TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 494.372 | Formula: C20H27IN6O
H donors: 2 H acceptors: 3 LogP: 3.51 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)Cc1nc2c(n1CCNCC(C)(C)C)ncnc2N)I
InChi: 1S/C20H27IN6O/c1-20(2,3)11-23-7-8-27-16(26-17-18(22)24-12-25-19(17)27)10-13-9-14(28-4)5-6-15(13)21/h5-6,9,12,23H,7-8,10-11H2,1-4H3,(H2,22,24,25)
InChiKey: FESSHDMIDYWMDR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock protein 90kDa alpha (cytosolic), class B member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Treponema pallidum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	putative heat shock protein 81-2	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90-like protein, related	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Theileria parva	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90, related	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium falciparum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein HSP90	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	heat shock protein 83,heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-alpha, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium hominis	heat shock protein 83	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Grp94/Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	hypothetical protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	Endoplasmin precursor	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium ulcerans	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Babesia bovis	hsp90 protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium parvum	Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K04079 molecular chaperone HtpG, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium berghei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	heat shock protein 86, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K09487 heat shock protein 90kDa beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock 90 kDa protein homolog	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	heat shock protein 90, putative	heat shock protein 90kDa alpha (cytosolic), class B member 1	724 aa	725 aa	35.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide receptor	0.0386	0.277	0.2736
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Onchocerca volvulus		0.0048	0.0118	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Echinococcus granulosus	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Brugia malayi	neuropeptide F receptor	0.0285	0.1977	0.4515
Echinococcus granulosus	tm gpcr rhodopsin	0.0285	0.1977	0.1939
Loa Loa (eye worm)	tubulin beta-2A chain	0.0361	0.257	0.5868
Loa Loa (eye worm)	ACC-1 protein	0.0048	0.0118	0.027
Echinococcus granulosus	beta tubulin	0.0361	0.257	0.2534
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0047	0.011	0.0247
Brugia malayi	Melatonin receptor type 1A	0.0285	0.1977	0.4515
Echinococcus multilocularis	sodium channel protein	0.028	0.194	0.1902
Brugia malayi	hypothetical protein	0.0057	0.0183	0.0419
Echinococcus multilocularis	dro:myosuppressin receptor	0.0285	0.1977	0.1939
Brugia malayi	G protein-coupled receptor	0.0285	0.1977	0.4515
Schistosoma mansoni	biogenic amine receptor	0.0285	0.1977	0.6714
Echinococcus multilocularis	g-protein coupled receptor	0.0285	0.1977	0.1939
Brugia malayi	RE15519p	0.0285	0.1977	0.4515
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Echinococcus granulosus	dro:myosuppressin receptor	0.0285	0.1977	0.1939
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0106	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0048	0.0118	0.0071
Echinococcus granulosus	g protein coupled receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	neuropeptide receptor	0.0285	0.1977	0.6714
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0574	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	neuropeptide F receptor	0.0285	0.1977	0.4515
Echinococcus granulosus	Tubulin beta 2C chain	0.0361	0.257	0.2534
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0048	0.0118	0.027
Echinococcus granulosus	Tubulin beta 2C chain	0.0361	0.257	0.2534
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0047	0.011	0.0251
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0048	0.0118	0.0071
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	G-protein coupled receptor	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0531	0.1212
Schistosoma mansoni	macroglobulin/complement	0.0124	0.0715	0.2321
Brugia malayi	Dopamine receptor	0.0285	0.1977	0.4515
Echinococcus multilocularis	glycine receptor subunit beta	0.0048	0.0118	0.0071
