Detailed information for compound 42862

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.641 | Formula: C26H45NO2
  • H donors: 2 H acceptors: 2 LogP: 10.05 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCNc1ccc(cc1)C(C(=O)O)(C)C
  • InChi: 1S/C26H45NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22-27-24-20-18-23(19-21-24)26(2,3)25(28)29/h18-21,27H,4-17,22H2,1-3H3,(H,28,29)
  • InChiKey: ZXAFFDOWSHOYJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Bile acid receptor homolog 0.0282 0.3238 0.5459
Onchocerca volvulus 0.0101 0.0915 0.1399
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0032
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0107 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0228 0.2552 0.2499
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0352 0.2908
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0303 0.0503
Echinococcus multilocularis aryl hydrocarbon receptor 0.0039 0.0114 0.0044
Brugia malayi Ets-domain containing protein 0.0081 0.0661 0.1097
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0107 0.0177
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0352 0.0311
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0107 0.0177
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0266 0.0442
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0039 0.0114 0.0045
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.5559 0.6055
Brugia malayi conserved hypotetical protein 0.0133 0.1325 0.22
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0088 0.0689
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0133 0.1325 0.1264
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0107 0.0076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0282 0.3238 0.319
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0282 0.3238 0.6628
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0282 0.3238 0.3495
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0107 0.0076
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Echinococcus granulosus neurogenic locus notch protein 0.005 0.026 0.021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0281 0.5581
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0088 0.0018
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Onchocerca volvulus 0.0282 0.3238 0.5459
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.013 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0281 0.0213
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.0953 0.1581
Brugia malayi Pre-SET motif family protein 0.0061 0.0401 0.0666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0282 0.3238 0.5374
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0114 0.0045
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0107 0.0177
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1737 0.1679
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0458 0.0811
Loa Loa (eye worm) DR-78 0.0133 0.1325 0.22
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0116
Brugia malayi Pre-SET motif family protein 0.0425 0.508 0.8433
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.013 0.2683
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0177
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0088 0.0146
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0352 0.2908
Loa Loa (eye worm) hypothetical protein 0.0247 0.2797 0.4642
Echinococcus granulosus tar DNA binding protein 0.0065 0.0458 0.0428
Schistosoma mansoni retinoic acid receptor RXR 0.0282 0.3238 0.6628
Brugia malayi Nuclear hormone receptor E75 0.0133 0.1325 0.22
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0282 0.3238 0.5374
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0282 0.3238 0.6628
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0114 0.1942
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.013 0.0215
Loa Loa (eye worm) hypothetical protein 0.0101 0.0916 0.1521
Loa Loa (eye worm) hypothetical protein 0.0149 0.153 0.254
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0228 0.2552 0.2738
Brugia malayi hypothetical protein 0.0133 0.1325 0.22
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0107 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.0282 0.3238 0.319
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0032
Schistosoma mansoni transcription factor LCR-F1 0.0228 0.2552 0.5192
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0458 0.0759
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0352 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0133 0.1325 0.1385
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2797 0.2746
Brugia malayi nuclear receptor NHR-67 0.0133 0.1325 0.22
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0107 0.004
Schistosoma mansoni intermediate filament proteins 0.0056 0.0331 0.0546
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1047 0.1738
Brugia malayi nuclear receptor RXR 0.0149 0.153 0.254
Brugia malayi Nuclear hormone receptor-like 1 0.0282 0.3238 0.5374
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0281 1
Brugia malayi RNA binding protein 0.0065 0.0458 0.0759
Onchocerca volvulus 0.0133 0.1325 0.2117
Onchocerca volvulus 0.005 0.0266 0.0266
Mycobacterium ulcerans putative regulatory protein 0.011 0.1031 1
Brugia malayi TAR-binding protein 0.0065 0.0458 0.0759
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0074 0.0123
Onchocerca volvulus 0.0484 0.5837 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.013 0.006
Brugia malayi nuclear hormone receptor family member odr-7 0.0133 0.1325 0.22
Onchocerca volvulus 0.0056 0.0331 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0401 0.0693
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0547 0.0999
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0107 0.0076
Loa Loa (eye worm) hypothetical protein 0.0076 0.0595 0.0987
Brugia malayi Fli-1 protein 0.0247 0.2785 0.4622
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.5559 0.5527
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0107 0.0076
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0081 0.0661 0.1097
