Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.2014 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.2014 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0126 | 0.2014 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0324 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0324 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0324 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.2014 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0126 | 0.2014 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0324 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0126 | 0.2014 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.2014 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0077 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0324 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0126 | 0.2014 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.2014 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0324 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0126 | 0.2014 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0324 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0126 | 0.2014 | 0.2014 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0126 | 0.2014 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0324 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0324 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0324 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0324 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0324 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0324 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8 uM | Inhibition of protein synthesis in Escherichia coli by coupled transcription-translation assay | ChEMBL. | 17188860 |
IC50 (functional) | = 8 uM | Inhibition of protein synthesis in Escherichia coli by coupled transcription-translation assay | ChEMBL. | 17188860 |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Staphylococcus aureus ATCC 25923 | ChEMBL. | 17188860 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Escherichia coli | ChEMBL23 | 17188860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.