Detailed information for compound 426181

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 422.866 | Formula: C17H17ClN5O4S-
  • H donors: 0 H acceptors: 5 LogP: 4.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2n(c1)c(/C=N\N(S(=O)(=O)c1cc(ccc1C)[N+](=O)[O-])C)cn2.[Cl-]
  • InChi: 1S/C17H17N5O4S.ClH/c1-12-4-7-17-18-9-15(21(17)11-12)10-19-20(3)27(25,26)16-8-14(22(23)24)6-5-13(16)2;/h4-11H,1-3H3;1H/p-1/b19-10+;
  • InChiKey: DRJWGGFLADGATI-ZIOFAICLSA-M  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0048 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0451 0.0653 0.0653
Loa Loa (eye worm) hypothetical protein 0.6656 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Schistosoma mansoni nephrin 0.0063 0.0069 0.0069
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0667 0.098 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Plasmodium falciparum plasmepsin IV 0.0085 0.0103 0.1719
Onchocerca volvulus 0.0035 0.0027 0.0339
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0101 0.0984
Brugia malayi Zona pellucida-like domain containing protein 0.002 0.0005 0.0005
Brugia malayi Pepsin A precursor 0.0048 0.0046 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4079 0.6118 1
Loa Loa (eye worm) sirtuin 4 0.0098 0.0123 0.0123
Onchocerca volvulus 0.0136 0.0179 0.2687
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0098 0.0123 0.1201
Leishmania major arginine N-methyltransferase, type I 0.0067 0.0075 0.0713
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Plasmodium falciparum plasmepsin III 0.0048 0.0046 0.0765
Schistosoma mansoni furin-1 (S08 family) 0.2874 0.4303 0.4303
Onchocerca volvulus 0.0035 0.0027 0.0339
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0041 0.0036 0.0036
Schistosoma mansoni chromatin regulatory protein sir2 0.0098 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0296 0.042 0.042
Giardia lamblia High cysteine membrane protein Group 2 0.2442 0.3652 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0036 0.0028 0.0028
Echinococcus granulosus protein kinase c epsilon type 0.0088 0.0106 0.0106
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0077 0.0091 0.0091
Toxoplasma gondii F5/8 type C domain-containing protein 0.0024 0.0011 0.0123
Mycobacterium tuberculosis Possible oxidoreductase 0.0084 0.0101 0.2312
Echinococcus granulosus twitchin 0.0063 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0067 0.0075 0.0075
Onchocerca volvulus 0.0296 0.042 0.6408
Toxoplasma gondii subtilisin SUB8 0.0296 0.042 0.7966
Brugia malayi ADAMTS-like protease 0.0025 0.0012 0.0012
Echinococcus multilocularis protein arginine methyltransferase 0.0119 0.0153 0.0192
Echinococcus granulosus discoidin domain containing receptor 2 0.0024 0.0011 0.0011
Echinococcus multilocularis protoporphyrinogen oxidase 0.0084 0.0101 0.0127
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Plasmodium falciparum apical sushi protein 0.0035 0.0027 0.0444
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0098 0.0123 0.1201
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0016 0.0016
Onchocerca volvulus 0.0035 0.0027 0.0339
Trichomonas vaginalis cyclins, putative 0.0028 0.0017 0.0027
Leishmania major hypothetical protein, conserved 0.003 0.0019 0.0141
Echinococcus multilocularis c4b binding protein beta chain 0.0035 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Toxoplasma gondii bicoid-interacting protein BIN3 0.0067 0.0075 0.135
Loa Loa (eye worm) Carm1-pending protein 0.0067 0.0075 0.0075
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0057 0.006 0.0165
Toxoplasma gondii aspartyl protease ASP1 0.0085 0.0103 0.1882
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0085 0.0103 0.0168
Loa Loa (eye worm) hypothetical protein 0.0063 0.0069 0.0069
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0053 0.0543
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0011
Plasmodium vivax apical sushi protein, putative 0.0035 0.0027 0.0371
Echinococcus granulosus dna polymerase kappa 0.0021 0.0006 0.0006
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0098 0.0123 0.0123
Schistosoma mansoni SWI/SNF complex-related 0.0035 0.0027 0.0027
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0072 0.0082 0.0082
Brugia malayi ADAM-TS Spacer 1 family protein 0.0025 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1341 0.1993 0.3259
Brugia malayi hypothetical protein 0.0048 0.0046 0.0046
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0296 0.042 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0296 0.042 1
Plasmodium vivax subtilisin-like serine protease, putative 0.0296 0.042 0.7006
Leishmania major subtilisin-like serine peptidase 0.0296 0.042 0.4259
Plasmodium vivax LCCL domain-containing protein 0.0024 0.0011 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0044
Onchocerca volvulus 0.0024 0.0011 0.0099
Toxoplasma gondii aspartyl protease ASP3 0.0048 0.0046 0.0789
