Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0234 | 0.2611 | 0.2611 |
Brugia malayi | Cytochrome P450 family protein | 0.0081 | 0.0689 | 0.0689 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0823 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.0059 | 0.0059 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0321 | 0.3703 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0823 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0031 | 0.0059 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.2519 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0321 | 0.3703 | 0.3703 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0321 | 0.3703 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0321 | 0.3703 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0823 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0.0059 | 0.0059 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0321 | 0.3703 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0823 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0823 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0031 | 0.0059 | 0.0059 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0321 | 0.3703 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0059 | 0.0233 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0823 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0321 | 0.3703 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0.0059 | 0.0059 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0823 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0823 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0823 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0823 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0823 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0081 | 0.0689 | 0.2735 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0321 | 0.3703 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0321 | 0.3703 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0823 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0321 | 0.3703 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0823 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0321 | 0.3703 | 0.3703 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0234 | 0.2611 | 0.7051 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0059 | 0.0233 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0321 | 0.3703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.228 | 0.9051 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0823 | 1 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0234 | 0.2611 | 0.7051 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0321 | 0.3703 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.5 | Agonist potency at beta2 adrenoreceptor in guinea pig trachea model relative to salmeterol | ChEMBL. | 17498952 |
Log D | = 2.2 | Distribution coefficient, log D of the compound | ChEMBL. | 17498952 |
Papp (ADMET) | 0 | Permeability from apical to basolateral side of the Caco2 cell membrane at 25 uM in pH 7.4 | ChEMBL. | 17498952 |
t1/2 (ADMET) | = 10 min | Half life in human liver microsome at 1 uM | ChEMBL. | 17498952 |
Time (functional) | = 4.6 hr | Effect on guinea pig trachea model assessed as duration of musle tone | ChEMBL. | 17498952 |
Time (functional) | = 4.6 hr | Effect on guinea pig trachea model assessed as duration of musle tone | ChEMBL. | 17498952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.