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0281 0.0442
Schistosoma mansoni RAR-like nuclear receptor 0.0282 0.3238 0.6628
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0114 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0953 0.1847
Entamoeba histolytica hypothetical protein 0.0228 0.2552 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0282 0.3238 0.5374
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0107 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0114 0.0045
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0282 0.3238 0.3495
Schistosoma mansoni cell polarity protein 0.005 0.026 0.0397
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0352 0.0585
Loa Loa (eye worm) hypothetical protein 0.0055 0.0318 0.0528
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0561 0.0494
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0401 0.0334
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.013 0.0168
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0699 0.1317
Echinococcus multilocularis thyroid hormone receptor alpha 0.0407 0.485 0.4813
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0282 0.3238 0.5374
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0107 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0282 0.3238 0.319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.013 0.2683
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0282 0.3238 0.5374
Onchocerca volvulus Protein ultraspiracle homolog 0.0282 0.3238 0.5459
Toxoplasma gondii exonuclease III APE 0.004 0.013 0.132
Brugia malayi hypothetical protein 0.0247 0.2797 0.4642
Schistosoma mansoni lamin 0.0056 0.0331 0.0546
Brugia malayi Latrophilin receptor protein 2 0.0035 0.007 0.0116
Onchocerca volvulus 0.0072 0.0547 0.0757
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0281 0.0467
Loa Loa (eye worm) hypothetical protein 0.0061 0.0401 0.0666
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0331 0.055
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.123 0.1168
Loa Loa (eye worm) transcription factor SMAD2 0.0385 0.4557 0.7564
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0133 0.1325 0.22
Echinococcus multilocularis FTZ F1 alpha 0.0282 0.3238 0.319
Loa Loa (eye worm) hypothetical protein 0.0149 0.153 0.254
Schistosoma mansoni alpha glucosidase 0.0037 0.0088 0.0038
Schistosoma mansoni survival motor neuron protein 0.005 0.0266 0.0411
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0039 0.0114 0.0044
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0107 0.0032
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0107 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0282 0.3238 0.5374
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0401 1
Echinococcus granulosus FTZ F1 alpha 0.0282 0.3238 0.3495
Trichomonas vaginalis ap endonuclease, putative 0.004 0.013 0.0072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0282 0.3238 0.319
Schistosoma mansoni steroid hormone receptor ad4bp 0.0282 0.3238 0.6628
Echinococcus multilocularis lamin 0.0056 0.0331 0.0263
Schistosoma mansoni nuclear hormone receptor 0.0133 0.1325 0.2627
Brugia malayi nuclear receptor NHR-88 0.0282 0.3238 0.5374
Brugia malayi Nuclear hormone receptor-like 1 0.0149 0.153 0.254
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0114 0.0045
Echinococcus granulosus lamin dm0 0.0056 0.0331 0.0288
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0281 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0114 0.1942
Onchocerca volvulus 0.0084 0.0699 0.1023
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0107 0.004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.013 0.5
Echinococcus multilocularis musashi 0.0056 0.0331 0.0263
Brugia malayi tailless protein 0.0133 0.1325 0.22
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0107 0.0037
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0699 0.0634
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0458 0.039
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0114 0.1942
Schistosoma mansoni laminin gamma-3 chain 0.005 0.026 0.0397
Echinococcus granulosus GA binding protein alpha chain 0.0081 0.0661 0.0652
Brugia malayi hypothetical protein 0.0038 0.0107 0.0177
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0331 0.055
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0039 0.0114 0.0045
Onchocerca volvulus 0.0151 0.1553 0.2514
Onchocerca volvulus 0.0101 0.0915 0.1399
Schistosoma mansoni single-minded 0.0149 0.1528 0.3049
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.013 0.5
Schistosoma mansoni hypothetical protein 0.005 0.0266 0.0411
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.508 0.8433
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0282 0.3238 0.5374
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0133 0.1325 0.1264
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.0915 0.1518
Brugia malayi Nuclear hormone receptor E75 0.0133 0.1325 0.22
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0114 0.1446
Schistosoma mansoni lamin 0.0056 0.0331 0.0546
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0352 0.0284
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.007 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0282 0.3238 0.5374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0177
Schistosoma mansoni ap endonuclease 0.004 0.013 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0385 0.4557 0.7564
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.026 0.0397
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0107 0.0076
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0088 0.002
Echinococcus multilocularis GA binding protein alpha chain 0.0081 0.0661 0.0595
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0133 0.1325 0.2627
Brugia malayi intermediate filament protein 0.0056 0.0331 0.055
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0107 0.0177
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.1047 0.1738
Schistosoma mansoni hypothetical protein 0.0125 0.123 0.2426