Leishmania major silent information regulator 2, putative 0.0667 0.098 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0006 0.0006
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0056 0.0059 0.0059
Echinococcus multilocularis Immunoglobulin 0.0063 0.0069 0.0086
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0006 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0028 0.0016 0.0016
Giardia lamblia Hypothetical protein 0.0667 0.098 0.2682
Loa Loa (eye worm) hypothetical protein 0.0063 0.0069 0.0069
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.0161 0.0161
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Echinococcus granulosus lysine specific histone demethylase 1A 0.0416 0.06 0.06
Brugia malayi Protein kinase domain containing protein 0.0036 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0012
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6656 1 1
Onchocerca volvulus 0.0048 0.0046 0.0635
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0084 0.0101 0.2312
Echinococcus granulosus Immunoglobulin 0.0063 0.0069 0.0069
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0098 0.0123 0.0153
Echinococcus granulosus neuroglian 0.0063 0.0069 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0028
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1637 0.244 0.244
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Toxoplasma gondii subtilisin SUB4 0.0296 0.042 0.7966
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0085 0.0103 0.1882
Toxoplasma gondii histone deacetylase SIR2 0.0098 0.0123 0.226
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0119 0.0153 0.0153
Toxoplasma gondii SWIRM domain-containing protein 0.0035 0.0027 0.0433
Mycobacterium ulcerans NAD-dependent deacetylase 0.0098 0.0123 0.282
Plasmodium falciparum plasmepsin I 0.0085 0.0103 0.1719
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0098 0.0123 0.282
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Trypanosoma cruzi cyclin, putative 0.0041 0.0036 0.0314
Entamoeba histolytica SWIRM domain protein 0.0035 0.0027 0.0277
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Echinococcus granulosus Furin 1 0.1637 0.244 0.244
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0019
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0088 0.0106 0.0106
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Brugia malayi neuroendocrine convertase 1 precursor 0.4214 0.6322 0.6322
Entamoeba histolytica hypothetical protein 0.0035 0.0027 0.0277
Echinococcus multilocularis protein will die slowly 0.0136 0.0179 0.0224
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0296 0.042 0.0527
Echinococcus granulosus cyclin B 0.0041 0.0036 0.0036
Brugia malayi Carm1-pending protein 0.0067 0.0075 0.0075
Schistosoma mansoni chromatin regulatory protein sir2 0.0098 0.0123 0.0123
Brugia malayi hypothetical protein 0.0186 0.0254 0.0254
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0098 0.0123 0.2048
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0118 0.0152 0.0249
Loa Loa (eye worm) transcriptional regulator 0.0667 0.098 0.098
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0084 0.0101 0.1633
Echinococcus multilocularis membrane bound transcription factor site 1 0.0296 0.042 0.0527
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0453 0.0657 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0186 0.0254 0.255
Echinococcus granulosus discoidin domain containing receptor 2 0.0024 0.0011 0.0011
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0416 0.06 0.0752
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2494 0.373 0.373
Brugia malayi proprotein convertase 2 0.4214 0.6322 0.6322
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0311 0.0442 0.4482
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0296 0.042 0.042
Echinococcus multilocularis cyclin B 0.0041 0.0036 0.0045
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0082 0.0836
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Loa Loa (eye worm) hypothetical protein 0.0063 0.0069 0.0069
Toxoplasma gondii subtilisin SUB12 0.0296 0.042 0.7966
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1341 0.1993 0.3259
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0084 0.0101 0.1696
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Echinococcus granulosus growth factor receptor bound protein 2 0.0124 0.0161 0.0161
Schistosoma mansoni chromatin regulatory protein sir2 0.0098 0.0123 0.0123
Schistosoma mansoni amine oxidase 0.0084 0.0101 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Schistosoma mansoni dihydroceramide desaturase 0.0018 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0084 0.0101 0.221
Brugia malayi SWIRM domain containing protein 0.0451 0.0653 0.0653
Plasmodium vivax plasmepsin V, putative 0.0414 0.0598 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1637 0.244 0.3988
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4079 0.6118 0.7665
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0067 0.0075 0.0094