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0285	0.1977	0.1939
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0048	0.0118	0.027
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0106	0.0242
Echinococcus multilocularis	neuropeptide Y receptor	0.0285	0.1977	0.1939
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0285	0.1977	0.1939
Brugia malayi	larval opioid receptor	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	sulfakinin receptor protein	0.0495	0.3623	0.8273
Echinococcus granulosus	adenylate cyclase 9	0.0153	0.0939	0.0896
Echinococcus granulosus	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Echinococcus granulosus	serotonin receptor	0.0285	0.1977	0.1939
Onchocerca volvulus		0.0285	0.1977	0.6333
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0048	0.0118	0.0071
Echinococcus multilocularis	g protein coupled receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	amine GPCR	0.0285	0.1977	0.6714
Echinococcus multilocularis	tubulin subunit beta	0.0361	0.257	0.2534
Echinococcus multilocularis	allatostatin A receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	hypothetical protein	0.0115	0.0644	0.2074
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Leishmania major	beta tubulin	0.0361	0.257	1
Plasmodium vivax	tubulin beta chain, putative	0.0361	0.257	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0285	0.1977	0.6714
Schistosoma mansoni	myosin xvIII	0.0285	0.1977	0.6714
Schistosoma mansoni	neuropeptide F-like receptor	0.0285	0.1977	0.6714
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0285	0.1977	0.6714
Echinococcus granulosus	neuropeptide s receptor	0.0285	0.1977	0.1939
Echinococcus granulosus	tubulin subunit beta	0.0361	0.257	0.2534
Echinococcus multilocularis	alpha 2 macroglobulin	0.0124	0.0715	0.067
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0048	0.0118	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	GPCR family 2	0.0047	0.0106	0.0059
Echinococcus multilocularis	integrin beta 2	0.051	0.3743	0.3713
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	tubulin subunit beta	0.0361	0.257	0.8776
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0106	0.0059
Leishmania major	beta tubulin	0.0361	0.257	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0285	0.1977	0.6714
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0285	0.1977	0.6714
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Onchocerca volvulus		0.0285	0.1977	0.6333
Onchocerca volvulus		0.0203	0.1336	0.417
Loa Loa (eye worm)	BEN-1 protein	0.0361	0.257	0.5868
Loa Loa (eye worm)	G-protein coupled receptor	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0147	0.0897	0.2049
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Entamoeba histolytica	tubulin family protein	0.0361	0.257	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0048	0.0118	0.027
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0285	0.1977	0.1939
Toxoplasma gondii	beta-tubulin, putative	0.0361	0.257	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0147	0.0897	0.2049
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0285	0.1977	0.1939
Echinococcus granulosus	allatostatin A receptor	0.0285	0.1977	0.1939
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0048	0.0118	0.0071
Schistosoma mansoni	tubulin subunit beta	0.0361	0.257	0.8776
Brugia malayi	Dopamine receptor protein 2	0.0285	0.1977	0.4515
Brugia malayi	AKH receptor	0.0285	0.1977	0.4515
Echinococcus granulosus	G protein coupled receptor 139	0.0285	0.1977	0.1939
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0285	0.1977	0.1939
Brugia malayi	putative neuropeptide receptor	0.0285	0.1977	0.4515
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Loa Loa (eye worm)	A-macroglobulin complement component family protein	0.0124	0.0715	0.1632
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Trichomonas vaginalis	alpha-amylase, putative	0.0095	0.0483	0.1724
Echinococcus granulosus	sex peptide receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Onchocerca volvulus	Putative nachr subunit	0.0048	0.0118	0.0058
Brugia malayi	neuropeptide F receptor	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	putative neuropeptide receptor NPR1	0.0285	0.1977	0.4515
Brugia malayi	G-protein coupled receptor	0.0285	0.1977	0.4515
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0285	0.1977	0.1939
Trichomonas vaginalis	starch branching enzyme II, putative	0.0047	0.011	0.0247
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0048	0.0118	0.0071
Schistosoma mansoni	amine GPCR	0.0285	0.1977	0.6714
