Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | endoplasmin, putative | 0.0046 | 0.0465 | 0.1074 |
Treponema pallidum | heat shock protein 90 | 0.0043 | 0.038 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0075 | 0.1346 | 0.2969 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.3459 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0039 | 0.0265 | 0.1968 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0174 | 0.4332 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0064 | 0.1002 | 0.7445 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0046 | 0.0465 | 0.3456 |
Echinococcus multilocularis | endoplasmin | 0.0043 | 0.038 | 0.0412 |
Trichomonas vaginalis | heat shock protein, putative | 0.0039 | 0.0265 | 0.4732 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Giardia lamblia | Grp94/Hsp90 | 0.0043 | 0.038 | 0.5748 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0363 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.4888 | 0.5295 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0075 | 0.1346 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0046 | 0.0465 | 0.3456 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0046 | 0.0465 | 0.1345 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0145 | 0.3459 | 0.3746 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0046 | 0.0465 | 0.1074 |
Brugia malayi | hypothetical protein | 0.0075 | 0.1346 | 0.1346 |
Brugia malayi | Endoplasmin precursor | 0.0046 | 0.0465 | 0.0465 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0046 | 0.0465 | 0.1074 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0034 | 0.0096 | 0.0104 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0034 | 0.0096 | 0.0104 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1002 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0075 | 0.1346 | 0.2969 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1086 |
Trichomonas vaginalis | heat shock protein, putative | 0.0043 | 0.038 | 0.776 |
Echinococcus granulosus | tar DNA binding protein | 0.0193 | 0.4888 | 0.5295 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.9231 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.4888 | 0.5295 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0075 | 0.1346 | 0.3108 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0046 | 0.0465 | 0.3456 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0039 | 0.0265 | 0.0287 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0064 | 0.1002 | 0.7445 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0046 | 0.0465 | 0.3456 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0543 | 0.0543 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0145 | 0.3459 | 0.3746 |
Echinococcus granulosus | heat shock protein 90 | 0.0039 | 0.0265 | 0.0287 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0043 | 0.038 | 0.5 |
Echinococcus multilocularis | heat shock protein 90 | 0.0039 | 0.0265 | 0.0287 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0075 | 0.1346 | 1 |
Brugia malayi | TAR-binding protein | 0.0193 | 0.4888 | 0.4888 |
Brugia malayi | isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1002 |
Schistosoma mansoni | heat shock protein | 0.0046 | 0.0465 | 0.0504 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0046 | 0.0465 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0039 | 0.0265 | 0.1968 |
Echinococcus multilocularis | geminin | 0.0337 | 0.9231 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0046 | 0.0465 | 0.0504 |
Brugia malayi | hypothetical protein | 0.0145 | 0.3459 | 0.3459 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.3459 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0046 | 0.0465 | 0.0465 |
Plasmodium falciparum | heat shock protein 90 | 0.0046 | 0.0465 | 0.0895 |
Loa Loa (eye worm) | TAR-binding protein | 0.0193 | 0.4888 | 0.4888 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0145 | 0.3459 | 0.3746 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0193 | 0.4888 | 0.4888 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.9231 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0046 | 0.0465 | 0.3456 |
Echinococcus multilocularis | heat shock protein 90 | 0.0046 | 0.0465 | 0.0504 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1086 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0064 | 0.1002 | 0.1086 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Brugia malayi | heat shock protein 90 | 0.0046 | 0.0465 | 0.0465 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0075 | 0.1346 | 1 |
Echinococcus granulosus | endoplasmin | 0.0043 | 0.038 | 0.0412 |
Schistosoma mansoni | heat shock protein | 0.0046 | 0.0465 | 0.0504 |
Schistosoma mansoni | endoplasmin | 0.0046 | 0.0465 | 0.0504 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0046 | 0.0465 | 0.3456 |
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.1346 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0043 | 0.038 | 0.2823 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0046 | 0.0465 | 0.0465 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0075 | 0.1346 | 0.3108 |
Schistosoma mansoni | endoplasmin | 0.0046 | 0.0465 | 0.0504 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0064 | 0.1002 | 0.2159 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0064 | 0.1002 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0046 | 0.0465 | 0.3456 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.2314 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0046 | 0.0465 | 0.1345 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.2314 |
Echinococcus granulosus | geminin | 0.0337 | 0.9231 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0064 | 0.1002 | 0.2314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.4888 | 0.5295 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Loa Loa (eye worm) | RNA binding protein | 0.0193 | 0.4888 | 0.4888 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.3459 | 0.3746 |
Trichomonas vaginalis | heat shock protein, putative | 0.0043 | 0.038 | 0.776 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1086 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.3459 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.3459 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1086 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0043 | 0.038 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0064 | 0.1002 | 0.7445 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0043 | 0.038 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Plasmodium vivax | heat shock protein, putative | 0.0174 | 0.4332 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0046 | 0.0465 | 0.1074 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0096 | 0.0104 |
Echinococcus multilocularis | tar DNA binding protein | 0.0193 | 0.4888 | 0.5295 |
Brugia malayi | Isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1346 | 0.1346 |
Trypanosoma brucei | heat shock protein, putative | 0.0046 | 0.0465 | 0.3456 |
Brugia malayi | RNA binding protein | 0.0193 | 0.4888 | 0.4888 |
Echinococcus multilocularis | heat shock protein | 0.0046 | 0.0465 | 0.0504 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1086 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0193 | 0.4888 | 0.4888 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0174 | 0.4332 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0363 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0064 | 0.1002 | 0.7445 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0046 | 0.0465 | 0.3456 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0064 | 0.1002 | 0.1086 |
Echinococcus granulosus | heat shock protein | 0.0046 | 0.0465 | 0.0504 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0064 | 0.1002 | 0.7445 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.4888 | 0.5295 |
Schistosoma mansoni | tar DNA-binding protein | 0.0193 | 0.4888 | 0.5295 |
Leishmania major | heat shock protein 83-1 | 0.0046 | 0.0465 | 0.3456 |
Trichomonas vaginalis | heat shock protein, putative | 0.0046 | 0.0465 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | NA 0 mg kg-1 | Anticonvulsant activity in mice using MES seizure test;Compound is neurotoxic at 30 mg/kg dose. | ChEMBL. | 6620301 |
ED50 (functional) | NA 0 mg kg-1 | Anticonvulsant activity in mice using sc Met seizure test;Compound is neurotoxic at 5 mg/kg. | ChEMBL. | 6620301 |
TD50 (ADMET) | = 1 mg kg-1 | Anticonvulsant activity expressed as toxic dose in rotorod test (0.5 hr) in mice | ChEMBL. | 6620301 |
TD50 (ADMET) | = 1 mg kg-1 | Anticonvulsant activity expressed as toxic dose in rotorod test (0.5 hr) in mice | ChEMBL. | 6620301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.