Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Mus musculus | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | chemokine (C-C motif) receptor 2 | 373 aa | 349 aa | 20.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0334 | 0.3712 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0855 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0855 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0855 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0334 | 0.3712 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0334 | 0.3712 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0855 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0334 | 0.3712 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0855 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0855 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0855 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2172 | 0.9051 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0334 | 0.3712 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0855 | 1 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0232 | 0.2487 | 0.2487 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0855 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0334 | 0.3712 | 0.3712 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0334 | 0.3712 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0855 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2399 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0334 | 0.3712 | 0.3712 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0855 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0334 | 0.3712 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0334 | 0.3712 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0855 | 1 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0232 | 0.2487 | 0.67 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0855 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0334 | 0.3712 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0855 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0334 | 0.3712 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0334 | 0.3712 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0232 | 0.2487 | 0.67 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = -7.17 | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
IC50 (binding) | = 67 nM | Displacement of [125I]MCP1 from human CCR2 I40L mutant expressed in CHO cells | ChEMBL. | 17482462 |
IC50 (functional) | = 67 nM | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
IC50 (binding) | = 67 nM | Displacement of [125I]MCP1 from human CCR2 I40L mutant expressed in CHO cells | ChEMBL. | 17482462 |
IC50 (functional) | = 67 nM | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
IC50 (binding) | = 193 nM | Displacement of [125I]MCP1 from mouse CCR2 receptor expressed in CHO cells | ChEMBL. | 17482462 |
IC50 (binding) | = 193 nM | Displacement of [125I]MCP1 from mouse CCR2 receptor expressed in CHO cells | ChEMBL. | 17482462 |
Log IC50 (functional) | = 7.17 | Antagonist activity at human CCR2b receptor | ChEMBL. | 18258426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.