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0149 0.153 0.3055
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0281 1
Echinococcus multilocularis expressed protein 0.0741 0.9134 0.9128
Plasmodium vivax SET domain protein, putative 0.0061 0.0401 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0699 0.0694
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0107 0.0177
Loa Loa (eye worm) hypothetical protein 0.0151 0.1553 0.2577
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0458 0.0759
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0107 0.0177
Brugia malayi isocitrate dehydrogenase 0.0052 0.0281 0.0467
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0281 0.0213
Loa Loa (eye worm) hypothetical protein 0.005 0.026 0.0432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0282 0.3238 0.5374
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0107 0.004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0331 0.055
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.026 0.0432
Schistosoma mansoni alpha-glucosidase 0.0142 0.1442 0.2871
Onchocerca volvulus 0.0095 0.0844 0.1275
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0177
Brugia malayi Cytochrome P450 family protein 0.0036 0.0074 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0401 0.0693
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0133 0.1325 0.2117
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0107 0.0076
Brugia malayi photoreceptor-specific nuclear receptor 0.0282 0.3238 0.5374
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0595 0.0987
Schistosoma mansoni nuclear receptor nhr-48 0.0133 0.1325 0.2627
Brugia malayi ecdysteroid receptor 0.0282 0.3238 0.5374
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0032
Entamoeba histolytica hypothetical protein 0.0038 0.0107 0.0075
Schistosoma mansoni nuclear hormone receptor 0.0133 0.1325 0.2627
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0699 0.1161
Brugia malayi Cytochrome P450 family protein 0.0037 0.0096 0.0159
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Entamoeba histolytica hypothetical protein 0.0228 0.2552 1
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0107 0.004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0281 0.6808
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0282 0.3238 0.5374
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0281 0.7446
Entamoeba histolytica hypothetical protein 0.0038 0.0107 0.0075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0282 0.3238 0.3495
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0953 0.0889
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.013 0.1998
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0769 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0114 0.0045
Onchocerca volvulus 0.0056 0.0331 0.0379
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0282 0.3238 0.6628
Echinococcus granulosus slit 2 protein 0.005 0.026 0.021
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0281 0.6164
Schistosoma mansoni hypothetical protein 0.0177 0.1896 0.382
Brugia malayi hypothetical protein 0.0124 0.1212 0.2011
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0107 0.0177
Echinococcus granulosus Nuclear hormone receptor HR96 0.0133 0.1325 0.1385
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0282 0.3238 0.5374
Brugia malayi nuclear receptor NHR-88 0.0133 0.1325 0.22
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0107 0.0037
Brugia malayi EGF-like domain containing protein 0.005 0.026 0.0432
Echinococcus granulosus nuclear receptor nhr 48 0.0133 0.1325 0.1385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0282 0.3238 0.3495
Schistosoma mansoni ap endonuclease 0.004 0.013 0.0124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0281 0.0213
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0149 0.153 0.254
Onchocerca volvulus 0.0133 0.1325 0.2117
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0133 0.1325 0.22
Brugia malayi hypoxia-induced factor 1 0.046 0.5528 0.9176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0282 0.3238 0.5374
Loa Loa (eye worm) nuclear hormone receptor 0.0133 0.1325 0.22
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0282 0.3238 0.319
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0373 0.0334
Onchocerca volvulus Huntingtin homolog 0.0124 0.1212 0.1918
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0114 0.1942
Schistosoma mansoni nuclear receptor 0.0133 0.1325 0.2627
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0769 0.1461
Brugia malayi nuclear hormone receptor family member nhr-6 0.0133 0.1325 0.22
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0133 0.1325 0.1264
Brugia malayi hypothetical protein 0.0038 0.0107 0.0177
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0114 0.0045
Brugia malayi hypothetical protein 0.0499 0.6025 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0133 0.1325 0.2117
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0282 0.3238 0.319
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0107 0.004
Trypanosoma brucei glucosidase, putative 0.0037 0.0088 0.0689
Brugia malayi hypothetical protein 0.0149 0.153 0.254
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0331 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0282 0.3238 0.5374
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0281 0.0467
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0107 0.0037
Brugia malayi PXA domain containing protein 0.0038 0.0107 0.0177
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0107 0.0177
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0352 0.0591
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.123 0.1279
Brugia malayi ecdysone receptor 0.0133 0.1325 0.22
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0107 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.013 0.2683
Trichomonas vaginalis adenylate cyclase, putative 0.0039 0.0114 0.0045
Echinococcus granulosus lamin 0.0056 0.0331 0.0288
Schistosoma mansoni slit 0.005 0.026 0.0397
