TDR Targets

Basic information

Technical information

TDR Targets ID: 427269
Name: (3E)-3-[(1-benzyl-2-chloro-5-methoxy-6-methyl indol-3-yl)methylidene]-1H-benzo[g]indol-2-on e
MW: 478.969 | Formula: C30H23ClN2O2
H donors: 1 H acceptors: 1 LogP: 7.12 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(C=C3C(=O)Nc4c3ccc3c4cccc3)c(n(c2cc1C)Cc1ccccc1)Cl
InChi: 1S/C30H23ClN2O2/c1-18-14-26-23(16-27(18)35-2)24(29(31)33(26)17-19-8-4-3-5-9-19)15-25-22-13-12-20-10-6-7-11-21(20)28(22)32-30(25)34/h3-16H,17H2,1-2H3,(H,32,34)/b25-15+
InChiKey: ANRDSSUOHJPZAR-MFKUBSTISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3E)-3-[(1-benzyl-2-chloro-5-methoxy-6-methyl-indol-3-yl)methylene]-1H-benzo[g]indol-2-one
(3E)-3-[(1-benzyl-2-chloro-5-methoxy-6-methyl-3-indolyl)methylene]-1H-benzo[g]indol-2-one
(3E)-3-[[2-chloro-5-methoxy-6-methyl-1-(phenylmethyl)indol-3-yl]methylidene]-1H-benzo[g]indol-2-one
(3E)-3-[[2-chloro-5-methoxy-6-methyl-1-(phenylmethyl)indol-3-yl]methylene]-1H-benzo[g]indol-2-one
(3E)-3-[[2-chloro-5-methoxy-6-methyl-1-(phenylmethyl)-3-indolyl]methylene]-1H-benzo[g]indol-2-one
(3E)-3-[[1-(benzyl)-2-chloro-5-methoxy-6-methyl-indol-3-yl]methylene]-1H-benzo[g]indol-2-one
NSC734204

