Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | < 0.4 uM | compound was tested for antiherpes activity against HCMV(AD 169) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 0.8 uM | compound was tested for antiherpes activity against MCMV(Smith) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 2 uM | compound was tested for antiherpes activity against HSV-1(Schooler) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 2 uM | compound was tested for antiherpes activity against HSV-2(186) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
ID50 (functional) | = 2 uM | compound was tested for antiherpes activity against VZV(Ellen) in tissue culture by plaque reduction assay | ChEMBL. | 1849998 |
Mean day of death for total dead (functional) | = 3.6 | Mean day of death for total no. of dead mouse at 25 mg/kg/day dose | ChEMBL. | 1849998 |
Mean day of death for total dead (functional) | = 3.9 | Mean day of death for total no. of dead mouse at 12.5 mg/kg/day dose | ChEMBL. | 1849998 |
Mean day of death for total dead (functional) | = 4.4 | Mean day of death for total no. of dead mouse at 6.3 mg/kg/day dose | ChEMBL. | 1849998 |
Mean day of death for total dead (functional) | = 6.3 | Mean day of death for total no. of dead mouse at 50 mg/kg/day dose | ChEMBL. | 1849998 |
Mean day of death for total dead (functional) | = 8.8 | Mean day of death for total no. of dead mouse at 12.5 mg/kg/day dosep<0.05 | ChEMBL. | 1849998 |
PD50 (functional) | = 9 mg kg-1 day-1 | subcutaneous efficacy of compound in a lethal MCMV infection on mouse | ChEMBL. | 1849998 |
PD50 (functional) | = 9 mg kg-1 day-1 | subcutaneous efficacy of compound in a lethal MCMV infection on mouse | ChEMBL. | 1849998 |
PD50 (functional) | = 36 mg kg-1 day-1 | subcutaneous efficacy of compound in a lethal MCMV infection on mouse | ChEMBL. | 1849998 |
PD50 (functional) | = 36 mg kg-1 day-1 | subcutaneous efficacy of compound in a lethal MCMV infection on mouse | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 1 | oral efficacy of the compound in a mouse cytomegalovirus infection at 12.5 mg/kg/day dose; Value expressed as survivors/total tested = 1/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 3 | oral efficacy of the compound in a mouse cytomegalovirus infection at 25 mg/kg/day dose; Value expressed as survivors/total tested = 3/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 4 | Subcutaneous efficacy of the compound in a mouse cytomegalovirus infection at 12.5 mg/kg/day dose; Value expressed as survivors/total tested = 4/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 4 | Subcutaneous efficacy of the compound in a mouse cytomegalovirus infection at 6.3 mg/kg/day dose; Value expressed as survivors/total tested = 4/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 6 | oral efficacy of the compound in a mouse cytomegalovirus infection at 50 mg/kg/day dose; Value expressed as survivors/total tested = 6/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 10 | Subcutaneous efficacy of the compound in a mouse cytomegalovirus infection at 100 mg/kg/day dose; Value expressed as survivors/total tested = 10/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 10 | Subcutaneous efficacy of the compound in a mouse cytomegalovirus infection at 50 mg/kg/day dose; Value expressed as survivors/total tested = 10/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 10 | Subcutaneous efficacy of the compound in a mouse cytomegalovirus infection at 25 mg/kg/day dose; Value expressed as survivors/total tested = 10/10 | ChEMBL. | 1849998 |
Survivors alive/total (functional) | = 10 | oral efficacy of the compound in a mouse cytomegalovirus infection at 100 mg/kg/day dose; Value expressed as survivors/total tested = 10/10 | ChEMBL. | 1849998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.