Schistosoma mansoni hypothetical protein 0.0076 0.0595 0.1098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0401 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0032
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0458 0.0759
Leishmania major protein kinase, putative 0.0039 0.0114 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0107 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0149 0.153 0.254
Brugia malayi hypothetical protein 0.0228 0.2552 0.4235
Brugia malayi hypothetical protein 0.0149 0.153 0.254
Brugia malayi Steroid receptor seven-up type 2 0.0282 0.3238 0.5374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0282 0.3238 0.5374
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0282 0.3238 0.319
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0281 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0281 0.0213
Schistosoma mansoni nuclear hormone receptor 0.0282 0.3238 0.6628
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.007 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0282 0.3238 0.5374
Schistosoma mansoni aryl hydrocarbon receptor 0.0149 0.1528 0.3049
Schistosoma mansoni hypothetical protein 0.0177 0.1896 0.382
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0114 0.1942
Echinococcus granulosus pikachurin 0.005 0.026 0.021
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0088 0.0513
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1737 0.184
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2797 0.3008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.0953 0.1581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0953 0.1847
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0133 0.1325 0.1385
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0107 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0282 0.3238 0.5374
Brugia malayi Ets-domain containing protein 0.0081 0.0661 0.1097
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Brugia malayi hypothetical protein 0.0101 0.0916 0.1521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0953 0.0889
Echinococcus multilocularis pikachurin 0.005 0.026 0.0191
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0107 0.0037
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0282 0.3238 0.3495
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0282 0.3238 0.5374
Loa Loa (eye worm) hypothetical protein 0.0149 0.153 0.254
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0282 0.3238 0.5374
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0282 0.3238 0.5374
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0149 0.153 0.1611
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0282 0.3238 0.5459
Loa Loa (eye worm) nuclear receptor NHR-67 0.0133 0.1325 0.22
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0282 0.3238 0.5374
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0458 0.0811
Loa Loa (eye worm) hypothetical protein 0.0069 0.051 0.0846
Schistosoma mansoni alpha-glucosidase 0.0142 0.1442 0.2871
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0282 0.3238 0.6628
Brugia malayi MH2 domain containing protein 0.0385 0.4557 0.7564
Schistosoma mansoni hypothetical protein 0.0228 0.2552 0.5192
Brugia malayi hypothetical protein 0.0151 0.1553 0.2577
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0458 0.0811
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0114 0.0045
Schistosoma mansoni nuclear receptor 0.0133 0.1325 0.2627
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0107 0.0037
Brugia malayi nuclear hormone receptor 0.0133 0.1325 0.22
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0133 0.1325 0.1264
Brugia malayi PAS domain containing protein 0.0149 0.1528 0.2535
Brugia malayi nuclear receptor RXR 0.0133 0.1325 0.22
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0074 0.0123
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1737 0.2884
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0039 0.0114 0.0189
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Schistosoma mansoni coup transcription factor 0.0282 0.3238 0.6628
Brugia malayi bHLH-PAS transcription factor 0.011 0.1031 0.1712
Schistosoma mansoni thyroid hormone receptor 0.0407 0.485 1
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.026 0.0191
Leishmania major protein kinase, putative 0.0039 0.0114 0.1446
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0281 0.6164
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.5559 0.5527
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0107 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0953 0.0974
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0107 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0953 0.0974
Loa Loa (eye worm) RNA binding protein 0.0065 0.0458 0.0759
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0039 0.0114 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.026 0.0432
Loa Loa (eye worm) hypothetical protein 0.0039 0.0114 0.0189
Loa Loa (eye worm) hypothetical protein 0.0084 0.0699 0.1161
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0107 0.0037
Echinococcus granulosus Nuclear hormone receptor HR96 0.0133 0.1325 0.1385
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0282 0.3238 0.6628
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0133 0.1325 0.1264
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0281 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0352 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.013 0.0066
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0107 0.0037
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1737 0.1679
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0107 0.004
Echinococcus granulosus geminin 0.0177 0.1896 0.2014
Echinococcus granulosus aryl hydrocarbon receptor 0.0039 0.0114 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.004 0.013 0.0072
Schistosoma mansoni gabp alpha 0.0081 0.0661 0.1236
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0133 0.1325 0.2627
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0281 0.0233
