Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0025 | 0.0079 | 0.0293 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0163 | 0.2059 | 0.2073 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.1778 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0025 | 0.0083 | 0.0125 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0025 | 0.0079 | 0.008 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0029 | 0.0141 | 0.2264 |
Loa Loa (eye worm) | RNA binding protein | 0.0161 | 0.2025 | 0.3716 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0029 | 0.0141 | 0.0794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0161 | 0.2025 | 0.3071 |
Brugia malayi | Isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.1145 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0025 | 0.0079 | 0.0146 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0025 | 0.0079 | 0.0146 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0033 | 0.0198 | 0.0362 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0027 | 0.0111 | 0.0168 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.0628 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0163 | 0.2059 | 0.3123 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0029 | 0.0141 | 1 |
Echinococcus granulosus | endoplasmin | 0.0028 | 0.0115 | 0.0175 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0025 | 0.008 | 0.1289 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0063 | 0.0624 | 0.0628 |
Schistosoma mansoni | survival motor neuron protein | 0.0033 | 0.0198 | 0.03 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0027 | 0.0111 | 0.0168 |
Schistosoma mansoni | Smad4 | 0.0027 | 0.0111 | 0.0168 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0399 | 0.545 | 1 |
Echinococcus granulosus | geminin | 0.0479 | 0.6594 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0383 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0027 | 0.0111 | 0.0203 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 0.3349 | 0.5078 |
Echinococcus granulosus | heat shock protein 90 | 0.0025 | 0.008 | 0.0122 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.0628 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0037 | 0.0253 | 0.0254 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.0946 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0046 | 0.0383 | 0.6139 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0111 | 0.1315 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0025 | 0.008 | 0.1289 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0173 | 0.0262 |
Schistosoma mansoni | tar DNA-binding protein | 0.0161 | 0.2025 | 0.3071 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0143 | 0.1778 | 0.2696 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0025 | 0.0079 | 0.0146 |
Echinococcus granulosus | smad | 0.0027 | 0.0111 | 0.0168 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0063 | 0.0624 | 0.0514 |
Schistosoma mansoni | thyroid hormone receptor | 0.0025 | 0.0079 | 0.012 |
Echinococcus granulosus | X box binding protein 1 | 0.0253 | 0.3349 | 0.5078 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0026 | 0.0096 | 0.0146 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0026 | 0.0096 | 0.0097 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0025 | 0.0079 | 0.0146 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.1778 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0063 | 0.0624 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0025 | 0.0079 | 0.012 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0026 | 0.0096 | 0.0733 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.1778 | 1 |
Brugia malayi | hypothetical protein | 0.0108 | 0.1263 | 0.2318 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0032 | 0.0173 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0479 | 0.6594 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Onchocerca volvulus | 0.0208 | 0.2704 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Echinococcus multilocularis | X box binding protein 1 | 0.0253 | 0.3349 | 0.3371 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0183 | 0.2341 | 0.4296 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0063 | 0.0624 | 0.4639 |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0025 | 0.0079 | 0.0146 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0046 | 0.0383 | 0.2912 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0046 | 0.0383 | 0.277 |
Schistosoma mansoni | tar DNA-binding protein | 0.0161 | 0.2025 | 0.3071 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0712 | 0.9932 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0399 | 0.545 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0183 | 0.2341 | 0.4296 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0025 | 0.0079 | 0.012 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0029 | 0.0141 | 0.1074 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0025 | 0.0079 | 0.012 |