Onchocerca volvulus	Adenylate cyclase type 3 homolog	0.0424	0.3064	1
Onchocerca volvulus		0.0048	0.0118	0.0058
Echinococcus granulosus	Tubulin beta 2C chain	0.0361	0.257	0.2534
Schistosoma mansoni	neuropeptide F-like receptor	0.0285	0.1977	0.6714
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0147	0.0897	0.2049
Brugia malayi	complement component C3-like protein	0.0046	0.0101	0.0231
Brugia malayi	Endoplasmin precursor	0.0039	0.0048	0.0109
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0285	0.1977	0.1939
Brugia malayi	Angiotensin-converting enzyme family protein	0.0163	0.1019	0.2326
Brugia malayi	A-macroglobulin complement component family protein	0.0124	0.0715	0.1632
Toxoplasma gondii	beta tubulin	0.0361	0.257	1
Onchocerca volvulus		0.0285	0.1977	0.6333
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0561	0.128
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0106	0.0242
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0048	0.0118	0.0071
Onchocerca volvulus		0.0285	0.1977	0.6333
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0048	0.0118	0.0071
Trichomonas vaginalis	tubulin gamma chain, putative	0.0361	0.257	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0048	0.0118	0.0071
Loa Loa (eye worm)	ACC-1 protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	tubulin beta chain	0.0361	0.257	0.5868
Loa Loa (eye worm)	LGC-31 protein	0.0048	0.0118	0.027
Brugia malayi	1,4-alpha-glucan branching enzyme	0.0047	0.011	0.0251
Brugia malayi	G protein-coupled receptor F59B2.13	0.0285	0.1977	0.4515
Loa Loa (eye worm)	BEN-1 protein	0.0361	0.257	0.5868
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0574	0.2086
Schistosoma mansoni	tubulin subunit beta	0.0361	0.257	0.8776
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0285	0.1977	0.4515
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0285	0.1977	0.4515
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0048	0.0118	0.0245
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0048	0.0118	0.0071
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0285	0.1977	0.6714
Schistosoma mansoni	amine GPCR	0.0285	0.1977	0.6714
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0285	0.1977	0.4515
Toxoplasma gondii	glycosyltransferase	0.0047	0.011	0.0247
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0048	0.0118	0.027
Giardia lamblia	1,4-alpha-glucan branching enzyme	0.0047	0.011	0.0247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Onchocerca volvulus		0.0285	0.1977	0.6333
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Schistosoma mansoni	nAChR subunit	0.0048	0.0118	0.0245
Onchocerca volvulus		0.0285	0.1977	0.6333
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0285	0.1977	0.6714
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0183	0.0419
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Schistosoma mansoni	netrin	0.0048	0.0119	0.0249
Echinococcus multilocularis	Tubulin beta 2C chain	0.0361	0.257	0.2534
Schistosoma mansoni	growth hormone secretagogue receptor	0.0285	0.1977	0.6714
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0048	0.0118	0.0071
Giardia lamblia	Beta tubulin	0.0361	0.257	1
Brugia malayi	heat shock protein 90	0.0039	0.0048	0.0109
Chlamydia trachomatis	1,4-alpha-glucan branching enzyme	0.0047	0.011	0.5
Schistosoma mansoni	hypothetical protein	0.0101	0.0531	0.1682
Echinococcus granulosus	integrin beta 2	0.051	0.3743	0.3713
Echinococcus multilocularis	neuropeptide receptor A26	0.0285	0.1977	0.1939
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Leishmania major	beta tubulin	0.0361	0.257	1
Onchocerca volvulus		0.0285	0.1977	0.6333
Entamoeba histolytica	alpha-amylase family protein	0.0106	0.0574	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0048	0.0118	0.027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Echinococcus multilocularis	adenylate cyclase 9	0.0153	0.0939	0.0896
Echinococcus granulosus	g-protein coupled receptor	0.0285	0.1977	0.1939
Leishmania major	beta tubulin	0.0361	0.257	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	Serotonin receptor	0.0285	0.1977	0.4515
Schistosoma mansoni	tubulin subunit beta	0.0361	0.257	0.8776
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0361	0.257	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0163	0.1019	0.2326
Giardia lamblia	Beta tubulin	0.0361	0.257	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0285	0.1977	0.1939
Schistosoma mansoni	opsin-like receptor	0.0285	0.1977	0.6714
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Onchocerca volvulus		0.0048	0.0118	0.0058