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	protein kinase c epsilon type	0.0511	0.6892	0.6892
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0117	0.0414	0.0512
Schistosoma mansoni	chromatin regulatory protein sir2	0.0228	0.223	0.223
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0717	0.0887
Entamoeba histolytica	protein kinase, putative	0.0102	0.0154	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Echinococcus granulosus	cyclin B	0.0105	0.0201	0.0201
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0105	0.0201	0.0275
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0395	0.4979	0.4979
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0167	0.1232	0.1232
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Brugia malayi	Hr1 repeat family protein	0.0169	0.1261	0.1723
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0228	0.223	1
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0105	0.0201	0.0902
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0117	0.0414	0.0414
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0228	0.223	0.223
Leishmania major	silent information regulator 2, putative	0.0228	0.223	1
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0169	0.1261	0.1261
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0124	0.0519	0.0519
Trypanosoma brucei	protein kinase, putative	0.0102	0.0154	0.0689
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0117	0.0414	0.0414
Entamoeba histolytica	protein kinase, putative	0.0169	0.1261	0.5656
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Schistosoma mansoni	protein kinase	0.0382	0.4771	0.4771
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0167	0.1232	0.1682
Schistosoma mansoni	serine/threonine protein kinase	0.0124	0.0519	0.0519
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0169	0.1261	0.1261
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0228	0.223	1
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0228	0.223	0.3045
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0117	0.0414	0.0414
Trichomonas vaginalis	cyclin B, putative	0.0105	0.0201	0.0902
Entamoeba histolytica	hypothetical protein	0.0117	0.0414	0.1856
Brugia malayi	protein kinase C II.	0.0511	0.6892	0.9412
Entamoeba histolytica	cyclin, putative	0.0105	0.0201	0.0902
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0331	0.3926	0.5362
Schistosoma mansoni	rac gtpase activating protein	0.0117	0.0414	0.0414
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0117	0.0414	0.0512
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0169	0.1261	0.156
Echinococcus granulosus	NDR protein kinase	0.0169	0.1261	0.1261
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Schistosoma mansoni	cyclin B	0.0105	0.0201	0.0201
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0169	0.1261	0.1261
Loa Loa (eye worm)	transcriptional regulator	0.0228	0.223	0.2758
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0395	0.4979	0.6159
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0375	0.4653	0.4653
Brugia malayi	Ras association domain family 1 isoform A	0.0117	0.0414	0.0565
Entamoeba histolytica	protein kinase, putative	0.0169	0.1261	0.5656
Schistosoma mansoni	serine/threonine protein kinase	0.0117	0.0414	0.0414
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0169	0.1261	0.156
Loa Loa (eye worm)	hypothetical protein	0.0583	0.8084	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0117	0.0414	0.0414
Giardia lamblia	G2/mitotic-specific cyclin B	0.0105	0.0201	0.0902
Schistosoma mansoni	hypothetical protein	0.0117	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0532	0.7237	0.8952
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0105	0.0201	0.0902
Trichomonas vaginalis	cyclins, putative	0.0105	0.0201	0.0902
Echinococcus granulosus	RNA directed DNA polymerase	0.0395	0.4979	0.4979
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0167	0.1232	0.1232
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0169	0.1261	0.156
Schistosoma mansoni	protein kinase	0.0382	0.4771	0.4771
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0102	0.0154	0.0154
Brugia malayi	Protein kinase domain containing protein	0.0124	0.0519	0.0708
Brugia malayi	Pleckstrin Homology Domain	0.0117	0.0414	0.0565
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0382	0.4771	0.4771
Schistosoma mansoni	serine/threonine protein kinase	0.0169	0.1261	0.1261
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0228	0.223	1
Brugia malayi	Protein kinase c protein 2	0.0537	0.7322	1
Onchocerca volvulus		0.0117	0.0414	0.0506
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0228	0.223	1
Trichomonas vaginalis	cyclin A, putative	0.0105	0.0201	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Schistosoma mansoni	protein kinase C mu	0.0117	0.0414	0.0414
Brugia malayi	protein kinase C3,putative	0.0346	0.4172	0.5698
Echinococcus granulosus	protein kinase c iota type	0.0508	0.685	0.685
Schistosoma mansoni	serine/threonine protein kinase	0.0124	0.0519	0.0519
Onchocerca volvulus		0.0414	0.5302	1
Schistosoma mansoni	cyclin B3	0.0167	0.1232	0.1232
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0169	0.1261	0.156
Schistosoma mansoni	chromatin regulatory protein sir2	0.0228	0.223	0.223
Trypanosoma brucei	mitotic cyclin 6	0.0105	0.0201	0.0902
Brugia malayi	diacylglycerol kinase	0.0117	0.0414	0.0565
Echinococcus multilocularis	myotubularin protein 13	0.0117	0.0414	0.0414
Brugia malayi	Protein kinase domain containing protein	0.0169	0.1261	0.1723
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0228	0.223	0.223
Schistosoma mansoni	protein kinase C mu	0.0124	0.0519	0.0519
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0228	0.223	1
Brugia malayi	RhoGAP domain containing protein	0.0117	0.0414	0.0565
Trypanosoma cruzi	cyclin 6, putative	0.0105	0.0201	0.0902
Entamoeba histolytica	protein kinase domain containing protein	0.0102	0.0154	0.0689
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0102	0.0154	0.1217
Brugia malayi	Protein kinase domain containing protein	0.0169	0.1261	0.1723
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0102	0.0154	0.0689
Schistosoma mansoni	chromatin regulatory protein sir2	0.0228	0.223	0.223
Echinococcus multilocularis	unc 13 (munc13)	0.0136	0.0717	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0169	0.1261	0.1261
Echinococcus granulosus	unc 13 munc13	0.0136	0.0717	0.0717
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0117	0.0414	0.0414
Entamoeba histolytica	protein kinase, putative	0.0169	0.1261	0.5656
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0117	0.0414	0.0414
Echinococcus multilocularis	serine threonine protein kinase	0.0582	0.8065	0.8065
Brugia malayi	intracellular kinase	0.0102	0.0154	0.021
Giardia lamblia	Kinase, CMGC GSK	0.0102	0.0154	0.0689
Echinococcus granulosus	protein kinase shaggy	0.0102	0.0154	0.0154
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0117	0.0414	0.0414
Leishmania major	cyclin	0.0105	0.0201	0.0902
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0382	0.4771	0.4771
Echinococcus granulosus	Rac GTPase activating protein 1	0.0117	0.0414	0.0414
Schistosoma mansoni	serine/threonine protein kinase	0.0169	0.1261	0.1261
