Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fatty acid desaturase, putative | 0.0086 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0085 | 0.9602 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0086 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0085 | 0.9602 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0085 | 0.9602 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0068 | 0.1008 | 0.1049 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0085 | 0.9602 | 0.5 |
Onchocerca volvulus | 0.0086 | 1 | 1 | |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0085 | 0.9602 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0085 | 0.9602 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0085 | 0.9602 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0085 | 0.9602 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0085 | 0.9602 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.9602 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0085 | 0.9602 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0068 | 0.1008 | 0.1049 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0085 | 0.9602 | 0.5 |
Onchocerca volvulus | 0.0086 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9602 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0086 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0085 | 0.9602 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.9602 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0085 | 0.9602 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0085 | 0.9602 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0085 | 0.9602 | 0.9602 |
Treponema pallidum | adenosine deaminase | 0.0085 | 0.9602 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 35 nM | Inhibition of human recombinant SCD1 expressed in S6 cells | ChEMBL. | 17530838 |
IC50 (binding) | < 40 nM | Inhibition of SCD1 in ob/ob mouse liver microsome | ChEMBL. | 17530838 |
IC50 (binding) | < 40 nM | Inhibition of SCD1 in ob/ob mouse liver microsome | ChEMBL. | 17530838 |
Stabilty (ADMET) | = 0.6 % | Metabolic stability in Sprague-Dawley rat liver microsome | ChEMBL. | 17530838 |
Stabilty (ADMET) | = 1.2 % | Metabolic stability in ob/ob mouse liver microsome | ChEMBL. | 17530838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.