TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 640.683 | Formula: C31H34F6N4O2S
H donors: 2 H acceptors: 3 LogP: 6.68 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: O=C(C(c1csc(n1)NC(=O)C(C)C)CCN1CCC(CC1)c1ccccc1)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
InChi: 1S/C31H34F6N4O2S/c1-19(2)27(42)40-29-39-26(18-44-29)25(10-13-41-11-8-22(9-12-41)21-6-4-3-5-7-21)28(43)38-17-20-14-23(30(32,33)34)16-24(15-20)31(35,36)37/h3-7,14-16,18-19,22,25H,8-13,17H2,1-2H3,(H,38,43)(H,39,40,42)
InChiKey: KJIGJEKEYRGJIH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin L precursor	0.0209	0.0252	0.5
Schistosoma mansoni	cathepsin s	0.0375	0.0746	0.248
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0209	0.0252	0.0839
Trypanosoma cruzi	cysteine peptidase, putative	0.0375	0.0746	0.1791
Echinococcus multilocularis	cysteine protease	0.1134	0.3006	0.3006
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Echinococcus granulosus	cathepsin b	0.0209	0.0252	0.0252
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.043	0.0909	0.0909
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Onchocerca volvulus	Cathepsin F homolog	0.1134	0.3006	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0209	0.0252	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0759	0.189	0.6286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Brugia malayi	Cathepsin L-like precursor	0.1134	0.3006	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1134	0.3006	1
Entamoeba histolytica	cysteine proteinase, putative	0.0584	0.1369	0.4054
Onchocerca volvulus		0.1134	0.3006	1
Plasmodium vivax	unspecified product	0.0584	0.1369	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.1134	0.3006	1
Toxoplasma gondii	cathepsin CPL	0.1134	0.3006	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0759	0.189	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0584	0.1369	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0375	0.0746	0.248
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1134	0.3006	0.3006
Entamoeba histolytica	cysteine proteinase, putative	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Brugia malayi	Papain family cysteine protease containing protein	0.0584	0.1369	0.4553
Onchocerca volvulus		0.1134	0.3006	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0584	0.1369	0.4054
Giardia lamblia	Cathepsin L-like protease	0.0209	0.0252	0.5
Loa Loa (eye worm)	hypothetical protein	0.1134	0.3006	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1134	0.3006	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0209	0.0252	0.5
Plasmodium vivax	unspecified product	0.0375	0.0746	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1134	0.3006	1
Loa Loa (eye worm)	ctsf protein	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0584	0.1369	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1134	0.3006	0.3006
Brugia malayi	cathepsin F-like cysteine proteinase	0.0375	0.0746	0.248
Giardia lamblia	Cathepsin L precursor	0.0209	0.0252	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0584	0.1369	0.4553
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Brugia malayi	cathepsin L-like precursor	0.0759	0.189	0.6286
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Giardia lamblia	Cysteine protease	0.0209	0.0252	0.5
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0209	0.0252	0.0839
Brugia malayi	cathepsin L-like cysteine proteinase	0.0209	0.0252	0.0839
Brugia malayi	Cathepsin L-like precursor	0.1134	0.3006	1
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1134	0.3006	1
Brugia malayi	Cathepsin L-like precursor	0.1134	0.3006	1
Brugia malayi	Cathepsin L-like precursor	0.0375	0.0746	0.248
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1134	0.3006	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0584	0.1369	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0252	0.0839
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0402	0.0825	0.208
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Loa Loa (eye worm)	fibroinase	0.1134	0.3006	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0209	0.0252	0.0839
Echinococcus multilocularis	cathepsin L	0.0584	0.1369	0.1369
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Echinococcus multilocularis	cathepsin L	0.0209	0.0252	0.0252
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.3482	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Loa Loa (eye worm)	hypothetical protein	0.0759	0.189	0.6286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Plasmodium vivax	vivapain-2	0.1134	0.3006	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Giardia lamblia	Cathepsin L precursor	0.0209	0.0252	0.5
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0252	0.0839
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Entamoeba histolytica	cysteine proteinase, putative	0.0759	0.189	0.5946
Brugia malayi	Papain family cysteine protease containing protein	0.0209	0.0252	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0373	0.074	0.2463
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1134	0.3006	0.3006
Loa Loa (eye worm)	hypothetical protein	0.0375	0.0746	0.248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1134	0.3006	1
Giardia lamblia	Cathepsin L precursor	0.0209	0.0252	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0584	0.1369	0.4553
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1134	0.3006	0.3006
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1134	0.3006	0.3006
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0584	0.1369	0.4054
Schistosoma mansoni	voltage-gated potassium channel	0.0469	0.1027	0.3416
Giardia lamblia	Hypothetical protein	0.0209	0.0252	0.5
Giardia lamblia	Cysteine protease	0.0209	0.0252	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1134	0.3006	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0759	0.189	0.6286
Giardia lamblia	Cysteine protease	0.0209	0.0252	0.5
Giardia lamblia	Cysteine protease	0.0209	0.0252	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Plasmodium vivax	vivapain-1	0.0584	0.1369	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0375	0.0746	0.1791
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0252	0.0839
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Onchocerca volvulus		0.1134	0.3006	1
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0759	0.189	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0375	0.0746	0.248
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0252	0.0839
Schistosoma mansoni	cathepsin B (C01 family)	0.0209	0.0252	0.0839
