Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0851 | 0.9051 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0859 | 0.3829 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0859 | 0.3829 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0239 | 0.0975 | 0.2546 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2199 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0077 | 0.023 | 0.2443 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2199 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2199 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2199 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2199 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.2199 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0859 | 0.3829 | 0.3829 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2199 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0011 | 0.0121 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0239 | 0.0975 | 0.2546 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2199 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0859 | 0.3829 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0859 | 0.3829 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0859 | 0.3829 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2199 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2199 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0029 | 0.0011 | 0.0011 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0859 | 0.3829 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2199 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0029 | 0.0011 | 0.0011 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0859 | 0.3829 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2199 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0011 | 0.0121 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0011 | 0.0011 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0859 | 0.3829 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0239 | 0.0975 | 0.0975 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0859 | 0.3829 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0859 | 0.3829 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0859 | 0.3829 | 0.3829 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0029 | 0.0011 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.094 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0011 | 0.0011 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2199 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0077 | 0.023 | 0.023 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2199 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0859 | 0.3829 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0011 | 0.0011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 | Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 17580847 |
Emax (functional) | 0 | Activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay relative to U69593 | ChEMBL. | 17580847 |
Ke (functional) | = 440 nM | Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 17580847 |
Ke (functional) | = 440 nM | Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 17580847 |
Ke (functional) | = 760 nM | Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 17580847 |
Ke (functional) | = 760 nM | Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 17580847 |
Ke (functional) | = 2830 nM | Antagonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 17580847 |
Ke (functional) | = 2830 nM | Antagonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 17580847 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.