Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Kappa opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0535 | 0.3773 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1371 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0126 | 0.0721 | 0.0721 |
Brugia malayi | Cytochrome P450 family protein | 0.0038 | 0.0067 | 0.0067 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1371 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0038 | 0.0067 | 0.0067 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0038 | 0.0067 | 0.0067 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1371 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0038 | 0.0067 | 0.0448 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0038 | 0.0067 | 0.0067 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0535 | 0.3773 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0535 | 0.3773 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0535 | 0.3773 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1371 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1371 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1371 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1371 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0038 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.1362 | 0.9041 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1371 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0535 | 0.3773 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0239 | 0.1562 | 0.1562 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0535 | 0.3773 | 0.3773 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1371 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1371 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0038 | 0.0067 | 0.0448 |
Brugia malayi | Cytochrome P450 family protein | 0.0038 | 0.0067 | 0.0067 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0535 | 0.3773 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1371 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0535 | 0.3773 | 0.3773 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1507 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0535 | 0.3773 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0038 | 0.0067 | 0.0448 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0535 | 0.3773 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1371 | 1 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0239 | 0.1562 | 0.4141 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1371 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0038 | 0.0067 | 0.0067 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1371 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0535 | 0.3773 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0535 | 0.3773 | 0.5 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0239 | 0.1562 | 0.4141 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0535 | 0.3773 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0126 | 0.0721 | 0.4783 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 2000 nM | Activity at human kappa opioid receptor expressed in HEK293 cells as intracellular calcium mobilization | ChEMBL. | 17303418 |
EC50 (functional) | > 2000 nM | Activity at human kappa opioid receptor expressed in HEK293 cells as intracellular calcium mobilization | ChEMBL. | 17303418 |
Emax (functional) | = 71 % | Activity at human kappa opioid receptor expressed in HEK293 cells as intracellular calcium mobilization | ChEMBL. | 17303418 |
Emax (functional) | = 71 % | Activity at human kappa opioid receptor expressed in HEK293 cells as intracellular calcium mobilization | ChEMBL. | 17303418 |
Ki (binding) | = 546 nM | Displacement of [3H]U69,593 from rat cloned KOR | ChEMBL. | 17303418 |
Ki (binding) | = 546 nM | Displacement of [3H]U69,593 from rat cloned KOR | ChEMBL. | 17303418 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.