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0085 0.0103 0.0103
Onchocerca volvulus 0.0451 0.0653 1
Schistosoma mansoni protein arginine n-methyltransferase 0.0067 0.0075 0.0075
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0084 0.0101 0.2312
Trypanosoma brucei subtilisin peptidase 0.0296 0.042 0.4259
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0043 0.0039 0.0049
Onchocerca volvulus 0.0165 0.0223 0.3362
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0005 0.0046
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0311 0.0442 0.4482
Echinococcus granulosus membrane bound transcription factor site 1 0.0296 0.042 0.042
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1341 0.1993 0.3259
Toxoplasma gondii aspartyl protease ASP5 0.0367 0.0527 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0119 0.0153 0.0153
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0063 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0077 0.009 0.009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0098 0.0123 0.1251
Plasmodium falciparum von Willebrand factor A domain-related protein 0.002 0.0005 0.0076
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0098 0.0123 0.0123
Mycobacterium ulcerans monoamine oxidase 0.0084 0.0101 0.2312
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.0161 0.0161
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0124 0.0161 0.0161
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0028 0.0016 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0186 0.0254 0.255
Plasmodium falciparum plasmepsin V 0.0414 0.0598 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0296 0.042 1
Toxoplasma gondii F5/8 type C domain-containing protein 0.0024 0.0011 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0094 0.0116 0.1183
Onchocerca volvulus 0.003 0.002 0.0231
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0296 0.042 1
Brugia malayi hypothetical protein 0.0084 0.0101 0.0101
Echinococcus multilocularis dna polymerase eta 0.0021 0.0006 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.009 0.0112
Plasmodium vivax NAD-dependent deacetylase, putative 0.0098 0.0123 0.1988
Loa Loa (eye worm) hypothetical protein 0.0043 0.0039 0.0039
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0416 0.06 0.06
Brugia malayi celfurPC protein 0.5316 0.7981 0.7981
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.004 0.0034 0.0055
Onchocerca volvulus 0.0035 0.0027 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Plasmodium falciparum plasmepsin VII 0.0048 0.0046 0.0765
Entamoeba histolytica hypothetical protein, conserved 0.0098 0.0123 0.1251
Brugia malayi GCC2 and GCC3 family protein 0.0043 0.004 0.004
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0063 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4079 0.6118 0.6118
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.002 0.0005 0.0005
Plasmodium falciparum subtilisin-like protease 1 0.0296 0.042 0.7028
Onchocerca volvulus 0.0035 0.0027 0.0339
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0018 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.003 0.0019 0.0019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0667 0.098 0.1601
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0667 0.098 0.1601
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0024 0.0011 0.013
Trichomonas vaginalis cyclin B, putative 0.0041 0.0036 0.0059
Brugia malayi SWIRM domain containing protein 0.0035 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0186 0.0254 0.2592
Brugia malayi aspartic protease BmAsp-2, identical 0.0048 0.0046 0.0046
Brugia malayi hypothetical protein 0.002 0.0005 0.0005
Schistosoma mansoni vesicular amine transporter 0.0063 0.0069 0.0069
Toxoplasma gondii rhoptry neck protein RON9 0.0035 0.0027 0.0421
Brugia malayi hypothetical protein 0.0056 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0186 0.0254 0.0254
Echinococcus granulosus C type lectin domian containing protein 0.0035 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Onchocerca volvulus 0.0035 0.0027 0.0339
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0097 0.0158
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0028 0.0028
Giardia lamblia Transcriptional regulator, Sir2 family 0.0098 0.0123 0.0335
Loa Loa (eye worm) endoprotease bli-4 0.6656 1 1
Trypanosoma brucei mitotic cyclin 6 0.0041 0.0036 0.0314
Echinococcus multilocularis 0.5316 0.7981 1
Schistosoma mansoni discoidin domain receptor 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0296 0.042 1
Schistosoma mansoni DNA polymerase eta 0.0021 0.0006 0.0006
Toxoplasma gondii PA14 domain-containing protein 0.0024 0.0011 0.0123
Brugia malayi hypothetical protein 0.0045 0.0042 0.0042
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0296 0.042 1
Schistosoma mansoni cell adhesion molecule 0.0072 0.0082 0.0082
Brugia malayi Protein arginine N-methyltransferase 0.0067 0.0075 0.0075
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0667 0.098 1