Brugia malayi | hypothetical protein | 0.0163 | 0.2059 | 0.3778 |
Brugia malayi | nuclear hormone receptor | 0.0025 | 0.0079 | 0.0146 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0025 | 0.0079 | 0.012 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0046 | 0.0383 | 0.277 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0032 | 0.0173 | 0.0317 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0383 | 0.0703 |
Echinococcus multilocularis | protein dispatched 1 | 0.0042 | 0.0328 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0025 | 0.0079 | 0.012 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0233 | 0.0354 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0018 | 0.0027 |
Echinococcus multilocularis | protein patched | 0.0037 | 0.0253 | 0.0254 |
Brugia malayi | MH1 domain containing protein | 0.0027 | 0.0111 | 0.0203 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0029 | 0.0141 | 0.2264 |
Brugia malayi | hypothetical protein | 0.0143 | 0.1778 | 0.3261 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0025 | 0.0079 | 0.012 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0026 | 0.0096 | 0.0146 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0025 | 0.0079 | 0.0146 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0025 | 0.0079 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.096 | 0.1762 |
Schistosoma mansoni | heat shock protein | 0.0029 | 0.0141 | 0.0214 |
Brugia malayi | MH2 domain containing protein | 0.0399 | 0.545 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0025 | 0.0079 | 0.0146 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0029 | 0.0141 | 0.2264 |
Schistosoma mansoni | endoplasmin | 0.0029 | 0.0141 | 0.0214 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0198 | 0.03 |
Schistosoma mansoni | endoplasmin | 0.0029 | 0.0141 | 0.0214 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0025 | 0.0079 | 0.012 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0025 | 0.0079 | 0.008 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Plasmodium vivax | heat shock protein, putative | 0.0111 | 0.1315 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0046 | 0.0383 | 0.6139 |
Brugia malayi | hypothetical protein | 0.003 | 0.0148 | 0.0272 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0143 | 0.1778 | 0.2696 |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0025 | 0.0079 | 0.012 |
Brugia malayi | Smad1 | 0.0027 | 0.0111 | 0.0203 |
Echinococcus granulosus | tar DNA binding protein | 0.0161 | 0.2025 | 0.3071 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0029 | 0.0141 | 0.0259 |
Plasmodium falciparum | heat shock protein 90 | 0.0029 | 0.0141 | 0.0895 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0233 | 0.0354 |
Schistosoma mansoni | nuclear hormone receptor | 0.0025 | 0.0079 | 0.012 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.4744 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0046 | 0.0383 | 0.2912 |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0124 | 0.1492 | 0.2263 |
Plasmodium vivax | SET domain protein, putative | 0.0026 | 0.0096 | 0.0733 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.0717 | 1 | 1 |
Echinococcus multilocularis | smad | 0.0027 | 0.0111 | 0.0112 |
Giardia lamblia | Grp94/Hsp90 | 0.0028 | 0.0115 | 0.5748 |
Echinococcus multilocularis | heat shock protein 90 | 0.0029 | 0.0141 | 0.0142 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.0628 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0029 | 0.0141 | 0.1074 |
Brugia malayi | isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.1145 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0025 | 0.0079 | 0.012 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.1778 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0037 | 0.0253 | 0.0383 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0173 | 0.0262 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0063 | 0.0624 | 0.4744 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0025 | 0.0079 | 0.012 |
Echinococcus multilocularis | tar DNA binding protein | 0.0161 | 0.2025 | 0.2039 |
Schistosoma mansoni | smad | 0.0027 | 0.0111 | 0.0168 |
Schistosoma mansoni | thyroid hormone receptor | 0.0025 | 0.0079 | 0.012 |
Trichomonas vaginalis | heat shock protein, putative | 0.0029 | 0.0141 | 0.0431 |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0025 | 0.0079 | 0.0293 |
Schistosoma mansoni | smad1 5 8 and | 0.0027 | 0.0111 | 0.0168 |
Onchocerca volvulus | 0.0026 | 0.0096 | 0.0357 | |
Echinococcus granulosus | Smad4 | 0.0027 | 0.0111 | 0.0168 |
Plasmodium vivax | heat shock protein 86, putative | 0.0029 | 0.0141 | 0.1074 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0096 | 0.0177 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0027 | 0.0111 | 0.0112 |
