059 0.0245 0.0355
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0426 0.2573 0.7663
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0335 0.0488
Echinococcus multilocularis expressed conserved protein 0.0099 0.0501 0.05
Loa Loa (eye worm) hypothetical protein 0.0049 0.0184 0.0182
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0179 0.101 0.1008
Schistosoma mansoni hypothetical protein 0.1085 0.6754 1
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0155 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0056 0.0054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.018 0.0299
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0335 0.0488
Trypanosoma brucei ingi protein (ORF1) 0.0051 0.0198 0.0592
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0117 0.0115
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.056 0.1579
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.0125 0.0123
Giardia lamblia GTOR 0.0049 0.018 0.008
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.095 0.095
Chlamydia trachomatis glycogen phosphorylase 0.0108 0.056 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.027 0.0468
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0111 0.0221
Brugia malayi RNase H family protein 0.0045 0.0155 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0117 0.0238
Schistosoma mansoni nuclear hormone receptor 0.0034 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0054 0.0049
Echinococcus granulosus tumor protein p63 0.0374 0.2242 0.2241
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0111 0.0221

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.12 uM Inhibitor concentration required to block 50% of the specific [3H]-PAF binding to rabbit platelet membranes. ChEMBL. 3027330
Inhibition (binding) = 68 % Percent inhibition of [3H]-PAF to platelet-activating factor (PAF) receptor from rabbit platelet membranes at 0.3 microM ChEMBL. 3027330
Inhibition (binding) = 84 % Percent inhibition of [3H]-PAF binding to platelet-activating factor (PAF) receptor from rabbit platelet membranes at 1.0 uM ChEMBL. 3027330
Inhibition (binding) = 95 % Percent inhibition of [3H]-PAF binding to platelet-activating factor (PAF) receptor from rabbit platelet membranes at 5.0 microM ChEMBL. 3027330
Ki (functional) = 0.000000058 M PAF antagonism was determined by rabbit platelet inhibition and neurophil aggregation and degranulation at 0.1 to 1 microM concentration. ChEMBL. 3027330

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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