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0107 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0458 0.0811
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0039 0.0114 0.0049
Echinococcus multilocularis lamin dm0 0.0056 0.0331 0.0263
Loa Loa (eye worm) hypothetical protein 0.0124 0.1212 0.2011
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0107 0.004
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0561 0.0541
Brugia malayi follicle stimulating hormone receptor 0.0233 0.2614 0.4338
Loa Loa (eye worm) hypothetical protein 0.0282 0.3238 0.5374
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0107 0.0076
Echinococcus multilocularis nuclear receptor nhr 48 0.0133 0.1325 0.1264
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1737 0.2884
Loa Loa (eye worm) hypothetical protein 0.0111 0.1047 0.1738
Brugia malayi Cytochrome P450 family protein 0.0036 0.0074 0.0123
Brugia malayi hypothetical protein 0.0133 0.1325 0.22
Trichomonas vaginalis set domain proteins, putative 0.0484 0.5835 1
Brugia malayi steroid hormone receptor 0.0282 0.3238 0.5374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0177
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0107 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0401 0.0366
Loa Loa (eye worm) hypothetical protein 0.005 0.026 0.0432
Echinococcus multilocularis slit 2 protein 0.005 0.026 0.0191
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0769 0.0771
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0281 0.0213
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0769 0.1461
Echinococcus granulosus ecdysone induced protein 78C 0.0282 0.3238 0.3495
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0282 0.3238 0.3495
Brugia malayi laminin alpha chain 0.005 0.026 0.0432
Loa Loa (eye worm) hypothetical protein 0.0149 0.153 0.254
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0177
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0458 0.0811
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.026 0.0432
Schistosoma mansoni thyroid hormone receptor 0.0407 0.485 1
Echinococcus granulosus neuropeptide s receptor 0.0463 0.5559 0.6055
Brugia malayi PXA domain containing protein 0.0038 0.0107 0.0177
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0107 0.0076
Brugia malayi nuclear hormone receptor 0.0282 0.3238 0.5374
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.026 0.0432
Echinococcus multilocularis geminin 0.0177 0.1896 0.1839
Echinococcus granulosus intermediate filament protein 0.0056 0.0331 0.0288
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0282 0.3238 0.3495
Entamoeba histolytica hypothetical protein 0.0038 0.0107 0.0075
Brugia malayi orphan nuclear receptor NR2E1 0.0133 0.1325 0.22
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0114 0.0045
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0088 0.0146
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.2614 0.4338
Loa Loa (eye worm) hypothetical protein 0.0124 0.1212 0.2011
Loa Loa (eye worm) fli-1 protein 0.0247 0.2785 0.4622
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0149 0.153 0.3055
Loa Loa (eye worm) hypothetical protein 0.0499 0.6025 1
Mycobacterium leprae Possible regulatory protein 0.0039 0.0114 0.5
Loa Loa (eye worm) hypothetical protein 0.0149 0.153 0.254
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0096 0.0159
Loa Loa (eye worm) hypothetical protein 0.0133 0.1325 0.22
Loa Loa (eye worm) steroid hormone receptor 0.0282 0.3238 0.5374
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0401 0.0334
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0074 0.0123
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.013 0.0581
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0107 0.004
Entamoeba histolytica hypothetical protein 0.0228 0.2552 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0088 0.0689
Schistosoma mansoni ets-related 0.0247 0.2785 0.5679
Echinococcus granulosus expressed protein 0.0741 0.9134 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0177
Entamoeba histolytica hypothetical protein 0.0228 0.2552 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0915 0.1518
Schistosoma mansoni zinc finger protein 0.0133 0.1325 0.2627
Onchocerca volvulus 0.011 0.1031 0.1603
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0149 0.153 0.147
Echinococcus granulosus single minded 2 0.011 0.1031 0.106
Echinococcus multilocularis transfer RNA-Lys 0.011 0.1031 0.0968
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1047 0.1738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0953 0.1847
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0114 0.1942
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0133 0.1325 0.1385
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0282 0.3238 0.6628
Loa Loa (eye worm) hypoxia-induced factor 1 0.046 0.5528 0.9176
Onchocerca volvulus Huntingtin homolog 0.0124 0.1212 0.1918
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.013 0.0215
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0107 0.0076

Activities

Activity type Activity value Assay description Source Reference
Diet (functional) = 93 % In vivo sterol lowering activity when dosed as 0.01 % of the diet ChEMBL. 6604817
Diet (functional) = 107 % In vivo sterol lowering activity at dose of 0.10 % of the diet ChEMBL. 6604817
Diet (functional) = 109 % In vivo triglyceride lowering activity when dosed as 0.01 % of the diet ChEMBL. 6604817
Diet (functional) = 111 % In vivo sterol lowering activity when dosed as 0.03 % of the diet ChEMBL. 6604817
Diet (functional) = 116 % In vivo triglyceride lowering activity dosed at 0.10 % of the diet. ChEMBL. 6604817
Diet (functional) = 121 % In vivo triglyceride lowering activity when dosed at 0.03 % of the diet ChEMBL. 6604817
Inhibition (binding) < 27 % In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604817
Inhibition (binding) < 27 % In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase ChEMBL. 6604817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.