TDR Targets

Basic information

Technical information

TDR Targets ID: 428440
Name: 6-[(4-fluorophenyl)sulfonylamino]-3-furan-3-y l-2-methoxybenzoic acid
MW: 391.37 | Formula: C18H14FNO6S
H donors: 2 H acceptors: 4 LogP: 3.29 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(C(=O)O)c(ccc1c1cocc1)NS(=O)(=O)c1ccc(cc1)F
InChi: 1S/C18H14FNO6S/c1-25-17-14(11-8-9-26-10-11)6-7-15(16(17)18(21)22)20-27(23,24)13-4-2-12(19)3-5-13/h2-10,20H,1H3,(H,21,22)
InChiKey: HCVSSQYRQFCKIO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

6-[(4-fluorophenyl)sulfonylamino]-3-(3-furyl)-2-methoxy-benzoic acid
6-[(4-fluorophenyl)sulfonylamino]-3-(3-furyl)-2-methoxybenzoic acid
6-[(4-fluorophenyl)sulfonylamino]-3-furan-3-yl-2-methoxy-benzoic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	methionyl aminopeptidase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Cryptosporidium hominis	methionine aminopeptidase, type II	Get druggable targets OG5_127231	All targets in OG5_127231
Brugia malayi	initiation factor 2-associated protein.	Get druggable targets OG5_127231	All targets in OG5_127231
Leishmania donovani	metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_127231	All targets in OG5_127231
Leishmania braziliensis	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Plasmodium berghei	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	Get druggable targets OG5_127231	All targets in OG5_127231
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	Get druggable targets OG5_127231	All targets in OG5_127231
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_127231	All targets in OG5_127231
Plasmodium yoelii	methionine aminopeptidase, type II, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Trypanosoma congolense	metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_127231	All targets in OG5_127231
Entamoeba histolytica	methionine aminopeptidase, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Loa Loa (eye worm)	initiation factor 2-associated protein	Get druggable targets OG5_127231	All targets in OG5_127231
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_127231	All targets in OG5_127231
Plasmodium knowlesi	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Plasmodium falciparum	methionine aminopeptidase 2	Get druggable targets OG5_127231	All targets in OG5_127231
Neospora caninum	hypothetical protein	Get druggable targets OG5_127231	All targets in OG5_127231
Schistosoma japonicum	ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative	Get druggable targets OG5_127231	All targets in OG5_127231
Leishmania mexicana	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_127231	All targets in OG5_127231
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_127231	All targets in OG5_127231
Theileria parva	methionine aminopeptidase, type II, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Echinococcus multilocularis	methionyl aminopeptidase 2	Get druggable targets OG5_127231	All targets in OG5_127231
Plasmodium vivax	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	Get druggable targets OG5_127231	All targets in OG5_127231
Cryptosporidium parvum	methionine aminopeptidase, type II, putative , an1 domain	Get druggable targets OG5_127231	All targets in OG5_127231
Babesia bovis	methionine aminopeptidase, type II family protein	Get druggable targets OG5_127231	All targets in OG5_127231
Giardia lamblia	Methionine aminopeptidase	Get druggable targets OG5_127231	All targets in OG5_127231
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	Get druggable targets OG5_127231	All targets in OG5_127231
Leishmania major	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	Get druggable targets OG5_127231	All targets in OG5_127231
Toxoplasma gondii	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Echinococcus granulosus	methionyl aminopeptidase 2	Get druggable targets OG5_127231	All targets in OG5_127231
Leishmania infantum	methionine aminopeptidase 2, putative	Get druggable targets OG5_127231	All targets in OG5_127231
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	Get druggable targets OG5_127231	All targets in OG5_127231
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_127231	All targets in OG5_127231
Trypanosoma brucei gambiense	methionine aminopeptidase 2, putative,metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_127231	All targets in OG5_127231

