Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0084 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.004 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0084 | 1 | 1 |
Trypanosoma cruzi | 20S proteasome subunit | 0.004 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.004 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0084 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0084 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0065 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0084 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0065 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0065 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.004 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0065 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0065 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.004 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0065 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain | 0.0084 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0084 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0084 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.004 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0065 | 0.7224 | 0.7224 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.004 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.0065 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0065 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0065 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0065 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0084 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.004 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.004 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0065 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.004 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0084 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.004 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0065 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0065 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0084 | 1 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.004 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0084 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.004 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0084 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0084 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.004 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0065 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.004 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.004 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.004 | 0.3546 | 0.3546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 52 nM | Agonist activity at human AR | ChEMBL. | 17292608 |
EC50 (functional) | = 52 nM | Agonist activity at human AR | ChEMBL. | 17292608 |
Ki (binding) | = 8.5 nM | Binding affinity to human AR | ChEMBL. | 17292608 |
Ki (binding) | = 8.5 nM | Binding affinity to human AR | ChEMBL. | 17292608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.