Schistosoma mansoni | smad1 5 8 and | 0.0027 | 0.0111 | 0.0168 |
Onchocerca volvulus | 0.0033 | 0.0198 | 0.0731 | |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0025 | 0.0079 | 0.012 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0025 | 0.008 | 0.0122 |
Schistosoma mansoni | patched 1 | 0.0037 | 0.0253 | 0.0383 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0025 | 0.0079 | 0.0146 |
Schistosoma mansoni | hypothetical protein | 0.0479 | 0.6594 | 1 |
Echinococcus multilocularis | geminin | 0.0479 | 0.6594 | 0.6639 |
Trichomonas vaginalis | heat shock protein, putative | 0.0028 | 0.0115 | 0.0334 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.0628 |
Brugia malayi | Pre-SET motif family protein | 0.0026 | 0.0096 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0025 | 0.0079 | 0.0146 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0025 | 0.0079 | 0.0293 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0025 | 0.0079 | 0.0146 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0063 | 0.0624 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0025 | 0.0079 | 0.012 |
Echinococcus multilocularis | endoplasmin | 0.0028 | 0.0115 | 0.0116 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0063 | 0.0624 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0063 | 0.0624 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0028 | 0.0115 | 0.1849 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0086 | 0.096 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.2059 | 0.3778 |
Schistosoma mansoni | tar DNA-binding protein | 0.0161 | 0.2025 | 0.3071 |
Brugia malayi | Endoplasmin precursor | 0.0029 | 0.0141 | 0.0259 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Brugia malayi | ecdysteroid receptor | 0.0025 | 0.0079 | 0.0146 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0025 | 0.0079 | 0.0146 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0372 | 0.0683 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0029 | 0.0141 | 0.2264 |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1263 | 0.2318 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0027 | 0.0111 | 0.0168 |
Schistosoma mansoni | heat shock protein | 0.0029 | 0.0141 | 0.0214 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0025 | 0.0079 | 0.008 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0025 | 0.0079 | 0.0146 |
Echinococcus granulosus | FTZ F1 alpha | 0.0025 | 0.0079 | 0.012 |
Onchocerca volvulus | Huntingtin homolog | 0.0108 | 0.1263 | 0.4673 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0086 | 0.096 | 0.1456 |
Schistosoma mansoni | coup transcription factor | 0.0025 | 0.0079 | 0.012 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0025 | 0.0079 | 0.0146 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0143 | 0.1778 | 0.179 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0029 | 0.0141 | 0.2264 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0032 | 0.0173 | 0.0262 |
Echinococcus multilocularis | heat shock protein 90 | 0.0025 | 0.008 | 0.0081 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0025 | 0.0079 | 0.008 |
Echinococcus multilocularis | expressed conserved protein | 0.0081 | 0.0885 | 0.0891 |
Brugia malayi | TAR-binding protein | 0.0161 | 0.2025 | 0.3716 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Trichomonas vaginalis | heat shock protein, putative | 0.0028 | 0.0115 | 0.0334 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0063 | 0.0624 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.4744 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0029 | 0.0141 | 0.2264 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.1778 | 0.2696 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0111 | 0.1315 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0025 | 0.0079 | 0.008 |
Echinococcus granulosus | heat shock protein 90 | 0.0029 | 0.0141 | 0.0214 |
Mycobacterium ulcerans | proteasome PrcA | 0.0717 | 1 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0027 | 0.0111 | 0.0203 |
Trypanosoma brucei | heat shock protein, putative | 0.0029 | 0.0141 | 0.2264 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0063 | 0.0624 | 0.0946 |
Leishmania major | heat shock protein 83-1 | 0.0029 | 0.0141 | 0.2264 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0025 | 0.0079 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0233 | 0.0354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0037 | 0.0253 | 0.0463 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0025 | 0.0079 | 0.0146 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0032 | 0.0173 | 0.0174 |
Treponema pallidum | heat shock protein 90 | 0.0028 | 0.0115 | 0.5 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0027 | 0.0111 | 0.0112 |