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0048	0.0118	0.027
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0285	0.1977	0.6714
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0285	0.1977	0.1939
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0285	0.1977	0.6714
Echinococcus multilocularis	Tubulin beta 2C chain	0.0361	0.257	0.2534
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0048	0.0118	0.027
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0285	0.1977	0.1939
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0048	0.0118	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0285	0.1977	0.1939
Echinococcus granulosus	biogenic amine 5HT receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	nAChR subunit	0.0048	0.0118	0.0245
Brugia malayi	ORL1-like opioid receptor	0.0285	0.1977	0.4515
Echinococcus granulosus	fmrfamide receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0119	0.0273
Schistosoma mansoni	nAChR subunit	0.0048	0.0118	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	neuropeptide Y receptor	0.0285	0.1977	0.1939
Echinococcus multilocularis	beta tubulin	0.0361	0.257	0.2534
Trichomonas vaginalis	amylase, putative	0.0106	0.0574	0.2086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Brugia malayi	Tubulin beta-1 chain	0.0361	0.257	0.5868
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	Cation transporter family protein	0.0048	0.0118	0.027
Onchocerca volvulus		0.0048	0.0119	0.0062
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0048	0.0118	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	melatonin receptor type 1A	0.0285	0.1977	0.4515
Schistosoma mansoni	hypothetical protein	0.0047	0.0106	0.0203
Schistosoma mansoni	biogenic amine receptor	0.0285	0.1977	0.6714
Echinococcus multilocularis	g protein coupled receptor	0.0285	0.1977	0.1939
Toxoplasma gondii	alpha amylase, catalytic domain-containing protein	0.0047	0.011	0.0247
Onchocerca volvulus		0.0285	0.1977	0.6333
Schistosoma mansoni	adenoreceptor	0.0285	0.1977	0.6714
Schistosoma mansoni	nAChR subunit	0.0048	0.0118	0.0245
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0048	0.0118	0.027
Brugia malayi	GnHR receptor homolog	0.0285	0.1977	0.4515
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Leishmania major	beta tubulin	0.0361	0.257	1
Trichomonas vaginalis	amylase, putative	0.0047	0.011	0.0247
Onchocerca volvulus		0.0285	0.1977	0.6333
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0285	0.1977	0.1939
Echinococcus multilocularis	glucan (1,4 alpha), branching enzyme 1	0.0047	0.011	0.0063
Loa Loa (eye worm)	neuropeptide F receptor	0.0285	0.1977	0.4515
Loa Loa (eye worm)	heat shock protein 90	0.0039	0.0048	0.0109
Echinococcus granulosus	Tubulin beta 2C chain	0.0361	0.257	0.2534
Echinococcus granulosus	hypothetical protein	0.0285	0.1977	0.1939
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0048	0.0118	0.027
Leishmania major	beta tubulin	0.0361	0.257	1
Brugia malayi	Cation transporter family protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0101	0.0231
Loa Loa (eye worm)	adenylyl cyclase 3	0.0153	0.0939	0.2144
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0285	0.1977	0.1939
Echinococcus multilocularis	netrin 1	0.0048	0.0119	0.0072
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0048	0.0118	0.027
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0285	0.1977	0.1939
Echinococcus multilocularis	Tubulin beta 2C chain	0.0361	0.257	0.2534
Leishmania major	beta tubulin	0.0361	0.257	1
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0105	0.0561	0.128
Onchocerca volvulus		0.0153	0.0939	0.2829
Leishmania major	beta tubulin	0.0361	0.257	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0361	0.257	1
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0574	0.2086
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0048	0.0118	0.0071
Echinococcus granulosus	glycine receptor subunit beta	0.0048	0.0118	0.0071
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0048	0.0118	0.027
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0574	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0048	0.0118	0.0245
Brugia malayi	Integrin beta pat-3 precursor	0.0591	0.4379	1
Trypanosoma brucei	beta tubulin	0.0361	0.257	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0285	0.1977	0.6714
Echinococcus granulosus	glucan 14 alpha branching enzyme 1	0.0047	0.011	0.0063
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0048	0.0118	0.027
Schistosoma mansoni	hypothetical protein	0.0047	0.0106	0.0203
Echinococcus granulosus	biogenic amine 5HT receptor	0.0285	0.1977	0.1939
