Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | proteasome subunit beta type 2 | 0.0056 | 0.1292 | 0.1292 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0056 | 0.1292 | 0.1292 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0235 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0235 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0056 | 0.1292 | 0.1292 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0056 | 0.1292 | 0.1292 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0235 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0056 | 0.1292 | 0.1292 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0083 | 0.2632 | 0.2632 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0056 | 0.1292 | 0.1292 |
Echinococcus granulosus | proteasome prosome macropain | 0.0235 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0235 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0056 | 0.1292 | 0.1292 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0056 | 0.1292 | 0.1292 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0056 | 0.1292 | 0.1292 |
Mycobacterium ulcerans | proteasome PrcB | 0.0235 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0235 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0083 | 0.2632 | 0.2632 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0235 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0235 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0083 | 0.2632 | 0.2632 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0083 | 0.2632 | 0.2632 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0235 | 1 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0056 | 0.1292 | 0.1292 |
Onchocerca volvulus | Notchless protein homolog | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0083 | 0.2632 | 0.2632 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0056 | 0.1292 | 0.1292 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0235 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0056 | 0.1292 | 0.1292 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0083 | 0.2632 | 0.2632 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0029 | 0 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0235 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0083 | 0.2632 | 0.2632 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0083 | 0.2632 | 0.2632 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0083 | 0.2632 | 0.2632 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0235 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0083 | 0.2632 | 0.2632 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0083 | 0.2632 | 0.2632 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0056 | 0.1292 | 0.1292 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0056 | 0.1292 | 0.1292 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0083 | 0.2632 | 0.2632 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0235 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0235 | 1 | 1 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0056 | 0.1292 | 0.1292 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0056 | 0.1292 | 0.1292 |
Brugia malayi | proteasome subunit beta type 1 | 0.0083 | 0.2632 | 0.2632 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0083 | 0.2632 | 0.2632 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0235 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0083 | 0.2632 | 0.2632 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0056 | 0.1292 | 0.1292 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0235 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 10000 nM | Agonist activity at human AR | ChEMBL. | 17292608 |
EC50 (functional) | > 10000 nM | Agonist activity at human AR | ChEMBL. | 17292608 |
Ki (binding) | = 7.8 nM | Binding affinity to human AR | ChEMBL. | 17292608 |
Ki (binding) | = 7.8 nM | Binding affinity to human AR | ChEMBL. | 17292608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.