Brugia malayi | heat shock protein 90 | 0.0029 | 0.0141 | 0.0259 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0026 | 0.0096 | 0.0097 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0027 | 0.0111 | 0.0203 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0025 | 0.0079 | 0.012 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0032 | 0.0173 | 0.0317 |
Plasmodium vivax | endoplasmin, putative | 0.0029 | 0.0141 | 0.1074 |
Brugia malayi | steroid hormone receptor | 0.0025 | 0.0079 | 0.0146 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0026 | 0.0096 | 0.0146 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0021 | 0.0018 | 0.0018 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0046 | 0.0383 | 0.6139 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0032 | 0.0173 | 0.0174 |
Loa Loa (eye worm) | TAR-binding protein | 0.0161 | 0.2025 | 0.3716 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0088 | 0.098 | 0.1485 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0021 | 0.0018 | 0.0027 |
Brugia malayi | CHE-14 protein | 0.0037 | 0.0253 | 0.0463 |
Brugia malayi | nuclear receptor NHR-88 | 0.0025 | 0.0079 | 0.0146 |
Brugia malayi | MH2 domain containing protein | 0.0027 | 0.0111 | 0.0203 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0253 | 0.0847 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0161 | 0.2025 | 0.3716 |
Brugia malayi | MH2 domain containing protein | 0.0027 | 0.0111 | 0.0203 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0025 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1263 | 0.2318 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0086 | 0.096 | 0.5403 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0086 | 0.096 | 0.1762 |
Echinococcus granulosus | heat shock protein | 0.0029 | 0.0141 | 0.0214 |
Schistosoma mansoni | smad1 5 8 and | 0.0027 | 0.0111 | 0.0168 |
Leishmania major | hypothetical protein, conserved | 0.0046 | 0.0383 | 0.6139 |
Loa Loa (eye worm) | endoplasmin | 0.0029 | 0.0141 | 0.0259 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0173 | 0.0262 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0026 | 0.0096 | 0.0146 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0025 | 0.0079 | 0.012 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0025 | 0.0079 | 0.008 |
Trichomonas vaginalis | set domain proteins, putative | 0.0208 | 0.2704 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0027 | 0.0111 | 0.0203 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0029 | 0.0141 | 0.2264 |
Onchocerca volvulus | 0.0025 | 0.0079 | 0.0293 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0161 | 0.2025 | 0.3716 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0025 | 0.0079 | 0.008 |
Trichomonas vaginalis | heat shock protein, putative | 0.0025 | 0.008 | 0.0204 |
Onchocerca volvulus | Huntingtin homolog | 0.0108 | 0.1263 | 0.4673 |
Echinococcus multilocularis | heat shock protein | 0.0029 | 0.0141 | 0.0142 |
Brugia malayi | RNA binding protein | 0.0161 | 0.2025 | 0.3716 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0029 | 0.0141 | 0.2264 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0025 | 0.0079 | 0.008 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0026 | 0.0096 | 0.0146 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0025 | 0.0079 | 0.012 |
Echinococcus multilocularis | Smad4 | 0.0027 | 0.0111 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0233 | 0.0354 |
Echinococcus granulosus | expressed conserved protein | 0.0081 | 0.0885 | 0.1342 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0253 | 0.0463 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0025 | 0.0079 | 0.0146 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0028 | 0.0115 | 0.5 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0029 | 0.0141 | 0.0794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0161 | 0.2025 | 0.3071 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0025 | 0.0079 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0079 | 0.0146 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0025 | 0.0079 | 0.0146 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0124 | 0.1492 | 0.1503 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0037 | 0.0253 | 0.0383 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0025 | 0.0079 | 0.0146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 715.9 uM | Cytotoxicity against Vero cells after 48 hrs | ChEMBL. | 17045364 |
IC50 (functional) | = 34.1 uM | Antiviral activity against Rubella virus strain THERIEN in Vero cells | ChEMBL. | 17045364 |
Inhibition (functional) | = 97.3 % | Inhibition of Rubella virus strain THERIEN in Vero cells after 48 hrs of high multiplicity infection by plaque assay | ChEMBL. | 17045364 |
Ratio CC50/IC50 (functional) | = 21 | Selectivity index, Ratio of CC50 for Vero cells to IC50 for Rubella virus strain THERIEN | ChEMBL. | 17045364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.