Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin D | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | cathepsin D | 412 aa | 339 aa | 28.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | plasmepsin I | 0.0059 | 0.2435 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.948 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.3387 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0182 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.3387 | 0.3387 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.3387 | 0.3387 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.3387 | 1 |
Brugia malayi | RNA binding protein | 0.0075 | 0.3387 | 0.3387 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3387 | 0.3573 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0.2435 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0.2435 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0.2435 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.948 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3387 | 0.3573 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.3387 | 0.3387 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3387 | 0.3573 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.3387 | 0.3387 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2435 | 0.2435 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0059 | 0.2435 | 0.7188 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0059 | 0.2435 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0059 | 0.2435 | 0.7188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3387 | 0.3573 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0059 | 0.2435 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0059 | 0.2435 | 0.2435 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3387 | 0.3573 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0.2435 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.3387 | 0.3387 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0059 | 0.2435 | 0.2568 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0.2435 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0.2435 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.