Trichomonas vaginalis	cyclins, putative	0.0105	0.0201	0.0902
Trypanosoma cruzi	cyclin, putative	0.0105	0.0201	0.0902
Echinococcus granulosus	Diacylglycerol kinase theta	0.0117	0.0414	0.0414
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Brugia malayi	Variant SH3 domain containing protein	0.0117	0.0414	0.0565
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0117	0.0414	0.0512
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0169	0.1261	0.1261
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0331	0.3926	0.4857
Toxoplasma gondii	AGC kinase	0.0169	0.1261	1
Echinococcus granulosus	chromatin regulatory protein sir2	0.0228	0.223	0.223
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0511	0.6892	0.8525
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0124	0.0519	0.0708
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0228	0.223	0.223
Brugia malayi	C1-like domain containing protein	0.0124	0.0519	0.0708
Brugia malayi	diacylglycerol kinase	0.0117	0.0414	0.0565
Echinococcus granulosus	protein kinase C gamma type	0.0582	0.8065	0.8065
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0102	0.0154	0.0154
Brugia malayi	RhoGEF domain containing protein	0.0117	0.0414	0.0565
Onchocerca volvulus		0.0136	0.0717	0.1095
Giardia lamblia	Kinase, CMGC GSK	0.0102	0.0154	0.0689
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0102	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0512	0.6914	0.8553
Echinococcus multilocularis	protein kinase c iota type	0.0508	0.685	0.685
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0102	0.0154	0.0154
Onchocerca volvulus		0.0105	0.0201	0.0092
Echinococcus granulosus	serine:threonine protein kinase N2	0.0169	0.1261	0.1261
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Schistosoma mansoni	unc-13 (munc13)	0.0136	0.0717	0.0717
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0169	0.1261	0.1261
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0362	0.4441	0.5493
Echinococcus granulosus	protein kinase c eta type	0.0117	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0201	0.0249
Onchocerca volvulus		0.0117	0.0414	0.0506
Giardia lamblia	Hypothetical protein	0.0228	0.223	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0169	0.1261	0.156
Schistosoma mansoni	protein kinase C	0.0136	0.0717	0.0717
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Schistosoma mansoni	unc-13 (munc13)	0.0136	0.0717	0.0717
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Toxoplasma gondii	diacylglycerol kinase, putative	0.0117	0.0414	0.3282
Trypanosoma cruzi	cyclin, putative	0.0105	0.0201	0.0902
Schistosoma mansoni	diacylglycerol kinase theta	0.0117	0.0414	0.0414
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0419	0.5387	0.6664
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0169	0.1261	0.1261
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0169	0.1261	0.156
Trichomonas vaginalis	cyclin B, putative	0.0105	0.0201	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0102	0.0154	0.019
Loa Loa (eye worm)	hypothetical protein	0.0414	0.5302	0.6558
Loa Loa (eye worm)	cyclin domain-containing protein	0.0167	0.1232	0.1524
Echinococcus multilocularis	protein kinase c eta type	0.0117	0.0414	0.0414
Plasmodium falciparum	glycogen synthase kinase 3	0.0102	0.0154	1
Echinococcus multilocularis	cyclin B	0.0105	0.0201	0.0201
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0169	0.1261	0.5656
Echinococcus granulosus	myotubularin protein 13	0.0117	0.0414	0.0414
Brugia malayi	Protein kinase domain containing protein	0.0169	0.1261	0.1723
Trichomonas vaginalis	cyclin B, putative	0.0105	0.0201	0.0902
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0163	0.1157	0.5187
Trichomonas vaginalis	AGC family protein kinase	0.0169	0.1261	0.5656
Schistosoma mansoni	serine/threonine protein kinase	0.0699	1	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Schistosoma mansoni	serine/threonine protein kinase	0.0169	0.1261	0.1261
Entamoeba histolytica	diacylglycerol kinase, putative	0.0117	0.0414	0.1856
Loa Loa (eye worm)	hypothetical protein	0.0414	0.5302	0.6558
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0105	0.0201	0.0275
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0228	0.223	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0117	0.0414	0.1856
Echinococcus multilocularis	protein kinase c epsilon type	0.0511	0.6892	0.6892
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0201	0.0249
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0136	0.0717	0.0717
Trichomonas vaginalis	CMGC family protein kinase	0.0102	0.0154	0.0689
Schistosoma mansoni	protein kinase	0.0382	0.4771	0.4771
Echinococcus multilocularis	RNA directed DNA polymerase	0.0395	0.4979	0.4979
Schistosoma mansoni	diacylglycerol kinase theta	0.0117	0.0414	0.0414
Entamoeba histolytica	protein kinase domain containing protein	0.0102	0.0154	0.0689
Schistosoma mansoni	vav2	0.0117	0.0414	0.0414
Echinococcus granulosus	serine:threonine protein kinase N2	0.0212	0.1976	0.1976
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0102	0.0154	0.0689
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0102	0.0154	0.019
Trichomonas vaginalis	CMGC family protein kinase	0.0102	0.0154	0.0689
Echinococcus multilocularis	protein kinase shaggy	0.0102	0.0154	0.0154
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0117	0.0414	0.0414
Trichomonas vaginalis	cyclin B, putative	0.0105	0.0201	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0414	0.0512
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0169	0.1261	0.156
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0136	0.0717	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0414	0.5302	0.6558
Schistosoma mansoni	serine/threonine kinase	0.0169	0.1261	0.1261
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0228	0.223	1
Schistosoma mansoni	serine/threonine protein kinase	0.0511	0.6892	0.6892
Schistosoma mansoni	atypical protein kinase C	0.0524	0.7118	0.7118
Echinococcus multilocularis	N chimaerin	0.0117	0.0414	0.0414
Trichomonas vaginalis	cyclins, putative	0.0105	0.0201	0.0902
Schistosoma mansoni	serine/threonine protein kinase	0.0169	0.1261	0.1261
Echinococcus granulosus	N chimaerin	0.0117	0.0414	0.0414
Entamoeba histolytica	protein kinase, putative	0.0169	0.1261	0.5656
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0117	0.0414	0.0512
Loa Loa (eye worm)	raf kinase	0.0117	0.0414	0.0512
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0212	0.1976	0.886
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0124	0.0519	0.0519
Schistosoma mansoni	serine/threonine protein kinase	0.0699	1	1
Trichomonas vaginalis	cyclins, putative	0.0105	0.0201	0.0902
Brugia malayi	p70 ribosomal S6 kinase beta	0.0169	0.1261	0.1723
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0169	0.1261	0.1261
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0124	0.0519	0.0642
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0699	1	1
Brugia malayi	RhoGAP domain containing protein	0.0117	0.0414	0.0565

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 482177
PubChem: 16738511

Bibliographic References

No literature references available for this target.

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Detailed information for compound 427269