Echinococcus granulosus voltage dependent calcium channel subunit 0.002 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Onchocerca volvulus 0.0045 0.0042 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Schistosoma mansoni cathepsin D (A01 family) 0.0182 0.0248 0.0248
Echinococcus multilocularis Furin 1 0.1637 0.244 0.3057
Echinococcus multilocularis voltage dependent calcium channel subunit 0.002 0.0005 0.0006
Echinococcus multilocularis discoidin domain containing receptor 2 0.0024 0.0011 0.0014
Mycobacterium ulcerans dehydrogenase 0.0084 0.0101 0.2312
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1637 0.244 0.3988
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0296 0.042 1
Entamoeba histolytica cyclin, putative 0.0041 0.0036 0.0369
Loa Loa (eye worm) TK/EGFR protein kinase 0.061 0.0893 0.0893
Brugia malayi Subtilase family protein 0.0296 0.042 0.042
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0084 0.0101 0.1633
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0067 0.0075 0.0713
Schistosoma mansoni chromatin regulatory protein sir2 0.0667 0.098 0.098
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0063 0.0069 0.0086
Echinococcus granulosus discoidin domain receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0101
Onchocerca volvulus 0.0035 0.0027 0.0339
Loa Loa (eye worm) hypothetical protein 0.0043 0.004 0.004
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0067 0.0075 0.0713
Echinococcus granulosus methyltransferase protein 5 0.0067 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.2577 0.3857 0.3857
Plasmodium falciparum cysteine repeat modular protein 1 0.003 0.0019 0.0322
Brugia malayi Probable ATP-dependent helicase DHX35 0.0035 0.0028 0.0028
Onchocerca volvulus 0.0035 0.0027 0.0339
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.0152 0.1555
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0046 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0006 0.0006
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0006 0.0057
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0296 0.042 0.042
Brugia malayi pregnancy-associated plasma protein-A 0.0035 0.0027 0.0027
Plasmodium falciparum plasmepsin VI 0.0085 0.0103 0.1719
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0006 0.0006
Plasmodium falciparum protoporphyrinogen oxidase 0.0084 0.0101 0.1696
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1637 0.244 0.3988
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0609 0.0892 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Loa Loa (eye worm) reprolysin 0.0043 0.0039 0.0039
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.004 0.0034 0.029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0063 0.0069 0.0069
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0667 0.098 1
Giardia lamblia Furin precursor putative serine protease 0.1341 0.1993 0.5458
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0098 0.0123 0.1201
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.0152 0.1507
Echinococcus multilocularis neuroglian 0.0063 0.0069 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Toxoplasma gondii subtilisin SUB2 0.0296 0.042 0.7966
Brugia malayi hypothetical protein 0.0048 0.0046 0.0046
Onchocerca volvulus 0.0041 0.0036 0.0487
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0098 0.0123 0.0153
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0119 0.0153 0.025
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Echinococcus granulosus roundabout 2 0.0072 0.0082 0.0082
Echinococcus granulosus protein arginine N methyltransferase 8 0.0119 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.012 0.0154 0.0154
Echinococcus granulosus adam 17 protease 0.0018 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0046
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0006 0.0009
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Chlamydia trachomatis protoporphyrinogen oxidase 0.0084 0.0101 0.5
Brugia malayi Angiotensin-converting enzyme family protein 0.0609 0.0892 0.0892
Schistosoma mansoni septate junction protein 0.0033 0.0024 0.0024
Brugia malayi Calcium binding EGF domain containing protein 0.0023 0.0009 0.0009
Onchocerca volvulus Putative cubilin 0.0023 0.0009 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0101 0.1633
Schistosoma mansoni cathepsin D (A01 family) 0.0182 0.0248 0.0248
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0091 0.0091
Echinococcus multilocularis tissue type plasminogen activator 0.003 0.0019 0.0024
Entamoeba histolytica elongation factor-2 kinase, putative 0.002 0.0005 0.0046
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0067 0.0075 0.135
Echinococcus granulosus neuroendocrine convertase 2 0.4214 0.6322 0.6322
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0019 0.0141
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0296 0.042 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0084 0.0101 0.0101