Onchocerca volvulus		0.0285	0.1977	0.6333
Echinococcus multilocularis	beta tubulin	0.0361	0.257	0.2534
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0285	0.1977	0.1939
Echinococcus multilocularis	neuropeptides capa receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Leishmania major	beta tubulin	0.0361	0.257	1
Echinococcus granulosus	glycine receptor subunit beta	0.0048	0.0118	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Echinococcus granulosus	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0285	0.1977	0.6714
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0285	0.1977	0.1939
Echinococcus granulosus	netrin 1	0.0048	0.0119	0.0072
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0048	0.0118	0.0071
Trypanosoma cruzi	beta tubulin, putative	0.0361	0.257	1
Trichomonas vaginalis	amylase, putative	0.0106	0.0574	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0417	0.3013	0.6879
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0048	0.0118	0.027
Trichomonas vaginalis	tubulin beta chain, putative	0.0361	0.257	1
Onchocerca volvulus		0.0285	0.1977	0.6333
Loa Loa (eye worm)	tubulin beta-4 chain	0.0361	0.257	0.5868
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0048	0.0118	0.027
Leishmania major	beta tubulin	0.0361	0.257	1
Echinococcus multilocularis	neuropeptide s receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0285	0.1977	0.6714
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Brugia malayi	excitatory GABA receptor EXP-1A	0.0048	0.0118	0.027
Schistosoma mansoni	hypothetical protein	0.0047	0.0106	0.0203
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0939	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Trichomonas vaginalis	tubulin, putative	0.0361	0.257	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0386	0.277	0.2736
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0285	0.1977	0.6714
Brugia malayi	Dopamine receptor protein 1	0.0285	0.1977	0.4515
Loa Loa (eye worm)	endoplasmin	0.0039	0.0048	0.0109
Onchocerca volvulus		0.0146	0.0888	0.2657
Schistosoma mansoni	opsin-like receptor	0.0285	0.1977	0.6714
Schistosoma mansoni	hypothetical protein	0.0285	0.1977	0.6714
Echinococcus granulosus	Tubulin beta 2C chain	0.0361	0.257	0.2534
Schistosoma mansoni	opsin-like receptor	0.0285	0.1977	0.6714
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0048	0.0118	0.0071
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0285	0.1977	0.4515
Onchocerca volvulus	Adenylate cyclase type 2 homolog	0.0153	0.0939	0.2829
Schistosoma mansoni	nAChR subunit	0.0048	0.0118	0.0245
Brugia malayi	follicle stimulating hormone receptor	0.0285	0.1977	0.4515
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0285	0.1977	0.1939
Loa Loa (eye worm)	beta-tubulin	0.0361	0.257	0.5868
Echinococcus multilocularis	cd109 antigen	0.0115	0.0644	0.0599
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0106	0.0059
Brugia malayi	Adenylyl cyclase protein	0.0153	0.0939	0.2144
Echinococcus granulosus	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Onchocerca volvulus		0.0285	0.1977	0.6333
Loa Loa (eye worm)	tubulin beta-1 chain	0.0361	0.257	0.5868
Echinococcus multilocularis	serotonin receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Mycobacterium ulcerans	glycogen branching protein	0.0047	0.011	0.5
Brugia malayi	G-protein coupled receptor	0.0285	0.1977	0.4515
Echinococcus granulosus	neuropeptide FF receptor 2	0.0285	0.1977	0.1939
Onchocerca volvulus		0.0285	0.1977	0.6333
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0106	0.0059
Leishmania major	beta tubulin	0.0361	0.257	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0048	0.0118	0.027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Brugia malayi	latrophilin 2 splice variant baaae	0.0101	0.0531	0.1212
Entamoeba histolytica	1,4-alpha-glucan branching enzyme, putative	0.0047	0.011	0.0247
Leishmania major	beta tubulin	0.0361	0.257	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0101	0.0231
Trypanosoma brucei	beta tubulin	0.0361	0.257	1
Echinococcus granulosus	sodium channel protein	0.028	0.194	0.1902
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0048	0.0118	0.027
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0897	0.2049
Echinococcus granulosus	g protein coupled receptor	0.0285	0.1977	0.1939
Echinococcus multilocularis	neuropeptides capa receptor	0.0285	0.1977	0.1939
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Trichomonas vaginalis	tubulin alpha chain, putative	0.0361	0.257	1
Leishmania major	beta tubulin	0.0361	0.257	1
Onchocerca volvulus		0.0285	0.1977	0.6333
