Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.0054 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1241 | 0.1671 |
Echinococcus multilocularis | heat shock protein | 0.0028 | 0.0116 | 0.0097 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0.0054 | 0.0037 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0081 | 0.0937 | 0.1256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0151 | 0.2004 | 0.2147 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0054 | 0.0037 |
Echinococcus multilocularis | smad | 0.0034 | 0.0214 | 0.0196 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0034 | 0.0214 | 0.0196 |
Trichomonas vaginalis | heat shock protein, putative | 0.0024 | 0.0055 | 0.0204 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.003 | 0.0147 | 0.0139 |
Echinococcus multilocularis | heat shock protein 90 | 0.0024 | 0.0055 | 0.0036 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0076 | 0.085 | 0.0837 |
Loa Loa (eye worm) | TAR-binding protein | 0.0151 | 0.2004 | 0.2716 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.003 | 0.0147 | 0.0175 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0028 | 0.0116 | 0.0767 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0076 | 0.085 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0172 | 0.2325 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0937 | 0.1256 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0076 | 0.085 | 0.0898 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0028 | 0.0116 | 0.0767 |
Brugia malayi | hypothetical protein | 0.0153 | 0.2039 | 0.2763 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Echinococcus granulosus | heat shock protein 90 | 0.0028 | 0.0116 | 0.0104 |
Brugia malayi | ecdysteroid receptor | 0.0024 | 0.0054 | 0.0047 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0054 | 0.0035 |
Trichomonas vaginalis | heat shock protein, putative | 0.0028 | 0.0116 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0483 | 0.0634 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.003 | 0.0147 | 0.0139 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0034 | 0.0214 | 0.0266 |
Onchocerca volvulus | Huntingtin homolog | 0.0101 | 0.1241 | 0.4582 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0.0054 | 0.0035 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0.0054 | 0.0037 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.009 | 0.0334 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0233 | 0.0292 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0034 | 0.0214 | 0.0196 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 0.0054 | 0.0047 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.0054 | 0.0047 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0483 | 0.0634 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0.0054 | 0.0035 |
Echinococcus multilocularis | geminin | 0.0626 | 0.9266 | 0.9328 |
Echinococcus granulosus | geminin | 0.0626 | 0.9266 | 1 |
Brugia malayi | Endoplasmin precursor | 0.0028 | 0.0116 | 0.0132 |
Echinococcus multilocularis | heat shock protein 90 | 0.0028 | 0.0116 | 0.0097 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0076 | 0.085 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0054 | 0.0035 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0.0054 | 0.0037 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0.0054 | 0.0037 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0076 | 0.085 | 0.1136 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Echinococcus granulosus | smad | 0.0034 | 0.0214 | 0.021 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0076 | 0.085 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.003 | 0.0147 | 0.0175 |
Onchocerca volvulus | 0.0031 | 0.0172 | 0.0573 | |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 0.0054 | 0.0047 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 0.0054 | 0.0047 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0172 | 0.2322 | 0.315 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0071 | 0.0056 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0034 | 0.0214 | 0.021 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0208 | 0.0204 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0054 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0071 | 0.007 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 0.0054 | 0.0047 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0025 | 0.0071 | 0.0056 |
Schistosoma mansoni | heat shock protein | 0.0028 | 0.0116 | 0.0104 |
Onchocerca volvulus | 0.0025 | 0.0071 | 0.0193 | |
Echinococcus granulosus | heat shock protein | 0.0028 | 0.0116 | 0.0104 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0025 | 0.0071 | 0.0056 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0233 | 0.0292 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0076 | 0.085 | 0.6374 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0347 | 0.0449 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0028 | 0.0116 | 0.0767 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0.0054 | 0.0129 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0214 | 0.0266 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0172 | 0.2325 | 0.2326 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 0.0054 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.0054 | 0.0047 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0116 | 0.147 | 0.1464 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0035 | 0.0227 | 0.0225 |
Entamoeba histolytica | hypothetical protein | 0.0172 | 0.2325 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.038 | 0.0494 |
Treponema pallidum | heat shock protein 90 | 0.0026 | 0.009 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0.0054 | 0.0035 |
Brugia malayi | hypothetical protein | 0.0101 | 0.1241 | 0.1671 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0081 | 0.0937 | 0.0992 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0081 | 0.0937 | 0.0926 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0214 | 0.021 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0026 | 0.009 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0757 | 0.1009 |
Echinococcus granulosus | Smad4 | 0.0034 | 0.0214 | 0.021 |