Toxoplasma gondii subtilisin SUB9 0.0296 0.042 0.7966
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0009
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0296 0.042 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0119 0.0153 0.0153
Brugia malayi Disintegrin family protein 0.0018 0.0001 0.0001
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0667 0.098 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0667 0.098 0.098
Echinococcus multilocularis Immunoglobulin 0.0063 0.0069 0.0086
Schistosoma mansoni chromatin regulatory protein sir2 0.0667 0.098 0.098
Loa Loa (eye worm) phosphatidylinositol 3 0.0198 0.0273 0.0273
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0024 0.0011 0.0011
Echinococcus multilocularis disintegrin and metalloproteinase 0.0018 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.042 0.0687
Entamoeba histolytica SWIRM domain protein 0.0035 0.0027 0.0277
Echinococcus multilocularis MAM 0.0045 0.0042 0.0052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0092 0.0092
Echinococcus granulosus protein arginine N methyltransferase 7 0.0067 0.0075 0.0075
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Toxoplasma gondii subtilisin SUB5 0.0296 0.042 0.7966
Onchocerca volvulus 0.0048 0.0046 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Plasmodium vivax cysteine repeat modular protein 1, putative 0.003 0.0019 0.0248
Plasmodium vivax subtilisin-like protease 1 0.0296 0.042 0.7006
Loa Loa (eye worm) hypothetical protein 0.0045 0.0042 0.0042
Brugia malayi angiogenesis inhibito 0.0025 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Trichomonas vaginalis cyclin B, putative 0.0041 0.0036 0.0059
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.004 0.0034 0.029
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.0152 0.1507
Echinococcus granulosus furin 0.6656 1 1
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0085 0.0103 0.0103
Giardia lamblia DINP protein human, muc B family 0.0021 0.0006 0.0015
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0667 0.098 0.1227
Brugia malayi transcriptional regulator, Sir2 family protein 0.0667 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0085 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0085 0.0103 0.0103
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0101 0.1633
Loa Loa (eye worm) hypothetical protein 0.0098 0.0123 0.0123
Brugia malayi Furin-like cysteine rich region family protein 0.061 0.0893 0.0893
Echinococcus multilocularis roundabout 2 0.0072 0.0082 0.0103
Loa Loa (eye worm) hypothetical protein 0.0045 0.0042 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4079 0.6118 1
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.042 0.0687
Toxoplasma gondii rhoptry neck protein RON1 0.0035 0.0027 0.0421
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0024 0.0011 0.0018
Echinococcus multilocularis C type lectin domian containing protein 0.0035 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0082 0.0082
Plasmodium vivax aspartyl protease, putative 0.0048 0.0046 0.0694
Trichomonas vaginalis cyclins, putative 0.0041 0.0036 0.0059
Brugia malayi Cyclin, N-terminal domain containing protein 0.0041 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0036
Echinococcus granulosus adam 0.0056 0.0059 0.0059
Brugia malayi Cyclin, N-terminal domain containing protein 0.0041 0.0036 0.0036
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0119 0.0153 0.2504
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0296 0.042 0.042
Brugia malayi Reprolysin 0.0025 0.0012 0.0012
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0011 0.0183
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0098 0.0123 0.0335
Plasmodium falciparum plasmepsin VIII, putative 0.0048 0.0046 0.0765
Echinococcus granulosus dna polymerase eta 0.0021 0.0006 0.0006
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0119 0.0153 0.025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Loa Loa (eye worm) aspartyl protease 6 0.0048 0.0046 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Toxoplasma gondii kringle domain-containing protein 0.003 0.0019 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.042 0.0687
Mycobacterium ulcerans Sir2-like regulatory protein 0.0098 0.0123 0.282
Schistosoma mansoni btb and poz domain-containing protein 0.0024 0.0011 0.0011
Echinococcus multilocularis chromatin regulatory protein sir2 0.0667 0.098 0.1227
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0119 0.0153 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0005
Loa Loa (eye worm) DEAH box polypeptide 35 0.0035 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Plasmodium vivax hypothetical protein, conserved 0.0098 0.0123 0.1988
Brugia malayi transcriptional regulator, Sir2 family protein 0.0098 0.0123 0.0123
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0035 0.0027 0.0034
Plasmodium falciparum subtilisin-like protease 2 0.0296 0.042 0.7028
Trypanosoma brucei SIR2-like protein 4, putative 0.0098 0.0123 0.1201