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cysteine protease	0.0191	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0535	0.4054	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0343	0.1791	0.1791
Echinococcus multilocularis	cysteine protease	0.1038	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0695	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Loa Loa (eye worm)	hypothetical protein	0.0695	0.5946	0.5946
Leishmania major	cathepsin L-like protease	0.1038	1	1
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Echinococcus granulosus	cathepsin l1	0.1038	1	1
Giardia lamblia	Hypothetical protein	0.0191	0	0.5
Leishmania major	cathepsin L-like protease	0.1038	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1038	1	1
Leishmania major	cysteine peptidase A (CPA)	0.1038	1	1
Brugia malayi	cathepsin L-like precursor	0.0695	0.5946	0.5946
Trypanosoma cruzi	cysteine peptidase, putative	0.1038	1	1
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Plasmodium vivax	vivapain-1	0.0535	0.4054	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.1038	1	1
Leishmania major	cathepsin L-like protease	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Loa Loa (eye worm)	hypothetical protein	0.0343	0.1791	0.1791
Schistosoma mansoni	cathepsin s	0.0343	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0535	0.4054	0.4054
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0191	0	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0535	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0191	0	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0191	0	0.5
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0695	0.5946	0.5946
Loa Loa (eye worm)	fibroinase	0.1038	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1038	1	1
Giardia lamblia	Cathepsin L precursor	0.0191	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1038	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.1038	1	1
Onchocerca volvulus		0.1038	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0343	0.1791	0.1791
Loa Loa (eye worm)	ctsf protein	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Brugia malayi	Cathepsin L-like precursor	0.0695	0.5946	0.5946
Plasmodium vivax	vivapain-2	0.1038	1	1
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Giardia lamblia	Cysteine protease	0.0191	0	0.5
Plasmodium vivax	vivapain-2	0.1038	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1038	1	1
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Loa Loa (eye worm)	cysteine protease	0.1038	1	1
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Giardia lamblia	Hypothetical protein	0.0191	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Giardia lamblia	Cathepsin L-like protease	0.0191	0	0.5
Onchocerca volvulus		0.1038	1	1
Loa Loa (eye worm)	hypothetical protein	0.1038	1	1
Leishmania major	cathepsin L-like protease	0.1038	1	1
Loa Loa (eye worm)	hypothetical protein	0.0695	0.5946	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Leishmania major	cathepsin L-like protease	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0535	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1038	1	1
Giardia lamblia	Encystation-specific protease	0.0191	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1038	1	1
Giardia lamblia	Cathepsin L precursor	0.0191	0	0.5
Trypanosoma cruzi	cysteine protease, putative	0.0535	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0695	0.5946	0.5946
Brugia malayi	Cathepsin L-like precursor	0.1038	1	1
Onchocerca volvulus	Cathepsin F homolog	0.1038	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1038	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.4054	0.4054
Leishmania major	cathepsin L-like protease	0.1038	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1038	1	1
Toxoplasma gondii	cathepsin CPL	0.1038	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0535	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0695	0.5946	0.5946
Echinococcus granulosus	cysteine protease	0.0535	0.4054	0.4054
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1038	1	1
Giardia lamblia	Cysteine protease	0.0191	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0191	0	0.5
Leishmania major	cathepsin L-like protease	0.1038	1	1
Leishmania major	cathepsin L-like protease	0.1038	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0343	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1038	1	1
Giardia lamblia	Cathepsin L precursor	0.0191	0	0.5
Plasmodium vivax	unspecified product	0.0343	0.1791	0.1791
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Giardia lamblia	Cathepsin B precursor	0.0191	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1038	1	1
Brugia malayi	Cathepsin L-like precursor	0.1038	1	1
Plasmodium vivax	unspecified product	0.0535	0.4054	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Brugia malayi	Cathepsin L-like precursor	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.1038	1	1
Giardia lamblia	Cathepsin L precursor	0.0191	0	0.5
Onchocerca volvulus	Cathepsin L homolog	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1038	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Onchocerca volvulus		0.1038	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0535	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0535	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0535	0.4054	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0343	0.1791	0.1791
Echinococcus multilocularis	cathepsin L	0.0535	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0695	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0535	0.4054	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0535	0.4054	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0343	0.1791	0.1791
Giardia lamblia	Cathepsin L precursor	0.0191	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0695	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1038	1	1
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Plasmodium vivax	vivapain-3	0.0535	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.1038	1	1
Onchocerca volvulus		0.1038	1	1
Loa Loa (eye worm)	hypothetical protein	0.0695	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0535	0.4054	0.4054
Brugia malayi	Cathepsin L-like precursor	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1038	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1038	1	1
Echinococcus multilocularis	cysteine protease	0.1038	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0535	0.4054	0.4054
Giardia lamblia	Cathepsin L-like protease	0.0191	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.1038	1	1
Giardia lamblia	Cysteine protease	0.0191	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0535	0.4054	0.4054
Onchocerca volvulus		0.1038	1	1
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0343	0.1791	0.1791
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0535	0.4054	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1038	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1038	1	1
Loa Loa (eye worm)	hypothetical protein	0.0343	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1038	1	1
Brugia malayi	Cathepsin L-like precursor	0.0343	0.1791	0.1791
Onchocerca volvulus		0.1038	1	1
Onchocerca volvulus		0.0695	0.5946	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.0535	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.1038	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0535	0.4054	0.4054
Echinococcus granulosus	cathepsin l1	0.0695	0.5946	0.5946
Giardia lamblia	Cathepsin L precursor	0.0191	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Echinococcus granulosus	cathepsin L	0.0535	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Entamoeba histolytica	cysteine protease, putative	0.0535	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0695	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1038	1	1
Onchocerca volvulus		0.1038	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 3.8 uM	Antiproliferative activity against HT1080 cells	ChEMBL.	17350258
EC50 (functional)	= 3.8 uM	Antiproliferative activity against HT1080 cells	ChEMBL.	17350258
IC50 (binding)	= 0.008 uM	Inhibition of MetAP2	ChEMBL.	17350258
IC50 (binding)	= 0.008 uM	Inhibition of MetAP2	ChEMBL.	17350258
IC50 (binding)	= 1.1 uM	Inhibition of MetAP2 in presence of 40 mg/ml HSA	ChEMBL.	17350258
IC50 (binding)	= 1.1 uM	Inhibition of MetAP2 in presence of 40 mg/ml HSA	ChEMBL.	17350258

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17350258

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL388245
PubChem: 23647769

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 428440