Schistosoma mansoni | smad | 0.0034 | 0.0214 | 0.021 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.0054 | 0.0037 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0025 | 0.0071 | 0.0052 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 0.0054 | 0.0047 |
Onchocerca volvulus | 0.0195 | 0.2685 | 1 | |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.003 | 0.0147 | 0.0139 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.0054 | 0.0035 |
Loa Loa (eye worm) | RNA binding protein | 0.0151 | 0.2004 | 0.2716 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0.0054 | 0.0129 |
Onchocerca volvulus | Huntingtin homolog | 0.0101 | 0.1241 | 0.4582 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.0054 | 0.0037 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.2325 | 0.2494 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.003 | 0.0147 | 0.0139 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.0054 | 0.0047 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0025 | 0.0071 | 0.0052 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0214 | 0.021 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 0.0054 | 0.0047 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0.0054 | 0.0035 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0069 | 0.0757 | 0.5856 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0208 | 0.0204 |
Echinococcus granulosus | tar DNA binding protein | 0.0151 | 0.2004 | 0.2147 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0082 | 0.0956 | 0.1013 |
Echinococcus multilocularis | protein dispatched 1 | 0.004 | 0.0303 | 0.0286 |
Giardia lamblia | Grp94/Hsp90 | 0.0026 | 0.009 | 0.5748 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0.0054 | 0.0037 |
Plasmodium vivax | heat shock protein 86, putative | 0.0028 | 0.0116 | 0.0367 |
Brugia malayi | Isocitrate dehydrogenase | 0.0076 | 0.085 | 0.1136 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0076 | 0.085 | 0.6374 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.003 | 0.0147 | 0.0129 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0151 | 0.2004 | 0.2716 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0.0054 | 0.0037 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0104 | 0.1292 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0208 | 0.0204 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.0673 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0076 | 0.085 | 0.6573 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0214 | 0.021 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | survival motor neuron protein | 0.0031 | 0.0172 | 0.0165 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0035 | 0.0227 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0483 | 0.0634 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0034 | 0.0214 | 0.021 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0.0054 | 0.0037 |
Plasmodium vivax | endoplasmin, putative | 0.0028 | 0.0116 | 0.0367 |
Schistosoma mansoni | tar DNA-binding protein | 0.0151 | 0.2004 | 0.2147 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1241 | 0.1671 |
Loa Loa (eye worm) | Smad1 | 0.0034 | 0.0214 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0626 | 0.9266 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0.0054 | 0.0129 |
Trichomonas vaginalis | set domain proteins, putative | 0.0195 | 0.2685 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.3331 | 0.3582 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0172 | 0.2325 | 0.2494 |
Brugia malayi | Smad1 | 0.0034 | 0.0214 | 0.0266 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0076 | 0.085 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0069 | 0.0757 | 0.5616 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0.0054 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2039 | 0.2763 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0069 | 0.0757 | 0.5616 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0669 | 0.9932 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0499 | 0.7328 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0076 | 0.085 | 0.0837 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0069 | 0.0757 | 0.5856 |
Plasmodium vivax | heat shock protein, putative | 0.0104 | 0.1292 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0054 | 0.0037 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0214 | 0.0266 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0153 | 0.2039 | 0.2184 |
Schistosoma mansoni | tar DNA-binding protein | 0.0151 | 0.2004 | 0.2147 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0.0054 | 0.0037 |
Echinococcus granulosus | endoplasmin | 0.0026 | 0.009 | 0.0076 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0076 | 0.085 | 0.0837 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 0.0054 | 0.0047 |
Echinococcus granulosus | X box binding protein 1 | 0.0238 | 0.3331 | 0.3582 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0.0054 | 0.0035 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0071 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0028 | 0.0116 | 1 |
Brugia malayi | TAR-binding protein | 0.0151 | 0.2004 | 0.2716 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0076 | 0.085 | 0.6374 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.0054 | 0.0047 |
Entamoeba histolytica | hypothetical protein | 0.0172 | 0.2325 | 1 |
Schistosoma mansoni | Smad4 | 0.0034 | 0.0214 | 0.021 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0028 | 0.0116 | 0.0767 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0076 | 0.085 | 0.0837 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0.0054 | 0.0037 |
Schistosoma mansoni | patched 1 | 0.0035 | 0.0227 | 0.0225 |
Echinococcus multilocularis | endoplasmin | 0.0026 | 0.009 | 0.0071 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0499 | 0.7328 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0626 | 0.9266 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0.0054 | 0.0037 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0076 | 0.085 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0069 | 0.0757 | 0.8781 |
Echinococcus granulosus | heat shock protein 90 | 0.0024 | 0.0055 | 0.0038 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.003 | 0.0147 | 0.0129 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.0054 | 0.0037 |