Toxoplasma gondii subtilisin SUB10 0.0296 0.042 0.7966
Schistosoma mansoni amine oxidase 0.0084 0.0101 0.0101
Schistosoma mansoni site-1 peptidase (S08 family) 0.0296 0.042 0.042
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0119 0.0153 0.2561
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.0095 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.002 0.0005 0.0005
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0067 0.0075 0.135
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0035 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0101 0.0984
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Echinococcus multilocularis protein kinase c epsilon type 0.0088 0.0106 0.0133
Schistosoma mansoni cyclin B 0.0041 0.0036 0.0036
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0067 0.0075 0.0075
Brugia malayi Protein kinase domain containing protein 0.003 0.002 0.002
Toxoplasma gondii subtilisin SUB7 0.0296 0.042 0.7966
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0005 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.004 0.0034 0.0055
Echinococcus granulosus c4b binding protein beta chain 0.0035 0.0027 0.0027
Brugia malayi transcriptional regulator, Sir2 family protein 0.0098 0.0123 0.0123
Trichomonas vaginalis cyclin B, putative 0.0041 0.0036 0.0059
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0136 0.0179 0.0179
Brugia malayi Kringle domain containing protein 0.003 0.0019 0.0019
Onchocerca volvulus 0.0035 0.0027 0.0339
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0039 0.0039
Brugia malayi Sex muscle abnormal protein 5 0.0124 0.0161 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0034 0.0034
Loa Loa (eye worm) proprotein convertase 2 0.1637 0.244 0.244
Loa Loa (eye worm) hypothetical protein 0.0063 0.0069 0.0069
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0186 0.0254 0.255
Plasmodium vivax subtilisin-like protease 2, putative 0.0296 0.042 0.7006
Echinococcus granulosus serine:threonine protein kinase N2 0.0071 0.0082 0.0082
Treponema pallidum 76K protein 0.002 0.0005 0.5
Giardia lamblia Sirtuin type 2 0.0098 0.0123 0.0335
Schistosoma mansoni discoidin domain receptor 0.0024 0.0011 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.0147 0.1501
Schistosoma mansoni chromatin regulatory protein sir2 0.0098 0.0123 0.0123
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Trichomonas vaginalis cyclins, putative 0.0041 0.0036 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Echinococcus granulosus epidermal growth factor receptor 0.061 0.0893 0.0893
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0005
Schistosoma mansoni memapsin-2 (A01 family) 0.0048 0.0046 0.0046
Loa Loa (eye worm) TK/ALK protein kinase 0.0051 0.005 0.005
Echinococcus granulosus disintegrin and metalloproteinase 0.0018 0.0001 0.0001
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.002 0.0005 0.0007
Echinococcus granulosus tissue type plasminogen activator 0.003 0.0019 0.0019
Brugia malayi Sushi domain 0.0035 0.0027 0.0027
Trypanosoma cruzi cyclin, putative 0.0041 0.0036 0.0314
Echinococcus granulosus protein arginine methyltransferase 0.0119 0.0153 0.0153
Schistosoma mansoni site-1 peptidase (S08 family) 0.0296 0.042 0.042
Trichomonas vaginalis WD repeat domain, putative 0.0136 0.0179 0.0292
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Echinococcus granulosus defective proboscis extension response 0.0063 0.0069 0.0069
Brugia malayi hypothetical protein 0.0063 0.0069 0.0069
Schistosoma mansoni c4b-binding protein beta chain 0.0035 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1637 0.244 0.3988
Trichomonas vaginalis cyclin B, putative 0.0041 0.0036 0.0059
Brugia malayi von Willebrand Factor 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0074 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0011
Echinococcus multilocularis growth factor receptor bound protein 2 0.0124 0.0161 0.0201
Loa Loa (eye worm) WD40 repeat protein 0.0136 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.042 0.0687
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0098 0.0123 0.0123
Toxoplasma gondii F5/8 type C domain-containing protein 0.0024 0.0011 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Toxoplasma gondii subtilisin SUB1 0.0296 0.042 0.7966
Trichomonas vaginalis conserved hypothetical protein 0.0296 0.042 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Schistosoma mansoni chromatin regulatory protein sir2 0.0667 0.098 0.098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Plasmodium vivax aspartyl protease, putative 0.0048 0.0046 0.0694
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Plasmodium vivax plasmepsin IV, putative 0.0085 0.0103 0.1655
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.004 0.0034 0.0055
Loa Loa (eye worm) hypothetical protein 0.0416 0.06 0.06
Echinococcus granulosus collagen alpha 1VII chain 0.002 0.0005 0.0005
