Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CYP4Cod1 | 0.0037 | 0.0059 | 0.0418 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0605 | 0.379 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0605 | 0.379 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0605 | 0.379 | 0.379 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.155 | 1 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.025 | 0.1456 | 0.3842 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.0059 | 0.0059 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.155 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0605 | 0.379 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.155 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.155 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0124 | 0.0627 | 0.4465 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.155 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.155 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.155 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.025 | 0.1456 | 0.1456 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.155 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0605 | 0.379 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0605 | 0.379 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1271 | 0.9049 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.1405 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.155 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0037 | 0.0059 | 0.0059 |
Brugia malayi | Cytochrome P450 family protein | 0.0124 | 0.0627 | 0.0627 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.155 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0037 | 0.0059 | 0.0059 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0605 | 0.379 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0605 | 0.379 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0605 | 0.379 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0605 | 0.379 | 0.379 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.025 | 0.1456 | 0.3842 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.0059 | 0.0418 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.0059 | 0.0418 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0605 | 0.379 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.0059 | 0.0059 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0605 | 0.379 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.155 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.155 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0037 | 0.0059 | 0.0059 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.155 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.155 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0037 | 0.0059 | 0.0059 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0605 | 0.379 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.