Schistosoma mansoni | endoplasmin | 0.0028 | 0.0116 | 0.0104 |
Echinococcus multilocularis | X box binding protein 1 | 0.0238 | 0.3331 | 0.3341 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.0054 | 0.0037 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0076 | 0.085 | 0.0898 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0233 | 0.0231 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 0.0054 | 0.0047 |
Brugia malayi | hypothetical protein | 0.0172 | 0.2325 | 0.3156 |
Echinococcus multilocularis | tar DNA binding protein | 0.0151 | 0.2004 | 0.2003 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0.0054 | 0.0037 |
Entamoeba histolytica | hypothetical protein | 0.0172 | 0.2325 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0214 | 0.0266 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0153 | 0.2039 | 0.2037 |
Echinococcus multilocularis | expressed conserved protein | 0.0076 | 0.0862 | 0.085 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 0.0054 | 0.0047 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0028 | 0.0116 | 0.0767 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0024 | 0.0055 | 0.0038 |
Echinococcus multilocularis | protein patched | 0.0035 | 0.0227 | 0.021 |
Brugia malayi | Pre-SET motif family protein | 0.0025 | 0.0071 | 0.007 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0076 | 0.085 | 0.0837 |
Brugia malayi | CHE-14 protein | 0.0035 | 0.0227 | 0.0285 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 0.0054 | 0.0047 |
Echinococcus granulosus | expressed conserved protein | 0.0076 | 0.0862 | 0.0911 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0069 | 0.0757 | 0.8738 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0034 | 0.0214 | 0.0266 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0.0054 | 0.0035 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0116 | 0.147 | 0.1569 |
Mycobacterium ulcerans | proteasome PrcA | 0.0673 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Schistosoma mansoni | endoplasmin | 0.0028 | 0.0116 | 0.0104 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0028 | 0.0116 | 0.0367 |
Brugia malayi | isocitrate dehydrogenase | 0.0076 | 0.085 | 0.1136 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0028 | 0.0116 | 0.0367 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0076 | 0.085 | 0.0767 |
Brugia malayi | RNA binding protein | 0.0151 | 0.2004 | 0.2716 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 0.0054 | 0.0047 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0035 | 0.0227 | 0.0225 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0034 | 0.0214 | 0.021 |
Schistosoma mansoni | tar DNA-binding protein | 0.0151 | 0.2004 | 0.2147 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0031 | 0.0172 | 0.0209 |
Loa Loa (eye worm) | endoplasmin | 0.0028 | 0.0116 | 0.0132 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0.0054 | 0.0037 |
Plasmodium falciparum | heat shock protein 90 | 0.0028 | 0.0116 | 0.0895 |
Schistosoma mansoni | tar DNA-binding protein | 0.0151 | 0.2004 | 0.2147 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0031 | 0.0171 | 0.0153 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0214 | 0.0266 |
Brugia malayi | heat shock protein 90 | 0.0028 | 0.0116 | 0.0132 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.003 | 0.0147 | 0.0139 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.009 | 0.0334 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0151 | 0.2004 | 0.2716 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0025 | 0.0071 | 0.0056 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0.0054 | 0.0037 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0081 | 0.0937 | 0.3716 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0499 | 0.7328 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0208 | 0.0204 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0172 | 0.0165 |
Schistosoma mansoni | heat shock protein | 0.0028 | 0.0116 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0227 | 0.0285 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 0.0054 | 0.0047 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0031 | 0.0171 | 0.0164 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0171 | 0.0164 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0.0054 | 0.0037 |
Onchocerca volvulus | 0.0024 | 0.0054 | 0.0129 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 0.0054 | 0.0047 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0104 | 0.1292 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0069 | 0.0757 | 0.8834 |
Brugia malayi | Pre-SET motif family protein | 0.0172 | 0.2322 | 0.315 |
Brugia malayi | steroid hormone receptor | 0.0024 | 0.0054 | 0.0047 |
Leishmania major | heat shock protein 83-1 | 0.0028 | 0.0116 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0172 | 0.2325 | 0.2494 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0024 | 0.0057 | 0.0041 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0054 | 0.0047 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0757 | 0.1009 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0028 | 0.0116 | 0.0132 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0483 | 0.0634 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0069 | 0.0757 | 0.8834 |
Echinococcus multilocularis | Smad4 | 0.0034 | 0.0214 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0054 | 0.0047 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0035 | 0.0227 | 0.021 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0227 | 0.0847 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 486.4 uM | Cytotoxicity against Vero cells after 48 hrs | ChEMBL. | 17045364 |
IC50 (functional) | = 22.6 uM | Antiviral activity against Rubella virus strain THERIEN in Vero cells | ChEMBL. | 17045364 |
Inhibition (functional) | = 95.3 % | Inhibition of Rubella virus strain THERIEN in Vero cells after 48 hrs of high multiplicity infection by plaque assay | ChEMBL. | 17045364 |
Ratio CC50/IC50 (functional) | = 21.6 | Selectivity index, Ratio of CC50 for Vero cells to IC50 for Rubella virus strain THERIEN | ChEMBL. | 17045364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.