Echinococcus granulosus chromatin regulatory protein sir2 0.0667 0.098 0.098
Leishmania major cyclin 0.0041 0.0036 0.0314
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.009 0.009
Echinococcus multilocularis discoidin domain receptor 0.0024 0.0011 0.0014
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.0101 0.2312
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0098 0.0123 0.1251
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0101 0.1696
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.0028 0.0236
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0311 0.0442 0.4482
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0084 0.0101 0.2312
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Plasmodium falciparum plasmepsin IX 0.0048 0.0046 0.0765
Leishmania major UDP-galactopyranose mutase 0.0084 0.0101 0.0984
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0024 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0027
Plasmodium falciparum plasmepsin X 0.0048 0.0046 0.0765
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0034 0.0345
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0067 0.0075 0.0713
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0041 0.0036 0.0314
Schistosoma mansoni hypothetical protein 0.0045 0.0042 0.0042
Trichomonas vaginalis hypothetical protein 0.0024 0.0011 0.0018
Brugia malayi amine oxidase, flavin-containing family protein 0.012 0.0154 0.0154
Trichomonas vaginalis cyclins, putative 0.0041 0.0036 0.0059
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0098 0.0123 0.02
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0222 0.0309 0.0387
Schistosoma mansoni hypothetical protein 0.0045 0.0042 0.0042
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0119 0.0153 0.2847
Loa Loa (eye worm) hypothetical protein 0.0072 0.0082 0.0082
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0098 0.0123 0.1201
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Plasmodium vivax aspartyl protease, putative 0.0048 0.0046 0.0694
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0067 0.0075 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Brugia malayi Will die slowly protein 0.0136 0.0179 0.0179
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0024 0.0011 0.0014
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0067 0.0075 0.0123
Echinococcus granulosus discoidin domain containing receptor 2 0.0024 0.0011 0.0011
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0119 0.0153 0.0192
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0222 0.0309 0.0309
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0222 0.0309 0.0309
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0034 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.1341 0.1993 0.3259
Brugia malayi aspartic protease BmAsp-1, identical 0.0048 0.0046 0.0046
Plasmodium falciparum thrombospondin-related anonymous protein 0.002 0.0005 0.0076
Mycobacterium ulcerans oxidoreductase 0.0084 0.0101 0.2312
Echinococcus multilocularis discoidin domain containing receptor 2 0.0024 0.0011 0.0014
Loa Loa (eye worm) transcriptional regulator 0.0098 0.0123 0.0123
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.0152 0.0152
Brugia malayi Eukaryotic aspartyl protease family protein 0.0048 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0072 0.0082 0.0082
Loa Loa (eye worm) subtilase 0.0296 0.042 0.042
Onchocerca volvulus 0.0045 0.0042 0.0575
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0006 0.0007
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.002 0.0005 0.0005
Treponema pallidum hypothetical protein 0.002 0.0005 0.5
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0067 0.0075 0.0094
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0097 0.0158
Brugia malayi Protein kinase domain containing protein 0.0051 0.005 0.005
Plasmodium vivax aspartyl proteinase, putative 0.0048 0.0046 0.0694
Loa Loa (eye worm) CUTiclin family member 0.002 0.0005 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0046 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1637 0.244 0.3988
Onchocerca volvulus 0.0029 0.0018 0.0201
Echinococcus granulosus lysine specific histone demethylase 1A 0.0084 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0296 0.042 0.042
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0043 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0186 0.0254 0.2592
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0006 0.0006
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.007 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0045 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Mycobacterium leprae Possible secreted protease 0.0296 0.042 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0048 0.0046 0.0046
Toxoplasma gondii subtilisin SUB11 0.0296 0.042 0.7966
Leishmania major arginine N-methyltransferase-like protein 0.0119 0.0153 0.1515
Giardia lamblia hypothetical protein 0.0035 0.0027 0.0074
Echinococcus granulosus MAM 0.0045 0.0042 0.0042