Echinococcus multilocularis	neuropeptide Y receptor	0.0285	0.1977	0.1939
Echinococcus multilocularis	glycine receptor subunit beta	0.0048	0.0118	0.0071
Entamoeba histolytica	tubulin family protein	0.0361	0.257	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.028	0.194	0.1902
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Echinococcus granulosus	neuropeptides capa receptor	0.0285	0.1977	0.1939
Brugia malayi	beta-tubulin, identical	0.0361	0.257	0.5868
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Echinococcus multilocularis	neuropeptide receptor	0.0386	0.277	0.2736
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0048	0.0118	0.027
Brugia malayi	Kelch motif family protein	0.0105	0.0561	0.128
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0048	0.0118	0.0071
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0285	0.1977	0.6714
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0048	0.0118	0.0245
Echinococcus multilocularis	somatostatin receptor	0.0285	0.1977	0.1939
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0048	0.0118	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3623	0.8273
Schistosoma mansoni	hypothetical protein	0.0285	0.1977	0.6714
Echinococcus multilocularis	serotonin receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	neuropeptide receptor	0.0285	0.1977	0.6714
Echinococcus multilocularis	Tubulin beta 2C chain	0.0361	0.257	0.2534
Echinococcus multilocularis	sex peptide receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0106	0.0059
Echinococcus multilocularis	fmrfamide receptor	0.0285	0.1977	0.1939
Onchocerca volvulus		0.0048	0.0118	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	hypothetical protein	0.0047	0.0106	0.0203
Echinococcus granulosus	7TM GPCR rhodopsin	0.0285	0.1977	0.1939
Loa Loa (eye worm)	TYRA-2 protein	0.0285	0.1977	0.4515
Leishmania major	beta tubulin	0.0361	0.257	1
Echinococcus multilocularis	orexin receptor type 2	0.0285	0.1977	0.1939
Echinococcus multilocularis	tubulin beta 1 chain	0.0361	0.257	0.2534
Onchocerca volvulus		0.0057	0.0183	0.0278
Toxoplasma gondii	1,4-alpha-glucan-branching enzyme	0.0047	0.011	0.0247
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0285	0.1977	0.4515
Leishmania major	beta tubulin	0.0361	0.257	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0285	0.1977	0.6714
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0285	0.1977	0.4515
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0048	0.0118	0.0071
Echinococcus granulosus	neuropeptide receptor A26	0.0285	0.1977	0.1939
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0285	0.1977	0.4515
Echinococcus granulosus	cd109 antigen	0.0115	0.0644	0.0599
Echinococcus granulosus	nAChR subunit	0.0048	0.0118	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0285	0.1977	0.6714
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0106	0.0059
Brugia malayi	hypothetical protein	0.0105	0.0561	0.128
Schistosoma mansoni	tubulin subunit beta	0.0361	0.257	0.8776
Plasmodium falciparum	tubulin beta chain	0.0361	0.257	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	hypothetical protein	0.0285	0.1977	0.6714
Schistosoma mansoni	amine GPCR	0.0285	0.1977	0.6714
Leishmania major	beta tubulin	0.0361	0.257	1
Brugia malayi	Serotonin receptor	0.0285	0.1977	0.4515
Leishmania major	beta tubulin	0.0361	0.257	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0285	0.1977	0.1939
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0285	0.1977	0.1939
Onchocerca volvulus		0.0048	0.0118	0.0058
Onchocerca volvulus		0.0048	0.0118	0.0058
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0048	0.0118	0.027
Echinococcus multilocularis	neuropeptide receptor	0.0285	0.1977	0.1939
Schistosoma mansoni	neuropeptide receptor	0.0285	0.1977	0.6714
Mycobacterium tuberculosis	1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme)	0.0047	0.011	0.5
Schistosoma mansoni	histamine h1 receptor	0.0285	0.1977	0.6714
Loa Loa (eye worm)	integrin beta-2	0.0591	0.4379	1
Onchocerca volvulus		0.0285	0.1977	0.6333
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0048	0.0118	0.0245
Onchocerca volvulus		0.0285	0.1977	0.6333
Schistosoma mansoni	starch branching enzyme II	0.0047	0.011	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0048	0.0118	0.0245
Echinococcus multilocularis	fmrfamide receptor	0.0285	0.1977	0.1939
Brugia malayi	Cation transporter family protein	0.0048	0.0118	0.027
Schistosoma mansoni	biogenic amine receptor	0.0285	0.1977	0.6714
Echinococcus granulosus	tubulin beta 1 chain	0.0361	0.257	0.2534
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0361	0.257	0.2534