Brugia malayi	Cathepsin L-like precursor	0.1134	0.3006	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0209	0.0252	0.0839
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0402	0.0825	0.208
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Brugia malayi	cathepsin B-like cysteine proteinase	0.0209	0.0252	0.0839
Onchocerca volvulus		0.1134	0.3006	1
Giardia lamblia	Hypothetical protein	0.0209	0.0252	0.5
Onchocerca volvulus		0.0759	0.189	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Trypanosoma cruzi	cysteine peptidase, putative	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0584	0.1369	0.4054
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1134	0.3006	1
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.1134	0.3006	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0759	0.189	0.6286
Trypanosoma cruzi	cysteine protease, putative	0.0584	0.1369	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.1134	0.3006	1
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Brugia malayi	Cathepsin L-like precursor	0.0759	0.189	0.6286
Entamoeba histolytica	cysteine proteinase, putative	0.0584	0.1369	0.4054
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0252	0.0839
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0209	0.0252	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1134	0.3006	1
Brugia malayi	Papain family cysteine protease containing protein	0.0584	0.1369	0.4553
Brugia malayi	cathepsin L precursor	0.0209	0.0252	0.0839
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0584	0.1369	0.4553
Plasmodium vivax	vivapain-3	0.0584	0.1369	0.4054
Brugia malayi	fibroinase precursor	0.0209	0.0252	0.0839
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.043	0.0909	0.3025
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0209	0.0252	0.5
Entamoeba histolytica	cysteine protease, putative	0.1134	0.3006	1
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Echinococcus granulosus	cathepsin L	0.0209	0.0252	0.0252
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.043	0.0909	0.3025
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Loa Loa (eye worm)	hypothetical protein	0.0375	0.0746	0.248
Giardia lamblia	Cathepsin L precursor	0.0209	0.0252	0.5
Echinococcus granulosus	cathepsin L	0.0584	0.1369	0.1369
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Echinococcus multilocularis	cathepsin b	0.0209	0.0252	0.0252
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0209	0.0252	0.0839
Onchocerca volvulus	Cathepsin L homolog	0.1134	0.3006	1
Leishmania major	cathepsin L-like protease	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0759	0.189	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Echinococcus multilocularis	cysteine protease	0.1134	0.3006	0.3006
Giardia lamblia	Encystation-specific protease	0.0209	0.0252	0.5
Giardia lamblia	Cathepsin L precursor	0.0209	0.0252	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Brugia malayi	Cathepsin L-like precursor	0.1134	0.3006	1
Leishmania major	cysteine peptidase A (CPA)	0.1134	0.3006	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Brugia malayi	Cathepsin L-like precursor	0.1134	0.3006	1
Echinococcus granulosus	cathepsin l1	0.0759	0.189	0.189
Giardia lamblia	Cathepsin B precursor	0.0209	0.0252	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0584	0.1369	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.1134	0.3006	1
Echinococcus granulosus	cysteine protease	0.0584	0.1369	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0759	0.189	0.6286
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0209	0.0252	0.0839
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0209	0.0252	0.0839
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0209	0.0252	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0375	0.0746	0.248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0209	0.0252	0.0839
Brugia malayi	cathepsin F-like cysteine proteinase	0.0209	0.0252	0.0839
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Trypanosoma cruzi	cysteine peptidase, putative	0.0584	0.1369	0.4054
Echinococcus granulosus	cathepsin b	0.0209	0.0252	0.0252
Brugia malayi	Cathepsin L-like precursor	0.0759	0.189	0.6286
Entamoeba histolytica	cysteine proteinase, putative	0.0584	0.1369	0.4054
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.043	0.0909	0.0909
Entamoeba histolytica	cysteine proteinase, putative	0.0584	0.1369	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0584	0.1369	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.1134	0.3006	0.3006
Trypanosoma cruzi	cysteine proteinase, putative	0.0584	0.1369	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Entamoeba histolytica	cysteine proteinase, putative	0.1134	0.3006	1
Onchocerca volvulus		0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Giardia lamblia	Cathepsin L-like protease	0.0209	0.0252	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1134	0.3006	1
Plasmodium vivax	vivapain-2	0.1134	0.3006	1
Loa Loa (eye worm)	cysteine protease	0.1134	0.3006	1
Echinococcus multilocularis	cathepsin b	0.0209	0.0252	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0252	0.0839
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0209	0.0252	0.5
Echinococcus granulosus	cathepsin l1	0.1134	0.3006	0.3006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1134	0.3006	1
Schistosoma mansoni	cathepsin C	0.0209	0.0252	0.0839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1134	0.3006	1
Brugia malayi	Papain family cysteine protease containing protein	0.0209	0.0252	0.0839
Onchocerca volvulus		0.1134	0.3006	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1134	0.3006	1
Entamoeba histolytica	cysteine proteinase 2	0.0584	0.1369	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0584	0.1369	0.4054
Onchocerca volvulus		0.1134	0.3006	1
Entamoeba histolytica	cysteine protease, putative	0.0584	0.1369	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0209	0.0252	0.0839
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0209	0.0252	0.0839
Schistosoma mansoni	voltage-gated potassium channel	0.0469	0.1027	0.3416
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0252	0.0839
Brugia malayi	Papain family cysteine protease containing protein	0.0209	0.0252	0.0839
Loa Loa (eye worm)	cathepsin B	0.0209	0.0252	0.0839
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0209	0.0252	0.0839

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.4 nM	Displacement of [125I]MCP1 from human CCR2 expressed in monocytes	ChEMBL.	17092717
IC50 (binding)	= 7.4 nM	Displacement of [125I]MCP1 from human CCR2 expressed in monocytes	ChEMBL.	17092717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 428312