Echinococcus multilocularis 0.0084 0.0101 0.0127
Brugia malayi NAD-dependent deacetylase SIRT1 0.0098 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0063 0.0069 0.0069
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0067 0.0075 0.0123
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0024 0.0011 0.0014
Echinococcus multilocularis neuroendocrine convertase 2 0.4214 0.6322 0.7922
Plasmodium vivax LCCL domain-containing protein 0.0024 0.0011 0.0108
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0067 0.0075 0.0123
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0067 0.0075 0.0713
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0039 0.0039
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0048 0.0046 0.0789
Onchocerca volvulus 0.003 0.0019 0.0227
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0296 0.042 0.042
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0085 0.0103 0.0129
Loa Loa (eye worm) CUTiclin-Like family member 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0012
Plasmodium falciparum subtilisin-like protease 3 0.0296 0.042 0.7028
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0024 0.0011 0.0018
Trichomonas vaginalis cyclin A, putative 0.0041 0.0036 0.0059
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0118 0.0152 0.0249
Toxoplasma gondii subtilisin SUB6 0.0296 0.042 0.7966
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0118 0.0152 0.0249
Schistosoma mansoni dock 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0035 0.0027 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.2241 0.3349 0.3349
Brugia malayi Zona pellucida-like domain containing protein 0.002 0.0005 0.0005
Loa Loa (eye worm) transcriptional regulator 0.0098 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0018
Toxoplasma gondii histone lysine-specific demethylase 0.0084 0.0101 0.1856
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0029 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.1341 0.1993 0.1993
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0067 0.0075 0.0765
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0084 0.0101 0.1856
Echinococcus multilocularis adam 0.0056 0.0059 0.0074
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.002 0.0005 0.0076
Leishmania major sir2-family protein-like protein 0.0098 0.0123 0.1201
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0067 0.0075 0.0713
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Echinococcus granulosus protein will die slowly 0.0136 0.0179 0.0179
Trypanosoma cruzi subtilisin peptidase 0.0296 0.042 0.4259
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Toxoplasma gondii histone deacetylase SIR2-like 0.0098 0.0123 0.226
Loa Loa (eye worm) hypothetical protein 0.0416 0.06 0.06
Echinococcus multilocularis collagen alpha 1(VII) chain 0.002 0.0005 0.0006
Trypanosoma cruzi CYC2-like cyclin, putative 0.0041 0.0036 0.0314
Echinococcus multilocularis discoidin domain containing receptor 2 0.0024 0.0011 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Trichomonas vaginalis cyclins, putative 0.0041 0.0036 0.0059
Echinococcus multilocularis epidermal growth factor receptor 0.061 0.0893 0.1118
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1637 0.244 0.3988
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0098 0.0123 0.2048
Plasmodium falciparum plasmepsin II 0.0085 0.0103 0.1719
Toxoplasma gondii aspartyl protease 0.0048 0.0046 0.0789
Trypanosoma cruzi cyclin 6, putative 0.0041 0.0036 0.0314
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0005 0.0005
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0667 0.098 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Brugia malayi protein kinase C II. 0.0088 0.0106 0.0106
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0296 0.042 0.4259
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0035 0.0027 0.0027
Trichomonas vaginalis hypothetical protein 0.1341 0.1993 0.3259
Giardia lamblia G2/mitotic-specific cyclin B 0.0041 0.0036 0.0099
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0037 0.0037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0296 0.042 0.0687
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0011 0.0183
Entamoeba histolytica hypothetical protein 0.0094 0.0116 0.1183
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Plasmodium vivax aspartyl proteinase, putative 0.0085 0.0103 0.1655
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0098 0.0123 0.0153
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0067 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.061 0.0893 0.0893

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.006 uM Inhibition of GST-tagged bovine p110alpha expressed in SF9/Baculovirus system by SPA ChEMBL. 17601739
IC50 (functional) = 0.12 uM Inhibition of serum-induced proliferation of human A375 cells ChEMBL. 17601739

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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