Trypanosoma brucei	beta tubulin	0.0361	0.257	1
Echinococcus granulosus	neuropeptide Y receptor	0.0285	0.1977	0.1939
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0048	0.0118	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Schistosoma mansoni	integrin beta subunit	0.0405	0.2922	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Echinococcus multilocularis	g protein coupled receptor	0.0285	0.1977	0.1939
Trypanosoma brucei	beta tubulin	0.0361	0.257	1
Schistosoma mansoni	nAChR subunit	0.0048	0.0118	0.0245
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0106	0.0242
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0285	0.1977	0.1939
Echinococcus granulosus	tubulin beta 4A class IVa	0.0361	0.257	0.2534
Toxoplasma gondii	beta-1 tubulin, putative	0.0361	0.257	1
Brugia malayi	hypothetical protein	0.0495	0.3623	0.8273
Leishmania major	beta tubulin	0.0361	0.257	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	neuropeptide receptor	0.0386	0.277	0.9473
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0285	0.1977	0.1939
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0285	0.1977	0.6714
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0285	0.1977	0.4515
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0285	0.1977	0.6333
Echinococcus granulosus	neuropeptides capa receptor	0.0285	0.1977	0.1939
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0048	0.0118	0.0071
Brugia malayi	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	hypothetical protein	0.0285	0.1977	0.6714
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1307	1	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Echinococcus granulosus	neuropeptide receptor	0.0285	0.1977	0.1939
Echinococcus granulosus	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Echinococcus multilocularis	Tubulin beta 2C chain	0.0361	0.257	0.2534
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0048	0.0118	0.0071
Brugia malayi	Unc-6 protein precursor	0.0048	0.0119	0.0273
Echinococcus granulosus	g protein coupled receptor	0.0285	0.1977	0.1939
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.028	0.194	0.7504
Schistosoma mansoni	amine GPCR	0.0285	0.1977	0.6714
Schistosoma mansoni	nAChR subunit	0.0048	0.0118	0.0245
Echinococcus granulosus	orexin receptor type 2	0.0285	0.1977	0.1939
Echinococcus multilocularis	nAChR subunit	0.0048	0.0118	0.0071
Echinococcus granulosus	beta tubulin	0.0361	0.257	0.2534
Entamoeba histolytica	alpha-amylase family protein	0.0106	0.0574	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0285	0.1977	0.4515
Schistosoma mansoni	netrin	0.0048	0.0119	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0118	0.027
Giardia lamblia	Beta tubulin	0.0361	0.257	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0048	0.0118	0.027
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0285	0.1977	0.6714
Onchocerca volvulus		0.0285	0.1977	0.6333
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0285	0.1977	0.1939
Schistosoma mansoni	neuropeptide f receptor 76f	0.0285	0.1977	0.6714
Schistosoma mansoni	tubulin subunit beta	0.0361	0.257	0.8776
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0048	0.0118	0.027
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0285	0.1977	0.6333
Echinococcus granulosus	somatostatin receptor	0.0285	0.1977	0.1939

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.09 uM	Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation	ChEMBL.	17488003
IC50 (binding)	= 0.09 uM	Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation	ChEMBL.	17488003
IC50 (functional)	= 0.1 uM	Antiproliferative activity against human BT474 cells by MTS assay	ChEMBL.	17488003
IC50 (functional)	= 0.1 uM	Antiproliferative activity against human BT474 cells by MTS assay	ChEMBL.	17488003
IC50 (binding)	= 0.15 uM	Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding	ChEMBL.	17488003
IC50 (binding)	= 0.15 uM	Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding	ChEMBL.	17488003
IC50 (functional)	= 0.5 uM	Antiproliferative activity against human MCF7 cells by MTS assay	ChEMBL.	17488003
IC50 (functional)	= 0.5 uM	Antiproliferative activity against human MCF7 cells by MTS assay	ChEMBL.	17488003
IC50 (binding)	= 0.9 uM	Binding affinity to human recombinant HSP90 assessed as inhibition of biotinylated-geldanamycin binding	ChEMBL.	17488003
IC50 (binding)	= 0.9 uM	Binding affinity to human recombinant HSP90 assessed as inhibition of biotinylated-geldanamycin binding	ChEMBL.	17488003

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17488003

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 426329