Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0131 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0411 | 0.0411 |
Brugia malayi | FAD binding domain containing protein | 0.0031 | 0.129 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0411 | 0.1157 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0031 | 0.129 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0411 | 0.0131 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0031 | 0.129 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0411 | 0.0411 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0411 | 0.0411 |
Onchocerca volvulus | 0.0021 | 0.0411 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0411 | 0.1157 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0028 | 0.0994 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0019 | 0.0296 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0411 | 0.0119 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0411 | 0.0131 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0031 | 0.129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0135 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0411 | 0.0119 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0131 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0411 | 0.0411 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0411 | 0.1157 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0031 | 0.129 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0411 | 0.0411 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0411 | 0.1157 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0031 | 0.129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.129 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0411 | 0.0131 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0019 | 0.0296 | 0.0296 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0411 | 0.0411 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0411 | 0.0411 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0031 | 0.129 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0411 | 0.0131 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0411 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0031 | 0.129 | 0.1025 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0124 | 0.9091 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0411 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0031 | 0.129 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0411 | 0.1157 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0031 | 0.129 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0119 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0031 | 0.129 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0031 | 0.129 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0411 | 0.1157 |
Trypanosoma cruzi | p450 reductase, putative | 0.0031 | 0.129 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0031 | 0.129 | 0.1131 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0031 | 0.129 | 0.1025 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0411 | 0.1157 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0411 | 0.0411 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0411 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0411 | 0.1157 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0031 | 0.129 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0031 | 0.129 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0031 | 0.129 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0411 | 0.0119 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0411 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0411 | 0.0411 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0411 | 0.0131 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0411 | 0.0119 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0411 | 0.0131 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0411 | 0.1157 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0411 | 0.0119 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0411 | 0.0119 |
Giardia lamblia | Hypothetical protein | 0.0028 | 0.0994 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0411 | 0.0119 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0031 | 0.129 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0031 | 0.129 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0411 | 0.1157 |
Leishmania major | p450 reductase, putative | 0.0031 | 0.129 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0031 | 0.129 | 0.129 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0411 | 0.1157 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0411 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 245.81 uM | Cytotoxicity against Vero cells after 72 hrs by MTT assay | ChEMBL. | 17276683 |
MIC (functional) | = 0.78 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method | ChEMBL. | 17276683 |
MIC (functional) | = 0.78 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method | ChEMBL. | 17276683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.